International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Through initiatives led by the Quality Control and Accreditation Committee, educational programs, and multidisciplinary stakeholder workshops, ISLB provides a structured framework to promote standardization and foster innovation. …”
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Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. …”
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Pre-Implementation Assessment of a Sexual Health eClinic in Canadian Oncology Care by Taylor Incze, Dalia Peres, Steven Guirguis, Sarah E. Neil-Sztramko, Jackie Bender, Dean Elterman, Shabbir M. H. Alibhai, Antonio Finelli, Phil Vu Bach, Emily Belita, Gerald Brock, Julia Brown, Jeffrey Campbell, Trustin Domes, Andrew Feifer, Ryan Flannigan, Celestia Higano, Jesse Ory, Premal Patel, Monita Sundar, Luke Witherspoon, Andrew Matthew

“…Data were analyzed using a hybrid deductive–inductive thematic approach guided by the Consolidated Framework for Implementation Research (CFIR) 2.0. …”
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Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice by Tao Lu, Huan Liu, Xiaoqing Yuan, Desheng Li, Guanqing Zhang, Yue Wang, Qiqiang Xie, Xinhao Wang, Jingjian Chi, Zhenzhen Wang, Shaoping Wang, Yanling Gao, Ling Zhou, Maolei Xu

“…The results confirmed, for the first time, that PET MPs can induce oxidative stress, lipid accumulation, and apoptosis in liver cells, resulting in structural damage and functional abnormalities in the liver. …”
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Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report by Manash Shrestha, Sanjaya Acharya, Josselyn Neukom, Karma Lhazeen, Ngo Duc Thang, Muhammad Naeem Habib, Lyndes Wini, Tobgyel Tobgyel, Kesang Wangchuk, Huy Rekol, Lek Dysoley, Siv Sovannaroth, Minerva Simatuopang, Helen Dewi Prameswari, Asik Surya, Zau Ring, Mohammad Qasim Khan, Boualam Khamlome, Mohd Hafizi Abdul Hamid, Ram Kumar Mahato, Top Thapa, Sheen Angelou Juangco, Hee Il Lee, Hyun Il Shin, Kumudu Gunasekera, Champa Aluthwera, Prayuth Sudathip, Rungrawee Timpontree, Hoang Dinh Canh, Sonia Cheung, Muhammad Zeeshan Haroon, Shreehari Acharya, Robert J. Commons, Bipin Adhikari, Varunika Ruwanpura, Phone Si Hein, Abhijit Sharma, Poe Poe Aung, Neena Valecha, Kamala Thriemer, Caroline A. Lynch

“…Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
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Farmers’ Perception of Ecosystem Services Provided by Historical Rubber Plantations in Sankuru Province, DR Congo by Joël Mobunda Tiko, Serge Shakanye Ndjadi, Jémima Lydie OBANDZA - AYESSA, Daniel Botshumo Banga, Julien Bwazani Balandi, Charles Mumbere Musavandalo, Jean Pierre Mate Mweru, Baudouin Michel, Olivia Lovanirina Rakotondrasoa, Jean Pierre Meniko To Hulu

“…This study used a mixed methodological approach, integrating semi-structured interviews, focus groups, and statistical analyses including chi-square testing and multiple correspondence factorial analysis (MCAFA) to obtain and analyze the data comprehensively. …”
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‘I Don't Think There Is a One‐Size‐Fits‐All’: A Qualitative Study Exploring Healthcare Professional and Service Provider Perspectives of Using Innovative Models of Cervical Screeni... by Claire Bavor, Tessa Saunders, Mikayla Wolfe, Megan A. Smith, Nicola Creagh, Deborah Bateson, Angela Kelly‐Hanku, Paula Jops, Marion Saville, Natalie Taylor, Kate Broun, Julia M. L. Brotherton, Claire Nightingale

“…Data were analyzed using template analysis, a form of thematic analysis. …”
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HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines by Agnieszka Gogler, Agata Małgorzata Wilk, Damian Robert Sojka, Małgorzata Adamiec-Organiściok, Natalia Matysiak, Daria Kania, Klaudia Wiecha, Ewa Małusecka, Alexander Jorge Cortez, Dawid Zamojski, Michał Marczyk, Agnieszka Maria Mazurek, Sylwia Oziębło, Dorota Scieglinska

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Exploring indigenous knowledge and practices of the Gurage community on the biosystematics and utilization of Enset landraces for bone fracture and regeneration: the case of Gurage... by Temesgen Negassa, Asfaw Meressa, Negera Abdissa, Sileshi Degu, Getachew Addis, Eyob Debebe, Negessa Abdisa, Samuel W/kidan, Dereilo Bekere Belitibo, Sintayehu Ashenef, Werku Shanko, Zeynu Zuber, Lemessa Kumsa, Mewded Kassahun, Frehiwot Teka Assamo, Milkyas Endale

“…Descriptive statistics were employed for data presentation.ResultsA total of 37 Enset landraces were identified across the study Woredas. …”
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The effects of parent-child relationship, study stress, and mobile phone use on depressive symptoms among Chinese elementary school students: a moderated mediation model by Yiting Kong, Yiting Kong, Zhewei Su, Zhewei Su, Rui Wang, Rui Wang, Jianyu Tan, Jianyu Tan, Yuancen Zhong, Yuancen Zhong, Ming Ai, Ming Ai, Wo Wang, Wo Wang, Su Hong, Su Hong, Qi Zhang, Qi Zhang, Li Kuang, Li Kuang

“…This study investigated the association between parent-child relationship and depressive symptoms among Chinese elementary school students while testing a moderated mediation model to examine the mediating role of significant study stress and the moderating effect of frequent mobile phone use on this relationship.MethodsWe recruited elementary school students from grades 3 to 6 in S district of Chongqing, China, totaling 33,285 participants (51.72% girls; mean age = 10.36 years, SD = 1.24). Data was analyzed using structural equation modeling to assess the mediating and moderating effects of study stress and mobile phone use, respectively, on the relationship between parent-child relationship and depressive symptoms.ResultsDepressive symptoms prevalence in our study population was 16.3%. …”
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Development and Assessment of a New Multichannel Electrocutaneous Device for Non-Invasive Somatosensory Stimulation for Magnetic Resonance Applications by Carolina Travassos, Alexandre Sayal, Paulo Fonte, Bruno Direito, Luis Lopes, Nuno Carolino, Sonia Afonso, Tania Lopes, Teresa Sousa, Miguel Castelo-Branco

“…Next, the device’s capacity to generate perceptible tactile sensations and user acceptability were assessed by testing the device on a single participant outside the MR environment. Finally, structural and functional data were acquired from three participants during a somatosensory stimulation experiment as a proof of concept to confirm the brain activity elicited by stimulation. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…Current propagation efforts face significant challenges, including low natural germination rates, and dependence on specific habitats and obligate mycorrhizal fungi, precluding the development of efficient large-scale cultivation and seedling production systems.ConclusionMarked progress has been made in characterizing small-molecule metabolites of G. conopsea, yet comprehensive structural elucidation of polysaccharides remains incomplete. …”
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Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial by Ambrose H Wong, James D Dziura, Mark Sevilla, Yue Hu, Megan Evans, Bidisha Nath, Rebekah Heckmann, Riddhi Desai, Anusha Kumar, Isaac V Faustino, Anthony J Pavlo, Joan M Cook, Kendra Davis-Plourde, Richard Youins, Kimberly Guy, Pastor Evelyn Smith, Pastor Dana Smith, Karen Kangas, Lou Hart, Seth Powsner, Chyrell Bellamy

“…The PACT intervention will integrate peer delivery of trauma-informed care within a structured, interprofessional, team-based response protocol for behavioural crisis management. …”
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Parental perceptions of a wearable vital signs monitor for observation of newborns: in-depth interviews in three tertiary hospitals, Southwest Nigeria by Yetunde Olufisayo John-Akinola, Adejumoke Idowu Ayede, Ayomide Adeyemi, Assumpta Nantume, Adesewa Oluwatomisin Olaleye, Olugbenga Akinrinoye, Olukemi Oluwatoyin Tongo, Michael Abe Alao, Adenike Oluleye, Oluseye Sobande, Olatayo Sunday Olayemi, Bertha Akinyi Oketch, Rosena Olubanke Oluwafemi, Rosena Olubanke Oluwafemi, Patricia Ireti Eniowo, Samuel Ojo, Omolayo Adebukola Olubosede, Emmanuel Olaseinde Bello, Ismaila Sani, Teresa Cauvel, Sona Shah

“…Interviews were moderated with a semi-structured interview guide and audio recorded. Data were transcribed, coded and analyzed thematically using NVivo software.ResultsThe majority of participants expressed positive reactions to the neoGuard device, although some initial concerns were reported. …”
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OP-13 CHOLANGIOCARCINOMA IN LATIN AMERICA: A MULTICENTER OBSERVATIONAL STUDY ALERTS ON ETHNICAL DISPARITIES IN TUMOR PRESENTATION AND OUTCOME by Leonardo G Da Fonseca, Laura Izquierdo Sanchez, Pedro H Hashizume, Yanina Carlino, Estefanía Liza Baca, Cristina Zambrano, Santiago Sepulveda, Andrea Bolomo, Pedro M Rodrigues, Ioana Riaño, Andre Boonstra, Jose D Debes, Luis Bujanda, Flair J Carrilho, Marco Arrese, Juan C Roa, Enrique Carrera, Javier Díaz Ferrer, Domingo Balderramo, Claudia P Oliveira, Jesus M Banales

“…These findings highlight structural challenges in cancer screening and healthcare access among diverse ethnic backgrounds and lower socioeconomic statuses in the region. …”
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Open Innovation the Impact of Social Capital on Tourism Growth Through the Mediating Role of Open Innovation (Case study: The municipality of Khomam County) by Seyed Hamed Hashemi, Hossein Poorghasem

“…This research is applied in terms of purpose and is survey-based for data collection. Moreover, from a methodological perspective, it employs a correlational design; the data collection tool used in this study was a questionnaire, rated using a Likert scale, and its reliability was assessed using Cronbach's alpha. …”
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A rare haplotype of the GJD3 gene segregating in familial Meniere’s disease interferes with connexin assembly by Alba Escalera-Balsera, Paula Robles-Bolivar, Alberto M. Parra-Perez, Silvia Murillo-Cuesta, Han Chow Chua, Lourdes Rodríguez-de la Rosa, Julio Contreras, Ewa Domarecka, Juan Carlos Amor-Dorado, Andrés Soto-Varela, Isabel Varela-Nieto, Agnieszka J. Szczepek, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez

“…The connexin monomer and the homomeric connexon structural models were predicted using AlphaFold2 and HDOCK. …”
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Serological Vulnerability and Active Infection Detection Among Recently Arrived Migrants in Spain: Results from a Targeted Screening Program by Guillermo Lens-Perol, Olalla Vázquez-Cancela, Magdalena Santana-Armas, Angeles Bouzas-Rodriguez, Victoria Tuñez-Bastida, Adrián Domínguez-Lago, Hugo Pérez-Freixo, Cristina Peiteado-Romay, Juan Manuel Vázquez-Lago, Cristina Fernández-Pérez

“…Sociodemographic and clinical data were collected, and individuals were offered vaccination according to an accelerated immunization schedule. …”
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“A cure might help, but it won't erase it all”: a qualitative study of policy challenges and priorities for long‐term survivors of HIV in the United States by Ali Ahmed, Jeff Taylor, Rachel Lau, Joyce Ching‐Jung Lai, Sithara Deshan Diunugala, Michael Louella, Thomas J. Villa, William Freshwater, Dawn Averitt, Maile Karris, Jeff Berry, Lynda Dee, Karine Dubé

“…Using inductive thematic analysis, we identified key policy concerns and recommendations based on participants’ lived experiences. Data collection continued until thematic saturation was reached. …”
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Nurses' experiences of participating in employee assistance program and factors influencing its effectiveness: a qualitative study by Xuanhao Fan, Xuanhao Fan, Jiehao Zhuang, Jiehao Zhuang, Zhongqing Chen, Ziyi Xiong, Niu Yang, Jiangfeng Pu, Jiangfeng Pu, Peng Xu, Lifang Chen, Huigen Huang, Huigen Huang

“…The themes of the interview data were distilled through thematic analysis using NVivo 15 software. …”
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