Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis by Min-Young Noh, Seong-il Oh, Young-Eun Kim, Sun Joo Cha, Wonjae Sung, Ki-Wook Oh, Yurim Park, Ji Young Mun, Chang-Seok Ki, Minyeop Nahm, Seung Hyun Kim

“…And, we confirmed that data found in patient fibroblasts were reproduced in iPSC-MNs model. …”
Get full text

Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model. by Emily A Kendall, Sourya Shrestha, Ted Cohen, Eric Nuermberger, Kelly E Dooley, Lice Gonzalez-Angulo, Gavin J Churchyard, Payam Nahid, Michael L Rich, Cathy Bansbach, Thomas Forissier, Christian Lienhardt, David W Dowdy

“…Limitations include sparse data on key model parameters and necessary simplifications to model structure and outcomes.…”
Get full text

A preliminary study on the clinical characteristics of lacrimal duct obstruction in patients with a history of anterior uveitis by Peng Wang, Peng Wang, Hai Tao, Fei Wang, Fang Bai, Xibin Zhou, Lihua Wang, Chuan Liu, YiFei Huang, YiFei Huang

“…AimThis study aimed to investigate the clinical features of lacrimal duct obstruction (LDO) in patients with a history of anterior uveitis (AU) and explore preventive strategies by analyzing their demographic, anatomical, and surgical outcome profiles.MethodsWe retrospectively reviewed 40 LDO patients (58 eyes) with a history of AU, treated between 2020 and 2024, comparing them to non-AU LDO controls. Data included demographics, AU–epiphora temporal relationships, obstruction characteristics (location, extent, and adhesions), and surgical outcomes. …”
Get full text

Left bundle branch block in coronary artery disease: toward novel electrocardiographic markers by Yuri N. Fedulaev, Irina V. Makarova, Alisa V. Grigorieva, Dzhamilya R. Kapitonova, Gulfiya A. Khairetdinova

“…Fragmented QRS, a less studied electrocardiographic parameter that reflects myocardial scarring, has emerged as a negative prognostic marker in coronary artery disease, being associated with recurrent cardiovascular events, hospitalizations, and mortality in patients with narrow QRS complexes. However, data on the value of fragmented QRS in the setting of wide QRS complexes remain limited. …”
Get full text

Environmental Impact of Physical Visits and Telemedicine in Nursing Care at Home: Comparative Life Cycle Assessment by Egid M van Bree, Lynn E Snijder, Hans C Ossebaard, Evelyn A Brakema

“…We collected anonymous user data in collaboration with a telemedicine service company, complemented by consulting staff members of four nursing organizations. …”
Get full text

Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns by Linnea Hoheisel, Linnea Hoheisel, Hannah Hacker, Gereon R Fink, Gereon R Fink, Silvia Daun, Silvia Daun, Joseph Kambeitz, Joseph Kambeitz

“…Recent advances in computational modelling allow us to investigate the relationship of both static FC (sFC) and dynamic FC (dFC) with neurobiology non-invasively.In this study, we modelled the brain activity of 200 healthy individuals based on empirical resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data. Simulations were conducted using a group-averaged structural connectome and four parameters guiding global integration and local excitation-inhibition balance: (i) G, a global coupling scaling parameter; (ii) Ji, an inhibitory coupling parameter; (iii) JN, the excitatory NMDA synaptic coupling parameter; and (iv) wp, the excitatory population recurrence weight. …”
Get full text

Mobile health (mHealth) interventions for health promotion during the perinatal period in India: a scoping review by Zara Small, Sophie Elizabeth Thompson, Ankita Sharma, Sreya Majumdar, Sudhir Raj Thout, Devarsetty Praveen, Devarsetty Praveen, Devarsetty Praveen, Jane Elizabeth Hirst, Jane Elizabeth Hirst

“…However, current interventions lack evidence of long term behavioural change and fail to report on features important in sustainability and scalability, namely network infrastructure, data security and interoperability. We propose the need for a framework to understand existing cultural beliefs and support structures to avoid early intervention failure. …”
Get full text

Optimal Airfoil Selection for Small Horizontal Axis Wind Turbine Blades: A Multi-Criteria Approach by Temesgen Batu, Hirpa G. Lemu, Besufekad Negash, Eaba Beyene, Dagim Tirfe, Eyob Hailemichael, Solomon Alemneh

Get full text

The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies by Bowen Wang, Desheng Xie, Jianming Huang, Zheyuan Huang, Weizong Weng, Danlei Huang, Ying Zhang, Xiaolin Chen

“…Methods: A comprehensive literature search was conducted across four major databases (PubMed, Embase, Cochrane, Web of Science), including animal studies that met predefined criteria. Data extraction and quality assessment were independently performed by two authors. …”
Get full text

Technical advances and research directions of borehole geophysical prospecting for coal mines by Jianyuan CHENG, Yu YAN, Yuteng LI, Pan WANG, Rui ZHAO, Bici JIANG

“…ProgressFor intra-borehole geophysical technology, high-frequency (HF) reflection radar within a near-horizontal borehole in coal mines allows for the coal-rock interface exploration and geological structure identification within a radial distance range of 0 to 10 m. …”
Get full text

HISTOCHEMICAL INVESTIGATION OF GLYCOSAMINOGLYCANS OF THE MANDIBULAR ALVEOLAR PROCESS IN PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL OSTEOPOROSIS AND PERIODONTITIS by O.I. Hodovana

“…In pathological process – systemic osteoporosis and periodontitis in group №2 in impairment of organization of all structural components of bone tissue, particularly modifications of compact and spongy substance, the level of basic GAGs drastically increased (71.74%) and slight amount of reserved acid GAGs (15.49%) appeared in all examined bones as a body’s reaction to damage. …”
Get full text

Service Innovation in Customer Value Co-Creation: The Mediating Role of Customer Engagement in the Hospitality Industry – A Case Study by Meysam Fakharyan, Ali Hosseinzadeh, Hadi Bastam

“…The questionnaires were gathered through an online survey, and their validity and reliability were duly confirmed. The descriptive data were analyzed by SPSS Software ver.16 and the research's model was analyzed by LISREL Software ver.8.5 that was based on Structural Equations Modeling (SEM). …”
Get full text

Choroidal blood flow in glaucoma patients in conditions of ophthalmic hypertension and compensated intraocular pressure by T. N. Yureva, S. I. Zhukova, I. V. Pomkina

“…The ophthalmic examination included optical coherence tomography of the optic disk and macular area, as well as assessment of the blood flow of these structures using optical coherence tomography in angio mode (OCTA) (RTVue XR Avanti, Optovue Inc., США). …”
Get full text

In Vitro Effects of Vanadate Erbium/Silver Oxide (ErVO4/AgO) and Vanadate Iron/Silver Oxide (FeVO4/AgO) Nanoparticles on the Adult of Fasciola hepatica by Arbabi Mohsen, Esmaili Monireh, Hooshyar Hossein, Delavari Mahdi, Sobhani Nasab Ali, Nejati Majid

“…To ensure the reliability of the data, the tests on the sample were performed twice. …”
Get full text

Multi-branch horizontal well hole docking pressure control extraction technology for close distance coal seam group by Liang CHEN, Zhiheng CHENG, Xin LUO, Hongyang YU, Zherui ZHANG, Peng WANG, Xiangdong WANG

“…Taking Shaqu well field in Lyuliang city, Shanxi province as an example, through theoretical analysis and data statistics, the geological structure of coalbed methane accumulation in the well field, the influence of hydrodynamic conditions, coalbed methane reservoir characteristics and gas-bearing distribution are obtained. …”
Get full text

IPHILOGENETIC TREE OF ART / ФИЛОГЕНЕТИЧЕСКОЕ ДРЕВО ИСКУССТВ by DRIKKER ALEKSANDR S. / ДРИККЕР А.С.

Get full text

In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review by Ramirez-Miranda A, Guerrero-Becerril J, Ramirez M, Vera-Duarte GR, Mangwani-Mordani S, Ortiz-Morales G, Navas A, Graue-Hernandez EO, Alio JL

“…From 1835 articles retrieved, studies published within the last seven years with clinical relevance were prioritized, yielding 51 articles. Data were synthesized to evaluate IVCM’s diagnostic capabilities, technical advancements, and applications across corneal pathologies, including infectious keratitis, dystrophies, and post-surgical outcomes.Results: IVCM was shown to provide unparalleled visualization of cellular and subcellular corneal structures, enabling early diagnosis and monitoring of conditions such as keratitis caused by Acanthamoeba and fungi, corneal dystrophies, and nerve regeneration following refractive or transplant surgeries. …”
Get full text

Emerging Human Fascioliasis in India: Review of Case Reports, Climate Change Impact, and Geo-Historical Correlation Defining Areas and Seasons of High Infection Risk by Santiago Mas-Coma, Pablo F. Cuervo, Purna Bahadur Chetri, Timir Tripathi, Albis Francesco Gabrielli, M. Dolores Bargues

Get full text

A comprehensive water quality assessment for a typical river–lake watershed in Northeast China: implications for the water management of boundary lake by Bingbo Ni, Xuemei Liu, Yanfeng Wu, Ming Jiang, Yuanchun Zou

“…These methods reduced data redundancy and enhanced the sensitivity of the comprehensive water quality index (WQI) model. …”
Get full text

Diagnosis of gilbert’s syndrome via pyrosequencing in clinical practice by L. I. Melnikova, L. Yu. Ilchenko, E. A. Dunaeva, M. V. Kozitsyna, O. P. Dribnokhodova, K. O. Mironov

“…For diagnosis of GS, molecular biological methods are used to determine single nucleotide polymorphisms (SNP). Data on the prevalence of SNP related to GS in Russia are scarce. …”
Get full text