Martinostat as a novel HDAC inhibitor to overcome tyrosine kinase inhibitor resistance in chronic myeloid leukemia by Haeun Yang, Vladimir Li, Su Jung Park, Sang Won Cheon, Anne Lorant, Aloran Mazumder, Jin Young Lee, Barbora Orlikova-Boyer, Claudia Cerella, Christo Christov, Gilbert Kirsch, Dag Erlend Olberg, Guy Bormans, Hyoung Jin Kang, Byung Woo Han, Michael Schnekenburger, Marc Diederich

“…Methods and results Structural and biochemical analyses confirmed the efficient and selective binding of martinostat to HDAC isoenzyme ligand-binding pockets, resulting in histone and tubulin hyperacetylation in both imatinib-sensitive and resistant CML cells, outperforming vorinostat, a clinically used HDAC inhibitor (HDACi). …”
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Phosphorescent PdII–PdII Emitter‐Based Red OLEDs with an EQEmax of 20.52% by Lige Qiao, Xiangjun Kong, Kechun Li, Lequn Yuan, Yunjun Shen, Yuzhen Zhang, Liang Zhou

“…Complexes 2 and 3 are characterized by single‐crystal X‐ray diffraction. The crystalline data of 2 and 3 reveal complex double‐layer structures, with Pd–Pd distances of 2.8690(9) Å and 2.8584(17) Å, respectively. …”
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Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests by Jinpan Hu, Zijing Jia, Meng Wang, Lingling Nie, Wangjun Fu, Qingfeng Zhang, Haiyang Qin, Jianhui Nie, Xiaoyu Xu, Lingjie Xu, Fengze Wang, Yingping Chen, Bo Xing, Tao Li, Danfeng Li, Shaowei Li, Ningshao Xia, Xiangxi Wang, Weijin Huang

“…The IVRP results were correlated with potency data from mouse models, offering an efficient alternative to in vivo potency experiments.…”
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Workload, job, and family satisfaction in dual-earning parents with adolescents: the mediating role of work-to-family conflict by Berta Schnettler, Berta Schnettler, Berta Schnettler, Berta Schnettler, Andrés Concha-Salgado, Ligia Orellana, Ligia Orellana, Mahia Saracostti, Katherine Beroiza, Héctor Poblete, Germán Lobos, Cristian Adasme-Berríos, María Lapo, Leonor Riquelme-Segura, José A. Sepúlveda, José A. Sepúlveda, Karol Reutter, Enid Thomas

“…Mothers and fathers completed assessments about workload, WtoFC, and the Overall Job Satisfaction Scale, while all three family members responded to the Satisfaction with Family Life Scale.ResultsThe data were analyzed using the mediation Actor-Partner Interdependence Model and structural equation modeling. …”
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Fully automatic HER2 tissue segmentation for interpretable HER2 scoring by Mathias Öttl, Jana Steenpass, Frauke Wilm, Jingna Qiu, Matthias Rübner, Corinna Lang-Schwarz, Cecilia Taverna, Francesca Tava, Arndt Hartmann, Hanna Huebner, Matthias W. Beckmann, Peter A. Fasching, Andreas Maier, Ramona Erber, Katharina Breininger

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Cultural impacts on shared decision-making: A cross-European study of psychiatrist preferences in 38 countries by Yasuhiro Kotera, Christopher Newby, Martina Rojnic Kuzman, Philip Gorwood, Andrea Fiorillo, Mike Slade

“…Culturally sensitive SDM interventions should address not only clinician attitudes but also healthcare structures and patient expectations. Findings offer an empirical foundation for tailoring SDM training and policy to diverse cultural contexts within European psychiatry. …”
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Recovery of Perennial Plant Communities in Disturbed Hyper-Arid Environments (Sharaan Nature Reserve, Saudi Arabia) by Sami Youssef, Mohamed Djamel Miara, Stéphane Boivin, Robin Sallio, Jérôme Nespoulous, Hassan Boukcim, Sami D. Almalki, Shauna K. Rees, Benjamin P. Y.-H. Lee, Ahmed H. Mohamed

“…Specific plant community structures were correlated with each habitat, and bioindicator plant species were identified. …”
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Phytochemical analysis and antioxidant activity of Azadirachta indica A. Juss from the Republic of Chad: in vitro and in silico studies by Brahim Mahamat Ousman, Asraoui Fadoua, Farihi Ayoub, Bouhrim Mohamed, Boussaoudi Ibtissam, El Ismaili Soumaya, Herqash Rashed N., Shahat Abdelaaty A., Otchom Brahim Boy, Saoud Younes

“…The analysis identified bioactive compounds with strong radical scavenging activity and conducted in silico studies by molecular docking with AutoDock Tools. Crystal structures were sourced from the Protein Data Bank, and the Swiss absorption, distribution, metabolism, and excretion platform analyzed the pharmacokinetic properties. …”
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Decision-making under epistemic, strategic and institutional uncertainty during COVID-19: findings from a six-country empirical study by Clare Wenham, Alexandra L Phelan, Winifred Ukponu, Sumegha Asthana, Tahmina Shirin, Claire J Standley, Adachioma Chinonso Ihueze, Sanjana Mukherjee, Ibrahim B Gobir, Mohannad Al Nsour, JJ Woo, Mohammad Mushtuq Husain, Nevashan Govender, Roujia Lin, Sumit Asthana, Renee Vongai Mutare

“…Decision-making under institutional uncertainty involved using or adapting pre-existing experiences, structures and relationships and establishing new institutions and processes.Conclusions We contribute to the theory and practice of public health crisis decision-making by presenting a unified national-level applied decision-making framework for events involving uncertainty. …”
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The functions and factors governing fungal communities and diversity in agricultural waters: insights into the ecosystem services aquatic mycobiota provide by Phillip Pham, Phillip Pham, Yichao Shi, Izhar Khan, Mark Sumarah, Justin Renaud, Mark Sunohara, Emilia Craiovan, David Lapen, Stéphane Aris-Brosou, Stéphane Aris-Brosou, Wen Chen, Wen Chen

“…IntroductionFungi are essential to the aquatic food web, nutrient cycling, energy flow, and ecosystem regulation. Fungal community structures in water can be influenced by adjacent terrestrial environments, which drive and control some ecosystem services they provide. …”
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Neuropathological correlations of 18F-florzolotau PET in a case with Pick’s disease by Hisaomi Suzuki, Manabu Kubota, Shin Kurose, Kenji Tagai, Hironobu Endo, Mitsumoto Onaya, Yasuharu Yamamoto, Naruhiko Sahara, Masahiro Ohgidani, Chie Haga, Hiroya Hara, Haruhiko Akiyama, Keisuke Takahata, Makoto Higuchi

“…In contrast, no such associations were found in subcortical structures. Furthermore, a substantial proportion of Pick bodies displayed fluorescence co-labelled with florzolotau and AT8 antibodies. …”
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Title: race and ethnicity and the risk of community-acquired third-generation cephalosporin-resistant uropathogens: a systematic review and meta-analysis by Sweta Balaji, Sarah Blackmon, Esther E. Avendano, Samson Alemu Argaw, Rebecca A. Morin, Nanguneri Nirmala, Shira Doron, Maya L. Nadimpalli

“…Conclusions: As antibiotic resistance rises in community settings, our findings support the need to understand the structural issues that underpin differential risk of 3GC-R uropathogens across race and ethnicity. …”
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Tertiary cancer center results of sterilized auto-graft prosthetic osteo-articular complex reconstruction following bone tumor resection by Himanshu Rohela, Anupam Lahiri, Irfan Ahmed, Kundan Singh Chufal, Kripa Mishra, Rajan Arora

“…Background: Bone tumor resections necessitate complex reconstruction methods to maintain limb function and structural integrity. Various approaches, including tumor prostheses and biological reconstructions, offer distinct advantages and disadvantages. …”
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Characterization of MADS-Box Gene Family in <i>Isatis indigotica</i> and Functional Study of <i>IiAP1</i> in Regulating Floral Transition and Formation by Yanqin Ma, Yanhong Lan, Ju Li, Haicheng Long, Yujie Zhou, Zhi Li, Mingjun Miao, Jian Zhong, Haie Wang, Wei Chang, Ziqin Xu, Liang Yang

“…IiMADS proteins in the same cluster had similar motifs and gene structures. In total, 102 IiMADS-box genes were unevenly distributed across seven chromosomes. …”
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Dramatic Enhancement of Macrozoobenthic Species β-Diversity in Response to Artificial Breakwater Construction Along a Tropical Coastline by Huan Chiao Lee, Christopher J. Glasby, Anja Schulze, Han Raven, Siong Kiat Tan, Takaomi Arai, Amirah Md Jin, Nurun Nazihah Tal’ah, Ainina Zarifi, David J. Marshall

“…The beneficial or detrimental effects of human-built marine structures (piers, breakwaters, and seawalls) on macrozoobenthic assemblages and diversities are currently underexplored. …”
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The extra-islet pancreas supports autoimmunity in human type 1 diabetes by Graham L Barlow, Christian M Schürch, Salil S Bhate, Darci J Phillips, Arabella Young, Shen Dong, Hunter A Martinez, Gernot Kaber, Nadine Nagy, Sasvath Ramachandran, Janet Meng, Eva Korpos, Jeffrey A Bluestone, Garry P Nolan, Paul L Bollyky

“…Finally, we identify lymphoid structures away from islets enriched in CD45RA+ T cells — a population also enriched in one of the inflamed islet sub-states. …”
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Presenting the model of academic resilience based on behavioral brain systems and academic perfectionism with the mediator role of emotional dyslexia by Esmaiel Soleimani, ali noori, mohammad narimani, ali esazadeghan

“…To analyze the obtained data, structural equations causal modeling method was used, along with AMOS software. …”
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Diagnostic yield of 1000 trio analyses with exome and genome sequencing in a clinical setting by Helena Malmgren, Helena Malmgren, Malin Kvarnung, Malin Kvarnung, Peter Gustafsson, Peter Gustafsson, Britt-Marie Anderlid, Britt-Marie Anderlid, Cecilia Arthur, Cecilia Arthur, Jonas Carlsten, Jonas Carlsten, Karl De Geer, Karl De Geer, Emma Ehn, Emma Ehn, Giedre Grigelioniené, Giedre Grigelioniené, Anna Hammarsjö, Anna Hammarsjö, Hafdis T. Helgadottir, Hafdis T. Helgadottir, Maritta Hellström-Pigg, Maritta Hellström-Pigg, Erik Iwarsson, Erik Iwarsson, Ekaterina Kuchinskaya, Ekaterina Kuchinskaya, Hillevi Lindelöf, Hillevi Lindelöf, Maria Mannila, Maria Mannila, Daniel Nilsson, Daniel Nilsson, Maria Pettersson, Maria Pettersson, Eva Rudd, Eva Rudd, Ellika Sahlin, Ellika Sahlin, Bianca Tesi, Bianca Tesi, Emma Tham, Emma Tham, Håkan Thonberg, Håkan Thonberg, Eini Westenius, Eini Westenius, Johanna Winberg, Johanna Winberg, Max Winerdal, Max Winerdal, Magnus Nordenskjöld, Magnus Nordenskjöld, Maria Johansson-Soller, Maria Johansson-Soller, Valtteri Wirta, Valtteri Wirta, Ann Nordgren, Ann Nordgren, Anna Lindstrand, Anna Lindstrand, Kristina Lagerstedt-Robinson, Kristina Lagerstedt-Robinson

“…Our current protocol for trio analysis is based on genome sequencing data, which allows for simultaneous detection of single nucleotide variants, insertion/deletions, structural variants, expanded short tandem repeats, as well as a copy number analysis corresponding to an array-CGH, and analysis regarding SMN1 gene copies.…”
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Optimizing the single-step model for predicting fumonisins resistance in maize hybrids accounting for the genotype-by-environment interaction by Jeniffer Santana Pinto Coelho Evangelista, Jeniffer Santana Pinto Coelho Evangelista, Kaio Olimpo das Graças Dias, Maria Marta Pastina, Saulo Chaves, Lauro José Moreira Guimarães, Jorge Hidalgo, Julian Garcia-Abadillo, Julian Garcia-Abadillo, Reyna Persa, Valéria Aparecida Vieira Queiroz, Dagma Dionísia da Silva, Leonardo Lopes Bhering, Diego Jarquin

“…We examined different manners to conduct the prediction of FUMO contamination using genomic and pedigree data, and combinations of these two via the single step model (B-matrix) which also offers the possibility of increasing training set sizes. …”
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體驗教育對建構大學生心理資本之研究 Effect of Experiential Education on College Students’ Psychological Capital Development by 陳淑媛 Shu-Yuan Chen, 許于仁 Yu-Ren Hsu

“…Quantitative data were collected from 31 valid responses submitted by 18 female and 13 male participants. 2. …”
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