Rainfall as an important process for net N gain during the initial phase of natural recovery in karst desertification by Xia Li, Yu Pang, Hengsheng Lao, Linfang Luo, Tongxin He, Guangting Pei, Shuangshuang Xiao, Baoqing Hu, Jianfei Sun

“…Abstract Nitrogen (N) losses driven by rapid hydrologic processes in karst regions were once considered a potentially key mechanism of N limitation during the initial phase of natural recovery following karst desertification. However, field data are still lacking for studying the hydrologic N budget. …”
Get full text

Efficacy and safety of cannabidiol in a single-center pediatric drug-resistant epilepsy cohort: a retrospective study by Ambra Butera, Ambra Butera, Giulia Spoto, Graziana Ceraolo, Maria Grella, Ivana Giunta, Maria Ludovica Albertini, Carla Consoli, Caterina Sferro, Maria Spanò, Gabriella Di Rosa, Antonio Gennaro Nicotera

“…Clinical, demographic, and instrumental data were retrospectively extracted from the medical records and caregivers’ reports. …”
Get full text

Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary... by Shigeharu Muto, Ayako Furuhama, Mika Yamamoto, Yasuteru Otagiri, Naoki Koyama, Seiji Hitaoka, Yusuke Nagato, Hirofumi Ouchi, Masahiro Ogawa, Kisako Shikano, Katsuya Yamada, Satoshi Ono, Minami Hoki, Fumiya Ishizuka, Soichiro Hagio, Chiaki Takeshita, Hisayoshi Omori, Kiyohiro Hashimoto, Satsuki Chikura, Masamitsu Honma, Kei-ichi Sugiyama, Masayuki Mishima

“…For internal PAAs, detailed Ames test data were scrutinized and final decisions were made using common evaluation criteria. …”
Get full text

Phenotypically distinguishable eosinophilic cells do not impact epithelial functions in a triple-culture in vitro intestinal model by Christoph Benkstein, Laurin Mosig, Daniel Vondran, Heidi Schlichting, Lea Kissing, Bente Wohlert, Ida Gensmer, Larissa Nogueira de Almeida, Peter König, Peter König, Kerstin Fibelkorn, Anna Kordowski, Stefanie Derer-Petersen, Christian Sina, Christian Sina, Yves Laumonnier, Yves Laumonnier

“…Furthermore, although the eosinophilic cells did not alter the epithelia, we observed the survival of butyrate-differentiated eosinophilic cells over a long period of time. Collectively, our data suggest that different triggers drive EoL-1 cells into phenotypically different eosinophilic cells with possibly distinct functions, mimicking the variability of eosinophils in vivo. …”
Get full text

Feasibility study of single-image super-resolution scanning system based on deep learning for pathological diagnosis of oral epithelial dysplasia by Zhaochen Liu, Zhaochen Liu, Peiyan Wang, Peiyan Wang, Nian Deng, Hui Zhang, Hui Zhang, Fangjie Xin, Xiaofei Yu, Xiaofei Yu, Mujie Yuan, Mujie Yuan, Qiyue Yu, Yuhao Tang, Keke Dou, Jie Zhao, Bing He, Jing Deng, Jing Deng

“…It preserves the diagnostic information of the OED and addresses the shortcomings of existing digital scanners, such as slow imaging speed, large data volumes, and challenges in rapid transmission and sharing. …”
Get full text

Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…Additionally, 2264 UC samples from five independent external cohorts, with genomic, transcriptomic, and clinical data, were used for validation.Results MDM2 amplification (MDM2Amp) or protein overexpression (MDM2OE) was associated with inferior overall survival (ZSHS cohort, Log-rank p<0.001; FUSCC cohort, Log-rank p=0.030) and reduced response to platinum-based chemotherapy (ZSHS cohort, Log-rank p<0.001) as well as anti-PD-1/PD-L1 immunotherapy (FUSCC cohort, Log-rank p=0.016) in patients with UC, irrespective of TP53/p53 status. …”
Get full text

Quality of Surface and Groundwater in the Sierra de Amula Region, Jalisco, Mexico by Oscar Raúl Mancilla-Villa, Fabiola Villafaña-Castillo, Álvaro Can-Chulim, Rubén Darío Guevara-Gutiérrez, José Luis Olguín-López, Elia Cruz-Crespo, Jonas Alan Luna-Fletes, Juan Uriel Avelar-Roblero

“…Each sample was evaluated for its pH, electrical conductivity, and ionic concentration (Ca²⁺, Mg²⁺, Na⁺, K⁺, CO₃²⁻, HCO₃⁻, CI⁻, SO₄²⁻). For data analysis, we determined the ionic concentrations and the salinity and sodicity indexes, including the electrical conductivity, pH, sodium adsorption ratio (SAR), and cationic ratio of soil structural stability (CROSS). …”
Get full text

Seasonal reversal in phytoplankton assembly mechanisms: stochastic dominance in autumn vs. deterministic control in spring within the middle and lower reaches of the Yellow River by Dahai Zeng, Dahai Zeng, Dahai Zeng, Houkuan Ding, Houkuan Ding, Houkuan Ding, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Yunni Gao, Yunni Gao, Yunni Gao, Jialin Jin, Jialin Jin, Jialin Jin, Xiaofei Gao, Xiaofei Gao, Xiaofei Gao, Jingxiao Zhang, Jingxiao Zhang, Jingxiao Zhang, Huatao Yuan, Huatao Yuan, Huatao Yuan, Jing Dong, Jing Dong, Jing Dong, Xuejun Li, Xuejun Li, Xuejun Li

“…This study investigated seasonal variations in phytoplankton community structure and assembly mechanisms in a riverine environment with high silt loads. …”
Get full text

PIEZO1 mechanical insensitivity in generalized lymphatic dysplasia with the potential for pharmacological rescue by Melanie J. Ludlow, Oleksandr V. Povstyan, Deborah M. Linley, Silvia Martin-Almedina, Charlotte Revill, Kevin Cuthbertson, Katie A. Smith, Emily Fay, Elisavet Fotiou, Andrew Bush, Claire Hogg, Tobias Linden, Natalie B. Tan, Susan M. White, Juan C. Del Rey Jimenez, Ege Sackey, Esther Dempsey, Sahar Mansour, Gregory Parsonage, Antreas C. Kalli, Richard Foster, Pia Ostergaard, David J. Beech

“…Two of the variants encode amino acid changes in the channel’s cap structure (Ile2270Thr and Arg2335Gln), one in the ninth transmembrane helical unit (THU) below the cap (Gly1978Asp) and one in the fifth THU distant from the cap (Glu829Val). …”
Get full text

Multimission Observations of Relativistic Electrons and High-speed Jets Linked to Shock-generated Transients by Savvas Raptis, Martin Lindberg, Terry Z. Liu, Drew L. Turner, Ahmad Lalti, Yufei Zhou, Primož Kajdič, Athanasios Kouloumvakos, David G. Sibeck, Laura Vuorinen, Adam Michael, Mykhaylo Shumko, Adnane Osmane, Eva Krämer, Lucile Turc, Tomas Karlsson, Christos Katsavrias, Lynn B. Wilson III, Hadi Madanian, Xóchitl Blanco-Cano, Ian J. Cohen, C. Philippe Escoubet

“…Shock-generated transients, such as hot flow anomalies (HFAs), upstream of planetary bow shocks, play a critical role in electron acceleration. Using multimission data from NASA’s Magnetospheric Multiscale and ESA’s Cluster missions, we demonstrate the transmission of HFAs through Earth’s quasi-parallel bow shock, accelerating electrons to relativistic energies in the process. …”
Get full text

Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a b... by Surajit Dey, Wenying Lu, Prabuddha S. Pathinayake, Maddison Waters, Greg Haug, Josie Larby, Heinrich C. Weber, Peter A. B. Wark, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal

“…Additionally, the degree of RBM fragmentation was evaluated, a key tissue structural marker of EMT.ResultsCompared to healthy controls and asthmatics, ACO had the greatest fragmentation of RBM (P < 0.01). …”
Get full text

Microstructural integrity of autonomic central nervous tracts is linked to cardiovascular health by Janis M. Nolde, Alexander Rau, Elias Kellner, Horst Urbach, Cornelius Weiller, Fabian Bamberg, Jakob Weiss, Marco Reisert, Jonas A. Hosp

“…Differential patterns were observed in cortical versus subcortical CAN structures, suggesting distinct pathophysiological roles within the heart-brain axis.…”
Get full text

Geological characteristics of biogenic gas formation and direction of favorable zones in the Quaternary mudstone of the Qaidam Basin, China by Jixian Tian, Zeyu Shao, Jian Li, Dekang Song, Zhou Fei, Ya'nan Li, Wei Sha, Hao Zhang, Lili Hou, Xiaoqiu Zhang, Haining Zhang, Yixuan Yang

“…In this study, we utilize core data from the mudstone sections of two newly drilled wells in the study area as the object, and carry out a comprehensive study of the formation and reservoir characteristics of mudstone biogas through systematic experimental analysis, on the basis of which, favourable exploration areas for mudstone biogas are identified. …”
Get full text

Analysis of ROH Characteristics Across Generations in Grassland-Thoroughbred Horses and Identification of Loci Associated with Athletic Traits by Wenqi Ding, Wendian Gong, Tugeqin Bou, Lin Shi, Yanan Lin, Xiaoyuan Shi, Zheng Li, Huize Wu, Manglai Dugarjaviin, Dongyi Bai

“…Principal component analysis (PCA) and STRUCTURE revealed clear distinctions among the generations, with a notable overlap between CY and F3. …”
Get full text

WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions by H. Huang, Y. Qian, G. Bisht, J. Wang, T. Chakraborty, D. Hao, J. Li, T. Thurber, B. Singh, Z. Yang, Y. Liu, P. Xue, P. Xue, W. J. Sacks, E. Coon, R. Hetland

“…It maintains the integrity of ELM's source code structure and facilitates the transfer of future developments in ELM to WRF-ELM.…”
Get full text

Co-circulation and genetic characterization of genotype I and II feline bocavirus strains in domestic cats from Northern Vietnam by Hieu Van Dong, Giang Thi Huong Tran, Yen Hoang Thi Nguyen, Thiet Chi Ngo, Amonpun Rattanasrisomporn, Chaiwat Boonkaewwan, Dao Anh Tran Bui, Jatuporn Rattanasrisomporn

“…The findings underscore the need for expanded surveillance, complete genome analyses, and investigation into FBoV’s pathogenic potential and co-infection dynamics in the feline population. These data will be instrumental in shaping future diagnostic and control strategies for feline viral enteritis in Vietnam.…”
Get full text

Cultural and behavioral drivers of zoonotic disease transmission and persistence among diverse pastoralist communities in East Africa by Dismas C.O. Oketch, Ruth Njoroge, Tonny O. Ngage, Asha Abdikadir Omar, Abdulai Magarre, Raphael Pasha, John Gachohi, Samuel Waiguru Muriuki, Samoel Ashimosi Khamadi, Ali Duba Boru, Boku Bodha, Lydia Kilowua, Nazaria Wanja Nyaga, Humphrey Kariuki Njaanake, Eunice Kamaara, Walter Jaoko, M. Kariuki Njenga, Eric Osoro, Dalmas Omia

“…Methods This study adopts a One Health approach, employing a range of participatory methods including informal observations, “go-along interviews,” narrative-, and key informant- interviews, to explore the cultural, behavioral, and structural drivers of zoonotic disease transmission among pastoralist communities in East Africa. …”
Get full text

Metabolic capabilities are highly conserved among human nasal-associated Corynebacterium species in pangenomic analyses by Tommy H. Tran, Isabel F. Escapa, Ari Q. Roberts, Wei Gao, Abiola C. Obawemimo, Julia A. Segre, Heidi H. Kong, Sean Conlan, Matthew S. Kelly, Katherine P. Lemon

“…Based on prevalence data, at least two Corynebacterium species likely coexist in the nasal microbiota of 82% of adults. …”
Get full text

Identification of serum biomarkers for cystic echinococcosis in sheep through untargeted metabolomic analysis using LC–MS/MS technology by Xiao-Xia Wu, Wan-Li Ban, Li-Jiang Wu, Wen-Jing Qi, Mehdi Borhani, Xiao-Ying He, Xiao-Lei Liu, Ming-Yuan Liu, Jing Ding

“…Orthogonal projections to latent structures–discriminant analysis (OPLS-DA) were used to analyze different metabolites in the serum of the two groups. …”
Get full text

FTIR-based molecular fingerprinting for the rapid classification of dengue and chikungunya from human sera using machine learning: an observational studyResearch in context by Souvik Das, Subhanita Roy, Aritri Bir, Arindam Ghosh, Tarun Kanti Bhattacharyya, Pooja Lahiri, Basudev Lahiri

“…The SVM, RF, and NN models, trained on FTIR data, achieved near-perfect classification (AUC = 1.000; CA-score ≥0.989), outperforming traditional diagnostic methods. …”
Get full text