Mechanisms of immune regulation and transplantation immunity in corneal transplants by V. V. Neroev, N. V. Balatskaya, E. V. Chentsova, Kh. M. Shamkhalova

“…Unlike other kinds of transplants, corneal grafting is often performed without tissue typing and systemic immunosuppression.High frequency of transparent corneal engraftment (up to 90% of cases) in the absence of risk factors is due to special immunoprivileged area in the anterior eye segment (functionally, a structural aggregation of the cornea and anterior chamber, AC) accomplished by local and systemic immunoregulatory mechanisms, i.e., phenomenon of immune deviation associated with anterior chamber of the eye (ACAID), components of the internal liquid medium, a watery moisture with immunosuppressive properties, e.g., IL-1ra, TSP-1,TGF-β2, regulatory complement proteins, α-MSH (alpha-melanocyte stimulating hormone), VIP (vasoactive intestinal peptide), indolamine 2,3-dioxygenase (IDO), calcitonin-gene-bound peptide (CGRP), somatostatin, etc.In addition to ACAID and liquid AC components, a contribution to the maintenance of immune privilege which is extremely important for a successful outcome of keratoplasty, is provided by other mechanisms, in particular, immunologically active membrane-associated molecules of corneal endothelium, i.e., PDL-1 (Programmed death ligand 1), and sVEGFR-1, sVEGFR-2, sVEGFR-3 involved in maintaining avascularity of the corneal tissue. …”
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DeepMiRBP: a hybrid model for predicting microRNA-protein interactions based on transfer learning and cosine similarity by Sasan Azizian, Juan Cui

“…The second component utilizes Convolutional Neural Networks (CNNs) to process the spatial data inherent in protein structures based on Position-Specific Scoring Matrices (PSSM) and contact maps to generate detailed and accurate representations of potential microRNA-binding sites and assess protein similarities. …”
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Providing financial protection in health for low-income populations: a comparison of health financing designs in East Asia by Qian Zhang, Julia Shu-Huah Wang, Alex Jingwei He, Chenhong Peng, Aya Abe, Inhoe Ku, Irene Y.H. Ng, Xi Zhao

“…However, prior cross-national comparative studies predominantly focused on examining financing structures or social health insurance (SHI) schemes, neglecting financing schemes targeting the poor, such as medical financial assistance (MFA). …”
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Development and psychometric evaluation of the Infertility Public Stigma Scale for Japanese women: protocol for an exploratory sequential mixed method study of the Japanese populat... by Rie Yokota, Tsuyoshi Okuhara, Hiroko Okada, Emi Furukawa, Ritsuko Shirabe, Toshie Agawa, Hisashi Kato, Takahiro Kiuchi

“…Quantitative research will be conducted using the initial scale. Structural validity will be examined using exploratory and confirmatory factor analyses. …”
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Involving Knowledge Users in Health Services Research: Collective Reflections and Learning From a National Evaluation of Recurrent Miscarriage Services by Marita Hennessy, Rebecca Dennehy, Hannah O'Leary, Keelin O'Donoghue, RE:CURRENT Research Advisory Group

“…Themes constructed from the Word Café discussions highlighted that structural and relational spaces shaped the accessibility and experience of involvement. …”
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Nexus among artificial intelligence implementation, healthcare social innovation, and green image of hospitals’ operations management in Egypt by Heba Mohamed Adel, Mennatallah Khaled, Mohamed Ahmed Yehya, Rahma Elsayed, Rawan Sameh Ali, Farah Emam Ahmed

“…After applying structural equation modeling using SmartPLS-v4, the results illustrated that AII has a positive significant impact on HSI, which has a positive significant influence on HGI. …”
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ASPECTS OF ASSESSING AESTHETIC PARAMETERS IN PATIENTS by P.Z. Ozhohan, Z.R. Ozhogan

“…We found that in a significant part of patients, fixed metal-ceramic or metal-acrylic fixed structures and direct composite restorations for a period of 3 years or more prevailed, which led to the development of an inflammatory process in the marginal periodontal tissues and gingival bleeding. …”
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Spatial disparities of antenatal care utilization among pregnant women in sub-Saharan Africa—Bayesian geo-additive modelling approach by Denekew Bitew Belay, Denekew Bitew Belay, Haile Mekonnen Fenta, Haile Mekonnen Fenta, Haile Mekonnen Fenta, Nigussie Adam Birhan, Najmeh Nakhaei Rad, Ding-Geng Chen, Ding-Geng Chen

“…Both Moran’s I and Geary’s C tests, with different neighborhood structures, evidenced the existence of spatial autocorrelation of ANC utilization among women in SSA countries. …”
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THE EFFECT OF SPLEEN LYMPHOCYTES TREATED WITH AN ORIGINAL ANTICONVULSANT ON HEMATOPOIESIS DURING LONG-TERM ALCOHOL CONSUMPTION by Irina Orlovskaya, Evgeniya Markova, Ivan Savkin, L. Toporkova, M. Knyazheva, E. Serenko, A. Smyk, E. Goiman

“…AbstractExcessive alcohol consumption has a negative effect on hematopoiesis, which is expressed in a significant suppression of both the production of blood cells and structural changes in precursors, namely in the suppression of their maturation, up to pancytopenia. …”
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An investigation into male infertility caused by hormonal imbalance and hypertension brought on by SARS-CoV-2 by Parameswari R, Kasthuri K, Babujanarthanam R, Ganesamoorthy R, Gomathi R, Yogesh T

“…Ethical approval was obtained from the relevant institutional review board prior to data collection. Semen samples were collected and analysed according to the World Health Organization (WHO) guidelines (2021) for conventional semen parameters. …”
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Predicting digital contact tracing tool adoption during COVID-19 from the perspective of TAM: The role of trust, fear, privacy, anxiety, and social media by Adi Alsyouf, Ala’a M Al-Momani, Nizar Alsubahi, Abdalwali Lutfi, Khalid Anwer Al-Mugheed, Mohammed Amin Almaiah, Rami J Anshasi, Main Naser Alolayyan, Abdallah Alsaad, Mahmaod Alrawad

“…Methods Using a quantitative, cross-sectional design, data were collected from Saudi participants through an online survey and analysed using Structural Equation Modeling (SEM) with SmartPLS4. …”
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Immune landscape and TAM density in endometrial cancer: implications for immune checkpoint inhibitors efficacy by Olivia Le Saux, Renaud Sabatier, Isabelle Treilleux, Léa-Isabelle Renaud, Pierre-Emmanuel Brachet, Alejandra Martinez, Jean-Sébastien Frenel, Cyril Abdeddaim, Justine Berthet, Sarah Barrin, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Lainé, Christophe Caux, Bertrand Dubois, Isabelle Ray-Coquard

“…T/B lymphoid aggregates (LA) and tertiary lymphoid structures (TLS) were separately quantified. Microsatellite status, presence of LA/TLS, and immune cell densities were correlated to response to treatment. …”
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Transdiagnostic mechanisms of mental health during the COVID-19 pandemic: associations of childhood trauma, maladaptive personality traits, emotion regulation, mentalizing, and pan... by Julia Holl, Julia Holl, Anna Berning, Laura Kling, Svenja Taubner, Anna K. Georg, Jana Volkert

“…The aim of this study is to examine the associations with these transdiagnostic factors in relation to PR distress and psychopathological symptoms.Materials and methodsUsing a cross-sectional study design, we investigated a convenience sample of 6,451 adults (mean age = 44.1; SD = 11.8; 69.1% female, 30.3% male, 0.01% diverse) recruited via social media platforms in German-speaking countries (August 2020 – February 2021) by utilizing self-report instruments (PID5BF+, MentS, DERS-SF, PHQ-9, GAD-7, a composite PR distress score). Structural equation modeling was performed for data analysis.ResultsThe results revealed significant associations between different types of childhood trauma and MPTs (−0.14 < β < 0.48) as well as a parallel mediation of the relationship between MPTs and psychopathological symptoms via mentalizing (βanxiety = −0.03; βdepression = 0.01) and emotion dysregulation (βanxiety = 0.24; βdepression = 0.23).DiscussionMentalizing and emotion dysregulation seem to play a significant role in relation between childhood trauma and MPTs and psychopathological symptoms during the COVID-19 pandemic. …”
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Gender differences in L1 vertebral strength in adults 50+ using automated CT-based finite element analysis by Hsiang-Ho Chen, Chieh-Wei Wu, Yen Cheng, Mao-Chieh Su, Yu-Jhen Chen, Po-Liang Lai

“…The focus is on establishing a prediction model for the structural strength of the L1 vertebral body using patient-specific CT data, thereby aiding in the prediction of vertebral fracture risk. …”
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Outcomes and complications of pre-assisted reproductive technology hysteroscopic evaluation and treatment: a cross-sectional study at a Nigerian teaching hospital by Abimbola Tawaqualit Ottun, Ayokunle Moses Olumodeji, Olufemi Ayanbode, Ayokunle Adebayo Ogunyemi, Faosat Olayiwola Jinadu, Adeniyi Abiodun Adewunmi

“…It is especially valuable for women seeking assisted reproductive technology (ART), as structural uterine abnormalities—such as adhesions, polyps, and fibroids—can reduce implantation success or increase the risk of miscarriage. …”
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Multi-scale channel attention U-Net: a novel framework for automated gallbladder segmentation in medical imaging by Yiming Zhou, Xiaobo Wen, Xiaobo Wen, Kang Fu, Meina Li, Lin Sun, Xiao Hu

“…It satisfies clinical requirements and enhances the efficiency of physicians, particularly in segmenting complex anatomical structures.…”
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A Remote-Sensing-Based Method Using Rockfall Inventories for Hazard Mapping at the Community Scale in the Arequipa Region of Peru by Cassidy L. Grady, Paul M. Santi, Gabriel Walton, Carlos Luza, Guido Salas, Pablo Meza, Segundo Percy Colque Riega

“…However, the only rockfall inventory available for Arequipa contains limited data of large, discrete events, which is insufficient for characterizing rockfall hazards at the community scale. …”
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A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1 by Trina Saha, Dipanjan Karati

“…Conclusion The most frequent BIN1 variants are found in non-coding regions immediately upstream of the gene, and it is thus likely that their impact is regulatory and not structural. The variants can influence the levels of BIN1 or splicing between isoforms, especially the distribution of isoforms. …”
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INNOVATIVE EXPERIMENTAL TESTING PROGRAM OF DIRECT SHEAR TEST IN SOIL MECHANICS by Zakaria OWUSU-YEBOAH, Mircea ANICULAES, Andreea Vasilica DASCALU, Iancu Bogdan TEODORU, Irina LUNGU

“…The research work aims at analyzing for the first time the data set obtained on cohesive soil samples following the publication of the Romanian Invention Patent RO 134239. …”
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Molecular Determinants for the Binding of the Highly Infectious SARS-CoV-2 Omicron (BA.1) Variant to the Human ACE2 Receptor by Majed S. Aljohani, Pawan Bhatta, Xiche Hu

“…Additionally, allosteric effects improve the contributions of non-mutated residues (notably A475, Y453, and F486) via structural realignment and novel hydrogen bonding with ACE2 residues such as S19, leading to an overall increase in the electrostatic and π-system interaction energy. …”
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