Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape by Salma Kabbashi, Yvonne Prince, Ndonwi Elvis Ngwa, Haly Holmes, Glenda Mary Davison, Saarah F. G. Davids, Manogari Chetty

“…Several alpha and beta-diversity metrics assessed biodiversity within-sample and population structure between different microbiota datasets, respectively. …”
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The COMBAT Project: study protocol for the development of a core outcome set for morbidity following surgery in paediatric brain tumour patients by Sandhya Trichinopoly Krishna, Nicola Harman, Conor Mallucci, Barry Pizer, Michael D. Jenkinson, Kristian Aquilina, Kim Bull, Jon Foss-Skiftesvik, Helen Hartley, James Hayden, Colin Kennedy, Ulrich W. Thomale, Sophie Wilne, Jeffrey H. Wisoff, Faris Bouaouiche, Liz Hull, John Robinson, Hannah L. Vickers, Carrol Gamble

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Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial by Jean-Yves Reginster, J Badurski, N Bellamy, W Bensen, R Chapurlat, X Chevalier, C Christiansen, H Genant, F Navarro, E Nasonov, P N Sambrook, T D Spector, C Cooper

“…Treatment with strontium ranelate 1 and 2 g/day is associated with a significant effect on structure in patients with knee osteoarthritis, and a beneficial effect on symptoms for strontium ranelate 2 g/day.Additional supplementary data are published online only. …”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…An online survey determined prospective network focus, structure and priorities, with responses analysed using mixed methods.Survey results suggested respondents have interests in synthesising data using systems-approaches and using certain disciplines such as ‘social sciences’ within network activities. …”
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QTL mapping associated with Verticillium wilt resistance in cotton based on MAGIC population by Muhammad Ayyaz, Zewei Chang, Shugen Ding, Peng Han, Lin Xu, Abudurezike Abudukeyoumu, Irfan Ali Siddho, Zhibo Li, Hairong Lin, Jianwei Xu, Yuanlong Wu, Xinhui Nie

“…Single nucleotide polymorphism (SNP) markers and phenotypic data can be used to identify genetic markers and loci associated with cotton resistance to Verticillium wilt. …”
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Stakeholder perspectives on the effects of environmental and socio-economic factors on children's health and learning: a qualitative study in Greater Manchester, England by Sarah Daniels, Hua Wei, Anne Clayson, Martie van Tongeren, Thomas Bannan, Melanie Carder, Luke Munford, Nicola Gartland

“…The identified air quality initiatives mainly targeted traffic reduction and active travel, but evaluation of initiatives faced challenges, particularly time constraints hindering data collection, and there were mixed opinions on effectiveness. …”
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Confirmatory study on the retention rate of ketogenic diet therapy and related factors in children with drug‐resistant epilepsy: A single‐center cohort study by Jie Zhang, Qiang Gu, Yuan Wu, Han Xie, Cuijie Wei, Yao Zhang, Taoyun Ji, Xinhua Bao, Xingzhi Chang, Yuehua Zhang, Yuwu Jiang, Ye Wu

“…Methods This was a single‐center cohort study. Baseline data were collected, and regular follow‐up was conducted after KDT treatment. …”
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Patient and public involvement in the SPRUCE methodology study investigating electronic patient reported outcomes in oncology clinical trials by Morgaine Stiles, Monisha Dewan, Georgina Manning, Jessica Maudsley, Diana King, Jacqui Gath, Andy Deutsch, Esme Radin, Kim Watson, Franko Kowalczuk, Stephanie Foster, Alexa Gillman, Joanne Haviland, Elizabeth Hill, Lisa Lloyd, Robert Huddart, Emma Hall, Lara Philipps, Rebecca Lewis

“…The SPRUCE study within a trial (SWAT) investigates the impact of PRO questionnaire modality (paper or electronic) on the data received. To ensure SPRUCE is acceptable and appropriately patient-focused, we involved Patient and Public Involvement (PPI) partners throughout development and oversight. …”
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Analysis of the changes and correlation of soft and hard tissues in the lower facial third before and after BSSRO with genioplasty in patients with unilateral mandibular asymmetry by HU Shuangyu, HE Shixi, MA Cheng, LIU Liyuan, HUANG Xuanping

“…Statistical analyses of the data, including calculation of the mean, standard deviation, correlation analysis as well as significance test, were performed using SPSS 23.0. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…Ceperognastat demonstrated > 95% OGA enzyme occupancy in Phase 1 trials. These occupancy data informed the dose selection for the Phase 2 clinical program. …”
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Explanatory models and coping with alcohol misuse among conflict-affected men in Ukraine by Sergiy Bogdanov, Kateryna Koss, Kimberly Hook, Quincy Moore, Catharina Van der Boor, Alessandro Masazza, Daniela C. Fuhr, Bayard Roberts, Carl May, Olha Fedorets, Oxana Bayer, Andrii Karachevskyy, Abhijit Nadkarni

“…Qualitative data received from each subgroup were analysed separately. …”
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PSYCHOSOCIAL FACTORS AND LIFE QUALITY IN CORONARY HEART DISEASE PATIENTS: RESULTS OF THE RUSSIAN PART OF INTERNATIONAL MULTICENTER STUDY EUROASPIRE IV by N. V. Pogosova, R. G. Oganov, S. A. Boytsov, A. K. Ausheva, O. Yu. Sokolova, A. A. Kursakov, Yu. M. Pozdnyakov, A. O. Salbieva, I. N. Lelchuk, T. A. Gusarova, N. V. Gomyranova, A. V. Karpova, N. A. Eliseeva, E. B. Akhmedova, K. K. Bedeynikova, M. N. Korneeva

“…Both anxiety and depression symptoms were more common among women; depression symptoms were more common for post-MI/ ACS patients than in the re-vascularized.Conclusion. By the data from European monitoring center of EUROASPIRE IV, in Russian cohort of CHD post MI/ACS, and revascularized patients there are specific differences in comparison with overall study population in psychosocial risk factors. …”
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A 3D reconstruction platform for complex plants using OB-NeRF by Sixiao Wu, Changhao Hu, Boyuan Tian, Yuan Huang, Shuo Yang, Shanjun Li, Shengyong Xu

“…IntroductionApplying 3D reconstruction techniques to individual plants has enhanced high-throughput phenotyping and provided accurate data support for developing "digital twins" in the agricultural domain. …”
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DEVELOPMENT AND JUSTIFICATION OF THE ESTIMATION ALGORITHM OF THE BONE SYSTEM METABOLISM IN CHILDREN WITH TYPE 1 DIABETES MELLITUS by L. G. Ivchenko, I. M. Bykov, A. A. Basov, F. N. Gilmiyarova, D. A. Domenyuk, G. M.-A. Budaychiev, S. O. Ivanyuta

“…There was carried out a general clinical, laboratory, X-ray examination of 114 children with type 1 diabetes mellitus aged 7 to 12 years with an endocrinopathy experience from eight months to ten years. The obtained data were compared with the results of the examination of 35 “healthy” and “practically healthy” children of this age group. …”
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Knowledge, attitudes, and referral practices regarding animal bites and prevention of human rabies among Traditional Health Practitioners in the eThekwini District in KwaZulu-Natal... by Maxwell Mabona, Maxwell Mabona, Maxwell Mabona, Thembekile Zwane, Babongile Mhlongo, Lazarus Kuonza, Lazarus Kuonza, Poncho Phafane, Poncho Phafane

“…Our study aimed to assess the knowledge, attitudes, and referral practices regarding human rabies and the associated factors among THPs in eThekwini District, KwaZulu-Natal.MethodsA cross-sectional study was conducted among registered THPs in eThekwini District, collecting data through a structured, standardized questionnaire. …”
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Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods by Xianzong Ma, Changwei Duan, Xiaoying Wang, Yurong Tao, Lang Yang, Yongsheng Teng, Yuanming Pan, Mingjie Zhang, Junfeng Xu, Jianqiu Sheng, Xin Wang, Peng Jin

“…ABSTRACT This study investigated the longitudinal effects of acute (7-day) and prolonged (3-month) high-altitude exposure on gut microbiota in healthy adult males, addressing the limited data available in human populations. A cohort of 406 healthy adult males was followed, and fecal samples were collected at three time points: baseline at 800 m (406 samples), 7 days after ascending to 4,500 m (406 samples), and 2 weeks post-return to 800 m following 3 months at high altitude (186 samples). …”
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A qualitative study on the experience of nurses in the health education for patients with ulcerative colitis based on the Ottawa decision support framework (基于渥太华决策支持框架的护士参与溃疡性结肠炎患... by LIANG Zhuolin (梁琢琳), LI Xumiao (李旭苗), WEI Rongsai (魏荣赛), LIU Jingying (刘璟莹), ZHANG Nan (张楠), MA Hongwen (马宏文)

“…Through purposive sampling, semi-structured interviews were conducted with 11 nurses from the Department of Gastroenterology. …”
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Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep by Samantha J. Murray, Mustafa M. Almuqbel, Simon A. Felton, Nickolas J. Palmer, Ashley R. Deane, Daniel J. Myall, Reza Shoorangiz, Arsène Ella, Matthieu Keller, David N. Palmer, Tracy R. Melzer, Nadia L. Mitchell

“…Method Sheep treated at a pre‐symptomatic timepoint underwent five T1‐weighted structural MRI scans between 5 and 18 months of age. …”
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Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design by Xuanming Hong, Hui Cao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Ruqin Gao, Min Yu, Jinyi Zhou, Xianping Wu, Yu Liu, Shengli Yin, Wenjing Gao, Liming Li

“…Despite more than a thousand of obesity-related DNAm sites (CpGs) being identified, studies that account for genetic influences in these associations are limited. Results Using data from 1,074 twins in the Chinese National Twin Registry and bivariate structural equation models (SEMs), we investigated the phenotypic (Rph), genetic (Ra), and environmental (Re) correlations between genome-wide DNAm and three obesity indices: BMI, waist circumference (WC), and waist-to-hip ratio (WHR). …”
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The Boost Team: transforming outreach for female veterans in rural communities by Jenny Krause Cohen, Jenny Krause Cohen, Kara Zamora-Rogoski, Caitlin McLean, Mariam Jacob, Tara Stacker, Caroline Dancu, Caroline Dancu, Jennifer Childers

“…Of Veterans who received the outreach, 58 completed a telephone survey using the Patient Empowerment Engagement Activation Survey (PEEAS), and 21 completed a semi-structured interview. Interviews focused on experiences with the NP, Boost's impact on access to and experience of VHA care, and suggestions for program improvement. …”
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