Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction by Yahong Li, Jiasheng Chen, Wenli Jiang, Jin Ye, Xuan Zhang, Chao Wang

“…Utilizing X-ray crystallography, we elucidate the high-resolution structure of the mammalian CIB2-TMC1 complex. Structural analyses reveal that cation-bound CIB2 forms a negatively charged surface that aligns with a positively charged surface on the TMC1 N-terminus. …”
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Improvement of Terrain Entropy Calculation for Grid Digital Elevation Models Considering Spatial Structural Features by Fangbin Zhou, Tianyi Yao, Junwei Bian, Yun Xiao

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Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery by Bingyong Xie, Haoyu Ni, Jiyuan Yao, Zhibin Xu, Sicheng Bian, Haoxiang Wang, Kun Zhu, Xianyong Wu, Peiwen Song, Yuanyuan Wu, Yongqiang Yu, Fulong Dong

“…Methods In this prospective cohort study, we conducted an analysis of data from 54 patients with DCM both before and after surgery, as well as 57 healthy controls (HC), using functional MRI in combination with high-resolution structural MRI. …”
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The impact of the structural state of the tubulin cytoskeleton on chlorophyll fluorescence indicators and auxin content in Solanum tuberosum by I.Yu. Makeeva, T.I. Puzina

“…Information on the dependence of light reactions of photosynthesis on the structural state of cytoskeletal elements is extremely limited. …”

Associations of Prenatal Socioeconomic Status and Childhood Working Memory: A Structural Equation Modeling Approach by Shelley H. Liu, David Bellinger, Kristen Dams-O’Connor, Jeanne A. Teresi, Ivan Pantic, Sandra Martínez-Medina, John Chelonis, Martha M. Téllez-Rojo, Robert O. Wright

“…Study Design: We used data from a prospective birth cohort study in Mexico City, Mexico, with N = 515 children aged 6–9 years. …”
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Comparative Analysis of Mitogenomes in Leafhopper Tribe Deltocephalini (Hemiptera: Cicadellidae: Deltocephalinae): Structural Conservatism and Phylogeny by Bingqing Xie, Xinyi Zhang, Yongxia Zhang, Christopher H. Dietrich, Yani Duan

“…ABSTRACT Previous studies on the gene order and composition of leafhopper mitochondrial genomes have revealed a high level of conservation in overall genome structure. Some members of Deltocephalinae, the largest subfamily, exhibit tRNA gene rearrangements; however, few mitogenomes have been sequenced in this group and the degree of structural variation within tribes remains unclear. …”
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Sodium alginate-based biochar gel spheres: synthesis, structural analysis, and ofloxacin adsorption efficiency by Qingrui Zhao, Hongpei Zhang, Xiaohui Zhao, Xiaodan Wang, Ke Zhang, Zheng Binguo, Songchao Wang, Baogui Wang, Fuzhi Guo, Yuqian Ma, Di Mao

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Reproductive toxicity in male rats induced by chronic arsenic exposure involves hormonal and structural changes by Syed Zahid Mahboob, Sarwat Jahan, Hussain Badshah, Razia Virk, Mehwish David, Riffat Bano, Jawaher Alzahrani, Muhammad Ayub, Azizullah Azizullah, Moona Nazish, Asif Kamal, Kamran Ullah, Muhammad Tahir Naseem

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Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design by Rezart Zhubi, Apirat Chaikuad, Christian J. Muñoz Sosa, Andreas C. Joerger, Stefan Knapp

“…In addition, we mapped the locations of missense mutations in MID1 associated with X-linked Opitz syndrome, suggesting that some of these mutations impair the conformational stability of the protein. Taken together, our data provide intriguing insights into the structural and functional divergence of TRIM family PRYSPRY domains, their potential druggability and substrate recognition, and the challenges of ligand design.…”
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Longitudinal structural MRI-based deep learning and radiomics features for predicting Alzheimer’s disease progression by Sepehr Aghajanian, Fateme Mohammadifard, Ida Mohammadi, Shahryar Rajai Firouzabadi, Ali Baradaran Bagheri, Elham Moases Ghaffary, Omid Mirmosayyeb

“…Conclusions These findings emphasize the value of structural MRI within the advanced DL architectures for predicting MCI-to-AD conversion. …”
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Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W by Bernardo A. Bustillos, Liam T. Cocker, Mathew A. Coban, Caleb A. Weber, Jenny M. Bredenberg, Paige K. Boneski, Joanna Siuda, Jaroslaw Slawek, Andreas Puschmann, Derek P. Narendra, Neill R. Graff-Radford, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Thomas R. Caulfield, Wolfdieter Springer, Fabienne C. Fiesel

“…The functional analysis was accompanied by structural investigation of PRKN p.R275W. We observed lower PRKN protein in fibroblasts with compound heterozygous p.R275W mutations. …”
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Relationships between structural stigma, societal stigma, and minority stress among gender minority people by Kristen D. Clark, Mitchell R. Lunn, Jae M. Sevelius, Carol Dawson-Rose, Sandra J. Weiss, Torsten B. Neilands, Micah E. Lubensky, Juno Obedin-Maliver, Annesa Flentje

“…We tested variables identified in the literature as measures of structural stigma inclusive of societal stigma (LGBT + Business Climate Index, state voting behaviors, and Google Trends search data), the most commonly used structural stigma variable (State Policy Environment Tally), and proxy variables (region, population density) for comparison. …”
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Tracing the aggregation pathway of the scaffold protein DISC1: Structural implications for chronic mental illnesses by Abhishek Cukkemane, Nina Becker, Tatsiana Kupreichyk, Henrike Heise, Dieter Willbold, Oliver H. Weiergräber

“…Disrupted in schizophrenia 1 (DISC1) is a pleiotropic scaffold protein that is postulated to comprise large disordered regions and four distinct structured segments with a high proportion of helical or coiled-coil fold. …”
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Development and distribution characteristics of geohazards based on sedimentary-structural evolution in Xide County, southwest Sichuan by Xiaohui XIONG, Yongjian BAI, Yongbo TIE, Yanchao GAO, Hua GE, Wei XU, Lingfeng GONG, Jiazhu WANG, Kai TIAN, Menglong HE, Zhihua ZHU

“…The wide and gentle fold structures in red beds are the disaster-prone environment for landslide. …”
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Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture by Rajendra A. Morey, Yuanchao Zheng, Henry Bayly, Delin Sun, Melanie E. Garrett, Marianna Gasperi, Adam X. Maihofer, C. Lexi Baird, Katrina L. Grasby, Ashley A. Huggins, Courtney C. Haswell, Paul M. Thompson, Sarah Medland, Daniel E. Gustavson, Matthew S. Panizzon, William S. Kremen, Caroline M. Nievergelt, Allison E. Ashley-Koch, Mark W. Logue

“…Even though we observed model instability in our application of genomic SEM to high-dimensional data, jointly modeling the genetic architecture of complex traits and investigating multivariate genetic links across neuroimaging phenotypes offers new insights into the genetics of cortical structure and relationships to psychopathology.…”
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Presence of Pain Shows Greater Effect than Tendon Structural Alignment During Landing Dynamics by Silvia Ortega-Cebrián, Diogo C. F. Silva, Daniela F. Carneiro, Victor Zárate, Leonel A. T. Alves, Diana C. Guedes, Carlos A. Zárate-Tejero, Aïda Cadellans-Arróniz, António Mesquita Montes

“…This study aims to investigate the relationship between tendon structure, presence of pain, and sex differences in landing kinematics and kinetics during countermovement jumps (CMJ) and tuck jump tests (TJT) in professional volleyball players. …”
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Structural placental changes in women with intra-pregnancy novel coronavirus infection COVID-19 (review) by A. V. Yakimova, S. Yu. Borovaya, V. R. Mukhamedshina, N. S. Datsenko, S. G. Kucherenko, I. M. Pozdnyakov, E. V. Nikitenko

“…In those that were excluded from the review, information about the clinical course of pregnancy and its outcome during novel coronavirus infection prevailed, or isolated cases of studying insignificant placental structural changes were discussed. Studies with a small number of observations were selected only in the case of the uniqueness of the published data, the absence of scientific papers where similar studies would have been conducted in larger sample.Results. …”
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The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis by Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang

“…Consequently, it is important to utilize relevant coordinate data for a comprehensive meta-analysis to identify the shared patterns of structural, functional, and multimodal alternations in TUD.MethodThe present study conducted a systematic retrieval of studies published on PubMed, Web of Science, and Scopus from January 1, 2010, to December 12, 2023, to identify studies on voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) for TUD. …”
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Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer by Ailith Ewing, Alison Meynert, Ryan Silk, Stuart Aitken, Devin P. Bendixsen, Michael Churchman, Stuart L. Brown, Alhafidz Hamdan, Joanne Mattocks, Graeme R. Grimes, Tracy Ballinger, Robert L. Hollis, C. Simon Herrington, John P. Thomson, Kitty Sherwood, Thomas Parry, Edward Esiri-Bloom, Clare Bartos, Ian Croy, Michelle Ferguson, Mairi Lennie, Trevor McGoldrick, Neil McPhail, Nadeem Siddiqui, Rosalind Glasspool, Melanie Mackean, Fiona Nussey, Brian McDade, Darren Ennis, The Scottish Genomes Partnership, Lynn McMahon, Athena Matakidou, Brian Dougherty, Ruth March, J. Carl Barrett, Iain A. McNeish, Andrew V. Biankin, Patricia Roxburgh, Charlie Gourley, Colin A. Semple

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Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

“…The mouse surrogate anti-TIGIT antibodies were identified and used to extensively investigate the mechanism of action of anti-TIGIT antibodies as monotherapy or in combination with anti-programmed cell death protein-1 (PD-1) antibody in vivo by gene expression profiling and flow cytometry analyses with a mouse syngeneic tumor model.Results Structural analyses with solution NMR and X-ray crystallography revealed that vibostolimab binds the CC’C’’FG loop interface of TIGIT, completely competing for the binding site of CD155 with a larger coverage area than another anti-TIGIT antibody tiragolumab, consistent with surface plasmon resonance analysis, though mouse models with similar antibodies revealed no functional difference in antitumor efficacy. …”
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