Tagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing by Jianxia Niu, Wenxi Wang, Zihao Wang, Zhe Chen, Xiaoyu Zhang, Zhen Qin, Lingfeng Miao, Zhengzhao Yang, Chaojie Xie, Mingming Xin, Huiru Peng, Yingyin Yao, Jie Liu, Zhongfu Ni, Qixin Sun, Weilong Guo

“…Abstract Background The massive structural variations and frequent introgression highly contribute to the genetic diversity of wheat, while the huge and complex genome of polyploid wheat hinders efficient genotyping of abundant varieties towards accurate identification, management, and exploitation of germplasm resources. …”
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Molecular characteristic, evolution, and pathogenicity analysis of avian infectious bronchitis virus isolates associated with QX type in China by Yuanlu Lu, Yiran Zeng, Haowei Luo, Bingchen Qiao, Qi Meng, Zijian Dai, Na Chen, Lingcai Zhao, Xianchen Meng, Haitao Zhang, Jun Xia, Jihui Ping

“…Our data indicate antigenicity variances between QX isolates and QXL87 vaccine strains, potentially resulting in immune evasion occurrences. …”
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Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…In this study, we systematically analyzed functional magnetic resonance imaging (fMRI) data from two distinct cohorts: an In-house dataset includes 59 AD patients (73.37 ± 6.42 years), and the ADNI dataset includes 117 AD patients (74.91 ± 7.91 years). …”
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Understanding the Broad-line Region of Active Galactic Nuclei with Photoionization. I. The Moderate-accretion Regime by Qiaoya Wu, Yue Shen, Hengxiao Guo, Scott F. Anderson, W. N. Brandt, Catherine J. Grier, Patrick B. Hall, Luis C. Ho, Yasaman Homayouni, Keith Horne, Jennifer I-Hsiu Li, Donald P. Schneider

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Prognostic impact of small size sutureless prostheses: results for 241 patients from an international registry by Giuseppe Santarpino, Roberto Lorusso, Giovanni Concistrè, Josè Cuenca Castillo, Vincenzo Argano, Alistair Royse, Angelo Lucas Nobre, Patrick Parrino, Gianluigi Bisleri, Max Baghai, Theodor Fischlein, Giovanni Troise, Generoso Mastrogiovanni, Raphael Fontaine, Davide Pacini, Giuseppe Minniti, Aniello Pappalardo, George Chad Hughes, Philippe Noirhomme, Jean-Philippe Grimaud, Maximilian Scherner, Ignacio Muñoz, George Asimakopoulos, Antony Walker, Daniela Zakova, Michele Torella, Giorgio Vigano, Mark Connolly, Christian Dinges, Pierre Corbi, Loris Salvador, Mauro Rinaldi, Luis Maroto, David Heimansohn, Basel Ramlawi, Mattia Glauber, Jlenia D’Agnano, Valeria Cosco, Veronica D’Anna, Marco Solinas

“…Abstract Background The treatment of aortic valve disease in small annuli remains a debated topic in terms of prosthetic choice - biological or mechanical - and risk of patient prosthesis mismatch. Methods The clinical data of the 241 patients who received a small size sutureless prosthesis from the Sorin Universal REgistry on Aortic Valve Replacement (SURE-AVR) (NCT02679404) were analysed at 30 days and at follow-up. …”
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Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model. by Ernesto Luna, Pankaj Agrawal, Riyaz Mehta, Maria E Boone, Charlotte Vernhes, Colombe Denys, Robert Small, Bhaswati Mukherjee, Norbert Tennagels, Stefan Maerten, Donald R Drake

“…<h4>Background</h4>The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. …”
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Validation of Quantitative Ultrasound and Texture Derivative Analyses-Based Model for Upfront Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer by Adrian Wai Chan, Lakshmanan Sannachi, Daniel Moore-Palhares, Archya Dasgupta, Sonal Gandhi, Rossanna Pezo, Andrea Eisen, Ellen Warner, Frances C. Wright, Nicole Look Hong, Ali Sadeghi-Naini, Mia Skarpathiotakis, Belinda Curpen, Carrie Betel, Michael C. Kolios, Maureen Trudeau, Gregory J. Czarnota

“…Among all patients, 53 were treated with neoadjuvant chemotherapy and three had unplanned changes in their chemotherapy cycles. Radio Frequency (RF) data were collected volumetrically prior to the start of chemotherapy. …”
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Genome-Wide Identification of <i>G3BP</i> Family in U’s Triangle <i>Brassica</i> Species and Analysis of Its Expression in <i>B. napus</i> by Alain Tseke Inkabanga, Qiheng Zhang, Shanshan Wang, Yanni Li, Jingyi Chen, Li Huang, Xiang Li, Zihan Deng, Xiao Yang, Mengxin Luo, Lingxia Peng, Keran Ren, Yourong Chai, Yufei Xue

“…We then analyzed their gene structure, protein motifs, gene duplication type, phylogeny, subcellular localization, SSR loci, and upstream miRNAs. …”
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Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease by Da-Ya Zhang, Da Li, Shi-Ju Chen, Li-Jun Zhang, Xu-Li Zhu, Fa-Di Chen, Chen Chen, Qi Wang, Yiping Du, Jian-Xin Xiong, Shi-Mei Huang, Xiao-Dong Zhang, Yan-Ting Lv, Fan Zeng, Run-Xiang Chen, Xianfeng Huang, Fengjiao Mao, Shuo Zhou, Qicen Yao, Yuliang Huang, Runyu Chen, Ying Mo, Yunqian Xie, Yue-Hong Jiang, Zhai Chen, Cui-Yi Mo, Jia-Jia Chen, Fei-Hu Bai

“…Combined analysis of metabolomic and metagenomic data achieved high diagnostic accuracy for MAFLD and hepatic steatosis severity (AUC = 0.93). …”
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Correlates of duration between initial drug use and first drug injection among people who inject drugs in Iran, 2020 by Zahra Abdolahinia, Zahra Jaafari, Ali Karamoozian, Soheil Mehmandoost, Nima Ghalekhani, Mehrdad Khezri, Ghazal Mousavian, Mostafa Shokoohi, Ali Mirzazadeh, Ali Akbar Haghdoost, Mohammad Karamouzian, Mohammad Mehdi Gooya, Samaneh Akbarpour, Hamid Sharifi, Fatemeh Tavakoli

“…Policymakers should prioritize evidence-based, multi-faceted approaches that target both individual and structural factors to delay or prevent the transition to injection drug use and reduce associated health risks.…”
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Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

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Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy by Jorge Barrios, Evan Porter, Dante P. I. Capaldi, Taman Upadhaya, William C. Chen, Julian R. Perks, Aditya Apte, Michalis Aristophanous, Eve LoCastro, Dylan Hsu, Payton H. Stone, Javier E. Villanueva-Meyer, Gilmer Valdes, Fei Jiang, Michael Maddalena, Ase Ballangrud, Kayla Prezelski, Hui Lin, Jinger Y. Sun, Muhtada A. K. Aldin, Oi Wai Chau, Benjamin Ziemer, Maasa Seaberg, Penny K. Sneed, Jean L. Nakamura, Lauren C. Boreta, Shannon E. Fogh, David R. Raleigh, Jessica Chew, Harish Vasudevan, Soonmee Cha, Christopher Hess, Ruben Fragoso, David B. Shultz, Luke Pike, Shawn L. Hervey-Jumper, Derek S. Tsang, Philip Theodosopoulos, Daniel Cooke, Stanley H. Benedict, Ke Sheng, Jan Seuntjens, Catherine Coolens, Joseph O. Deasy, Steve Braunstein, Olivier Morin

“…Additionally, the deep brain structures are relatively spared from metastasis, regardless of primary cancer type. …”
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Population-based cross-sectional seroprevalence study of SARS-CoV-2 infection in urban residential areas in Ghana by John H Amuasi, Aurélia Souares, Eva Lorenz, Wibke Loag, Anthony Afum-Adjei Awuah, Sylvester Newton, Christian Obirikorang, Evans Asamoah Adu, Eric Ebenezer Amprofi Boham, Alexander Owusu Boakye, Hakim Alani, Nana Safi Almoustapha, James Deke, Welbeck Odame Dzadey, Louis Adu-Amoah, Sally-Ann Kroduah, Mary Ama Grant, Gracelyn Asare, Amos Amoako-Adusei, Jenny Kettenbeil, Yaw Adu Sarkodie, Ebenezer Oduro, Alfred E Yawson, Stephen Apanga, Rose Odotei Adjei, Austin Gideon Adobasom Anane, Oumou Maiga Ascofare, May Jurgen, Nicole S Struck

“…Bayesian models with poststratification weighting of the demographic structure of the sample population were used for seroprevalence estimates, accounting for the uncertainty of diagnostic assay in a hierarchical model. …”
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Enhancing regeneration and functionality of excitable tissues via integrating bioelectronics and bioengineered constructs by Zijie Meng, Bingsong Gu, Cong Yao, Jiaxin Li, Kun Yu, Yi Ding, Pei He, Nan Jiang, Dichen Li, Jiankang He

“…These interactions enable precise data acquisition and localized modulation of cell and tissue functionalities through intricately designed electronic components according to physiological needs. …”
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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

“…Intensive study of the T6SS structure has led to an understanding of certain issues related to its functional activity, but the exact regulatory mechanisms of E-I protein pair activity remain unclear. …”
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The MaNGA Dwarf Galaxy Sample (MaNDala): Stellar Profiles and Gradients Characterization by M. Cano-Díaz, A. Rodríguez-Puebla, A. C. Robleto-Orús, V. Ávila-Reese, H. M. Hernández-Toledo, J. A. Vázquez-Mata, O. Valenzuela, J. J. González, H. J. Ibarra-Medel, J. C. Clemente-González, L. Pavón-Alvarez

“…We derived robust radial profiles and inner/outer gradients of various stellar population (SP) properties for a sample of 124 bright dwarf galaxies, 10 ^7.53 ≤ M _* / M _⊙ ≤ 10 ^9.06 , from the MaNDala sample, using integral field spectroscopy observations. Given the complex structure of dwarf galaxies, we explored four different methods to derive SP radial profiles: two based on concentric elliptical rings, and the other two exploiting the spatially resolved nature of the data. …”
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A Rare Case of Exophiala Dermatitidis Isolation in a Patient with Non-Cystic Fibrosis Bronchiectasis: Colonization or True Infection? by Francesco Rocco Bertuccio, Nicola Baio, Simone Montini, Valentina Ferroni, Vittorio Chino, Lucrezia Pisanu, Marianna Russo, Ilaria Giana, Elisabetta Gallo, Lorenzo Arlando, Klodjana Mucaj, Mitela Tafa, Maria Arminio, Emanuela De Stefano, Alessandro Cascina, Angelo Guido Corsico, Giulia Maria Stella, Valentina Conio

“…The detection of <i>E. dermatitidis</i> should prompt a comprehensive evaluation, integrating clinical, radiologic, and microbiologic data to guide management. Voriconazole is currently the antifungal agent of choice, though therapeutic thresholds and duration remain undefined. …”
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The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree by Chaochao Li, Yuan Yuan, Zhiyi Nie, Tingkai Wu, Zhiyuan Wang, Jiangxia Qiao, Zhi Deng, Xiaobo Wang, Dong Xu, Xu Wang, Shuo Cao, Bingqin Li, Zewei An, Wenguan Wu, Zhongxin Jin, Huasun Huang, Wei Hu, Yongfeng Zhou, Han Cheng

“…By integrating transcriptomic and metabolomic data, we reconstruct the rubber biosynthesis pathway and confirm the mevalonate (MVA) pathway as the major carbon source for rapid latex regeneration during tapping. …”
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Academic response to improving value and reducing waste: A comprehensive framework for INcreasing QUality In patient-oriented academic clinical REsearch (INQUIRE). by Belinda von Niederhäusern, Gordon H Guyatt, Matthias Briel, Christiane Pauli-Magnus

“…The Delphi process ultimately achieved consensus on structure and content. The framework addresses 5 study stages (concept, planning and feasibility, conduct, analysis and interpretation, and reporting and knowledge translation) and includes the following dimensions: (i) protection of patient safety and rights, (ii) relevance/patient centeredness and involvement, (iii) minimization of bias (internal validity), (iv) precision, (v) transparency/access to data, and (vi) generalizability (external validity) of study results. …”
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Effects of biochar, ligneous soil amendments, and a microbial stimulant on soil biological activity, and carbon content and stability after two-years of their application in a bore... by J. Heinonsalo, K. Peltokangas, P. Barré, F. Baudin, L. Cécillon, S. Kalu, S. Kanerva, K. Karhu, L. Kulmala, J. Liski, A.-R. Salonen, R. Shrestha, H. Soinne, E. Virtanen, K. Huusko, O.-M. Sietiö

“…We investigated their impacts on soil organic carbon content and its stability, as well as on soil microbial abundance, activities, and community structures. Based on the extensive data we collected, mainly biochars increased soil organic carbon content enough to be detectable after two years. …”
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