Utilization and dose optimization of beta-blockers in chronic heart failure therapy: a mixed-methods study by Sisay Sitotaw Anberbr, Tilaye Arega Moges, Abebech Tewabe Gelaye, Aragaw Dagnew Lakew, Samuel Berihun Dagnew, Gebremariam Wulie Geremew, Getachew Yitayew Tarekegn, Fisseha Nigussie Dagnew

“…A total sample size of 420 patients was determined using a systematic random sampling technique. Data were collected through structured questionnaires capturing socio-demographic details, clinical characteristics, and medication usage. …”
Get full text

Community-Based Approaches to Healthy Aging: Lessons from Japanese Blue Zones by Hiroko Oe, Kai Weeks, Sitsada Sartamorn

“…The study employed qualitative fieldwork methods including semi-structured interviews with 60 residents aged 65 and above, equally divided between the two study sites. …”
Get full text

MODERN METHODS OF DIAGNOSIS AND TREATMENT IN PATIENTS WITH DENTITION DEFECTS COMPLICATED OF DISORDERS OF THE TEMPOROMANDIBULAR JOINT by R. Ozhohan, M. Rozhko, Z. Ozhohan

“…Based on the results one suggest the algorithm of treatment, which includes the study of models in 3D scanner 3SHAPE, the use of temporary structures, kappa and modern aesthetic prosthetics. …”
Get full text

A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes) by Tamás Visnovitz, Dorina Lenzinger, Anna Koncz, Péter M Vizi, Tünde Bárkai, Krisztina V Vukman, Alicia Galinsoga, Krisztina Németh, Kelsey Fletcher, Zsolt I Komlósi, Csaba Cserép, Ádám Dénes, Péter Lőrincz, Gábor Valcz, Edit I Buzas

“…We previously found evidence that human colorectal cancer cells in vivo release large multivesicular body-like structures en bloc. Here, we tested whether this large EV type is unique to colorectal cancer cells. …”
Get full text

Phosphorescent PdII–PdII Emitter‐Based Red OLEDs with an EQEmax of 20.52% by Lige Qiao, Xiangjun Kong, Kechun Li, Lequn Yuan, Yunjun Shen, Yuzhen Zhang, Liang Zhou

“…Complexes 2 and 3 are characterized by single‐crystal X‐ray diffraction. The crystalline data of 2 and 3 reveal complex double‐layer structures, with Pd–Pd distances of 2.8690(9) Å and 2.8584(17) Å, respectively. …”
Get full text

Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests by Jinpan Hu, Zijing Jia, Meng Wang, Lingling Nie, Wangjun Fu, Qingfeng Zhang, Haiyang Qin, Jianhui Nie, Xiaoyu Xu, Lingjie Xu, Fengze Wang, Yingping Chen, Bo Xing, Tao Li, Danfeng Li, Shaowei Li, Ningshao Xia, Xiangxi Wang, Weijin Huang

“…The IVRP results were correlated with potency data from mouse models, offering an efficient alternative to in vivo potency experiments.…”
Get full text

Fully automatic HER2 tissue segmentation for interpretable HER2 scoring by Mathias Öttl, Jana Steenpass, Frauke Wilm, Jingna Qiu, Matthias Rübner, Corinna Lang-Schwarz, Cecilia Taverna, Francesca Tava, Arndt Hartmann, Hanna Huebner, Matthias W. Beckmann, Peter A. Fasching, Andreas Maier, Ramona Erber, Katharina Breininger

Get full text

“You do it for the patient”: a qualitative analysis of changes to primary care nurses’ workplace demands and resources during the COVID-19 pandemic in Canada by Sarah Spencer, Lindsay Hedden, Julia Lukewich, Emily Gard Marshall, Maria Mathews, Samina Idrees, Jennifer E. Isenor, Ruth Martin-Misener, Leslie Meredith, Crystal Vaughan, Dana Ryan, Dana Ryan

“…Accordingly, we sought to understand the personal and professional experiences of nurses working in primary care settings in Canada during the COVID-19 pandemic to inform future pandemic responses and health workforce planning that account for primary care nurses’ mental and physical needs.MethodsWe conducted semi-structured interviews with licensed and registered practical nurses, registered nurses, and nurse practitioners working in primary care in four Canadian provinces: British Columbia, Newfoundland and Labrador, Nova Scotia, and Ontario. …”
Get full text

Cultural impacts on shared decision-making: A cross-European study of psychiatrist preferences in 38 countries by Yasuhiro Kotera, Christopher Newby, Martina Rojnic Kuzman, Philip Gorwood, Andrea Fiorillo, Mike Slade

“…Culturally sensitive SDM interventions should address not only clinician attitudes but also healthcare structures and patient expectations. Findings offer an empirical foundation for tailoring SDM training and policy to diverse cultural contexts within European psychiatry. …”
Get full text

Myths and misconceptions of intimate partner violence among sexual and gender minorities: a qualitative exploration by Stefan Kurbatfinski, Stefan Kurbatfinski, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Susanne Marshall, Dawn McBride, Jason Novick, Keira Griggs, Arielle Perrotta, Arielle Perrotta, Morgan Daye, Carrie McManus, Kendra Nixon

“…This study sought to: (1) develop a compendium of myths and misconceptions that SGM individuals exposed to IPV and relevant service providers shared they encountered; (2) describe the impacts of these myths and misconceptions on SGM individuals experiencing IPV; and (3) make recommendations to address these myths and misconceptions.MethodsThis qualitative study used data from a larger project focused on SGM IPV where SGM individuals who experienced IPV (n = 18) and service providers who supported SGM individuals experiencing IPV (n = 8) were interviewed using semi-structured formats. …”
Get full text

Recovery of Perennial Plant Communities in Disturbed Hyper-Arid Environments (Sharaan Nature Reserve, Saudi Arabia) by Sami Youssef, Mohamed Djamel Miara, Stéphane Boivin, Robin Sallio, Jérôme Nespoulous, Hassan Boukcim, Sami D. Almalki, Shauna K. Rees, Benjamin P. Y.-H. Lee, Ahmed H. Mohamed

“…Specific plant community structures were correlated with each habitat, and bioindicator plant species were identified. …”
Get full text

Phytochemical analysis and antioxidant activity of Azadirachta indica A. Juss from the Republic of Chad: in vitro and in silico studies by Brahim Mahamat Ousman, Asraoui Fadoua, Farihi Ayoub, Bouhrim Mohamed, Boussaoudi Ibtissam, El Ismaili Soumaya, Herqash Rashed N., Shahat Abdelaaty A., Otchom Brahim Boy, Saoud Younes

“…The analysis identified bioactive compounds with strong radical scavenging activity and conducted in silico studies by molecular docking with AutoDock Tools. Crystal structures were sourced from the Protein Data Bank, and the Swiss absorption, distribution, metabolism, and excretion platform analyzed the pharmacokinetic properties. …”
Get full text

Decision-making under epistemic, strategic and institutional uncertainty during COVID-19: findings from a six-country empirical study by Clare Wenham, Alexandra L Phelan, Winifred Ukponu, Sumegha Asthana, Tahmina Shirin, Claire J Standley, Adachioma Chinonso Ihueze, Sanjana Mukherjee, Ibrahim B Gobir, Mohannad Al Nsour, JJ Woo, Mohammad Mushtuq Husain, Nevashan Govender, Roujia Lin, Sumit Asthana, Renee Vongai Mutare

“…Decision-making under institutional uncertainty involved using or adapting pre-existing experiences, structures and relationships and establishing new institutions and processes.Conclusions We contribute to the theory and practice of public health crisis decision-making by presenting a unified national-level applied decision-making framework for events involving uncertainty. …”
Get full text

The functions and factors governing fungal communities and diversity in agricultural waters: insights into the ecosystem services aquatic mycobiota provide by Phillip Pham, Phillip Pham, Yichao Shi, Izhar Khan, Mark Sumarah, Justin Renaud, Mark Sunohara, Emilia Craiovan, David Lapen, Stéphane Aris-Brosou, Stéphane Aris-Brosou, Wen Chen, Wen Chen

“…IntroductionFungi are essential to the aquatic food web, nutrient cycling, energy flow, and ecosystem regulation. Fungal community structures in water can be influenced by adjacent terrestrial environments, which drive and control some ecosystem services they provide. …”
Get full text

Evaluating the new family medicine internship programmes in the Western Cape, South Africa by Lauren N. Hutton, Louis S. Jenkins, Robert Mash, Klaus von Pressentin, Steve Reid, Jennie Morgan, Paul Kapp

“…Many interns reported no structured teaching programme (41.7% – 55.6%). Most supervision was from medical officers and registrars. …”
Get full text

Neuropathological correlations of 18F-florzolotau PET in a case with Pick’s disease by Hisaomi Suzuki, Manabu Kubota, Shin Kurose, Kenji Tagai, Hironobu Endo, Mitsumoto Onaya, Yasuharu Yamamoto, Naruhiko Sahara, Masahiro Ohgidani, Chie Haga, Hiroya Hara, Haruhiko Akiyama, Keisuke Takahata, Makoto Higuchi

“…In contrast, no such associations were found in subcortical structures. Furthermore, a substantial proportion of Pick bodies displayed fluorescence co-labelled with florzolotau and AT8 antibodies. …”
Get full text

Bayesian trial of adalimumab versus secukinumab for children with juvenile idiopathic arthritis associated uveitis or chronic anterior uveitis by Athimalaipet V Ramanan, Andrew D Dick, Thomas Jaki, Gianmarco Caruso, David S Robertson, Ashley P Jones, Ben Hardwick, Sian Drake, Balini Balasubramaniam, Coziana Ciurtin, Ivan Foeldvari, Elke O Kreps, Alice Leahy, Kristina May, Pierre Quartier, Matthieu P Robert, Gabriele Simonini, Catherine Guly, Michael W Beresford

“…Methods Nine international experts in paediatric rheumatology, paediatric ophthalmology and/or paediatric uveitis took part in a structured Bayesian prior elicitation meeting. Results The final consensus was that adalimumab is expected to yield a higher response rate than secukinumab (mean 0.67 vs. 0.55). …”
Get full text

Characterization of MADS-Box Gene Family in <i>Isatis indigotica</i> and Functional Study of <i>IiAP1</i> in Regulating Floral Transition and Formation by Yanqin Ma, Yanhong Lan, Ju Li, Haicheng Long, Yujie Zhou, Zhi Li, Mingjun Miao, Jian Zhong, Haie Wang, Wei Chang, Ziqin Xu, Liang Yang

“…IiMADS proteins in the same cluster had similar motifs and gene structures. In total, 102 IiMADS-box genes were unevenly distributed across seven chromosomes. …”
Get full text

Knowledge, attitudes, practices, and vaccination coverage of medical students toward hepatitis B virus in North Sudan, 2023 by Osama M.I. Mohamed, Hassan S.H. Mohammedali, Shimaa N.A. Mohamed, Hussein A.S. Ahmed, Alaa A.M. Mohamedsalih, Ola M.A. Abdalgani, Tebian A.A. Mohammedosman, Alaa A.A. Ali, Thuiba A.H. Ali, Othman N.O. Amin, Mohamed A. Issak, Mohamed O. Abdelaziz

“…Methods A cross-sectional study was conducted from January to June 2023 among medical students in North Sudan. Data were collected using a structured scale using online Google Forms. …”
Get full text

Assessment of knowledge, attitude, anxiety level and perceived mental healthcare needs toward mpox infection among nursing students: A multi-center cross-sectional study by Mona Gamal Mohamed, Md Rabiul Islam, Sirwan Khalid Ahmed, Shimaa Abdelrahim Khalaf, Hanan Abdelrazik Abdelall, Kochr Ali Mahmood, Ekram M. Abdel Khalek, Judie Arulappan, Syed Masudur Rahman Dewan

“…Participants completed a structured questionnaire covering sociodemographic information, knowledge of mpox, attitudes towards the disease, levels of anxiety, and perceived mental healthcare needs. …”
Get full text