Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms by Lucia Lage, Ana I. Rodriguez-Perez, Jose Luis Labandeira-Garcia, Antonio Dominguez-Meijide

“…The effects of fasudil are mostly related to ROCK inhibition, which we have shown using two structurally different ROCK inhibitors and knockdown data, and further supported by using RT-QuiC.…”
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Different Land Use Systems in the Brazilian Cerrado and Their Effects on Soil Bacterial Communities by Jefferson Brendon Almeida dos Reis, Thayssa Monize Rosa de Oliveira, Maria Regina Silveira Sartori da Silva, Fabyano Alvares Cardoso Lopes, Alessandra Monteiro de Paula, Nadson de Carvalho Pontes, Helson Mario Martins do Vale

“…Thus, knowledge about how different land use systems in the Cerrado influence the diversity and taxonomic structure of microbial communities under the same soil type remains limited. …”
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Observations and Studies on the Transiting Systems HAT-P-36, XO-2 and WASP-76 by Weilong Wang, Shenghong Gu, Xiaobin Wang, Leilei Sun, Byeong-Cheol Lee, Chi-Tai Kwok, Ho-Keung Hui, Jiangpei Dou, Yue Xiang, Dongtao Cao, Fukun Xu

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Nonlinear forecasting of stream flows using a chaotic approach and artificial neural networks by Hakan Tongal

“…However, as a result from the kNN model structure, the model failed in the prediction of peak values. …”
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Effects of Elevated Temperature and CO2 Enrichment on Stability of Soil Organic Carbon Storage in Mollisols by Xue Haiqing, Yue Ya, Feng Qian, Long Jieqi, Miao Huan, Miao Shujie, Qiao Yunfa

“…[Objective] The effects of climate change on the stability of organic carbon were revealed from the perspective of the molecular structure of organic carbon in order to provide a theoretical basis for clarifying the impact of future climate change on organic carbon stability and soil fertility in mollisols. …”
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MEDULLARY CARCINOMA OF THE BREAST: ROENTGENOLOGIC AND ULTRASOUND SEMIOTICS by A. B. Abduraimov, K. A. Lesko, V. Yu. Pletneva, I. A. Blokhin

“…Along with the most common type of BC – ductal carcinoma, there are a lot of histological types, distinguished by structure features, which lead to a variable clinical and instrumental semiotics.These histological types of BC in the group marked out special types of BC, including medullary carcinoma. …”
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Seismic Performance of Steel Column Base of Disc-spring Self-centering Energy-consuming Damper by SUN Jiateng, LIU Jianming, ZHU Guangzhi

“…ObjectiveThe rapid restoration of the column base connection's functionality after an earthquake is crucial to the seismic performance of the structure. Currently, the existing self-centering column base connections have the drawbacks of complex construction, inability to integrate energy dissipation, self-resetting and replaceability. …”
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Healthcare providers' perspectives on the organization of health services to manage people with multiple long-term conditions in primary care settings in Kerala, India: a qualitati... by Thoniparambil Ravindranathanpillai Lekha, Linju Joseph, Linju Joseph, Neethu Vasantha Sasidharan, Athira Krishnan, Justine Davies, Paramjit Gill, Sheila Greenfield, Sivadasanpillai Harikrishnan, Jissa Vinoda Thulaseedharan, Mathew Joseph Valamparampil, Semira Manaseki-Holland, Panniyammakal Jeemon, Panniyammakal Jeemon

“…We aimed to explore the challenges healthcare providers (HCPs) face in managing people with MLTCs in a south Indian primary care setting.MethodsSemi-structured interviews were conducted with HCPs in four districts of Kerala, India. …”
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Factors Associated with Antidiabetic Medications and Dietary Recommendation Adherence Among Patients with Type 2 Diabetes by Godwin Gideon Kwaku Dorvlo, Augustine Kumah, Samuel Kwabena Ofosu, Stephen Henry Afakorzi, Yvette Eyram Avorgbedor, Emmanuel Obot, Chinwe Nnenna Nwogu, Malik Abdul Rahman, Henry Okorie Ugorji, Lawrencia Antoinette Aidoo, Anthony Bless Dogbedo, Abdul - Razak Issah, Abigail Abiba Fuseini, Deborah Terkperkie Kanamitie, Gustav Boni

“…Phone calls were used to collect responses from participants using the structured questionnaire, which included the United Kingdom Diabetes Diet Questionnaire and Morisky Adherence Scale. …”
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Practitioner perspectives on informing decisions in One Health sectors with predictive models by Kim M. Pepin, Keith Carlisle, Richard B. Chipman, Dana Cole, Dean P. Anderson, Michael G. Baker, Jackie Benschop, Michael Bunce, Rachelle N. Binny, Nigel French, Suzie Greenhalgh, Dion RJ O’Neale, Scott McDougall, Fraser J. Morgan, Petra Muellner, Emil Murphy, Michael J. Plank, Daniel M. Tompkins, David TS Hayman

“…We used inductive qualitative analysis of the interview data with iterative coding to identify key themes for maximizing the value of model-based evidence in One Health applications. …”
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Transcriptomics and proteomics provide insights into the adaptative strategies of Tibetan naked carps (Gymnocypris przewalskii) to saline-alkaline variations by Bingzheng Zhou, Ruichen Sui, Luxian Yu, Delin Qi, Shengyun Fu, Ying Luo, Hongfang Qi, Xiaohuan Li, Kai Zhao, Sijia Liu, Fei Tian

“…In the kidney, the tight junction formed dense structure in the renal tubules under lake water condition compared with the loose structure in freshwater. …”
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Investigation of genomic and pathogenicity characteristics of Streptococcus suis ST1 human strains from Guangxi Zhuang Autonomous Region (GX) between 2005 and 2020 in China by Weiming Kang, Mingliu Wang, Xueli Yi, Jianping Wang, Xiyan Zhang, Zongfu Wu, Yan Wang, Hui Sun, Marcelo Gottschalk, Han Zheng, Jianguo Xu

“…Our research offers novel insights into the population structure, evolution, genomic features, and pathogenicity of ST1 strains. …”
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Learning new surgical techniques in low and middle income countries, approval processes, and the impact of artificial intelligence by Long Cong Duy Tran, Long Cong Duy Tran, Helal Metwalli, Helal Metwalli, Dat Tien Le, Dat Tien Le, Samuel Amo-Afful, Samuel Amo-Afful, Mario Salib Todry Gerges, Mario Salib Todry Gerges, Hajer Hatim Hassan Ahmed, Hajer Hatim Hassan Ahmed, Dinh Thi Kim Quyen, Dinh Thi Kim Quyen, Abdelrahman Gamil Gad, Abdelrahman Gamil Gad, Phillip Tran, Nguyen Tien Huy, Nguyen Tien Huy, Nguyen Tien Huy

“…Training in surgery and approval of new techniques in low- and middle-income countries (LMICs), usually depends on informal apprenticeship systems, that is often lacking standardization, structured mentorship and produce inconsistent patient outcomes. …”
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Observational Comparison between Confined and Eruptive Flares: Magnetohydrodynamics Instability Parameters in a Similar Magnetic Configuration by Kouhei Teraoka, Daiki Yamasaki, Yusuke Kawabata, Shinsuke Imada, Toshifumi Shimizu

“…Unstable states of the solar coronal magnetic field structure result in various flare behaviors. In this study, we compared the confined and eruptive flares that occurred under similar magnetic circumstances in the active region 12673, on 2017 September 6, using the twist number, decay index, and height of magnetic field lines to identify observational behaviors of the flare eruption. …”
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Unacceptable Behaviors Towards Health Professional Clinical Students: Protocol For a Mixed‐Methods Study by Ibrahim S. Al‐Busaidi, Geoff Noller, Jim M. Ross, Andrew R. Gray, Aynsley Peterson, Daniela Aldabe, Joy Rudland, Katrina Pōtiki Bryant, Paul Kane, Susan M. Moffat, Sunyoung Ma, Virginia Jones, Lynley Anderson

“…The second phase will recruit students to participate in semi‐structured interviews. Descriptive and thematic analysis will be applied. …”
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Systematic literature review as knowledge base for the research efforts towards the inception of a National Programme for Cardiovas-cular Rehabilitation and of a National Electroni... by Mihaela Mandu, Gelu Onose, Cătălina Andrei, Ioana Andone, Aura Spinu, Cristina Popescu, Andreea Lăcraru, Dragoș-Alin Trache, Constantin Munteanu, Vlad Ciobanu, Liliana Andronache, Ștefan Sebastian Busnatu

“…Aim. We aimed at a structured National protocol for cardiovascular rehabilitation, as for a national electronic register for cardiovascular diseases. …”
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Cluster-Based Flight Path Construction for Drone-Assisted Pear Pollination Using RGB-D Image Processing by Arata Kuwahara, Tomotaka Kimura, Sota Okubo, Rion Yoshioka, Keita Endo, Hiroyuki Shimizu, Tomohito Shimada, Chisa Suzuki, Yoshihiro Takemura, Takefumi Hiraguri

“…Flower detection is performed using a YOLO (You Only Look Once)-based object detection algorithm, and three-dimensional flower positions are estimated by integrating depth information with the drone’s positional and orientation data in the east-north-up coordinate system. To enhance pollination efficiency, the method applies the OPTICS (Ordering Points To Identify the Clustering Structure) algorithm to group detected flowers based on spatial proximity that correspond to branch-level distributions. …”
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Ante-Mortem Clinical Characterization with Post-Mortem Family Interview and Medical Record Abstraction in a Traumatic Brain Injury Brain Donor Program by Amelia J. Hicks, Enna Selmanovic, Ariel Pruyser, Carley R. Trentman, Joshua C. Klein, Kaitlyn Wilkey, Miguel X. Escalon, Natalia Bernal-Fernández, Belinda Yew, Kristen Dams-O’Connor

“…We describe the content development and structure of the LETBI PFI; interviewer training and qualifications; and considerations regarding interview duration, informant selection, and interview timing, as well as PFI inter-rater reliability. …”
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Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment by Toby Landeryou, Rosie Maddren, Jack Hearn, Mahlet Belachew, Santiago Rayment Gomez, Ewnetu Firdawek Liyew, Kathryn Forbes, Birhan Mengistu, Scott P. Lawton, Jude Eze, Geremew Tasew, Ufaysa Angulo, Roy Anderson

“…We found that fine-scale population structure exists in spatially distinct clusters of infected individuals with reinfection occurring within or between geographically close households. …”
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Developing a Cloud and IoT-Integrated Remote Laboratory to Enhance Education 4.0: An Approach for FPGA-Based Motor Control by Héctor A. Guerrero-Osuna, Fabián García-Vázquez, Salvador Ibarra-Delgado, Marcela E. Mata-Romero, Jesús Antonio Nava-Pintor, Gerardo Ornelas-Vargas, Rodrigo Castañeda-Miranda, Víktor I. Rodríguez-Abdalá, Luis Octavio Solís-Sánchez

“…The testing phase involved 50 robotics and mechatronics engineering students who participated in hands-on sessions for one month, followed by a structured survey evaluating their experience, interaction, and the educational relevance of the platform. …”
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