Actions to Improve the Secondary Prevention of Fragility Fractures in Women with Postmenopausal Osteoporosis: A Social Return on Investment (SROI) Study by Olmo-Montes FJ, Caeiro-Rey JR, Peris P, Pérez del Río V, Etxebarria-Foronda Í, Cancio-Trujillo JM, Pareja T, Jódar E, Naranjo A, Moro-Álvarez MJ, García-Goñi M, Vergés J, Maratia S, Campos Tapias I, Prades M, Aceituno S

“…Unitary costs were sourced from scientific literature and official data, and intangible costs were estimated through surveys on women’s willingness to pay for better health-related quality of life. …”
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Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer by Vladimira Zlinska, Zuzana Feketova, Aleksandra Czyrek, Julia Chudzian, Martina Lenarcic Zivkovic, Vlad-Constantin Ursachi, Pooja Dudeja, Bohumil Fafilek, Jan Rynes, Gustavo Rico-Llanos, Adolf Koudelka, Tanaya Roy, Martyna Biadun, Vendula Raskova, Katerina Svozilova, Michaela Stroblova, Mateusz Krzyscik, Kalina Hristova, Daniel Krowarsch, Silvie Foldynova-Trantirkova, Malgorzata Zakrzewska, Lukas Trantirek, Pavel Krejci

“…We show that the VZ23 inhibits FGFR1 signaling in the presence of cognate fibroblast growth factor (FGF) ligands and its inhibitory activity is linked to its capacity to form unusual G-quadruplex structure. Our data suggest that targeting FGFR1 with DNA aptamers could be an effective alternative to TKIs for treating impaired FGFR1 signaling in human craniosynostoses.…”
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Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…Methods: This registry study collected data up to 10 years posttransplant. Survival analysis for a composite end point of graft loss or estimated glomerular filtration rate (eGFR) ≤ 30 ml/min per 1.73 m2 or ≥50% decline from eGFR at month 3 posttransplant was performed. …”
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Key technologies for exploration and geological evaluation of deep carbon storage spaces by Wenping LI, Danping CAO, Wei QIAO, Zhengwu ZHOU, Qingliang CHANG, Songhang ZHANG, Shuangxing LIU, Yi SHEN, Wanjun LI, Xin FU, Bo LIU, Yan WANG, Qiqing WANG, Xiaoqin LI, Zhi YANG, Cong LIU, Zheng ZHANG, Hongjie XU, Zhennan ZHU, Xianggang CHENG

“…To address the complexity of deep carbon storage spaces, integrated seismic and electrical exploration technologies significantly improve reservoir identification accuracy: full-waveform inversion (FWI) characterizes pore-fracture structures, gravity-magnetic inversion constructs deep structural models, and multiphysical data fusion reduces the non-uniqueness of inversion results. …”
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Possible Carbon Dioxide above the Thick Aerosols of GJ 1214 b by Everett Schlawin, Kazumasa Ohno, Taylor J. Bell, Matthew M. Murphy, Luis Welbanks, Thomas G. Beatty, Thomas P. Greene, Jonathan J. Fortney, Vivien Parmentier, Isaac R. Edelman, Samuel Gill, David R. Anderson, Peter J. Wheatley, Gregory W. Henry, Nishil Mehta, Laura Kreidberg, Marcia J. Rieke

“…Further modeling of the planet’s atmosphere, interior structure and origins will provide valuable insights about how sub-Neptunes like GJ 1214 b form and evolve.…”
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Nematodes exposed to furfural acetone exhibit a species-specific vacuolar H+-ATPase response by Wanli Cheng, Wei Dai, Wen Chen, Hua Xue, Zhengzheng Zhao, Zhengbing Jiang, Huanan Li, Jiashu Liu, Feng Huang, Minmin Cai, Longyu Zheng, Ziniu Yu, Donghai Peng, Jibin Zhang

“…Our results illuminate the molecular mechanism underlying the differential toxicity of FAc to different nematodes, and provide valuable data for the comprehensive risk assessment of FAc release into the environment.…”
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Design and rationale of MYOFLAME-19 randomised controlled trial: MYOcardial protection to reduce post-COVID inFLAMmatory heart disease using cardiovascular magnetic resonance Endpo... by Valentina O. Puntmann, Dietrich Beitzke, Andreas Kammerlander, Inga Voges, Dominik D. Gabbert, Marcus Doerr, Bishwas Chamling, Biykem Bozkurt, Juan Carlos Kaski, Erica Spatz, Eva Herrmann, Gernot Rohde, Philipp DeLeuw, Lenka Taylor, Christine Windemuth-Kieselbach, Cornelia Harz, Marta Santiuste, Laura Schoeckel, Juliana Hirayama, Peter C. Taylor, Colin Berry, Eike Nagel

“…Secondary endpoints include assessment of changes of symptoms, CMR parameters, and CPET after W16, and frequency of major adverse cardiac events after 1 year. Safety data will be analyzed for frequency, severity, and types of adverse events (AEs) for all treatment groups. …”
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Identification, Evolution and Expression Analyses of the Hox Family in Procambarus clarkii by Xiaoyu WEI, Qian HU, Zemao GU, Yanhe LI

“…The sequence structure, protein physicochemical properties, motif composition, phylogenetic characteristics, and adaptive evolutionary features were analyzed. …”
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The issue of sustainable land use in Ukraine taking into account the consequences of the war by Liudmyla Datsenko, Svitlana Titova, Marharyta Dubnytska, Oksana Kustovska

“…The land use system reveals an interconnected set of objects and subjects that function as a single whole in the natural environment, operating with information that is a product that comes from the environment, or a pragmatic part of structural information accumulated by the system itself. …”
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Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…However, the levels of endogenous IgG in this brain structure were significantly elevated in DS mice compared to controls, directly indicating the occurrence of extravasation into the brain parenchyma and indirectly that the BBB in DS mice may be relatively affected, a fact confirmed by the reduction in the levels of BBB-related proteins such as ZO-1 in these mice. …”
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A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response by Xiao‐Ming Lyu, Xiao‐Wei Zhu, Manli Zhao, Xian‐Bo Zuo, Zhong‐Xi Huang, Xiao Liu, Tao Jiang, Xue‐Xi Yang, Xin Li, Xiao‐Bing Long, Jian‐Guo Wang, Jin‐Bang Li, Ming‐Yu Han, Shuang Wang, Teng‐Fei Liu, Bo Zhang, Tao Sun, Zhi Cheng, Mo‐Chang Qiu, Lei Dong, Lu Zheng, Long‐Cheng Zhang, Jia‐Hong Wang, Gan‐Guan Wei, Kaitai Yao, Qian Wang, Hou‐Feng Zheng, Xin Li

“…Abstract The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes. …”
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Mapping the Filamentary Nebula of NGC 1275 with Multiwavelength SITELLE Observations by Carter Lee Rhea, Julie Hlavacek-Larrondo, Marie-Lou Gendron-Marsolais, Benjamin Vigneron, Megan Donahue, Auriane Thilloy, Laurie Rousseau-Nepton, Mar Mezcua, Norbert Werner, Jorge Barrera-Ballesteros, Hyunseop Choi, Alastair Edge, Andrew Fabian, G. Mark Voit

“…The filamentary nebula encompassing the central galaxy of the Perseus Cluster, NGC 1275, is a complex structure extending dozens of kiloparsecs from NGC 1275. …”
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Social networks, environmental, and individual factors associated with COVID-19 vaccination and booster uptake– The prospective PRIME cohort study by Céline J.A. van Bilsen, Lisanne C.J. Steijvers, Stephanie Wagner, Demi M.E. Pagen, Senne M.C.E. Wijnen, Kevin Konings, Christian J.P.A. Hoebe, Annemarie Koster, Nicole H.T.M. Dukers-Muijrers

“…Methods: In the PRIME longitudinal cohort study, we used online questionnaires to collect baseline data at the end of 2021, including participants' COVID-19 vaccination status and various factors, i.e., structural and functional social network characteristics (interpersonal factors), societal (social and physical living environment) community (work and social participation), and individual (sociodemographics, health) factors. …”
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Brain dynamics alterations induced by partial sleep deprivation: An energy landscape study by Yutong Wu, Liming Fan, Wei Chen, Xing Su, Simeng An, Nan Yao, Qian Zhu, Zi-Gang Huang, Youjun Li

“…We found that the energy landscapes of the younger and older groups had similar hierarchical structures, including two major states and two minor states. …”
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MWA and VLA Observations of Diffuse Radio Lobes in M87 by Linhui Wu, Fu-Guo Xie, Qian Zheng, Quan Guo, Huanyuan Shan, Dan Hu, Stefan W. Duchesne, Nick Seymour, Jingying Wang, Junhua Gu, Qingwen Wu, Zhenghao Zhu, Melanie Johnston-Hollitt, Christopher J. Riseley, Xu-Liang Fan

“…This study investigates the projected, quasi-symmetric ∼46 kiloparsec-scale diffuse radio lobes surrounding the giant elliptical galaxy M87, utilizing well-sampled wideband (60 MHz–10.55 GHz) observations from the Murchison Widefield Array and Very Large Array, supplemented by data from the Low-frequency Array and Effelsberg. …”
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Open Innovation the Impact of Social Capital on Tourism Growth Through the Mediating Role of Open Innovation (Case study: The municipality of Khomam County) by Seyed Hamed Hashemi, Hossein Poorghasem

“…This research is applied in terms of purpose and is survey-based for data collection. Moreover, from a methodological perspective, it employs a correlational design; the data collection tool used in this study was a questionnaire, rated using a Likert scale, and its reliability was assessed using Cronbach's alpha. …”
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Genealogy of the Arab tribes living in Syria during the Caliphate of Imam Ali (AS)Typology of the Arab Tribes Living in the Levant during the Caliphate of Imam Ali (AS) Typology... by Akram sadat Hoseini, Yahya Mirhoseini

“…It can be said that without such statistical data, in-depth historical analyses would be unavailable. …”
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Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency by A. Jerrod Anzalone, Sharon Patrick, Amber Abel, Brad Price, Elizabeth Reisher, Kent Ripplinger, Mary Emmett, Ronald Horswell, San Chu, William B. Hillegass, Francisco S. Sy, Brian Melancon, H. Timothy Bunnell, Lucio Miele, Mary Helen Mays, Joseph Keawe‘aimoku Kaholokula, Elizabeth S. Chen, Karen M. Crowley, Indra Neil Sarkar, Susan L. Santangelo, Clifford J. Rosen, Jeremy Harper, David Bard, William Beasley, Sally L. Hodder

“…Methods: We developed an organizational structure across the IDeA-CTRs to improve research productivity in resource-challenged areas of the U.S. …”
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Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis by Tingting Zhu, Qixia Shen, Lingling Shen, Yucheng Wang, Bochen Zhu, Lifeng Ma, Shi Feng, Cuili Wang, Sijing Yan, Jingyi Li, Zhimin Chen, Jingyi Zhou, Hongfeng Huang, Bingjue Li, Zhouji Shen, Qian Wang, Jianwei Wang, Wilfried Gwinner, Irina Scheffner, Song Rong, Bing Yang, Junwen Wang, Hermann Haller, Xiaoping Han, Guoji Guo, Zhinan Yin, Jin Jin, Hui-Yao Lan, Jianghua Chen, Hong Jiang

“…Age-related functional and structural changes in the immune system have been observed, yet the precise influence of aged immunity on kidney transplant remains unclear. …”
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Surgical management and postoperative outcomes of orbital cavernous malformations: A systematic literature review by the EANS skull base section by Edoardo Agosti, Vittorio Ricciuti, Giorgio Mantovani, Giorgia De Rosa, Pier Paolo Panciani, Marco Maria Fontanella, Cesare Zoia, Moncef Berhouma, Michaël Bruneau, Luigi Maria Cavallo, Jan Frederick Cornelius, Sebastien Froelich, Emmanuel Jouanneau, Diego Mazzatenta, Torstein R. Meling, Mahmoud Messerer, Dimitris Paraskevopoulos, Pierre-Hugues Roche, HenryWS. Schroeder, Marcos Tatagiba, Idoya Zazpe, Roy Thomas Daniel

“…Studies reporting surgical treatment of OCMs with clinical outcome data were included. Study quality was assessed using the Newcastle-Ottawa Scale. …”
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