Multifractal Analysis and Experimental Evaluation of MCM-48 Mesoporous Silica as a Drug Delivery System for Metformin Hydrochloride by Mousa Sha’at, Maria Ignat, Liviu Sacarescu, Adrian Florin Spac, Alexandra Barsan (Bujor), Vlad Ghizdovat, Emanuel Nazaretian, Catalin Dumitras, Maricel Agop, Cristina Marcela Rusu, Lacramioara Ochiuz

“…The multifractal dynamics-based theoretical release curves closely matched the experimental data. <b>Conclusions</b>: MCM-48 mesoporous silica effectively enhanced metformin delivery, offering a controlled release profile well-suited for type 2 diabetes management. …”
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Global variation in antibiotic prescribing guidelines and the implications for decreasing AMR in the future by Emmama Jamil, Emmama Jamil, Zikria Saleem, Brian Godman, Brian Godman, Brian Godman, Matti Ullah, Afreenish Amir, Abdul Haseeb, Johanna C. Meyer, Johanna C. Meyer, Muhammad Usman Qamar, Safa S. Almarzoky Abuhussain

“…The findings highlighted significant disparities in the development, adaptation, and implementation of guidelines across different WHO regions, confirming the previously noted lack of standardization and comprehensiveness in LMICs.ConclusionSignificant disparities exist in the availability, structure, and methodological rigor of antibiotic prescribing guidelines across countries with different income levels. …”
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Mechanical signaling regulates vascular smooth muscle cell adaptation in aging by Amin Mohajeri, Song Yi Shin, Samuel Padgham, Devon J. Boland, Dana Pittman Ratterree, Jacob Blizman, Gang Han, Christopher R. Woodman, Andreea Trache, Andreea Trache

“…To dissect the mechanisms involved, the structural and functional properties of VSM cells were assessed by using mechanical stimulation combined with fluorescence confocal microscopy. …”
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Chronic unilateral vestibular hypofunction: a qualitative study exploring the full spectrum of symptoms and impacts through the ICF framework by Mustafa Karabulut, Hamide Avci, Eda Yalçınkaya, Merel Kimman, Wolfgang Viechtbauer, Alfarghal Mohamad, Vincent Van Rompaey, Nils Guinand, Angélica Perez Fornos, Levent Özlüoğlu, Osman Nuri Özgirgin, Raymond van de Berg

“…Data collection continued until thematic saturation was reached. …”
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New Epitopes for the Serodiagnosis of Human Borreliosis by Mônica E. T. Alcón-Chino, Virgínia L. N. Bonoldi, Rosa M. R. Pereira, Gilberto S. Gazeta, João P. R. S. Carvalho, Paloma Napoleão-Pêgo, Andressa M. Durans, André L. A. Souza, Salvatore G. De-Simone

“…Cross-reactivity was assessed through data bank access and in vitro analysis. Among the 19 epitopes identified, four were selected for further investigation based on their signal intensity, secondary structure, and peptide matching. …”
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Dalbavancin to facilitate early discharge in the treatment of complex musculoskeletal infections: a multi-centre real-life application by T. Azamgarhi, S. Warren, A. Scobie, N. Karunaharan, C. Perez-Sanchez, R. Houghton, S. Hassan, J. Lourtet-Hascoët, J. Lourtet-Hascoët, H. Kershaw, P. Sendi, K. Saeed, K. Saeed

“…Although dalbavancin is approved for acute bacterial skin and skin structure infections, its off-label use in complex musculoskeletal infection (MSKI) is increasing. …”
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Targeting macrophages and ion homeostasis in T2D: new genes and therapeutic pathways identified by Lisha Mou, Lisha Mou, Tony Bowei Wang, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Yuxian Chen, Ziqi Luo, Xinyu Wang, Zuhui Pu, Zuhui Pu

“…Machine learning models were developed to predict T2D, and structural predictions of the hub proteins were performed. …”
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Genome-wide identification of the regulatory network of mitogen-activated protein kinase signaling cascades gene families in Hevea Brasiliensis by Xiaojuan Huang, Manman Sun, Xiaoyu Du, Lin Quan, Jinquan Chao, Xiaomin Deng, Hongze Liao

“…Conserved motifs, gene structure, and motif analysis further bolster the validity of phylogenetic classification. …”
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STREAM: a system for tracing radiative transfer and energy balance in heterogeneous surfaces by Tengyuan Fan, Zunjian Bian, Jean-Louis Roujean, Huaguo Huang, Hua Li, Junhua Bai, Biao Cao, Yongming Du, Qing Xiao, Qinhuo Liu

“…To address this problem, this study introduces a system for tracing radiative transfer and energy balance in heterogeneous surfaces, hereafter called STREAM, in which the three-dimensional structural heterogeneity is obtained through LiDAR data and a voxel-based radiosity method is proposed for radiative transfer process. …”
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Efficacy of psychosocial interventions on social functioning in individuals with childhood maltreatment experiences: a protocol for a systematic review and network meta-analysis by Natalia E. Fares-Otero, Silvia Amoretti, Brisa Solé, Sarah L. Halligan, Eduard Vieta, Stefan Leucht, Soraya Seedat, Mathias Harrer

“…Study drop-out will be a secondary outcome that will serve as a measure of acceptability. Study selection and data extraction will be performed by at least two independent reviewers. …”
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Mapping, Modeling and Designing a Marble Quarry Using Integrated Electric Resistivity Tomography and Unmanned Aerial Vehicles: A Study of Adaptive Decision-Making by Zahid Hussain, Hanan ud Din Haider, Jiajie Li, Zhengxing Yu, Jianxin Fu, Siqi Zhang, Sitao Zhu, Wen Ni, Michael Hitch

“…UAV methodology involved data collection using a DJI Mavic 2 Pro (20 MP camera) with 4 K resolution images captured at 221 m altitude and 80 min flight duration. …”
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Ethical issues in implementation science: perspectives from a National Heart, Lung, and Blood Institute workshop by Neal W. Dickert, Donna Spiegelman, Jennifer S. Blumenthal-Barby, Garth Graham, Steven Joffe, Jeremy M. Kahn, Nancy E. Kass, Scott Y. H. Kim, Meeta P. Kerlin, Aisha T. Langford, James V. Lavery, Daniel D. Matlock, Kathleen N. Fenton, George A. Mensah

“…Similarly, even when research is exempt and informed consent unnecessary, Data Safety and Monitoring Board oversight of implementation studies may be advisable to ensure quality, address unexpected consequences, and identify overwhelming evidence of benefit. …”
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Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An in vivo biomechanical study by Mingfeng Lu, Mingfeng Lu, Wei Chen, Jinpeng Lin, Jinpeng Lin, Wenhan Huang, Junqing Gao, Junqing Gao, Lilian Zhao, Shilin Li, Lilei He, Yu Zhang

“…ObjectiveThe aim of this study is to assess the kinematic changes in the knee joint during walking in patients with isolated PCL-deficiency (PCLD) to determine the presence of walking-related joint instability (mechanical instability—abnormal displacement form structural damage). Additionally, the study seeks to provide biomechanical insights into the observed differences between subjective and objective assessments.Methods35 healthy volunteers and 27 patients with isolated PCLD (both involved and uninvolved sides) were included in the study. …”
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Enhancing nurses’ communication about psychosocial needs and changes in intimacy and sexuality in patients with advanced cancer: a mixed-method study by Susanne A.M. Arends, Corien M. Eeltink, Floortje K. Ploos van Amstel, Astrid W. Oosten, Donna C. Ruijter, Nelleke van der Loo, Barbara Harterink-Poker, Anneke L. Francke, Irene P. Jongerden

“…Methods: Between 2022 and 2023, we conducted a mixed methods study in six hospitals in The Netherlands. Data were collected three months before and three months after the training course. …”
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Usefulness of differential somatic cell count for udder health monitoring: Effect of intramammary infections, days in milk, quarter location, and parity on quarter-level differenti... by Mariana Fonseca, Daryna Kurban, Jean-Philippe Roy, Débora E. Santschi, Elouise Molgat, Simon Dufour

“…Given the hierarchical structure of the data, a 4-level, linear mixed model with herd, cow, and quarter as random intercepts was built with either SCS or DSCC as the outcome. …”
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Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…Characterization techniques such as FTIR, XRD, SEM, and EDS reveal a highly porous morphology due to NiO nanoparticle integration within the OP matrix, a structure that provides numerous active sites for adsorption. …”
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Synthesis of the serotonin derivative 5-PT and establishment of a research system for protein serotonylation by XIAO Shuyu, TULAMATI Aziguli, YANG Yan, ZHANG Zhigang, YANG Xiaomei, DU Chang, ZHANG Xueli

“…Mass spectrometry analysis data showed that a significant amount of serotonylated proteins were enriched in various cells treated with 5-PT. …”
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Seroprevalence of anti-SARS-CoV-2 antibodies and risk of viral exposure among healthcare workers in the South Kivu province, eastern Democratic Republic of the Congo: a cross-secti... by Denis Mukwege, Andreas Kalk, Tim Eckmanns, Andreas Nitsche, Fabian H Leendertz, Tshass B Chasinga, Jean-Paul Buhendwa Cikwanine, Sarah Kribi, Jonathan Tunangoya Yoyu, Natalie Hofmann, Marica Grossegesse, Sara Tomczyk, Ann C Vietor, Aline B Kusinza, Eric Munguakonkwa, Maroyi Raha, Nelson S Kambale, Rodrigue B Ayagirwe, Grit Schubert

“…The present study aims to measure the impact of SARS-CoV-2 on HCWs in central sub-Saharan Africa.Setting A cross-sectional serological study was conducted at six urban and five rural hospitals during the first pandemic wave in the South Kivu province, Democratic Republic of the Congo (DRC).Participants Serum specimens from 1029 HCWs employed during the first pandemic wave were collected between August and October 2020, and data on demographics and work-related factors were recorded during structured interviews.Primary and secondary outcome measures The presence of IgG antibodies against SARS-CoV-2 was examined by ELISA. …”
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Complementary medicine among individuals experiencing homelessness in Switzerland: a quantitative and qualitative descriptive study by Véronique S. Grazioli, Evelyne Hangartner, Patrick Bodenmann, Luana Schaad, Léa Grosjean, Justin Nikles, David J. T. Campbell, Laurent Hyvert, Tshahé Anongba Varela, Susan E. Collins, Caroline Leblanc, Christine Loignon, Chantal Berna

“…A subsample of the survey participants (n = 18) and 14 professionals working in the homeless-serving sector participated in semi-structured interviews exploring perceived utility of CM for PEH. …”
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Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of <i>Streptococcal</i> Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China by Zhen Cheng, Qingquan Shi, Bo Peng, Zijun Zhang, Zhenyu Wei, Zhiqun Wang, Yang Zhang, Kexin Chen, Xizhan Xu, Xinxin Lu, Qingfeng Liang

“…<b>Methods:</b> This retrospective study reviewed data from 350 patients diagnosed with <i>Streptococcal</i> keratitis at Beijing Tongren Hospital between January 2006 and December 2023, including demographics, risk factors, clinical signs, in vivo confocal microscopy (IVCM) imaging, and antibiotic susceptibility testing. …”
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