Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy by Florencia B. González, Florencia B. González, Antonella Pacini, Araceli Castro, Susana Lioi, Silvina R. Villar, Silvina R. Villar, Luciano D’Attilio, Luciano D’Attilio, Rodolfo D. Leiva, Rodolfo D. Leiva, Liliana Favaloro, Oscar A. Bottasso, Oscar A. Bottasso, Carlos A. Vigliano, Carlos A. Vigliano, Ana Rosa Pérez, Ana Rosa Pérez

“…IntroductionChronic Chagasic Cardiomyopathy (CCC) has an infectious and inflammatory nature. Recent data also suggest an association with altered regulation of glucocorticoid (GC)-mediated circuits failing to control systemic inflammation. …”
Get full text

SMOC2 inhibits calcification of osteoprogenitor and endothelial cells. by Tine Peeters, Silvia Monteagudo, Przemko Tylzanowski, Frank P Luyten, Rik Lories, Frédéric Cailotto

“…Furthermore, SMOC2 was able to impair mineralization in transdifferentiated human umbilical vein endothelial cells. Taken together, our data indicate that SMOC2 can act as an inhibitor of mineralization. …”
Get full text

Application of the monitoring and early warning system for internal solitary waves: Take the second natural gas hydrates production test in the South China Sea as an example by Dan-yi Su, Bin-bin Guo, Qian-yong Liang, Chu-jin Liang, Fei-long Lin, Su-meng Jiang, Yi-fei Dong, Xue-min Wu

“…To avoid their damage to offshore engineering, a new generation of monitoring and early warning system for ISWs was developed using technologies of double buoys monitoring, intelligent real-time data transmission, and automatic software identification. …”
Get full text

The Pavlov University experience in medical assistance for patients with the novel coronavirus infection: first results and lessons by S. F. Bagnenko, Yu. S. Polushin, I. V. Shlyk, V. M. Teplov, E. A. Karpova, E G. Gavrilova, A. A. Afanasyev, A. A. Khryapa, I. V. Bovkun, L. M. Kalmanson, D. A. Malinina, R. D. Skvortsova, E. A. Korobenkov

“…Here we compare the organizational approaches during the first and second waves of the pandemic and present the characteristics of the demographic data of the treated patients, the incidence of certain complications, and outcomes.Results. …”
Get full text

Genetic Diversity of Selective Breeding Populations of Giant Freshwater Prawn (<i>Macrobrachium rosenbergii</i>) Based on SSR and Mitochondrial D-Loop Gene by Salifu Ibrahim, Amin Ruhul, Jingfen Li, Guoliang Yang, Shaokui Yi, Zhenglong Xia, Miaoying Cai, Yuewen Deng, Qiongying Tang

“…The microsatellite data revealed that all 16 loci have high diversity, with all values of polymorphism information content (<i>PIC</i>) more than 0.5. …”
Get full text

Engagement of Indigenous peoples in commercial tobacco reform strategies: a scoping review protocol by Andrew Waa, Raglan Maddox, El-Shadan Tautolo, Michelle Kennedy, Patricia Nez Henderson, Hershel Clark, Priscilla Nez, Penney Upton, Andrew Daniel Perusco, Sydney A. Martinez, Sierra Wilcox, Jeyasakthi Venugopal

“…Papers will be screened by two reviewers to determine eligibility, followed by full-text data extraction. Findings will be synthesised descriptively for each review question and by region. …”
Get full text

The Role of Potassium and KUP/KT/HAK Transporters in Regulating Strawberry (<i>Fragaria</i> × <i>ananassa</i> Duch.) Fruit Development by José A. Mercado-Hornos, Claudia Rodríguez-Hiraldo, Consuelo Guerrero, Sara Posé, Antonio J. Matas, Lourdes Rubio, José A. Mercado

“…The chromosomal distribution of the FaKUP gene family and phylogenetic relationship and structure of predicted proteins were thoroughly examined. …”
Get full text

Disruption and recovery of family planning, contraception and other sexual and reproductive health services in Brazil with COVID-19 pandemic: a mixed methods approach by Luis Bahamondes, Jose G. Cecatti, Aline Munezero, Rachel E. Soeiro, Karayna G. Fernandes, Samira M. Haddad, Silvana Ferreira Bento, Karla S. Padua, Vilma Zotareli, Charles M. Charles, Montas Laporte, Caron Kim, Vanessa Brizuela, Moazzam Ali, for the WHO HRP Social Science Research Team

“…Abstract Background Limited scientific evidence is available on the impact of COVID-19 on Sexual and Reproductive Health (SRH). Some data shows that severe disruptions in SRH services expose women to preventable health risks. …”
Get full text

Barriers and supports for Indigenous youth and young adults with childhood- onset chronic health conditions transitioning from pediatric to adult healthcare: a qualitative study by Andrew S. Mackie, Mandi Gray, Alyssa Chappell, Kira Dlusskaya, Rick Lightning, Larry Listener, Arrol Crier, Barbara Dumigan-Jackson, Audrey Thomas, Bonny Graham, Randy Littlechild, Joshua Lightning, Azure Johnson, Patricia Rain, Maxine Cutarm, Richard T. Oster

“…Methods The research was done in the province of Alberta, Canada, in collaboration with a Community Advisory Committee comprised of Indigenous healthcare providers, Elders and Knowledge Keepers and guided by a community-based participatory research approach. Semi-structured qualitative interviews (n = 46) were conducted with Indigenous youth, caregivers, and healthcare providers. …”
Get full text

Modeling and Simulation of Automotive FMCW RADAR Sensor for Environmental Perception by Arsalan Haider, Abdulkadir Eryildirim, Marcell Pigniczki, Lukas Haas, Birgit Schlager, Thomas Zeh, David Nickel, Alexander W. Koch

“…This work presents the design and structure of a ray-tracing-based, high-fidelity, tool-independent baseband FMCW RADAR sensor model. …”
Get full text

Social Determinants of Health Associated With SARS-CoV-2 Testing and Vaccine Attitudes in a Cross-Sectional Study of Latinx Individuals in Oregon by Elizabeth L. Budd, PhD, MPH, Stephanie De Anda, PhD, Sven Halvorson, MS, Leslie D. Leve, PhD, Anne Marie Mauricio, PhD, Ellen H. McWhirter, PhD, Jorge I. Ramírez García, PhD, David S. DeGarmo, PhD

“…Methods: Cross-sectional survey data were collected between January and December 2022. …”
Get full text

Exploring prevalence and factors associated with depression and anxiety symptoms among Bangladeshi graduates: a GIS-based cross-sectional study by Abdullah Al Habib, Imtiaz Uddin, Mehedee Hasan, Firoj Al-Mamun, Moneerah Mohammad Almerab, David Gozal, Mohammed A. Mamun

“…A cross-sectional study was conducted among graduates from two public universities in Bangladesh, using face-to-face interviews and a semi-structured questionnaire. Data were collected between March and April 2024 through convenience sampling. …”
Get full text

Dishwashing practice and its determinants among food handlers in food and drinking service establishments in Dessie City and Kombolcha Town, Northeastern Ethiopia by Mekonnen Moges, Metadel Adane, Balew Adane, Genanew Mulugeta Kassaw, Abraham Teym, Getasew Yirdaw, Lake Kumlachew, Agernesh Ayele, Yenewa Bewket, Mesfin Gebrehiwot

“…To bridge this gap, this study proposes to evaluate the dishwashing practice employed by food handlers in food and drinking establishments and its determinants in Dessie City and Kombolcha Town, Northeastern Ethiopia.Methods and MaterialsAn institution-based cross-sectional study was done on 405 food handlers from 405 food and drinking establishments from 25 June 2022 to 25 August 2022 in Dessie City and Kombolcha Town. Data were collected by pre-tested semi-structured questionnaires and observational checklists. …”
Get full text

Development and Validation of the EBP‐Affinity Questionnaire: A Mixed‐Method Study by Lenny J. Tange, Maud Heinen, Raymond T.C.M. Koopmans, Dirk F. deKorne, Anke Persoon, Robert Lindeboom, Debby L. Gerritsen, Marleen H. Lovink

Get full text

Case Report: Phenotypic heterogeneity within an NF1 family: assessment of the pathogenicity of a de novo c.6640dupA shift mutation and a splice variant with an epilepsy phenotype by Sijing Ren, Sijing Ren, Sijing Ren, Yanling Wang, Xinhua Tong, Xiaoyu Wu, Xiaoyu Wu, Huan Yan, Huan Yan, Qing-Xia Kong, Qing-Xia Kong, Qing-Xia Kong

“…The identified genes were validated using Sanger sequencing, and alterations in the tertiary structural physicochemical properties of the mutant proteins were analyzed using AlphaFold2 bioinformatics software.ResultsWe identified two mutation sites in the NF1 gene of the patient. …”
Get full text

Patient navigation in German emergency care (NODE). Study protocol of a multi-center mixed-methods trial by Daniela Krüger, Maria Altendorf, Felix Holzinger, Cornelia Wäscher, Hanna Winkler, Martin Möckel, Christoph Heintze, Judith Stumm, Konrad Schmidt, Konrad Schmidt, Anna Slagman

“…This study includes four working modules: (1) a systematic literature review; (2) qualitative semi-structured interviews with patients (n∼15–20), as well as four focus group interviews with health care providers (n∼5); (3) a prospective multi-centre cohort study in adult, self-referred emergency patients at two time points (t0: n = 1,031; t1: n = 344), primary endpoint: proportion of patients treated other than standard emergency care, secondary endpoints: secondary efficiency, patient-reported outcome measures (PROMs), patient safety, quality of care, clinical outcomes, and cost-effectiveness; participant observation of patients' treatment trajectories and organizational processes at three different patient navigation models (n∼10–15), an online provider survey; and (4) data triangulation and recommendations for practice and policy.DiscussionThis is the first study to compare different patient navigation and cooperation models to standard ED care in Germany and evaluate their effectiveness. …”
Get full text

Knowledge, perception, and attitude toward COVID-19 vaccines in the Ho township, Volta region by Vivian Tackie, Christiana Asiedu, Ewoenam Darkey, Beatrice Hammond, Linda Jailer, Janet Osei Konadu, Samuel Otieku Cyril, Williams Marie Noel, Isaac Aidoo Erzuah

“…The response rate was 99.5% (441). A structured questionnaire was used to collect the data. …”
Get full text

Community-Dwelling Filipino Older Adults’ Experiences with Virtual Coach for Health-Enhancing Physical Activity (HEPA): A Phenomenology by Michael Joseph S. Dino, Kenneth W. Dion, Peter M. Abadir, Chakra Budhathoki, Patrick Tracy Balbin, Ma. Kristina G. Malacas, Rommel P. Hernandez, Jacquelyn Joyce G. Nicolas, Jhal Barcial-Espinosa, Cheryl R. Dennison Himmelfarb, Patricia M. Davidson, Ladda Thiamwong

“…MAXQDA was used to thematically analyze the qualitative data. <b>Results:</b> Nine key informants shared their experiences with the virtual coach-driven physical exercise program using mixed reality. …”
Get full text

The relationship between educational and scientific regulatory interventions and socio-economic development in military conflict-affected countries: A Sustainable Development Goals... by Dariusz Krawczyk, Nadiia Artyukhova, Dmytro Svynarenko, Anna Vorontsova, Artem Artyukhov, Robert Rehak, Tetiana Vasylieva

“…Type of the article: Research Article AbstractThis study investigates the structural relationships between educational and scientific regulatory interventions and socio-economic development in countries affected by armed conflict and political instability, using the framework of Sustainable Development Goals (SDGs), specifically SDG 4 (Quality Education), SDG 8 (Decent Work and Economic Growth), and SDG 9 (Industry, Innovation and Infrastructure). …”
Get full text

Identity in turmoil: Investigating the morally injurious dimensions of minority stress by Andrew A. Nicholson, Sandhya Narikuzhy, Jakub Wolf, Mina Pichtikova, Magdalena Siegel, James Mirabelli, Taylor Hatchard, Niki Hosseini-Kamkar, Ella Bawagan, Sophia L. Roth, Christina Mutschler, Ruth A. Lanius, Fardous Hosseiny, Kristen Eckstrand, Brigitte Lueger-Schuster

“…Using a convergent parallel mixed-methods design, we conducted semi-structured qualitative interviews, performed clinical assessments, and administered a comprehensive battery of quantitative measures. …”
Get full text