ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA by Ole Kristian Greiner-Tollersrud, Máté Krausz, Vincent Boehler, Aikaterini Polyzou, Maximilian Seidl, Ambra Spahiu, Zeinab Abdullah, Katarzyna Andryka-Cegielski, Felix Immunuel Dominick, Katrin Huebscher, Andreas Goschin, Cristian R. Smulski, Eirini Trompouki, Regina Link, Hilmar Ebersbach, Honnappa Srinivas, Martine Marchant, Georgios Sogkas, Dieter Staab, Cathrine Vågbø, Danilo Guerini, Sebastian Baasch, Eicke Latz, Gunther Hartmann, Philippe Henneke, Roger Geiger, Xiao P. Peng, Bodo Grimbacher, Eva Bartok, Ingrun Alseth, Max Warncke, Michele Proietti

“…We characterize its DNA substrate preferences and provide data suggesting that DNA, rather than free adenosine, is its natural substrate. …”
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Longitudinal analysis of lifestyle risk factors, nutrition status and drivers of food choice among urban migrants in Ulaanbaatar, Mongolia, and Almaty, Kazakhstan: a formative stud... by Sabri Bromage, Shamil Tazhibayev, Xin Zhou, Chang Liu, Enkhtsetseg Tserenkhuu, Oksana Dolmatova, Munkhbat Khishignemekh, Leyla Musurepova, Wusigale, Soninkhishig Tsolmon, Enkhjargal Tsendjav, Davaasambuu Enkhmaa, Rajesh Kumar Rai, Bayarmaa Enkhbat, Bilige Menghe, Davaasambuu Ganmaa

“…Design: We collected panel data on household structure, drivers of food choice, nutrition knowledge and diverse measures of nutrition status and lifestyle risk from urban migrants at 0, 3, 6 and 9 months using harmonised methodology in two cities. …”
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Episodic thrusting and sequence-sedimentary responses and their petroleum geological significance in Kuqa foreland basin, NW China by Haijun YANG, Suyun HU, Xianzhang YANG, Mingyi HU, Huiwen XIE, Liang ZHANG, Ling LI, Lu ZHOU, Guowei ZHANG, Haoyu LUO, Qingjie DENG

“…This study integrates field outcrop profiles, drilling cores, 2D seismic profiles, and 3D seismic data of key areas to analyze the Triassic tectonic-sequence stratigraphy in the Kuqa foreland basin, and investigates the impact of episodic thrust structures on sedimentary evolution and source rock distribution. (1) The Kuqa foreland basin has experienced stages of initial strong, weakened activities, relaxation and inactivity of episodic thrusting, resulting in the identification of 4 second-order sequences (Ehebulake Formation, Karamay Formation, Huangshanjie Formation, Taliqike Formation) and 11 third-order sequences (SQ1–SQ11) in the Triassic strata. …”
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Two novel plasmids harbouring the multiresistance gene cfr in porcine Staphylococcus equorum by Ning Xie, Tengfei Ma, Yuan Gao, Jiani Fu, Chune Tan, Zheng Wang, Zhuo Wang, Henrike Krüger-Haker, Andrea T. Feßler, Congming Wu, Jianzhong Shen, Stefan Schwarz, Yang Wang

“…De novo hybrid assembly was performed by Unicycler. Genomic data were assessed by in silico prediction and bioinformatic tools. …”
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Profiling of Bacterial Communities of Hospital Wastewater Reveals Clinically Relevant Genera and Antimicrobial Resistance Genes by Clemente Cruz-Cruz, Javier Gaytán-Cervantes, Carolina González-Torres, Andres Emmanuel Nolasco-Rojas, Miguel Ángel Loyola-Cruz, Laura Delgado-Balbuena, Josué Delgado-Balbuena, Marianela Paredes-Mendoza, María Concepción Tamayo-Ordóñez, Yahaira de Jesús Tamayo-Ordoñez, Emilio Mariano Durán-Manuel, Araceli Rojas-Bernabé, Carlos Alberto Jiménez-Zamarripa, Oscar Sosa-Hernández, Omar Agni García-Hernández, Esther Ocharan-Hernández, Paola Berenice Zárate-Segura, Elizabeth González-Terreros, Daniel Alejandro Ramírez-Villanueva, Claudia Camelia Calzada-Mendoza, Juan Manuel Bello-López

“…So far, there are no studies that analyse this problem comprehensively, relating bacterial population structures, chemical contaminants, and seasonality. …”
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Identification and expression analysis of ACBPs family members of Hippophae rhamnoides subsp. sinensis Rousi in response to lead stress by CHEN Ke, LI Xinjuan, ZHANG Tian, REN Qiandan, SUN Jing, ZHOU Wu

“…Multiple sequence alignment and gene structure analyses were conducted using MEGA software and the GSDS website. …”
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Constraints on self-interaction cross-sections of dark matter in universal bound states from direct detection by G. Angloher, S. Banik, G. Benato, A. Bento, A. Bertolini, R. Breier, C. Bucci, J. Burkhart, E. Cipelli, L. Canonica, A. D’Addabbo, S. Di Lorenzo, L. Einfalt, A. Erb, F. v. Feilitzsch, S. Fichtinger, D. Fuchs, A. Garai, V. M. Ghete, P. Gorla, P. V. Guillaumon, S. Gupta, D. Hauff, M. Ješkovský, J. Jochum, M. Kaznacheeva, A. Kinast, S. Kuckuk, H. Kluck, H. Kraus, A. Langenkämper, M. Mancuso, L. Marini, B. Mauri, L. Meyer, V. Mokina, M. Olmi, T. Ortmann, C. Pagliarone, L. Pattavina, F. Petricca, W. Potzel, P. Povinec, F. Pröbst, F. Pucci, F. Reindl, J. Rothe, K. Schäffner, J. Schieck, S. Schönert, C. Schwertner, M. Stahlberg, L. Stodolsky, C. Strandhagen, R. Strauss, I. Usherov, F. Wagner, V. Wagner, V. Zema, CRESST Collaboration

“…Abstract $$\varLambda $$ Λ -Cold Dark Matter ( $$\varLambda $$ Λ CDM) has been successful at explaining the large-scale structures in the universe but faces severe issues on smaller scales when compared to observations. …”
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Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Ju Huang, Jing Li, Jing Li, Zhijun Geng, Zhijun Geng, Lixia Yin, Lixia Yin, Minzhu Niu, Qingqing Li, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Xue Song, Yueyue Wang, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu, Jianguo Hu

“…Background and aimsPatients with Crohn’s disease (CD) exhibit excessive apoptosis of intestinal epithelial cells (IECs), which contributes to damage to the intestinal barrier structure and function, thereby playing a role in the progression of colitis. …”
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Study of the influence of population immunity to tick-borne encephalitis virus on the characteristics of the epidemic process in Russia by Temur K. Muminov, Vladimir A. Gushchin, Vladimir A. Gushchin, Vladimir A. Gushchin, Denis A. Kleymenov, Artem P. Tkachuk, Artem P. Tkachuk, Viktor A. Manuylov, Viktor A. Manuylov, Andrei E. Siniavin, Andrei E. Siniavin, Daria A. Ogarkova, Nadezhda A. Kuznetsova, Vladimir I. Zlobin, Alexander L. Gintsburg, Alexander L. Gintsburg

“…All volunteers completed questionnaires to collect demographic data, information about residence, TBE vaccination, and tick bites.ResultsOur study included participants from non-endemic (Moscow and the Republic of Dagestan) and endemic regions (Moscow Region, St. …”
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Childbearing and Family Instability: The Impact of Children on Women's Divorce Probability in Iran by Davoud Shahpari Sani, Mohammad Jalal Abbasi Shavazi

“…A secondary analysis of two-percent sample from the 2016 census data reveals that both childlessness and the number of children in a household significantly affect the probability of divorce among women. …”
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Fertility intentions among Chinese adults: a cross-sectional study using a national survey by Mingyan Hao, Chenxiao Zhang, Haofeng Fu, Jingting Zhang, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Chen Chen, Yajing Zhou, Jianzhong Zheng, Wei Liu, Lizheng Wang

“…Methods In our research, we performed a cross-sectional analysis using data gathered in 2022 from the Psychology and Behavior Investigation of Chinese Residents (PBICR), which encompassed 21,916 participants aged 18 to 49 years. …”
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Measurement-guided therapeutic-dose prediction using multi-level gated modality-fusion model for volumetric-modulated arc radiotherapy by Changfei Gong, Changfei Gong, Changfei Gong, Yuling Huang, Yuling Huang, Yuling Huang, Junming Jian, Junming Jian, Junming Jian, Wenheng Zheng, Wenheng Zheng, Wenheng Zheng, Xiaoping Wang, Xiaoping Wang, Xiaoping Wang, Shenggou Ding, Shenggou Ding, Shenggou Ding, Yun Zhang, Yun Zhang, Yun Zhang

“…The purpose of this study is to develop a novel deep learning model for measurement-guided therapeutic-dose (MDose) prediction from head and neck cancer radiotherapy data.MethodsThe enrolled 310 patients underwent volumetric-modulated arc radiotherapy (VMAT) were randomly divided into the training set (186 cases, 60%), validation set (62 cases, 20%), and test set (62 cases, 20%). …”
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Cross-species comparison of rodent and human decision-making in the Iowa Gambling Task in select neurological and psychiatric disorders: translational approach to examine age- and... by Varsha Singh, Manjari Tripathi, Sarat P. Chandra, Rohit Verma, Sushil Kumar Jha, Harvinder Singh Chhabra, Mrinmoy Chakravarty, Mrinmoy Chakravarty, Shambhovi Mitra, Indupriya B, Ankit Jha, Sakshi Sharma, Jyotsna Pandey, Divyanshi Pandey, Insha Shamshad, Ekta Ahlawat, Titli Saha, Chloé César, Suman Jain

“…This non-analogous structural–functional mapping of brain regions and cognitive deficits result in rodent models that fail to establish causal links of brain pathophysiology and clinical conditions, and the model remains a poor depiction of cognitive deficits experienced by humans. …”
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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…A two-compartment model with first-order absorption and elimination best described the data. Ceftriaxone one-hour infusions only achieved the minimum PK/PD target when the 2 g/12 h regimen was tested. …”
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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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Distinct subnetworks of the mouse anterior thalamic nuclei by Houri Hintiryan, Mitchell Rudd, Sumit Nanda, Adriana E. Gutierrez, Darrick Lo, Tyler Boesen, Luis Garcia, Jiandong Sun, Christian Estrada, Hyun-Seung Mun, Seita Yamashita, Yeji E. Han, Ian Bowman, Lin Gou, Chunru Cao, Jennifer Gonzalez, Keivan Moradi, Qiuying Zhao, Inga Yenokian, Aishwarya Dev, Brian Zingg, Hanpeng Xu, Qing Xue, Muye Zhu, Lijuan Liu, Xin Chen, Zhixi Yun, Hanchuan Peng, Nicholas N. Foster, Hong-Wei Dong

“…Therefore, the ATN provide a promising avenue to investigate the relationship between structural and functional complexity with neuron type diversity. …”
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An Integrated Global‐To‐Regional Scale Workflow for Simulating Climate Change Impacts on Marine Ecosystems by Kelly Ortega‐Cisneros, Denisse Fierros‐Arcos, Max Lindmark, Camilla Novaglio, Phoebe Woodworth‐Jefcoats, Tyler D. Eddy, Marta Coll, Elizabeth Fulton, Ricardo Oliveros‐Ramos, Jonathan Reum, Yunne‐Jai Shin, Cathy Bulman, Leonardo Capitani, Samik Datta, Kieran Murphy, Alice Rogers, Lynne Shannon, George A. Whitehouse, Ezekiel Adekoya, Beatriz S. Dias, Alba Fuster‐Alonso, Cecilie Hansen, Bérengère Husson, Vidette McGregor, Alaia Morell, Hem‐Nalini Morzaria Luna, Jazel Ouled‐Cheikh, James Ruzicka, Jeroen Steenbeek, Ilaria Stollberg, Roshni C. Subramaniam, Vivitskaia Tulloch, Andrea Bryndum‐Buchholz, Cheryl S. Harrison, Ryan Heneghan, Olivier Maury, Mercedes Pozo Buil, Jacob Schewe, Derek P. Tittensor, Howard Townsend, Julia L. Blanchard

“…Standardizing input and output data is a crucial step in evaluating and communicating results, but can be challenging when using models with diverse structures, assumptions, and outputs that address region‐specific issues. …”
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Abstract 082: Angiographic Features and Treatment Results of Dural Arteriovenous Fistulas Cognitive Impairment by Sebastian A. Sanchez, Linder Wendt, Chen Ching‐Jen, Minako Hayakawa, Edgar Samaniego, Jason Sheehan, Louis Kim, Issac Abecassis, Michael Levitt, Michael Meyer, Ridhima Guniganti, Akash Pabaney, Giuseppe Lanzino, Enrico Giordan, Waleed Brinjikji, Diederik Bulters, Santiago Ortega, Andrew Durnford, Gregory Zipfel, W Fox, Colin Derdeyn, Jessica Smith, Bradley Gross, Sepideh Amin‐Hanjani, Ali Alaraj

“…Venous hypertension may impair critical structures such as the thalamus or the cortex leading to rapid cognitive impairment. …”
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Unearthing the climate history of the Atacama Desert in northern Chile – deep drilling in two clay pans of the Coastal Cordillera by V. Wennrich, J. Diederich-Leicher, B. N. Blanco-Arrué, B. N. Blanco-Arrué, C. Büttner, S. Buske, E. Campos Sepulveda, T. Dunai, J. Feller, E. Galego, A. Hasberg, N. Leicher, D. A. López, J. Maldonado, A. Medialdea, A. Medialdea, L. Ninnemann, L. Ninnemann, R. Perryman, J. C. Ríos-Contesse, B. Ritter, S. Scheidt, B. Vargas-Machuca, P. Yogeshwar, P. Yogeshwar, M. Melles

“…</p> <p>Lithological data and downhole-logging results of the deep-drilling operations reveal strong heterogeneities in the sediment composition that presumably can be traced back to major climatic and/or tectonic shifts in the catchments of the clay pans. …”
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Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study by Hussein Okasha, Eyad Gadour, Ghias Un Nabi Tayyab, Andrada Seicean, Elbacha Hicham, Emad Emad, Turki Alamri, Nadeem Tehami, Heero Ismael Faraj, Ahmed Alzamzamy, Hiwa Hussein, Mohammed Tag-Adeen, Mohamed Elbasiony, Abed Al-Lehibi, Shereen Saleh, Zaher Houmani, Mohamed Abdelghani, Khaled Ragab, Zahi Ismaili, Othmane Drir, Elsayed Ghoneem, Omar Abdallah, Souad Rebiai, Nonthalee Pausawasdi, Fedoua Rouibaa, Mohamed Borahma, Hassan Atalla, Mahmoud Farouk, Ahmed Altonbary

“…Abstract Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. …”
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