CTV-MIND: A cortical thickness-volume integrated individualized morphological network model to explore disease progression in temporal lobe epilepsy by Xinyan Liu, Jiaqi Han, Xiating Zhang, Boxuan Wei, Lu Xu, Qilin Zhou, Yuping Wang, Yicong Lin, Jicong Zhang

“…This study aimed to investigate progressive changes in TLE by constructing a novel individualized morphological brain network based on T1-weighted structural magnetic resonance imaging (MRI). MRI data were collected from 34 postoperative seizure-free TLE patients and 28 age- and sex-matched healthy controls (HC), with patients divided into LONG-TERM and SHORT-TERM groups. …”
Get full text

Prevalence and risk factors of Helicobacter pylori infection in urban children aged 6–13 years in Fuzhou, China: a cross-sectional study in a high gastric cancer incidence region by Youtao Chen, Youtao Chen, Youtao Chen, Xiaoting Pan, Xiaoting Pan, Xiaoting Pan, Yanyan Wang, Yanyan Wang, Longzhen Lin, Xiaoyan Chen, Xiaoyan Chen, Yan Chen, Yan Chen, Hong Ye, Hong Ye, Hong Ye

“…BackgroundThe burden of Helicobacter pylori infection remains a global public health concern, particularly due to its lifelong risk of gastric cancer starting from childhood. Comprehensive data on the prevalence of H. pylori infection and associated risk factors among children are limited. …”
Get full text

Safety of mycophenolate mofetil in systemic lupus erythematosus maintenance therapy: insights from the LUNA registry in a nationwide prospective cohort study by Ken-ei Sada, Shuhei Yoshida, Kenji Saito, Yuya Fujita, Eisuke Inoue, Kiyoshi Migita, Naoki Matsuoka, Hiroshi Kajiyama, Ryusuke Yoshimi, Kunihiro Ichinose, Yoshia Miyawaki, Shigeru Ohno, Nobuyuki Yajima, Yasuhiro Shimojima, Shuzo Sato, Michio Fujiwara, Keisuke Nishimura, Takashi Kida, Yuya Sumichika, Haruki Matsumoto, Jumpei Temmoku, Tomoyuki Asano, Shotaro Ogawa, Jumpei Fukita, Yusuke Matsuo, Takahisa Onishi

“…Objective We aimed to compare the incidence of severe infections between mycophenolate mofetil (MMF) and other immunosuppressants in patients with systemic lupus erythematosus (SLE) on maintenance therapy using data from the Lupus Registry of Nationwide Institutions in Japan.Methods This study employed a prospective cohort design, including patients with SLE undergoing maintenance therapy. …”
Get full text

Bringing a Systems Approach to Living Donor Kidney Transplantation by Anna Horton, Katya Loban, Peter Nugus, Marie-Chantal Fortin, Lakshman Gunaratnam, Greg Knoll, Istvan Mucsi, Prosanto Chaudhury, David Landsberg, Michel R. Pâquet, Marcelo Cantarovich, Shaifali Sandal

“…Findings may be used to guide structured organizational change toward increasing LDKT and mitigating the global burden of kidney failure.…”
Get full text

The mediating role of physical activity avoidance in the association between weight stigma and physical activity by Po-Ching Huang, Hung-Ching Wu, Ji-Kang Chen, Xavier C.C. Fung, Nadia Bevan, Daniel Kwasi Ahorsu, Mark D. Griffiths, Jung-Sheng Chen, Kuo-Hsin Lee, Amir H. Pakpour, Chung-Ying Lin

“…Measurement invariance of the TAPAS was tested to ensure that the combining of data from Hong Kong and Taiwan participants was appropriate for further analysis. …”
Get full text

Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia by Melanie A. Matyi, Hamsanandini Radhakrishnan, Christopher A. Olm, Jeffrey S. Phillips, Philip A. Cook, Emma Rhodes, James C. Gee, David J. Irwin, Corey T. McMillan, Lauren Massimo

“…Methods: In a sample of 90 patients with bvFTD and 71 age-matched CNC with diffusion MRI data we generated probabilistic tractography maps and calculated system segregation, a metric that compares within-network to between-network connectivity, to reflect the extent to which brain networks were differentiated. …”
Get full text

Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains by Yue Xiang, Saixian Zhang, Yi Huang, Zhuqing Zheng, Jiahui Sun, Qiulin Zhao, Peng Zhou, Xiaolong Qi, Jingjin Li, Fuyang Xiong, Jing Xu, Shengquan Wang, Liangliang Fu, Xinyun Li

“…Results In this study, we profiled 71,798 cells from domestic pig and wild boar cerebral cortex and cerebellum, identifying nine cell types, and integrated single-cell RNA sequencing data to explore cell type-specific regulatory landscapes and oligodendrocyte developmental trajectory. …”
Get full text

Advancing molecular diagnostics of myotonic dystrophy type 1 using short-read whole genome sequencing by Ingrid Lojova, Marcel Kucharik, Zuzana Pös, Andrej Balaz, Andrea Zatkova, Eva Tothova Tarova, Jaroslav Budis, Ludevit Kadasi, Tomas Szemes, Jan Radvanszky

“…WGS was found to be superior in elucidating the sequence structure of the motifs, even if they fall outside the sizing limit (from partial reads). …”
Get full text

White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder by Xiaofu He, Diana V. Rodriguez-Moreno, Yael M. Cycowicz, Keely Cheslack-Postava, Huilan Tang, Zhishun Wang, Lawrence V. Amsel, Megan Ryan, Lupo Geronazzo-Alman, George J. Musa, Adam Bisaga, Christina W. Hoven

“…We acquired diffusion tensor-imaging (DTI) and resting state fMRI data across the whole brain. Structural connectivity was examined by measuring fractional anisotropy (FA) using DTI, to indicate integrity of the white matter tracts. …”
Get full text

The microbiologist's guide to metaproteomics by Tim Van Den Bossche, Jean Armengaud, Dirk Benndorf, Jose Alfredo Blakeley‐Ruiz, Madita Brauer, Kai Cheng, Marybeth Creskey, Daniel Figeys, Lucia Grenga, Timothy J. Griffin, Céline Henry, Robert L. Hettich, Tanja Holstein, Pratik D. Jagtap, Nico Jehmlich, Jonghyun Kim, Manuel Kleiner, Benoit J. Kunath, Xuxa Malliet, Lennart Martens, Subina Mehta, Bart Mesuere, Zhibin Ning, Alessandro Tanca, Sergio Uzzau, Pieter Verschaffelt, Jing Wang, Paul Wilmes, Xu Zhang, Xin Zhang, Leyuan Li, The Metaproteomics Initiative

“…Topics covered include experimental design, sample preparation, mass spectrometry techniques, data analysis strategies, and statistical approaches.…”
Get full text

Genomic landscape of diffuse glioma revealed by whole genome sequencing by Ben Kinnersley, Josephine Jung, Alex J. Cornish, Daniel Chubb, Ross Laxton, Anna Frangou, Andreas J. Gruber, Amit Sud, Giulio Caravagna, Andrea Sottoriva, David C. Wedge, Thomas Booth, Safa Al-Sarraj, Samuel E. D. Lawrence, Erminia Albanese, Giulio Anichini, David Baxter, Alexandros Boukas, Yasir A. Chowdhury, Pietro D’Urso, Robert Corns, Andrew Dapaah, Ellie Edlmann, Fay Greenway, Paul Grundy, Ciaran S. Hill, Michael D. Jenkinson, Sandhya Trichinopoly Krishna, Stuart Smith, Susruta Manivannan, Andrew J. Martin, Samir Matloob, Soumya Mukherjee, Kevin O’Neill, Puneet Plaha, Jonathan Pollock, Stephen Price, Ola Rominiyi, Bobby Sachdev, Fozia Saeed, Saurabh Sinha, Lewis Thorne, Ismail Ughratdar, Peter Whitfield, Amir Saam Youshani, Helen Bulbeck, Prabhu Arumugam, Richard Houlston, Keyoumars Ashkan

Get full text

Development of a zoonotic influenza distribution assessment and ranking system (ZIDAR): Technical application in Nepal to support cross-sectoral risk-based surveillance by Adam Charette-Castonguay, Dipendra Gautam, Binay Shrestha, Hemant Chandra Ojha, Barun Kumar Sharma, Mukul Upadhayaya, Sujan Rana, Roshika Shrestha, Lok Bandu Chaudhary, Bhawana Kandel, Rudra Prasad Marasini, Sharmila Chapagain, Tulsi Ram Gompo, Surendra Karki, Apsara Poudel, Saugat Shrestha, Avinash Sunny Kayastha, Arun Kumar Govindakarnavar, Reuben Samuel, Allison Gocotano, Pushpa Ranjan Wijesinghe, Nilesh Buddha, Edwin Ceniza Salvador, Manish Kakkar, Ricardo J. Soares Magalhães

“…This is then followed by a technical phase involving model building, model structure validation, data gathering and assessment of model performance. …”
Get full text

Humoral and cellular response to SARS-CoV-2 mRNA vaccine in paediatric heart transplant recipients by Amanda Bermejo-Gómez, Laura Tarancon-Diez, Beatriz Lazaro-Martin, Begoña Santiago-Garcia, Nuria Gil Villanueva, Roberto Alonso, Mª Ángeles Muñoz-Fernández, Manuela Camino López, Alicia Hernanz-Lobo, María Luisa Navarro Gómez

“…Obtaining satisfactory data on this type of response could potentially challenge the current vaccine guideline recommendations.…”
Get full text

The meaning of ‘quality’ of homecare for older people: a scoping review by Alex Hall, Vanessa Davey, Lisa McGarrigle, Jayne Astbury, Kimberly Lazo Green, Nisar Ahmed, Oleta Williams, Fiona Beyer, Barbara Hanratty, Debora Price

“…Articles were included if they reported views of any stakeholder on quality of care in the context of homecare for older people (aged 65 and above). Data were summarised using a qualitative content analysis approach to identify key dimensions of quality. …”
Get full text

Assessing antibiotic use practices on central Burkina Faso cattle farms and the associated risks to environmental and human health contamination: A pilot study by Djifahamaï Soma, Fatimata Bintou J. Diarra, Isidore Juste O. Bonkoungou, Namwin Siourimè Somda, Evariste Bako, Marguerite Edith M. Nikiema, Souleymane Sore, Natéwindé Sawadogo, Nicolas Barro, Daouda Kassié

“…Materials and Methods: In April 2023, a survey was conducted among 50 cattle farm owners and managers across four peri-urban area of Ouagadougou, Burkina Faso. Data were collected using structured questionnaires through Kobo Toolbox. …”
Get full text

NDVI Estimation Throughout the Whole Growth Period of Multi-Crops Using RGB Images and Deep Learning by Jianliang Wang, Chen Chen, Jiacheng Wang, Zhaosheng Yao, Ying Wang, Yuanyuan Zhao, Yi Sun, Fei Wu, Dongwei Han, Guanshuo Yang, Xinyu Liu, Chengming Sun, Tao Liu

“…This study utilizes field data from five major crops (cotton, rice, maize, rape, and wheat) throughout their whole growth periods. …”
Get full text

Machine learning enhanced metal 3D printing: high throughput optimization and material transfer extensibility by Yuanjie Zhang, Cheng Lin, Yuan Tian, Jianbao Gao, Bo Song, Hao Zhang, Min Wang, Kechen Song, Binghui Deng, Dezhen Xue, Yonggang Yao, Yusheng Shi, Kun Kelvin Fu

“…The high throughput methodologies are mostly on obtaining the printed samples and their structural and physical properties, while ML is used for data analysis by model building for prediction (optimization), and understanding. …”
Get full text

Short-term PM1 exposure and sleep duration: a nationwide study using consumer-grade wearable devices by Jiajun Liu, Mintao Su, Junxiong Ma, Qinfeng Zhou, Hanxu Shi, Yujie Shi, Shuyu Huang, Yuchuan Tang, Peining Zhou, Kunyao Yu, Rui Su, Rui Zhou, Jing Wei, Jing Ma, Zhenyu Zhang

“…This nationwide study included 1,100,294 records from 4,783 individuals nationwide using wearable devices to collect sleep data across China. Daily PM _1 exposure levels were derived from the China High Air Pollutants (CHAP) dataset, and hourly nighttime temperatures were obtained from the ERA5-Land dataset. …”
Get full text

MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis by Maika Itsuno, Hirokazu Tanabe, Etsuko Sano, Takashi Sasaki, Chisato Oyama, Hiroko Bannai, Koichi Saito, Kazuhiko Nakata, Setsu Endoh-Yamagami, Hideyuki Okano, Sumihiro Maeda

“…In addition, transcriptomic analysis revealed structural changes specific to excitatory neurons with the A152T mutation. …”
Get full text

OptiNeoCare: optimisation of routine care in the management of severe perinatal asphyxia in full-term or near-term newborns – study protocol for analysis of suboptimal care by conf... by Pierre-Yves Ancel, Thierry Debillon, Gilles Cambonie, Geraldine Favrais, Gilles Kayem, Hendy Abdoul, Ayoub Mitha, Isabelle Guellec, Gauthier Loron, Charles Garabedian, Thomas Desplanches, Pierre Delorme, Eric Verspyck, Cyril Huissoud, Marie Delnaud, Blanche Graesslin, Pierre Tourneux, Maliha Badr, Sophie Chapeliere, Marie Brasseur-Daudruy, Max Gonzalez Estevez, Agnes Rigouzzo

“…The quality of care will be assessed based on a structured classification of medical errors (diagnostic, therapeutic, preventive and systemic) by a panel of experts including an obstetrician or midwife and a paediatrician. …”
Get full text