Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-κB Signaling Pathway by Ai Z, Yuan D, Li Y, Cai J, Zhou D, Liu W

“…Transcriptomic sequencing of anorectal tissues was integrated with experimental validation using ELISA, immunohistochemistry (IHC), and Western blotting to delineate molecular mechanism. Data were analyzed by one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparison post hoc test (significance at p< 0.05).Results: MHG significantly reduced ARC, macroscopic severity score, and Evans blue extravasation, restored intestinal villus structure and goblet cell numbers, and alleviated inflammation. …”
Get full text

Digitalization as a Socioeconomic Challenge: Assessing the Mediating Role of Digital Service Quality on Digitalization’s Impact on Sustainable Competitive Advantage by Wageeh A. Nafei, Manal A. Ghoneim, Bahaudin G. Mujtaba, Nile M. Khanfar

“…The results revealed that there is a significant relationship between the dimensions of digitization (such as strategic planning, preparing leaders, institutional structure, and attracting skills) and digital service quality and sustainable competitive advantage. …”
Get full text

Research on the application of non-contact continuous vital signs monitoring in the assessment of patients with chronic obstructive pulmonary disease by LIU Shuang, LONG Zhicong, ZHOU Yuqi, LUO Yinghua, YANG Hailing

“…All patients underwent deployment of a novel non-contact vital signs monitoring system and completed standardized pulmonary function assessments. Clinical baseline data were collected， and nocturnal physiological signals were recorded， with core monitoring indicators including heart rate variability （HRV）， respiratory characteristics， and sleep structure. …”
Get full text

Business network accessibility: Innovation capability as a connecting factor between Customer Relationship Management and market orientation on SMEs’ performance by Muhammad Fahmi, Muhammad Andi Prayogi, Muhammad Taufik Lesmana, Maharani Citra Kencana, Syahnita

“…The method used is quantitative through surveys and data analysis using the Structural Equation Modeling (SEM) Partial Least Squares (PLS) technique. …”
Get full text

A 20-week, randomized controlled trial to determine the efficacy of the Aging Well through Interaction and Scientific Education – Action Plan (AgeWISE-AP) program in older Veterans... by Maureen K. O’Connor, Julianne Szemko, Jaye E. McLaren, Lauren R. Moo, Emily E. Metcalf, Andrew Nguyen, Malissa L. Kraft, Brandon Frank, David Salat, John J. Randolph, Yorghos Tripodis

“…An exploratory outcome will focus on structural imaging data acquired from a subset of participants at baseline and one year to investigate potential volumetric changes in brain regions of interest. …”
Get full text

Fingolimod as a potent anti-Staphylococcus aureus: pH-dependent cell envelope damage and eradication of biofilms/persisters by Yongpeng Shang, Yu Huang, Qingyin Meng, Zhijian Yu, Zewen Wen, Fangyou Yu

“…Conclusion Fingolimod exhibits bactericidal activity against diverse gram-positive bacteria, with remarkable effects on S. aureus (including MRSA), disrupting bacterial cell structural integrity in a pH-dependent way and eradicating biofilms and persisters of S. aureus.…”
Get full text

Role of Psychological Distress in the Assessment of Chronic Illness Care and Self-Management Behaviors of Elderly Patients with T2DM Chronic Complications by Sun X, Wang X, Zhou R, Deng W, Jiang J, Shi Y

“…Student’s t-test, one-way ANOVA or the nonparametric analysis (Mann–Whitney U-test), Pearson correlation coefficient and structural equation model (SEM) were used to analyse the data.Results: A total of 264 participants (157 males [59.47%], with an average age of 71.07± 6.47 years) were included in the study; their duration of T2DM ranged from 5 to 30 years, with a mean duration of 11.19± 6.96 years. …”
Get full text

Risk Factors and Vascular Features Associated With Local Recurrence in Pancreatic Cancer Post‐Pancreaticoduodenectomy: A Retrospective Cohort Study by Ting‐Kai Liao, Ying Jui Chao, Wei‐Hsun Lu, Ping‐Jui Su, Chih‐Jung Wang, Yan‐Shen Shan

“…However, the relationship between vascular structural changes and LR post‐operation remains unclear. …”
Get full text

Preoperative imaging and intraoperative navigation of the parathyroid glands neoplasms in primary hyperparathyroidism by K. Yu. Slashchuk, M. V. Degtyarev, P. O. Rumyantsev, A. K. Eremkina, N. V. Tarbaeva, D. G. Beltsevich, I. V. Kim, G. A. Melnicthhenko, N. G. Mokrysheva

“…A single-stage, open-label comparative study was carried out, including clinical, laboratory and instrumental data of patients. The follow-up period after surgery for primary hyperparathyroidism was at least 6 months.Results. …”
Get full text

Values of some topographic parameters of optic nerve head obtained by Heidelberg retina tomograph II in volunteers and different stage primary open-angle glaucoma patients by B. Anguelov, A. Toshev

“…In this respect the acquired data is an initial step at the development of POAG staging system based on the topographic parameters of ONH obtained by HRT II.…”
Get full text

Prediction of uterine rupture in singleton pregnancies with one prior cesarean birth undergoing TOLAC: A cross‐sectional study by Brittany J. Arkerson, Giulia M. Muraca, Nisha Thakur, Ali Javinani, Asma Khalil, Rohan D'Souza, Hiba J. Mustafa

“…We excluded pregnancies with major structural anomalies and chromosomal abnormalities. …”
Get full text

Hidden origami in Trypanosoma cruzi nuclei highlights its non-random 3D genomic organization by Natália Karla Bellini, Pedro Leonardo Carvalho de Lima, David da Silva Pires, Julia Pinheiro Chagas da Cunha

“…We deciphered part of the origami structure hidden in the T. cruzi nucleus, showing the unidimensional genomic features are non-randomly 3D organized in the nuclear organelle. …”
Get full text

Comparison and application of depression screening tools for adolescents: scale selection and clinical practice by Xinyu Li, Wei Jin, Lu Han, Xingyu Chen, Lihong Li

“…A total of 102 articles were ultimately selected for data extraction to determine the reliability and validity of these scales. …”
Get full text

Description of a New Simple and Cost-Effective Molecular Testing That Could Simplify MUC1 Variant Detection by Victor Fages, Florentin Bourre, Romain Larrue, Andrea Wenzel, Jean-Baptiste Gibier, Fabrice Bonte, Claire-Marie Dhaenens, Kendrah Kidd, Stanislav Kmoch, Anthony Bleyer, François Glowacki, Olivier Grunewald

Get full text

Effects of binocularity and eye dominance on visually-driven ocular tracking by Kimia Seyedmadani, Kimia Seyedmadani, Keith A. Tucker, Mark R. Anderson, Mark R. Anderson, Yasemin M. Akay, Metin Akay, Leland S. Stone

Get full text

Using GIS And Geophysics In Selecting Suitable Basins With Freshwater Aquifers For An Efficient Exploration Strategy - A Case Study From Petra-Region, Jordan by Mohammmad Al Farajat, Bernhard Schaefers, Hussein Al Hassanat, Nedal Al Atteyat, Nidal Al Jahed, Jamal Khataibeh

“…In the first step, geological, structural and geomorphological knowledge was applied to determine the parts of the sedimentary basin having potentials of being local groundwater aquifers. …”
Get full text

Design and psychometric testing of a moral intelligence instrument for pre-hospital emergency medical services personnel: a sequential-exploratory mixed-method study by Fateme Mohammadi, Rasoul Salimi, Salman Khazaei, Mostafa Bijani

“…Confirmatory validity also confirmed the structure of the tool obtained from the previous step. …”
Get full text

Vulvovaginal atrophy: modern approaches to diagnostics and management by V. H. Siusiuka, N. V. Avramenko, M. I. Pavliuchenko, M. Yu. Serhiienko, A. O. Kniazieva

“…The aim of the review is to analyze the latest data on the current state of diagnosis and management of a common benign vulvar and vaginal disease in postmenopausal women – atrophic vulvovaginitis. …”
Get full text

The Neuromusculoskeletal Modeling Pipeline: MATLAB-based model personalization and treatment optimization functionality for OpenSim by Claire V. Hammond, Spencer T. Williams, Marleny M. Vega, Di Ao, Geng Li, Robert M. Salati, Kayla M. Pariser, Mohammad S. Shourijeh, Ayman W. Habib, Carolynn Patten, Benjamin J. Fregly

“…The Model Personalization toolset contains four tools for personalizing 1) joint structure models, 2) muscle–tendon models, 3) neural control models, and 4) foot–ground contact models. …”
Get full text

Analysis of mitochondrial-targeted antioxidant SkQ1 effectiveness on myocardial ischemia-reperfusion injury in a rat model: Focus on morphological and ultrastructural tissue study by E. A. Senokosova, E. A. Velikanova, R. A. Mukhamadiyarov, O. D. Sidorova, E. O. Krivkina, L. V. Antonova, E. V. Grigoriev

“…Cytochrome C was distributed evenly.Conclusion. 12 ng/mL of SkQ1 demonstrates pronounced antioxidant effects in the ischemic myocardium leading to a higher degree preservation of the heart muscle compared to 120 ng/mL of SkQ1 that was associated with an aggravated oxidative stress and structural changes of the tissue.…”
Get full text