Benchmarking AlphaMissense pathogenicity predictions against APP, PSEN1, and PSEN2 variants of unknown significance by Joshua Pillai, Sophia Liu, Kijung Sung, Linda Shi, Chengbiao Wu

“…AlphaMissense (AM) is a novel technology that uses population frequency data along with structural and sequential contexts from AlphaFold to predict the pathogenicity of missense mutations. …”
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Implementing Continuous All-sky Monitoring with the OVRO-LWA to Identify Prompt and Precursor Counterparts of Gravitational Wave Events by Nikita Kosogorov, Gregg Hallinan, Casey Law, Jack Hickish, Jayce Dowell, Marin M. Anderson, Judd D. Bowman, Ruby Byrne, Morgan Catha, Bin Chen, Sherry Chhabra, Larry D’Addario, Ivey Davis, Katherine Elder, Dale Gary, Charlie Harnach, Greg Hellbourg, Rick Hobbs, David Hodge, Mark Hodges, Yuping Huang, Andrea Isella, Daniel C. Jacobs, Ghislain Kemby, John T. Klinefelter, Matthew Kolopanis, James Lamb, Nivedita Mahesh, Surajit Mondal, Brian O’Donnell, Kathryn Plant, Corey Posner, Vinand Prayag, Andres Rizo, Andrew Romero-Wolf, Jun Shi, Greg Taylor, Mike Virgin, Akshatha Vydula, Sandy Weinreb, David Woody, Sijie Yu, Peijin Zhang, Yifan (Amy) Zhao

“…We detail the system’s buffer structure that allows data collection from several minutes before a trigger event, up to 30 minutes after an event. …”
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A systematic review on environmental DNA (eDNA) Science: An eco-friendly survey method for conservation and restoration of fragile ecosystems by Ashish Sahu, Mahender Singh, Adnan Amin, Monisa Mehboob Malik, Shariq Nazir Qadri, Adnan Abubakr, S.Surya Teja, Shabir Ahmad Dar, Ishtiyaq Ahmad

“…It addresses various pipelines, databases, and software tools, essential for accurate data interpretation. The areas for improvement in eDNA science and future directions are also presented that can improve sensitivity, scalability, and reliability. …”
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Impact of residential density on heavy metal mobilization in urban soils: Human activity patterns and eco-health risks in the Beijing-Tianjin-Hebei region by Siyu Wang, Lingqing Wang, Xiaoyong Liao, Guangjin Zhou, Yizhong Huan, Shun Li, Tao Liang

“…Co-occurrence network and Partial Least Squares Structural Equation Modeling (PLS-SEM) suggested that human activities may indirectly influence metal dispersion by altering soil organic carbon (TOC) and nitrogen dynamics, rather than directly increasing bulk metal content. …”
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Abundant Molecular Gas in the Central Region of Lenticular Galaxy PGC 39535 by Jiantong Cui, Qiusheng Gu, Shiying Lu, Zhengyi Chen, Can Xu, Zeyu Gao

“…In this paper, we investigate one massive ( M _* ∼ 5 × 10 ^10 M _⊙ ) star-forming S0, PGC 39535, with the Northern Extended Millimeter Array (NOEMA). Using optical data from the Sloan Digital Sky Survey IV Mapping Nearby Galaxies at the Apache Point Observatory survey, we find star formation mainly concentrates in the central region of PGC 39535. …”
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Diabetes and periodontitis: the role of a high-glucose microenvironment in periodontal tissue cells and corresponding therapeutic strategies by Dan-dan Xiang, Yu-xin Sun, Chen Jiao, Yu-qian Guo, Yu-xiang Fei, Bai-qiang Ren, Xiao-Tao He, Xuan Li

“…Both of these diseases affect many people worldwide. Epidemiological data have revealed a close relationship between periodontitis and diabetes. …”
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Evaluation of the oil and gas preservation conditions, source rocks, and hydrocarbon-generating potential of the Qiangtang Basin: New evidence from the scientific drilling project by Li-jun Shen, Jian-yong Zhang, Shao-yun Xiong, Jian Wang, Xiu-gen Fu, Bo Zheng, Zhong-wei Wang

“…Moreover, the Qiangtang Basin has favorable oil and gas preservation conditions, as verified by the comprehensive study of the sealing capacity of seals, basin structure, tectonic uplift, magmatic activity, and groundwater motion. …”
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Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation by Chiara Sassoli, Federica Pierucci, Alessia Tani, Alessia Frati, Flaminia Chellini, Francesca Matteini, Ambra Vestri, Giulia Anderloni, Daniele Nosi, Sandra Zecchi-Orlandini, Elisabetta Meacci

“…Notably, active S1PR1/MMP-2 signalling is required for F-actin structure assembly (lamellipodia, microspikes, and stress fibers) and, in turn, cell proliferation. …”
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Immunization Coverage and Barriers among Hajj and Umrah Pilgrims: Insights into Vaccine Uptake and Compliance by Adeeb A. Bulkhi, Hani M. Almoallim, Majed S. Obaid, Nahla H. Hariri, Hamsah S. Alqashqri, Ismail A. Alghamdi, Amar Mohammad A. Alkhotani, Muhammad Irfanullah Siddiqui, Heba M. Adly, Mohammed A. Garout, Elbagir A. Elfaki, Saleh A. K. Saleh, Noura Mohammed Bakhsh, Raghda Sami Hassan H. Alhazmi, Aous S. Alhazmi, Jaffar A. Al-Tawfiq, Fahad A. Alamri, Anas A. Khan

“…Methods A cross-sectional study was conducted during the 2024 Hajj season, with data collected via structured interviews from 5,355 participants. …”
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Embracing Growth, Adaptability, Challenges, and Lifelong Learning: A Qualitative Study Examining the Lived Experience of Early Career Nurses by Liz Ryan, Di Stratton-Maher, Jessica Elliott, Tracey Tulleners, Geraldine Roderick, Thenuja Jayasinghe, Joanne Buckley, Jamie-May Newman, Helen Nutter, Jo Southern, Lisa Beccaria, Georgina Sheridan, Danielle Gleeson, Haiying Wang, Sita Sharma, Jing-Yu (Benjamin) Tan, Linda Ng, Blake Peck, Tao Wang, Daniel Terry

“…Thematic analysis was used to analyse data while adhering to the consolidated criteria for reporting qualitative research (COREQ) guidelines. …”
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Mammography in 2022, from Computer-Aided Detection to Artificial Intelligence Applications by Filippo Pesapane, Chiara Trentin, Marta Montesano, Federica Ferrari, Luca Nicosia, Anna Rotili, Silvia Penco, Mariagiorgia Farina, Irene Marinucci, Francesca Abbate, Lorenza Meneghetti, Anna Bozzini, Antuono Latronico, Alessandro Liguori, Giuseppe Carrafiello, Enrico Cassano

“…Objective: During the last decades, advances in computing power, structured data, and algorithm development, developed a technology based on Artificial intelligence (AI) which is currently applied in medicine. …”
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From ECG to Ablation: A Modern Review of Wolff-Parkinson-White Syndrome by Agata Krupa, Maria Potrykus, Przemysław Klasicki, Maciej Mozer, Wiktor Możarowski, Anna Krawczyk, Michał Pałuchowski, Jan Mateńko, Julia Kiełbratowska, Wiktoria Pietruszka

“…Based on current data, the prevalence of electrographic features of pre-excitation is estimated at 0.15-0.25% in the general population. …”
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A Probability Fusion Approach for Foot Placement Prediction in Complex Terrains by Jingfeng Xiong, Chuheng Chen, Yuanwen Zhang, Xinxing Chen, Yuepeng Qian, Yuquan Leng, Chenglong Fu

“…In the first part, a deep learning model is trained on augmented data to predict the probability distribution of preliminary foot placement. …”
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Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis by Ruth Steinberg, Nadja Mostacci, Elisabeth Kieninger, Bettina Frauchiger, Carmen Casaulta, Jakob Usemann, Alexander Moeller, Daniel Trachsel, Isabelle Rochat, Sylvain Blanchon, Dominik Mueller-Suter, Barbara Kern, Maura Zanolari, Urs Frey, Kathryn A. Ramsey, Markus Hilty, Philipp Latzin, Insa Korten, SCILD study group, BILD study group

“…While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF. …”
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Factors influencing the perceived usability of line pay: An extended technology acceptance model approach by Yogi Tri Prasetyo, Krisna Chandra Susanto, Ko-Hui Chuang, Ruo-Ting Yin, Jia-Wei Chen, Yu-Xuan Zhang, Omar Paolo Benito, Zachariah John A. Belmonte, Maela Madel L. Cahigas, Reny Nadlifatin, Ma. Janice J. Gumasing

“…Utilizing an extended Technology Acceptance Model (TAM), the research integrated additional variables such as social influence, trust, security, and environmental concerns, offering a comprehensive framework to understand user adoption dynamics. 120 Taiwanese participants were surveyed by employing the Purposive Sampling Method and data were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). …”
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Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential by Pengfei Bao, Taiwei Wang, Xiaofan Liu, Shaozhen Xing, Hanjin Ruan, Hongli Ma, Yuhuan Tao, Qing Zhan, Efres Belmonte-Reche, Lizheng Qin, Zhengxue Han, Minghui Mao, Mengtao Li, Zhi John Lu

“…When test in real and artificial cfRNA sequencing (cfRNA-seq) data, cfPeak shows an improved performance compared with other applicable methods. …”
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Epidemiological and clinical features of lymphoproliferative diseases in the head and neck region by F. Sh. Kamolova, A. M. Mudunov, P. A. Zeynalova, L. Yu. Grivtsova, G. F. Allakhverdieva, R. I. Azizyan, A. A. Akhundov, I. A. Zaderenko, M. V. Bolotin, D. K. Stelmakh, V. I. Sokorutov, K. D. Il’kaev, V. T. Tsiklauri, I. M. Gelfand, M. B. Pak, O. L. Timofeeva, Yu. E. Ryabukhina, F. M. Abbasbeyli, Ts. Chzhao

“…The frequency of head and neck lymphoproliferative diseases detection was estimated based on the study of epicrisis and clinical data of 174 patients hospitalized at the N.N. Blokhin National Medical Research Center of Oncology in the period from 2000 to 2020.Results. …”
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Protocol for a systematic review and meta-analysis on the effects of cold-water exposure on mental health by Steven Schepanski, Steven Schepanski, Florian Batta, Florian Batta, Marleen Schröter, Marleen Schröter, Georg Seifert, Georg Seifert, Anna Katharina Koch, Anna Katharina Koch

“…Random-effects meta-analyses will be conducted where sufficient data are available. The review will provide a structured quantitative synthesis of cold-water exposure’s effects on mental health, helping to bridge the gap between popular claims and empirical evidence. …”
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Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV by Evans O. Mudibo, Jasper Bogaert, Caroline Tigoi, Moses M. Ngari, Benson O. Singa, Christina L. Lancioni, Abdoulaye Hama Diallo, Emmie Mbale, Ezekiel Mupere, John Mukisa, Johnstone Thitiri, Molline Timbwa, Elisha Omer, Narshion Ngao, Robert Musyimi, Eunice Kahindi, Roseline Maïmouna Bamouni, Robert H. J. Bandsma, Paul Kelly, Andrew J. Prendergast, Christine J. McGrath, Kirkby D. Tickell, Judd L. Walson, James A. Berkley, James M. Njunge, Gerard Bryan Gonzales

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Response of Montane Fish Biodiversity to Landscape and Anthropogenic Activity Under Potential Water Quality Pathways by Wenjun Zhong, Wanjuan Bi, Yan Zhang, Feilong Li, Zehua Zhang, Xiangyun Huang, Xunjie Liu, Yifan Wang, Song Zhang, Shan Xu, Loïc Pellissier, Xiaowei Zhang

“…First, eDNA‐derived taxonomic composition (R = 0.97 against catch data) demonstrated Cypriniformes and Perciformes dominance. …”
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