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3141
Bioinformatic Characterization of the Functional and Structural Effect of Single Nucleotide Mutations in Patients with High-Grade Glioma
Published 2024-10-01“…A structural comparison between normal and mutated residues for disease-associated coding SNPs was performed using TM-aling and the SWISS MODEL. …”
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3142
Structural Strength Analysis Method of Urban Rail Transit Vehicle under Traction and Braking Conditions
Published 2025-02-01“…[Objective] Excessive traction and braking loads are significant factors contributing to inducing fatigue cracks in the welded joints of the ′TBB (traction beam-bolster beam-buffer beam) structure′ in urban rail transit vehicles. To effectively mitigate the risk of structural cracking, it is essential to thoroughly investigate the methods for analyzing the structural strength of vehicles under traction and braking conditions during design phase. …”
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3143
Digital twin-based structural health monitoring and measurements of dynamic characteristics in balanced cantilever bridge
Published 2025-09-01“…This study developed a digital twin (DT) and structural health monitoring (SHM) system for a balanced cantilever bridge, utilizing advanced measurement techniques to enhance accuracy. …”
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3144
Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction
Published 2025-02-01“…Utilizing X-ray crystallography, we elucidate the high-resolution structure of the mammalian CIB2-TMC1 complex. Structural analyses reveal that cation-bound CIB2 forms a negatively charged surface that aligns with a positively charged surface on the TMC1 N-terminus. …”
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3146
Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery
Published 2025-05-01“…Methods In this prospective cohort study, we conducted an analysis of data from 54 patients with DCM both before and after surgery, as well as 57 healthy controls (HC), using functional MRI in combination with high-resolution structural MRI. …”
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3147
The impact of the structural state of the tubulin cytoskeleton on chlorophyll fluorescence indicators and auxin content in Solanum tuberosum
Published 2024-11-01“…Information on the dependence of light reactions of photosynthesis on the structural state of cytoskeletal elements is extremely limited. …”
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3148
Associations of Prenatal Socioeconomic Status and Childhood Working Memory: A Structural Equation Modeling Approach
Published 2025-04-01“…Study Design: We used data from a prospective birth cohort study in Mexico City, Mexico, with N = 515 children aged 6–9 years. …”
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3149
Comparative Analysis of Mitogenomes in Leafhopper Tribe Deltocephalini (Hemiptera: Cicadellidae: Deltocephalinae): Structural Conservatism and Phylogeny
Published 2024-12-01“…ABSTRACT Previous studies on the gene order and composition of leafhopper mitochondrial genomes have revealed a high level of conservation in overall genome structure. Some members of Deltocephalinae, the largest subfamily, exhibit tRNA gene rearrangements; however, few mitogenomes have been sequenced in this group and the degree of structural variation within tribes remains unclear. …”
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3152
Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design
Published 2025-12-01“…In addition, we mapped the locations of missense mutations in MID1 associated with X-linked Opitz syndrome, suggesting that some of these mutations impair the conformational stability of the protein. Taken together, our data provide intriguing insights into the structural and functional divergence of TRIM family PRYSPRY domains, their potential druggability and substrate recognition, and the challenges of ligand design.…”
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3153
Longitudinal structural MRI-based deep learning and radiomics features for predicting Alzheimer’s disease progression
Published 2025-08-01“…Conclusions These findings emphasize the value of structural MRI within the advanced DL architectures for predicting MCI-to-AD conversion. …”
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3154
Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W
Published 2024-09-01“…The functional analysis was accompanied by structural investigation of PRKN p.R275W. We observed lower PRKN protein in fibroblasts with compound heterozygous p.R275W mutations. …”
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3155
Relationships between structural stigma, societal stigma, and minority stress among gender minority people
Published 2025-01-01“…We tested variables identified in the literature as measures of structural stigma inclusive of societal stigma (LGBT + Business Climate Index, state voting behaviors, and Google Trends search data), the most commonly used structural stigma variable (State Policy Environment Tally), and proxy variables (region, population density) for comparison. …”
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3156
Tracing the aggregation pathway of the scaffold protein DISC1: Structural implications for chronic mental illnesses
Published 2025-06-01“…Disrupted in schizophrenia 1 (DISC1) is a pleiotropic scaffold protein that is postulated to comprise large disordered regions and four distinct structured segments with a high proportion of helical or coiled-coil fold. …”
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3157
Development and distribution characteristics of geohazards based on sedimentary-structural evolution in Xide County, southwest Sichuan
Published 2025-05-01“…The wide and gentle fold structures in red beds are the disaster-prone environment for landslide. …”
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3158
Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture
Published 2024-10-01“…Even though we observed model instability in our application of genomic SEM to high-dimensional data, jointly modeling the genetic architecture of complex traits and investigating multivariate genetic links across neuroimaging phenotypes offers new insights into the genetics of cortical structure and relationships to psychopathology.…”
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3159
Presence of Pain Shows Greater Effect than Tendon Structural Alignment During Landing Dynamics
Published 2025-02-01“…Kinetics varied significantly by sex and jump type, while pain and tendon structure revealed limited differences.…”
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3160
Structural placental changes in women with intra-pregnancy novel coronavirus infection COVID-19 (review)
Published 2023-01-01“…In those that were excluded from the review, information about the clinical course of pregnancy and its outcome during novel coronavirus infection prevailed, or isolated cases of studying insignificant placental structural changes were discussed. Studies with a small number of observations were selected only in the case of the uniqueness of the published data, the absence of scientific papers where similar studies would have been conducted in larger sample.Results. …”
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