An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli by Irina Kalita, Ira Alexandra Iosub, Lorna McLaren, Louise Goossens, Sander Granneman, Meriem El Karoui

“…RecB transcription shows high fluctuations, yet cell-to-cell protein variability remains remarkably low. Here, we show that the post-transcriptional regulator Hfq binds to recB mRNA and downregulates RecB protein translation in vivo. …”
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Systematic Evaluation of Isolation Techniques and Freeze‐Thaw Effects on Plasma Extracellular Vesicle Heterogeneity and Subpopulation Profiling by Xueqi Li, Xiangyu Li, Lingjun Tong, Liqiao Hu, Yanfen Hong, Ruoyu Zhou, Zonghong Li, Ming Dong, Junjie Hou, Tao Xu, Wen Zhong

“…However, standardizing blood‐derived EV isolation remains challenging due to the heterogeneity of EV populations and variability among isolation techniques. In this study, we systematically evaluated three distinct EV isolation methods, including asymmetrical flow field‐flow fractionation (AF4), size‐exclusion chromatography (SEC) and automated centrifugal microfluidic disc system combined with functionalized membranes (Exo‐CMDS), to compare their efficiency in isolating EVs from both freshly frozen and freeze‐thawed plasma samples. …”
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Investigating the influence of soil organic carbon on pore structure within aggregates by Jingjing Liu, Yu Tian, Chiara Pasut, Mark Farrell, Shenggao Lu

“…The results revealed that the hydrogen peroxide treatment variably reduced organic carbon in soil aggregates, with Cambisol samples showing a higher removal efficiency (38.58–63.31%) compared to Ultisol samples (27.33–45.74%). …”
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FVPNet: A Fuzzy Visual Positioning Perception Network for Small Object Segmentation in Remote Sensing Images by Yu Yan, Jindong Xu, Qianpeng Chong, Guangyi Wei, Zhixiang Wang

“…Furthermore, grayscale variability intensifies boundary uncertainty, complicating accurate segmentation. …”
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Optimizing Load Frequency Control of Multi-Area Power Renewable and Thermal Systems Using Advanced Proportional–Integral–Derivative Controllers and Catch Fish Algorithm by Saleh A. Alnefaie, Abdulaziz Alkuhayli, Abdullah M. Al-Shaalan

“…Renewable energy sources (RESs) are increasingly combined into the power system due to market liberalization and environmental and economic benefits, but their weather-dependent variability causes power production and demand mismatches, leading to issues like frequency and regional power transmission fluctuations. …”
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Organic Dye Photodegradation Using Niobium-Alkali Perovskite Photocatalysts: The Effect of the Alkali by Mirtha Z. L. L. Ribeiro, Igor F. Gomes, Edher Z. Herrera, Alexandre Mello, Marília O. Guimarães, Patrícia A. Carneiro, Débora C. M. Rodrigues, Wanderlã L. Scopel, Rodrigo G. Amorim, Mauro C. Ribeiro

“…This arises as a direct result of the variably deformed NbO₆ octahedra resulting from the different alkali used. …”
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Identification and leveling of factors affecting the acceptance of excellence model in Islamic Azad University by Seyedeh Somayeh Mousavi Siah Deleh, Samad Jabbari Asl, Musa Rezvani Chaman Zamin

“…Their research showed that the variables of human resources, knowledge production infrastructure, interactions, strategy, culture, and laws and policies respectively have the greatest impact on organizational readiness for academic knowledge commercialization. …”
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Optimal selection of satellite XCO₂ images for urban CO₂ emission monitoring by A. Danjou, G. Broquet, A. Schuh, F.-M. Bréon, T. Lauvaux, T. Lauvaux

“…This study analyzes the performances of an automated method for estimating urban emissions as a function of the targeted cities and of the atmospheric conditions. …”
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Effects of curing age and magnesium slag grinding time on mechanical properties and hydration characteristics of magnesium slag-based backfill materials by Xiaobing Yang, Jian Yang, Xi Wang, Shenghua Yin, Zepeng Yan, Xizhi Zhang, Gongcheng Li, Xun Chen, Yaobin Qi, Wei Chen

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Recent Advances in Vitamin E TPGS-Based Organic Nanocarriers for Enhancing the Oral Bioavailability of Active Compounds: A Systematic Review by Chee Ning Wong, Siew-Keah Lee, Yang Mooi Lim, Shi-Bing Yang, Yik-Ling Chew, Ang-Lim Chua, Kai Bin Liew

“…Despite using the same excipient, variability in particle size, zeta potential, and encapsulation efficiency among nanocarriers indicates the need for tailored formulations. …”
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Degradation of Tetracycline in Wastewater by Persulfate Activated by Sulfidated Nanometer Zero-valent Iron by Qiuyue YE, Zhengchun HU, Ziyi WANG, Wen XU, Shiyi ZHAO, Xuying DENG, Minghao GUO, Na GUO, Bing LIAO

“…Sulfidated zero-valent iron (S–nZVI) has been extensively utilized in wastewater treatment in recent years due to its superior electron transfer efficiency and selectivity. Integrating S–nZVI with advanced oxidation technology enhances the catalytic performance of the material, leading to efficient pollutant degradation. …”
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Adult education and training for the development of problem-solving skills by I. A. Korshunov, S. V. Lubnikov, N. N. Shirkova

“…At the same time, problem-solving skills barely provide any increase in labour productivity in the routine fields, because such type of jobs does not involve behavioural variability, operational problem solving, and constant cooperation with other people.   …”
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Optimizing processing methods for maximum bioactive retention: comparative metabolomic analysis of dried loquat (Eriobotrya japonica) flowers and their powdered extracts by Mingzheng Duan, Jieming Feng, Jing-Han Feng, Xi Wang, Xu Xiao, Shirong He, Hengcui Guo, Wenyan Zhang, Zhumao Jiang, Tongfa Wan, Muhammad Junaid Rao

“…These insights guide the development of standardized loquat flower products, balancing bioactive preservation with processing efficiency for functional food and herbal medicine applications.…”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The DL model exhibited high accuracy in tissue quantification and TP53 status prediction, outperforming traditional methods in terms of precision and efficiency. DL-based approaches offer significant promise for enhancing biomarker testing and precision oncology by reducing intra- and inter-observer variability, but further validation is required to optimize their integration into real-world clinical workflows. …”
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Enhanced neurological anomaly detection in MRI images using deep convolutional neural networks by Ahmed Mateen Buttar, Zubair Shaheen, Abdu H. Gumaei, Mogeeb A. A. Mosleh, Mogeeb A. A. Mosleh, Indrajeet Gupta, Samah M. Alzanin, Muhammad Azeem Akbar

“…This study introduces a deep learning framework designed to automate neuro-diagnostics, addressing the limitations of current manual interpretation methods, which are often time-consuming and prone to variability.MethodsWe propose a specialized deep convolutional neural network (DCNN) framework aimed at detecting and classifying neurological anomalies in MRI data. …”
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Human saliva exerts strong type-dependent effects on adenovirus infectivity by Erwan Sallard, Wenli Zhang, Nikita Chilakamarri, Setareh Farzanehkari, Setareh Farzanehkari, Inga Marte Charlott Seuthe, Anja Ehrhardt, Malik Aydin, Malik Aydin

“…All human Ads used were replication-competent and expressed a GLN cassette containing a green-fluorescent protein, nano-luciferase, and neomycin resistance. Loss-of-function experiments were conducted by immunoprecipitation or enzymatic digestion of specific saliva components to decipher related mechanisms.ResultsTemporal and inter-individual variability in saliva samples were observed, validating the use of a saliva pool to represent the population. …”
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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. …”
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Neutralizing monoclonal antibodies protect against human adenovirus type 55 infection in transgenic mice and tree shrews by Xinglong Liu, Zhengfeng Li, Xiao Li, Xiaoyan Zhang, Yali Zheng, Wan Su, Ying Feng, Yutong Liu, Weixuan Wu, Xikui Sun, Nana Wang, Xianmiao Ye, Zhichao Zhou, Wenkuan Liu, Jun He, Wei Wang, Linbing Qu, Rong Zhou, Ling Chen, Liqiang Feng

“…These mAbs recognized the hyper-variable-region (HVR) 1, 2, or 7 of viral hexon protein, or the fibre knob. …”
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Supply chain management and optimization in transportation logistics by Saoussen Krichen

“…The volatile economic environment and customers’ demands variability require supply chains to be able to anticipate, control and react to disruptions and volatility, in collaboration with customers, suppliers and logistics partners. …”
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Sensitivity Analysis of Soil Hydraulic Parameters for Improved Flow Predictions in an Atlantic Forest Watershed Using the MOHID-Land Platform by Dhiego da Silva Sales, Jader Lugon Junior, David de Andrade Costa, Renata Silva Barreto Sales, Ramiro Joaquim Neves, Antonio José da Silva Neto

“…The hydraulic soil parameters of VGM are dependent on soil type and are typically estimated from experimental data; however, they are often obtained using pedotransfer functions, which carry significant uncertainty. As a result, calibration is frequently required to account for both the natural spatial variability of soil and uncertainties estimation. …”
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