Phytochemical Study and In Vitro Antioxidant Activity of <i>Helianthemum cinereum</i> Along with Antitumor Activity of the Isolated <i>trans</i>-Tiliroside and Luteolin 4′-<i>O</i>... by Anis Bertella, Abla Smadi, Hakim Benhabrou, Diana Salvador, Magdalena Wrona, Helena Oliveira, Abouamama Sidaoui, Georgiana Gavril-Luminita, Diana C. G. A. Pinto, Ewa Olewnik-Kruszkowska, Cristina Nerín, Artur M. S. Silva, Fatma Bitam

“…All compounds were isolated by applying different chromatographic procedures, such as silica gel, RP-18 and Sephadex LH-20 columns. The structures were elucidated by extensive spectroscopic methods, mainly nuclear magnetic resonance NMR 1D and 2D, and mass spectrometry, as well as by comparison with the reported spectroscopic data. …”
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The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking by Jia-Qi Wang, Jia-Qi Wang, Yuan-Yu Liang, Yuan-Yu Liang, Zhong-Xue Zhao, Zhong-Xue Zhao, Wei Xie, Wan-Ning Sun, Wan-Ning Sun, Ji-Yu Zou, Ji-Yu Zou, Xiao-Dong Lv, Xiao-Dong Lv, Youfu He, Li-Jian Pang, Li-Jian Pang

“…Despite global advances in asthma control, little attention has been paid to the evolving composition and geographic disparity of modifiable risk factors in this age group.MethodsWe utilized data from the Global Burden of Disease Study 2021 to evaluate the long-term trends (1990–2021) in asthma burden attributable to high body-mass index (BMI), smoking, and occupational asthmagens among adults aged 60 years and older. …”
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Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture by Hui Chen, Hanqi Zhang, Chao Niu, Bianlin Wang, Biao Gao, Zhijun Liu, Guangmin Yao, Haji Akber Aisa

“…Using a molecular networking approach, five pairs of potent analgesic alkaloid enantiomers were isolated from the roots of Anacyclus pyrethrum (A. pyrethrum). Their structures were elucidated by comprehensive spectroscopic data analysis, including LR-HSQMBC and 1H–15N HMBC, quantum 13C NMR DP4+ and ECD calculations, and single-crystal X-ray diffraction analysis. …”
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Unlocking winter maize potential: pioneering on-farm strategies for resilient yields in challenging climates by Raj Kumar Jat, Shubham Durgude, Vijay Singh Meena, Vijay Singh Meena, RK Sohane, RN Singh, Illathur R. Reddy, Suneel Kumar, S. Pazhanismy, Sunita Kumari Meena, Kumari Sharda, Susheel Singh, Rama Kant Singh, Rama Kant Singh, Seema Kumari, Seema Kumari, Pankaj Kumar, Govind Kumar, Amit Kumar Lenka, Asheesh Chaurasiya, Anup Das, Anil Kumar Jha, Dhananjay Pati Tripathi, Swati Sagar

“…The key factors evaluated for maize yields encompassed sowing windows, varietal performance, topography, seed treatment, earthing up, planting methods, spacing, tillage practices, irrigation, and nutrient management. Data was collected using a structured questionnaire that was validated by visiting on-farm experimentation at fields. …”
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Efficacy and safety of cannabidiol in a single-center pediatric drug-resistant epilepsy cohort: a retrospective study by Ambra Butera, Ambra Butera, Giulia Spoto, Graziana Ceraolo, Maria Grella, Ivana Giunta, Maria Ludovica Albertini, Carla Consoli, Caterina Sferro, Maria Spanò, Gabriella Di Rosa, Antonio Gennaro Nicotera

“…Clinical, demographic, and instrumental data were retrospectively extracted from the medical records and caregivers’ reports. …”
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Prognostic Role of Ultrasound Diagnostic Methods in Patients with Acute Decompensated Heart Failure by Zhanna D. Kobalava, Tolkacheva Veronika Vladimirovna, Sarlykov Bekbolot Kanatbekovich, Rena Sh Aslanova, Lapshin Artem Alekseevich, Nazarov Ivan Sergeevich, Smirnov Ilya Pavlovich, Maria V Vatsik-Gorodetskaya, Ghazaal Alavi Tabatabaei, Ibrahim Al-Zakwani, Mohammed Al Jarallah, Georgiana Luisa Baca, Peter A Brady, Rajesh Rajan, Bhavesh Talera

“…Clinical outcomes were assessed using a structured telephone survey method at 1, 3, 6, and 12 months after discharge. …”
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Conceptualizing the implementation of post-discharge malaria chemoprevention in Malawi using a co-design approach by Myness Kasanda Ndambo, Kristine Bærøe, Kamija Samuel Phiri, Isabel-Kazanga Chiumia, Inger Lise Teig, Bjarne Robberstad, Oddvar Martin Kaarbøe, Melf-Jakob Kühl, Jobiba Chinkhumba, Thandile Nkosi-Gondwe, Tinashe Alinafe Tizifa, Elisabeth Mamani-Mategula, Lumbani Munthali, Lucinda Manda-Taylor

“…Results The inductive analysis yielded four overarching themes from the data. These key themes are PDMC adaptability, trialability, implementability, and sustainability. …”
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Performance of GPT-4 for automated prostate biopsy decision-making based on mpMRI: a multi-center evidence study by Ming-Jun Shi, Zhi-Xiang Wang, Shuang-Kun Wang, Xuan-Hao Li, Yan-Lin Zhang, Ying Yan, Ran An, Li-Ning Dong, Lei Qiu, Tian Tian, Jia-Xin Liu, Hong-Chen Song, Ya-Fan Wang, Che Deng, Zi-Bing Cao, Hong-Yin Wang, Zheng Wang, Wei Wei, Jian Song, Jian Lu, Xuan Wei, Zhen-Chang Wang

“…GPT-4 generated structured reports with given prompts. The performance of GPT-4 was quantified using confusion matrices, and sensitivity, specificity, as well as area under the curve were calculated. …”
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A qualitative study on dietary behaviors and nutritional management needs of patients with active systemic lupus erythematosus (系统性红斑狼疮活动期患者饮食行为与营养管理需求的质性研究)... by SONG Weiting (宋炜婷), LI Yuwei (李雨蔚), QIAO Caicai (乔彩彩), WANG Sa (王飒), XUE Fei (薛菲), WANG Yuzhen (王玉珍), MIAO Huali (苗华丽)

“…Methods A descriptive study was conducted, involving semi-structured interviews with 10 patients with active SLE and 6 healthcare providers. …”
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Phenotypically distinguishable eosinophilic cells do not impact epithelial functions in a triple-culture in vitro intestinal model by Christoph Benkstein, Laurin Mosig, Daniel Vondran, Heidi Schlichting, Lea Kissing, Bente Wohlert, Ida Gensmer, Larissa Nogueira de Almeida, Peter König, Peter König, Kerstin Fibelkorn, Anna Kordowski, Stefanie Derer-Petersen, Christian Sina, Christian Sina, Yves Laumonnier, Yves Laumonnier

“…Furthermore, although the eosinophilic cells did not alter the epithelia, we observed the survival of butyrate-differentiated eosinophilic cells over a long period of time. Collectively, our data suggest that different triggers drive EoL-1 cells into phenotypically different eosinophilic cells with possibly distinct functions, mimicking the variability of eosinophils in vivo. …”
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Feasibility study of single-image super-resolution scanning system based on deep learning for pathological diagnosis of oral epithelial dysplasia by Zhaochen Liu, Zhaochen Liu, Peiyan Wang, Peiyan Wang, Nian Deng, Hui Zhang, Hui Zhang, Fangjie Xin, Xiaofei Yu, Xiaofei Yu, Mujie Yuan, Mujie Yuan, Qiyue Yu, Yuhao Tang, Keke Dou, Jie Zhao, Bing He, Jing Deng, Jing Deng

“…It preserves the diagnostic information of the OED and addresses the shortcomings of existing digital scanners, such as slow imaging speed, large data volumes, and challenges in rapid transmission and sharing. …”
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Evidence based consensus statements for digital tools to address youth mental health literacy by Stephana Julia Moss, Sonia Siddiqui, Cristina Zuniga Chacon, Cynthia Sriskandarajah, Maia Stelfox, Ben Gaunce, Micaela Harley, Stacie Smith, Sofia B. Ahmed, Kathryn Birnie, Donna Halperin, Scott Halperin, Christine Hampson, Jia Hu, Laura Leppan, Angie Nickle, Kristine Russell, Andrea Soo, May Solis, Henry T. Stelfox, Sharon Straus, Perri R. Tutelman, Quincy Wiele, Kirsten M. Fiest, Nicole Racine, Jeanna Parsons Leigh

“…Phase II consisted of a modified Delphi consensus process to determine evidence-based consensus statements (N = 352 (13% youth) Round 1; N = 87 (33% youth) Round 2). Semi-structured focus groups in Phase III were conducted to refine the consensus statements (N = 16, 25% youth) and design the digital mental health literacy tool (N = 24, 33% youth). …”
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Quality of Surface and Groundwater in the Sierra de Amula Region, Jalisco, Mexico by Oscar Raúl Mancilla-Villa, Fabiola Villafaña-Castillo, Álvaro Can-Chulim, Rubén Darío Guevara-Gutiérrez, José Luis Olguín-López, Elia Cruz-Crespo, Jonas Alan Luna-Fletes, Juan Uriel Avelar-Roblero

“…Each sample was evaluated for its pH, electrical conductivity, and ionic concentration (Ca²⁺, Mg²⁺, Na⁺, K⁺, CO₃²⁻, HCO₃⁻, CI⁻, SO₄²⁻). For data analysis, we determined the ionic concentrations and the salinity and sodicity indexes, including the electrical conductivity, pH, sodium adsorption ratio (SAR), and cationic ratio of soil structural stability (CROSS). …”
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A qualitative analysis on the awareness of noise pollution and occupational protection among staff members of the Central Sterile Supply Department (消毒供应中心工作人员对噪声污染的认知及职业防护质性分析)... by HUANG Xuanxuan (黄玄玄), FU Li (付立), SUN Ziwen (孙子文), YU Jiang (于江), ZHANG Shenhong (张沈弘), ZHANG Tianqiang (张天强)

“…The interview data were analyzed using the Colaizzi 7-step procedure of phenomenological analysis. …”
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Risk factors for low knowledge and negative attitudes among caregivers of children with autism spectrum disorder in Iraq: a multi-centre cross-sectional study by Hiba Qahttan Khaleel Al-Juhaishi, Hiba Qahttan Khaleel Al-Juhaishi, Osamah Abbas Jaber, Osamah Abbas Jaber, Faris Lami, Faris Lami, Shatha Mohammed Jasim, Shatha Mohammed Jasim, Nahid Dehghan Nayeri, Nahid Dehghan Nayeri, Mahdi Shafiee Sabet, Mahdi Shafiee Sabet, Ghaith Al-Gburi, Ghaith Al-Gburi

“…Before educational interventions can address these issues, local knowledge and attitudes must be assessed, including the identification of high-risk groups that require prioritisation.MethodsBetween February 17 and September 10, 2024, Al-Subtain Academy for Autism and Baghdad’s National Centre for Autism and Child Psychiatry conducted a cross-sectional study. Data was collected using a structured questionnaire developed based on the Autism Stigma and Knowledge Questionnaire (ASK-Q) and a review of previous studies. …”
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Advancing dementia care: a review of Italy’s public health response within the WHO Global Action Plan and European strategies by Giancarlo Logroscino, Daniele Imperiale, Nicola Vanacore, Nicola Veronese, Giorgio Fumagalli, Cristina Basso, Federica Asta, Marco Canevelli, Eleonora Lacorte, Anna Maria Bargagli, Angela Giusti, Ilaria Bacigalupo, Guido Bellomo, Ilaria Palazzesi, Paola Piscopo, Emanuela Salvi, Valerio Zaccaria, Francesca Zambri, Martina Valletta, Massimo Corbo, Teresa Di Fiandra, Alessio Crestini, Francesco Saverio Mennini, Rosella Saulle, Alessandra Lombardi, Antonio Guaita, Luciano Sagliocca, Rosa Liperoti, MARCO TRABUCCHI, Maria Cotelli, Carlo Gabelli, Gianfranco Spalletta, Carlo Petrini, Vincenza Frisardi, Alice Fauci, Marcello Giordano, Luca Vignatelli, Luciana Riva, Camillo Marra, Francesco Nonino, Antonio Ancidoni, Simone Salemme, Domitilla Marconi, Sara Maria Pani, Nicoletta Locuratolo, Flavia Lucia Lombardo, Elisa Fabrizi, Francesco Sciancalepore, Patrizia Lorenzini, Alice Paggetti, Francesco Della Gatta, Annachiara Di Nolfi, Vittorio Palermo, Paolo Sciattella, Chiara Bini, Caterina Bianca Neve Aurora Bianchi, Fiammetta Landoni, Maria Assunta Giannini, Stefano Sensi, Cristina Lupinetti, Valeria Panetta, Antonio Matera, Francesca Lubian, Carla Melani, Gennarina Arabia, Maria Pompea Bernardi, Annarita Greco, Annalisa Di Palma, Andrea Fabbo, Federica Boschi, Antonino Riolo, Antonio Zaccardi, Antonio Mastromattei, Silvia Scalmana, Ernesto Palummeri, Elisa Lidonnici, Alessandro Amorosi, Lorenzo Blandi, Filippo Masera, Fabio Izzicupo, Alfonso Di Costanzo, Carla Severino, Patrizia Spallino, Piero Secreto, Elena Memeo, Stefano Piras, Serena Meloni, Tommaso Piccoli, Sara Madrigali, Antonella Notarelli, Micaela Gilli, Anna Laura Spinelli, Nando Scarpelli, Monica Seganfreddo, Alessandra Caci, Amalia Cecilia Bruni, Francesco Mazzoleni, Alessandro Pirani, Massimiliano Massaia, Luisa Bartorelli, Susanna Cipollari, Gabriella Porro, Mario Possenti, Manlio Matera, Patrizia Spadin, Paolo Caffarra, Andrea Capasso, Maria Pia Cozzari, Sabina Gainotti, Giuseppe Gambina, Marina Michela Gasparini, Andrea Stracciari, Gilda Losito, Elena Rendina, Federica Francescone, Francesca Galeotti, Teresa Di Fiandra, Flaminia Camilli, Elena Carbone, Giulia Carnevale, Daniela Coclite, Benedetta Contoli, Francesco Della Gatta, Annachiara Di Nolfi, Eugenio Distaso, Ylenia Druda, Sabrina Esposito, Francesco Giaquinto, Flavia L. Lombardo, Gabriella Martelli, Maria Masocco, Fabio Matascioli, Alberto Milanese, Valentina Minardi, Sandra Morelli, Antonello Napoletano, Maria Cristina Porrello, Giulia Remoli, Roberto Rivabene, Paola Scardetta, Roberta Vaccaro, Petronilla Battista, Consuelo Borgarelli, Chiara Cerami, Annalisa Chiari, Alfredo Costa, Alessandra Dodich, Elisa Faè, Elisa Favaretto, Lidia Fubini, Monica Gandelli, Donata Gollin, Claudio Ivaldi, Alessandro Lanzoni, Valentina Lavermicocca, Margherita Lazzarino, Giacomo Menabue, Maria Angela Molinari, Alessia Morelli, Fabrizio Piazza, Anna Peruzzi, Clara Ricci, Stefano Russo, Davide Zenaro, Alessandra Ceccarini, Scilla Pizzarelli, Zuzana Mitrova, Salvatore De Masi

“…Two reviewers independently screened and extracted data with a predefined matrix mapped to the seven WHO GAP Action Areas. …”
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Multimission Observations of Relativistic Electrons and High-speed Jets Linked to Shock-generated Transients by Savvas Raptis, Martin Lindberg, Terry Z. Liu, Drew L. Turner, Ahmad Lalti, Yufei Zhou, Primož Kajdič, Athanasios Kouloumvakos, David G. Sibeck, Laura Vuorinen, Adam Michael, Mykhaylo Shumko, Adnane Osmane, Eva Krämer, Lucile Turc, Tomas Karlsson, Christos Katsavrias, Lynn B. Wilson III, Hadi Madanian, Xóchitl Blanco-Cano, Ian J. Cohen, C. Philippe Escoubet

“…Shock-generated transients, such as hot flow anomalies (HFAs), upstream of planetary bow shocks, play a critical role in electron acceleration. Using multimission data from NASA’s Magnetospheric Multiscale and ESA’s Cluster missions, we demonstrate the transmission of HFAs through Earth’s quasi-parallel bow shock, accelerating electrons to relativistic energies in the process. …”
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Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a b... by Surajit Dey, Wenying Lu, Prabuddha S. Pathinayake, Maddison Waters, Greg Haug, Josie Larby, Heinrich C. Weber, Peter A. B. Wark, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal

“…Additionally, the degree of RBM fragmentation was evaluated, a key tissue structural marker of EMT.ResultsCompared to healthy controls and asthmatics, ACO had the greatest fragmentation of RBM (P &lt; 0.01). …”
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Factors associated with knowledge, attitudes, and practices of mixed crop-livestock farmers on Crimean-Congo hemorrhagic fever (CCHF) and other zoonoses in Burkina Faso by Abdoul Kader Ilboudo, Michel Dione, Ard M. Nijhof, Martin H. Groschup, Ousmane Traoré, Guy S. Ilboudo, Zekiba Tarnagda, Madi Savadogo, Bernard Bett

“…Consenting participants aged six and above were randomly included, and a structured questionnaire that collected socio-economic data, knowledge, attitudes, and practices concerning CCHF and other zoonoses was administered. …”
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Microstructural integrity of autonomic central nervous tracts is linked to cardiovascular health by Janis M. Nolde, Alexander Rau, Elias Kellner, Horst Urbach, Cornelius Weiller, Fabian Bamberg, Jakob Weiss, Marco Reisert, Jonas A. Hosp

“…Differential patterns were observed in cortical versus subcortical CAN structures, suggesting distinct pathophysiological roles within the heart-brain axis.…”
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