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53481
Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs
Published 2025-06-01“…In the DrugBank database, 98 structurally novel candidate compounds with potential senolytic activity were identified. …”
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53482
Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells
Published 2025-01-01“…Results: We established that Enoxacin, but not the structurally similar compound nalidixic acid, exhibits strong anti-HIV-1 effects in the T-cell line CEM-SS, but not MT-4. …”
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53483
Smart Digital Solutions for EARLY Treatment of COGNitive Disability (EARLY-COGN^3): A Study Protocol
Published 2025-02-01“…Neurophysiological markers and biomolecular data will be collected at T0 and T1. <b>Conclusions:</b> EARLY-COGN^3 project could lead to a complete paradigm shift from the traditional therapeutic approach, forcing a reassessment on how CNDs could take advantage of a digital solution. …”
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53484
Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report
Published 2025-06-01“…Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
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53485
Treatment of loiasis: a review of clinical management recommendations
Published 2025-05-01“…Renowned tropical medicine textbooks were also consulted. Data were extracted with a detailed table collaboratively developed and reviewed by multiple researchers to ensure consistency and accuracy. …”
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53486
AI-based thematic exploration to understand patients with myasthenia gravis by serological subtype
Published 2025-07-01“…Advanced search techniques and AI-powered algorithms were used to extract/organize data by topics into a large, unstructured dataset. …”
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53487
Engagement of Indigenous peoples in commercial tobacco reform strategies: a scoping review protocol
Published 2025-07-01“…This review supports the global goal of eradicating commercial tobacco-related harms – reframing commercial tobacco use as a structurally imposed harm sustained by colonial and commercial forces rather than personal choice. …”
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53488
The antioxidant property of CAPE depends on TRPV1 channel activation in microvascular endothelial cells
Published 2025-03-01“…Herein, we hypothesized that a subfamily of TRP ion channels works as the molecular entity that recognizes CAPE at the plasma membrane and allows a fast shift in the antioxidant capacity of intact endothelial cells (EC).By monitoring cytoplasmic Ca2+ in a microvascular EC model, we compared the calcium responses evoked by three structurally related compounds: caffeic acid phenethyl ester, neochlorogenic acid and caffeic acid. …”
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53489
Newly diagnosed diseases and the frequency of their occurrence in patients after a new coronavirus infection. Results of an International Register "Dynamics Analysis of Comorbiditi...
Published 2023-05-01“…Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. …”
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53490
The effects of active play interventions on children’s fundamental movement skills: a systematic review
Published 2025-01-01“…Active play (AP) holds significant potential for enhancing children’s FMS based on its free-choice and unstructured nature, as well as its ease of implementation and dissemination. …”
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53491
Extracting Multifaceted Characteristics of Patients With Chronic Disease Comorbidity: Framework Development Using Large Language Models
Published 2025-05-01“…In addition, we demonstrated the strengths and limitations of this framework. MethodsWe used data sourced from a grassroots community health service center in China. …”
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53492
Environmental Impact of Physical Visits and Telemedicine in Nursing Care at Home: Comparative Life Cycle Assessment
Published 2025-04-01“…Telemedicine visits were elementary in nature, such as supporting patients in taking their medication or structuring their daily agenda. We quantified average environmental impacts from cradle to grave, using the Environmental Footprint method, and verified the robustness of the comparison via uncertainty analysis. …”
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53493
Multi-element Accurate Analysis of Sulfide Minerals by Low-temperature Ablation LA-ICP-MS
Published 2023-10-01“…The ablation craters on the chalcopyrite showed a two-layer cyclic structure, in which the inner layer was a light-colored melting zone, and the outer layer was a white aerosol vapor sediment. …”
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53494
Autonomous International Classification of Diseases Coding Using Pretrained Language Models and Advanced Prompt Learning Techniques: Evaluation of an Automated Analysis System Usin...
Published 2025-01-01“…However, it faces challenges such as small datasets, diverse writing styles, unstructured records, and the need for semimanual preprocessing. …”
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53495
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53496
Real-Time FTM-Based Victim Positioning System Using Heterogeneous Robots in Remote and Outdoor Scenarios
Published 2025-01-01“…A centralized Feedback Information System (FIS) processes real-time RTT data from the field, executes a multilateration algorithm, and provides live geolocation updates to SAR coordinators. …”
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53497
Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice
Published 2025-03-01“…Careful characterization of strong positive and clear negative PACs is needed in order to lay the foundation for generating robust immunotoxicity data for structurally diverse PACs that have not yet been evaluated.MethodsIn the current study, adult B6C3F1/N female mice were treated daily for 28 consecutive days by oral administration of B(a)P to provide dose levels ranging between 2 and 150 mg/kg bodyweight/day. …”
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53498
Top 10 palliative care research priorities in France: a 3-step, mixed-methods protocol (AXEPRO study)
Published 2025-02-01“…A multidisciplinary steering committee including board-certified PC physicians, methodologists, nurses, a sociologist, an anthropologist and an information specialist will analyse the data collected in order to delete duplicate questions, do a thematic and population classification of the responses, modify questions using the PICO (patient problem, intervention, comparison and outcome) format and perform a literature review on each question to identify any relevant systematic review.Ethics and dissemination We expect the results to have wide-ranging benefits, for example, by prompting investment in the 10 prioritised research questions. …”
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53499
Exploring the Strong Interaction of Three-Body Systems at the LHC
Published 2024-09-01“…The analysis of the p-d correlation shows that only a full three-body calculation that accounts for the internal structure of the deuteron can explain the data. In particular, the sensitivity of the observable to the short-range part of the interaction is demonstrated. …”
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53500
Association of cancer and outcomes of patients hospitalized for COVID-19 between 2020 and 2023 [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]
Published 2025-04-01“…Methods We conducted an analysis on data collected in a large prospective cohort study set-up by the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC). …”
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