Intra-host genomic variation of serologically nontypeable Haemophilus influenzae isolates from otitis media by Randall J. Olsen, S. Wesley Long, Yuvanesh Vedaraju, Sandra Tomasdottir, Helga Erlendsdottir, Karl G. Kristinsson, James M. Musser, Gunnsteinn Haraldsson

“…While research has begun advancing our understanding of the population genomic structure of H. influenza strains infecting humans, little is known about intra-host genomic variation. …”
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ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke by Ivan B. Filippenkov, Yana Yu. Shpetko, Vasily V. Stavchansky, Alina E. Denisova, Leonid V. Gubsky, Lyudmila A. Andreeva, Nikolay F. Myasoedov, Svetlana A. Limborska, Lyudmila V. Dergunova

“…Thus, our results may be useful for selecting more effective structures for future anti-stroke drugs and appropriate post-stroke time points for their testing.…”
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Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape by Salma Kabbashi, Yvonne Prince, Ndonwi Elvis Ngwa, Haly Holmes, Glenda Mary Davison, Saarah F. G. Davids, Manogari Chetty

“…Several alpha and beta-diversity metrics assessed biodiversity within-sample and population structure between different microbiota datasets, respectively. …”
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Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial by Jean-Yves Reginster, J Badurski, N Bellamy, W Bensen, R Chapurlat, X Chevalier, C Christiansen, H Genant, F Navarro, E Nasonov, P N Sambrook, T D Spector, C Cooper

“…Treatment with strontium ranelate 1 and 2 g/day is associated with a significant effect on structure in patients with knee osteoarthritis, and a beneficial effect on symptoms for strontium ranelate 2 g/day.Additional supplementary data are published online only. …”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…An online survey determined prospective network focus, structure and priorities, with responses analysed using mixed methods.Survey results suggested respondents have interests in synthesising data using systems-approaches and using certain disciplines such as ‘social sciences’ within network activities. …”
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QTL mapping associated with Verticillium wilt resistance in cotton based on MAGIC population by Muhammad Ayyaz, Zewei Chang, Shugen Ding, Peng Han, Lin Xu, Abudurezike Abudukeyoumu, Irfan Ali Siddho, Zhibo Li, Hairong Lin, Jianwei Xu, Yuanlong Wu, Xinhui Nie

“…Single nucleotide polymorphism (SNP) markers and phenotypic data can be used to identify genetic markers and loci associated with cotton resistance to Verticillium wilt. …”
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Analysis of the changes and correlation of soft and hard tissues in the lower facial third before and after BSSRO with genioplasty in patients with unilateral mandibular asymmetry by HU Shuangyu, HE Shixi, MA Cheng, LIU Liyuan, HUANG Xuanping

“…Objective To investigate the effects and alterations in soft and hard tissues in the lower third of the facial structure in patients exhibiting facial asymmetry following bilateral sagittal split ramus osteotomy (BSSRO) with genioplasty, and to examine the correlation between the changes observed in soft and hard tissues. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
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Characterization of the 1966 Camp Century subglacial core: a multiscale analysis by C. M. Collins, N. Perdrial, N. Perdrial, P.-H. Blard, P.-H. Blard, N. Keulen, W. C. Mahaney, H. Mastro, J. Souza, D. M. Rizzo, Y. Marrocchi, P. C. Knutz, P. R. Bierman

“…Microscale grain size and shape analysis, conducted using scanning electron microscopy, showed an abundance of fine-grained materials in the lower part of the core and no correspondence between grain shape parameters and sedimentary structures. These multiscale data define five distinct stratigraphic units within the core based on sedimentary process; <span class="inline-formula"><i>k</i></span>-means clustering analysis supports this unit delineation. …”
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Overexpression of Egr1 Transcription Regulator Contributes to Schwann Cell Differentiation Defects in Neural Crest-Specific <i>Adar1</i> Knockout Mice by Lisa Zerad, Nadjet Gacem, Fanny Gayda, Lucie Day, Ketty Sinigaglia, Laurence Richard, Melanie Parisot, Nicolas Cagnard, Stephane Mathis, Christine Bole-Feysot, Mary A. O’Connell, Veronique Pingault, Emilie Dambroise, Liam P. Keegan, Jean Michel Vallat, Nadege Bondurand

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A preliminary study of the pathological characteristics of the internal orifice and the local mucosal microbial community in complex anal fistula by Zhu Jingyi, Zhang Ling, He Li, Zhang Jun, Mei Zubing, Wang Zhenyi, Chen Qiyi, Wang Qingming

“…[Objectives] To observe the histological morphology and Mucoprotein 2 (MUC2) expression in the internal orifice of complex anal fistula, as well as to compare the difference of the composition and structure of the microbial community in the mucosal tissue of the internal orifice of patients with complex anal fistula with the anal sinus mucosa of the healthy population. …”
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Differential diagnosis of juvenile idiopathic arthritis and multiple epiphyseal dysplasia: Experience of multidisciplinary interaction by D. V. Osipova, T. V. Markova, V. M. Kenis, E. V. Melchenko, T. S. Nagornova, I. P. Nikishina, E. Yu. Zakharova, E. L. Dadali, S. I. Kutsev

“…Juvenile idiopathic arthritis (JIA) is a common multifactorial disease characterized by the presence of chronic inflammation in the joints, entheses and other structures of the musculoskeletal system in combination with a certain range of extraskeletal disorders. …”
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Humic acid from leonardite for cadmium adsorption and potential applications by MENG Fande, YUAN Guodong, WEI Jing, BI Dongxue, WANG Hailong, LIU Xingyuan

“…In contrast, Leo-HA is beneficial to soil structure and soil quality, as well as safe to handle in the field. …”
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PSYCHOLOGICAL FACTORS OF THE FORMATION OF LEGAL AWARENESS OF STUDENTS OF HISTORICAL AND MEDICAL EDUCATION PROFILES by Dribas Svetlana, Semenov Konstantin

“…The purpose of the article is to determine psychological factors and compare the predictor structure of legal awareness among students of historical and medical education profiles. …”
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SERIES IN SEARCH OF INTERACTIVITY / ИНТЕРАКТИВНЫЕ СЕРИАЛЫ: В ПОИСКАХ ОБРАТНОЙ СВЯЗИ by SMOLEV DANIIL D. / СМОЛЕВ Д.Д.

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Development, Validation and Approbation Analytical Method for the Quantitative Determination of Taurine by HPLC-UV Method in the Test of Comparative Dissolution Kinetics by A. M. Poluyanov, A. Kochug, L. S. Mitrofanova, I. D. Nikitin, O. Yu. Vergasov, I. E. Shohin, E. N. Fisher

“…To solve this problem, one can apply the method of pre-column derivatization, because of which an fragment is introduced into the structure, providing a bathochromic shift in the UV spectrum of the starting compound.Aim. …”
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Cell-derived exosome therapy for diabetic peripheral neuropathy: a preclinical animal studies systematic review and meta-analysis by Xianying Lu, Ran Xu, Xiaohui Dong, Dingxi Bai, Wenting Ji, Xinyu Chen, Huan Chen, Chaoming Hou, Jing Gao

“…The outcome indicators consisted of at least one of the three key DPN endpoints (electrophysiology, behavioural assessment, and nerve structure) based on the Neurodiab guidelines. R 4.4.2 software was used to conduct all statistical analyses. …”
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Short-term PM1 exposure and sleep duration: a nationwide study using consumer-grade wearable devices by Jiajun Liu, Mintao Su, Junxiong Ma, Qinfeng Zhou, Hanxu Shi, Yujie Shi, Shuyu Huang, Yuchuan Tang, Peining Zhou, Kunyao Yu, Rui Su, Rui Zhou, Jing Wei, Jing Ma, Zhenyu Zhang

“…Although individual sleep duration changes appear modest, the cumulative impact of PM _1 on sleep structure, especially in vulnerable populations, poses significant public health risks in physiological restoration. …”
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Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease by Shruti Singh Kakan, Sara Abdelhamid, Sara Abdelhamid, Yaping Ju, Yaping Ju, J. Andrew MacKay, J. Andrew MacKay, J. Andrew MacKay, Maria C. Edman, Indu Raman, Chengsong Zhu, Prithvi Raj, Sarah F. Hamm-Alvarez, Sarah F. Hamm-Alvarez

“…The LG produces the protein-rich aqueous component of tears, and SjD-associated autoimmune dacryoadenitis (AD) may thus alter tear autoantibody composition.MethodsThe presence of tertiary lymphoid structures (TLS) in LG from two murine models of SjD-associated AD, male non-obese diabetic (NOD) and male non-obese insulitis resistant (NOR) mice, were evaluated using immunofluorescence. …”
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Effects of intermittent theta burst stimulation (iTBS) on appetite change and body weight in inpatients with schizophrenia in China: study protocol for a randomised controlled tria... by Jun Yang, Jing Huang, Jin Yang, Yue Qin, Renrong Wu, Jieyu Liu, Baoyan Xu, Haiyu Chen, Tianxiang Zou, Ziwei Teng, Tengteng Zhang, Yuhan Su, Zaiwen Dong, Chong Yang

“…MRI examination will be conducted to detect brain structure, perfusion and functional connectivity. Data analysis will be conducted in a modified intention-to-treat population. …”
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