Rapid escalation and release of risks to forest ecosystems triggered by warming: Insights from tree growth synchrony in temperate forests by Liangjun Zhu, Danyang Yuan, J. Julio Camarero, David J. Cooper, Mai-He Li, Shuguang Liu, Xiaochun Wang, Paolo Cherubini

“…These results provide crucial insights for forest management practice to enhance structural diversity and resilience capacity against climate change-induced synchrony shifts.…”
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How national leaders keep ‘us’ safe: A longitudinal, four-nation study exploring the role of identity leadership as a predictor of adherence to COVID-19 non-pharmaceutical interven... by Niklas K Steffens, S Alexander Haslam, Svenja B Frenzel, Nina M Junker, Aidos Bolatov, Valerie A Erkens, Jan A Häusser, Ronit Kark, Ines Meyer, Andreas Mojzisch, Lucas Monzani, Stephen D Reicher, Adil Samekin, Sebastian C Schuh, Liliya Sultanova, Dina Van Dijk, Llewellyn E van Zyl, Rolf van Dick

“…Hypotheses testing was conducted with structural equation modelling.Setting Data collection during the COVID-19 pandemic in China, Germany, Israel and the USA in April/May 2020 and four weeks later.Participants Adults in China (n=548, 66.6% women), Germany (n=182, 78% women), Israel (n=198, 51.0% women) and the USA (n=108, 58.3% women).Measures Identity leadership (assessed by the four-item Identity Leadership Inventory Short-Form) at Time 1, perceived shared national identification (PSNI; assessed with four items) and adherence to health-protective NPIs (assessed with 10 items that describe different health-protective interventions; for example, wearing face masks) at Time 2.Results Identity leadership was positively associated with PSNI (95% CI 0.11 to 0.30, p<0.001) in all countries. …”
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The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking by Jia-Qi Wang, Jia-Qi Wang, Yuan-Yu Liang, Yuan-Yu Liang, Zhong-Xue Zhao, Zhong-Xue Zhao, Wei Xie, Wan-Ning Sun, Wan-Ning Sun, Ji-Yu Zou, Ji-Yu Zou, Xiao-Dong Lv, Xiao-Dong Lv, Youfu He, Li-Jian Pang, Li-Jian Pang

“…Gender-stratified analysis showed that the risk burden of smoking was higher in older men in Asia, whereas the high BMI-related burden was higher in women in more developed regions.ConclusionThis study demonstrates a structural shift in the composition of asthma risk factors among older adults, with high BMI emerging as a dominant contributor amid declining traditional behavioral risks such as smoking. …”
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Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development by Yuan‐Tao Liu, Le‐Le Zhang, Zi‐Ying Jiang, Xian‐Shu Tian, Peng‐Lin Li, Pei‐Huang Wu, Wen‐Ting Du, Bo‐Yu Yuan, Chu Xie, Guo‐Long Bu, Lan‐Yi Zhong, Yan‐Lin Yang, Ting Li, Mu‐Sheng Zeng, Cong Sun

“…It highlights AI's ability to achieve >75% hit validation in virtual screening, design protein binders with sub‐Ångström structural fidelity, enhancing antibody binding affinity to the picomolar range, and optimize nanoparticles to achieve over 85% functionalization efficiency. …”
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Comparison of post-stroke white matter assessment using disconnectome-symptom mapping versus quantitative diffusion MRI by Martin Domin, Sook-Lei Liew, Brenton Hordacre, Lara A Boyd, Adriana B Conforto, Justin W Andrushko, Michael R Borich, Richard C Craddock, Miranda R Donnelly, Adrienne N Dula, Steven J Warach, Steven A Kautz, Bethany P Tavenner, Na Jin Seo, Shraddha Srivastava, Kristin A Wong, Artemis Zavaliangos-Petropulu, Paul M Thompson, Martin Lotze

“…Indirect structural disconnection‐symptom mapping allows white matter impairment to be determined without the need for multi-directional diffusion (MDDW) imaging for each individual. …”
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Efficacy and safety of cannabidiol in a single-center pediatric drug-resistant epilepsy cohort: a retrospective study by Ambra Butera, Ambra Butera, Giulia Spoto, Graziana Ceraolo, Maria Grella, Ivana Giunta, Maria Ludovica Albertini, Carla Consoli, Caterina Sferro, Maria Spanò, Gabriella Di Rosa, Antonio Gennaro Nicotera

“…Clinical, demographic, and instrumental data were retrospectively extracted from the medical records and caregivers’ reports. …”
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Phenotypically distinguishable eosinophilic cells do not impact epithelial functions in a triple-culture in vitro intestinal model by Christoph Benkstein, Laurin Mosig, Daniel Vondran, Heidi Schlichting, Lea Kissing, Bente Wohlert, Ida Gensmer, Larissa Nogueira de Almeida, Peter König, Peter König, Kerstin Fibelkorn, Anna Kordowski, Stefanie Derer-Petersen, Christian Sina, Christian Sina, Yves Laumonnier, Yves Laumonnier

“…In-depth characterization by real-time PCR, flow cytometry, functional assay and electron microscopy showed that only butyrate and dibutyryl-cAMP generated phenotypically distinct eosinophilic cells with different activation statuses, marked by differential expression of surface markers CD11c and CD62L, increased expression of eosinophil specific genes, and development of eosinophilic structural features. Then, a triple-culture system encompassing the enterocytic cell line Caco-2 and the secretory cell line HT29-MTX complemented with eosinophilic differentiated cells was established. …”
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Feasibility study of single-image super-resolution scanning system based on deep learning for pathological diagnosis of oral epithelial dysplasia by Zhaochen Liu, Zhaochen Liu, Peiyan Wang, Peiyan Wang, Nian Deng, Hui Zhang, Hui Zhang, Fangjie Xin, Xiaofei Yu, Xiaofei Yu, Mujie Yuan, Mujie Yuan, Qiyue Yu, Yuhao Tang, Keke Dou, Jie Zhao, Bing He, Jing Deng, Jing Deng

“…Both the DS30R and Nikon scanners demonstrate high sensitivity and specificity for detecting structural features in OED pathological images; however, DS30R excels at identifying certain cellular features. …”
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Quality of Surface and Groundwater in the Sierra de Amula Region, Jalisco, Mexico by Oscar Raúl Mancilla-Villa, Fabiola Villafaña-Castillo, Álvaro Can-Chulim, Rubén Darío Guevara-Gutiérrez, José Luis Olguín-López, Elia Cruz-Crespo, Jonas Alan Luna-Fletes, Juan Uriel Avelar-Roblero

“…Each sample was evaluated for its pH, electrical conductivity, and ionic concentration (Ca²⁺, Mg²⁺, Na⁺, K⁺, CO₃²⁻, HCO₃⁻, CI⁻, SO₄²⁻). For data analysis, we determined the ionic concentrations and the salinity and sodicity indexes, including the electrical conductivity, pH, sodium adsorption ratio (SAR), and cationic ratio of soil structural stability (CROSS). …”
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Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a b... by Surajit Dey, Wenying Lu, Prabuddha S. Pathinayake, Maddison Waters, Greg Haug, Josie Larby, Heinrich C. Weber, Peter A. B. Wark, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal

“…Additionally, the degree of RBM fragmentation was evaluated, a key tissue structural marker of EMT.ResultsCompared to healthy controls and asthmatics, ACO had the greatest fragmentation of RBM (P < 0.01). …”
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Co-circulation and genetic characterization of genotype I and II feline bocavirus strains in domestic cats from Northern Vietnam by Hieu Van Dong, Giang Thi Huong Tran, Yen Hoang Thi Nguyen, Thiet Chi Ngo, Amonpun Rattanasrisomporn, Chaiwat Boonkaewwan, Dao Anh Tran Bui, Jatuporn Rattanasrisomporn

“…DNA was extracted and screened for FBoV using conventional polymerase chain reaction targeting the non-structural (NS)-1 gene. Positive samples were subjected to Sanger sequencing, and partial NS1 sequences were analyzed using MEGA X for phylogenetic inference. …”
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Cultural and behavioral drivers of zoonotic disease transmission and persistence among diverse pastoralist communities in East Africa by Dismas C.O. Oketch, Ruth Njoroge, Tonny O. Ngage, Asha Abdikadir Omar, Abdulai Magarre, Raphael Pasha, John Gachohi, Samuel Waiguru Muriuki, Samoel Ashimosi Khamadi, Ali Duba Boru, Boku Bodha, Lydia Kilowua, Nazaria Wanja Nyaga, Humphrey Kariuki Njaanake, Eunice Kamaara, Walter Jaoko, M. Kariuki Njenga, Eric Osoro, Dalmas Omia

“…Methods This study adopts a One Health approach, employing a range of participatory methods including informal observations, “go-along interviews,” narrative-, and key informant- interviews, to explore the cultural, behavioral, and structural drivers of zoonotic disease transmission among pastoralist communities in East Africa. …”
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Efficacy and mechanisms underlying MRI-guided high-definition transcranial direct current stimulation for depression among university students: study protocol for a stepped wedge c... by Yuanle Chen, Rongxun Liu, Jinnan Yan, Peng Luo, Luhan Yang, Yongbin Wang, Guangjun Ji, Chuansheng Wang, Wei Zheng, Fei Wang, Yong Meng, Yange Wei

“…All groups will be receiving active intervention in week 5. Structural MRI data for each participant will be acquired to select the optimal electrode placement and correct for individual anatomical differences. …”
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The association between the gut microbiome and antituberculosis drug-induced liver injury by Shengfei Pei, Li Yang, Huixia Gao, Yuzhen Liu, Jianhua Lu, Er hei Dai, Chunyan Meng, Fumin Feng, Yuling Wang

“…At the same time, we constructed mouse models to explore the effects of different anti-tuberculosis drugs on gut microbiota.ResultsFollowing anti-TB treatment, we observed a decrease in microbial diversity and significant structural changes in the gut microbiota of TB patients (P < 0.05). …”
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Hsa_Circ_0105596/FTO inhibits progression of Parkinson's disease by sponging miR-187-3p and regulating eEF2 by Jiahao Feng, Jin Zhao, Yong Kuang, Yuheng Zhou, Ziheng Ye, Yutong He, Dandan Chen, Li Zhang, Tingying Zhang, Qingqing Zhu, Shumin Cheng, Taoli Liu

“…The binding regulation relationship between circFTO-miR-187-3p-EEF2 was determined through structural analysis, RIP, and dual luciferase reporter assay. …”
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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice by Victor J. Johnson, Cynthia V. Rider, Michael I. Luster, Cynthia J. Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback, Reshan Fernando, Suramya Waidyanatha, Gary R. Burleson, Dori R. Germolec

“…Careful characterization of strong positive and clear negative PACs is needed in order to lay the foundation for generating robust immunotoxicity data for structurally diverse PACs that have not yet been evaluated.MethodsIn the current study, adult B6C3F1/N female mice were treated daily for 28 consecutive days by oral administration of B(a)P to provide dose levels ranging between 2 and 150 mg/kg bodyweight/day. …”
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The accumulation characteristics and exploration potential of oil and gas in the back-arc basin of Japan under the background of high heat flow by Jian-qiang Wang, Jie Liang, Jian-wen Chen, Qing-fang Zhao, Yin-guo Zhang, Jian-wei Zhang, Sen Li, Chang-qing Yang, Jian Zhang, Jing Sun, Chuan-sheng Yang, Yong Yuan, Lee-Jel Jiang

“…The trap types are mainly structural traps, lithologic traps and composite traps. …”
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Tagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing by Jianxia Niu, Wenxi Wang, Zihao Wang, Zhe Chen, Xiaoyu Zhang, Zhen Qin, Lingfeng Miao, Zhengzhao Yang, Chaojie Xie, Mingming Xin, Huiru Peng, Yingyin Yao, Jie Liu, Zhongfu Ni, Qixin Sun, Weilong Guo

“…Abstract Background The massive structural variations and frequent introgression highly contribute to the genetic diversity of wheat, while the huge and complex genome of polyploid wheat hinders efficient genotyping of abundant varieties towards accurate identification, management, and exploitation of germplasm resources. …”
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Prognostic impact of small size sutureless prostheses: results for 241 patients from an international registry by Giuseppe Santarpino, Roberto Lorusso, Giovanni Concistrè, Josè Cuenca Castillo, Vincenzo Argano, Alistair Royse, Angelo Lucas Nobre, Patrick Parrino, Gianluigi Bisleri, Max Baghai, Theodor Fischlein, Giovanni Troise, Generoso Mastrogiovanni, Raphael Fontaine, Davide Pacini, Giuseppe Minniti, Aniello Pappalardo, George Chad Hughes, Philippe Noirhomme, Jean-Philippe Grimaud, Maximilian Scherner, Ignacio Muñoz, George Asimakopoulos, Antony Walker, Daniela Zakova, Michele Torella, Giorgio Vigano, Mark Connolly, Christian Dinges, Pierre Corbi, Loris Salvador, Mauro Rinaldi, Luis Maroto, David Heimansohn, Basel Ramlawi, Mattia Glauber, Jlenia D’Agnano, Valeria Cosco, Veronica D’Anna, Marco Solinas

“…At a maximum follow-up of 8.1 years, 10 cardiovascular deaths, 4 valve related reinterventions (3 structural valve deterioration (SVD) requiring TAVI Valve-in-Valve, 1 endocarditis) occurred. …”
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Correlates of duration between initial drug use and first drug injection among people who inject drugs in Iran, 2020 by Zahra Abdolahinia, Zahra Jaafari, Ali Karamoozian, Soheil Mehmandoost, Nima Ghalekhani, Mehrdad Khezri, Ghazal Mousavian, Mostafa Shokoohi, Ali Mirzazadeh, Ali Akbar Haghdoost, Mohammad Karamouzian, Mohammad Mehdi Gooya, Samaneh Akbarpour, Hamid Sharifi, Fatemeh Tavakoli

“…Policymakers should prioritize evidence-based, multi-faceted approaches that target both individual and structural factors to delay or prevent the transition to injection drug use and reduce associated health risks.…”
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