Unraveling novel variants in the NF1 gene and investigating potential therapeutic strategies by Jianmei Huang, Ke Yang, Yaoping Wang, Xinrui Ma, Wenke Yang, Xiaodong Huo, Jie Bai, Hongjie Zhu, Jinming Wang, Yibing Lv, Shixiu Liao

“…A retrospective analysis of 49 clinical trials over the past 20 years revealed that NF1 therapies predominantly target neurofibromin’s GTPase function. Gene therapies aiming to restore neurofibromin by transducing the truncated NF1-GRD gene have been developed but faced pre-clinical challenges, including cloning capacity, transduction efficiency, and immunogenicity caused by gene delivery. …”
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Peroral endoscopic myotomy for complex achalasia and the POEM difficulty score: An update by Carmen Ching Hui Yee, Michael Youssef, Matthew Woo, Robert Bechara

“…Demographic and procedural variables were compared using descriptive and inferential statistics. …”
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Classification of traffic accidents’ factors using TrafficRiskClassifier by Wei Sun, Lili Nurliyana Abdullah, Fatimah binti Khalid, Puteri Suhaiza binti Sulaiman

“…Furthermore, the TrafficRiskClassifier model delineates a functional nexus between accident risk and variables such as weather, road conditions, and personal factors, employing a polynomial regression approach. …”
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Evaluating the level of digitalization of the innovation process with artificial intelligence approach in the digital transformation of knowledge-based companies by ali Bagheri, reza radfar, sepehr ghazinoory

“…In this method, the number of membership functions is 5 functions representing very low, low, medium, high and very high. …”
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Field Testing of a Smart Geomat Based on Fiber Optic Sensors and Sensor Fusion for Levee Monitoring by Manuel Bertulessi, Francesca Ceccato, Francesco Ioli, Federico Barbieri, Livio Pinto, Paolo Simonini, Giovanni Menduni

“…ABSTRACT Real‐time monitoring of the functionality of river embankments, especially during flood events, is an increasingly important topic in the new scenario outlined by climate change. …”
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EEGUnity: Open-Source Tool in Facilitating Unified EEG Datasets Toward Large-Scale EEG Model by Chengxuan Qin, Rui Yang, Wenlong You, Zhige Chen, Longsheng Zhu, Mengjie Huang, Zidong Wang

“…To tackle the challenges, this paper introduces EEGUnity, an open-source tool that incorporates modules of "EEG Parser", "Correction", "Batch Processing", and "Large Language Model Boost". Leveraging the functionality of such modules, EEGUnity facilitates the efficient management of multiple EEG datasets, such as intelligent data structure inference, data cleaning, and data unification. …”
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Fuzzy System for the Quality Assessment of Educational Multimedia Edition Design by Vsevolod Senkivskyy, Liubomyr Sikora, Nataliia Lysa, Alona Kudriashova, Iryna Pikh

“…A multilevel model of fuzzy logical inference is constructed, representing the dependency between quality factors. Membership functions for linguistic variables are formed and their weight coefficients are determined using pairwise comparison matrices. …”
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Elucidating Genotypic Variation in Quinoa via Multidimensional Agronomic, Physiological, and Biochemical Assessments by Samreen Nazeer, Muhammad Zubair Akram

“…The results revealed that significant variation was observed across all measured parameters, highlighting the diverse adaptive strategies and functional capacities among the tested genotypes. More specifically, genotypes Q4, Q11, Q15, and Q126 demonstrated superior agronomic potential and canopy-level physiological efficiencies, including high biomass accumulation, low infrared canopy temperatures and sustained NDVI values. …”
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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…In this way, productivity can act as a variable in forecasting and planning. For example, it is possible to predict the total output in the future by planning the growth of the labor force and the productivity of the labor force. …”
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Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…Although RNAi holds great promise as a functional genomics tool for larval schistosomes, our finding of potential off-target or nonspecific effects of some dsRNA treatments and variable efficiencies in specific gene knockdown indicate a critical need for gene-specific testing and optimization as an essential part of experimental design, execution and data interpretation.…”
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Comparative Analysis of Fully Guided and Free-Hand Orthognathic Surgery: Advancements, Precision, and Clinical Outcomes by Sophia Tsokkou, Ioannis Konstantinidis, Antonios Keramas, Georgios Kiosis, Kanellos Skourtsidis, Danai Alexiou, Georgia-Nektaria Keskesiadou, Sofia Karachrysafi, Theodora Papamitsou, Ioannis Chatzistefanou

“…Key parameters analyzed include surgical precision, operative efficiency, complication rates, and functional/aesthetic results. …”
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Neutral Mode Dominates the Forced Global and Regional Surface Temperature Response in the Past and Future by Fukai Liu, Jian Lu, L. Ruby Leung

“…Abstract Using a large suite of Green's function perturbation experiments, we construct the emergent dynamical operator for surface temperature and extract the most excitable mode. …”
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Analysis of value-based healthcare (VBHC) framework by incremental cost-effectiveness of surgical and therapeutic interventions: a retrospective study at tertiary private health gr... by Mona Khamis, Zainab Almoosa, Marie Santos, Engineer Diaa Kamal, Suhail Yaghmor, Muhammad Daniyal, Abbas Al Mutair

“…Knee and ACL therapies were the most cost-effective, while lower cost-effectiveness in CP and LBP treatments may stem from the chronic nature, variable patient responses, and high resource use. …”
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Optimization of the Fc-fusion protein refolding method produced from the bacterial expression system by P. S. Astrelina, S. A. Ishchuk, A. V. Kabanova, R. V. Drai

“…Increasing the buffer pH led to improved refolding efficiency.…”
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The Hydrodynamic Performance of a Vertical-Axis Hydro Turbine with an Airfoil Designed Based on the Outline of a Sailfish by Aiping Wu, Shiming Wang, Chenglin Ding

“…Through Latin hypercube experimental design combined with optimization algorithms, four key geometric variables governing the airfoil’s hydrodynamic characteristics were systematically analyzed. …”
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The operational municipal solid waste management policy focuses on identifying waste generation behavior across multiple levels in mega cities, a case study by Hamed Alimoradiyan, Ahmad Hajinezhad, Hossein Yousefi, Mario Giampietro

“…This study demonstrates how impact indicators other than income, like district size, financial types, and economic activity, can be identified as explanatory variables when employing Python software and the K-means method to analyze MSW generation behavior across multiple organizational levels. …”
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Swarm Intelligence Integrated Graph-Cut for Liver Segmentation from 3D-CT Volumes by Maya Eapen, Reeba Korah, G. Geetha

“…In this paper, we focus on liver segmentation from contrast-enhanced abdominal CT volumes, a challenging task due to intensity overlapping, blurred edges, large variability in liver shape, and complex background with cluttered features. …”
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Explainable AI-driven assessment of hydro climatic interactions shaping river discharge dynamics in a monsoonal basin by Prashant Parasar, Akhouri Pramod Krishna

“…The main findings of this study are (1) KAN demonstrated high predictive performance with root mean squared error (RMSE) values ranging from 42.7 to 58.3 m3/s, Nash–Sutcliffe efficiency (NSE) between 0.80 and 0.87, mean absolute error (MAE) between 28.9 to 52.7 and R2 values between 0.84 and 0.90 across stations. (2) SHAP based feature contribution analysis identified Relative humidity (hurs), specific humidity (huss), and temperature (tas) as key predictors, while (pr) showed limited contribution due to spatial inherent inconsistencies in GCM precipitation data. (3) The bootstrapped SHAP distributions highlighted substantial variability in feature importance, particularly for humidity variables, revealing station specific uncertainty patterns in model interpretation. (4) The KAN framework results indicate strong temporal alignment and physical realism, confirming KAN’s robustness in capturing seasonal discharge dynamics and extreme flow events under monsoon influence environments. (5) In this study KAN with SHAP (SHapley additive exPlanations) is implemented for hydrological modeling under monsoon-influenced and data-limited regions such as SRB, offering improved accuracy, functional precision and efficiency compared to traditional models. …”
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A Fractional Time–Space Stochastic Advection–Diffusion Equation for Modeling Atmospheric Moisture Transport at Ocean–Atmosphere Interfaces by Behrouz Parsa Moghaddam, Mahmoud A. Zaky, António Mendes Lopes, Alexandra Galhano

“…The framework employs the Caputo fractional derivative to represent temporal persistence and the fractional Laplacian to model non-local turbulent diffusion, and incorporates a stochastic term with a <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1</mn><mo>/</mo><mi>f</mi></mrow></semantics></math></inline-formula> power spectral density to simulate environmental variability. An efficient numerical solution methodology is derived utilizing complementary Fourier and Laplace transforms, which elegantly converts spatial fractional operators into algebraic expressions and yields closed-form solutions via Mittag–Leffler functions. …”
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Estimation of carbon sequestration capacity of urban green infrastructure by fusing multi-source remote sensing data by Jiahui Chang, Zhenfeng Shao, Jinyang Wang, Zhu Mao, Tao Cheng, Xiaodi Xu, Qingwei Zhuang

“…Urban green infrastructure significantly contributes to the carbon storage functions of urban ecosystems. Accurate selection and efficiently integrating remote sensing data are paramount for evaluating carbon storage at the small-scale of urban green infrastructure. …”
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