Behavioural activation in nursing homes to treat depression (BAN-Dep): study protocol for a pragmatic randomised controlled trial by Simon Gilbody, Christopher Etherton-Beer, Kathryn A Ellis, Leon Flicker, Diana Velasquez Reyes, Hema Patel, Nicola Lautenschlager, Andrew H Ford, Eleanor Curran, Rachael Kelly, Rhoda Lai, Terence Chong, David Ekers, Dina Lo Giudice, Angelita Martini, Osvaldo P Almeida

“…Only de-identified group data will be presented.Trial registration ACTRN12618000634279.…”
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Design and methods of an adaptive trial to test comparative effectiveness of readmission reduction approaches following infection and sepsis hospitalizations (ACCOMPLISH) by Kristin Mayes, Victor B. Talisa, Adelina Malito, Florian B. Mayr, Kelly Williams, Kalpana Char, Richard Wadas, Elizabeth Lorenzi, Kert Viele, Rana Awdish, Derek C. Angus, Chung-Chou Ho Chang, Sachin Yende

“…Methods: Adults admitted to the hospital with sepsis or lower respiratory tract infection (index admission) are recruited and randomized to usual care (structured telephonic support [STS]) or one of four post-discharge RPM care models in addition to STS. …”
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Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate <i>Prorocentrum lima</i> Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microg... by Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv, Xin-Sheng Yao

“…Through this approach, four new (<b>1</b>–<b>4</b>) and nine known (<b>5</b>–<b>13</b>) PUFA analogues were obtained from large-scale cultures of the marine dinoflagellate <i>Prorocentrum lima</i>, with lipidomic profiling identifying FA18:5 (<b>5</b>), FA18:4 (<b>7</b>), FA22:6 (<b>8</b>), and FA22:6 methyl ester (<b>11</b>) as major constituents of the algal oil extract. Structural elucidation was achieved through integrated spectroscopic analyses of IR, 1D and 2D NMR, and HR-ESI-MS data. …”
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Implementation of a Patient Navigation Program to Support Representative Participation in Cancer Clinical Trials by Sukh Makhnoon, Fabian Robles, Jessica L. Lee, D'Angelo Grant, Marisol Rojas, Ang Gao, Carla Pezzia, Venkata Eluri, Navid Sadeghi, Song Zhang, Thomas Hulsey, Rebecca Renn, Erin L. Williams, Heather Kitzman, David E. Gerber

“…Evaluation was guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework and incorporated programmatic data, structured surveys of patients and staff, and qualitative patient interviews. …”
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E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness by Alf Spitschak, Prabir Dhar, Krishna P. Singh, Rosaely Casalegno Garduño, Shailendra K. Gupta, Shailendra K. Gupta, Julio Vera, Luca Musella, Nico Murr, Anja Stoll, Brigitte M. Pützer, Brigitte M. Pützer

“…To explore E2F1’s role in immune regulation in presence of aggressive melanoma cells, we established a coculture system and utilized transcriptome and cytokine arrays combined with bioinformatics and structural modeling. We identified an E2F1-dependent gene regulatory network with IL6 as a central hub. …”
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Australian treatment outcome study: protocol for the 18–20-year follow-up of a prospective longitudinal cohort examining the natural history of heroin dependence and associated mor... by Maree Teesson, Paul S Haber, Christina Marel, Katherine Mills, Rachel Visontay, Jack Wilson, Shane Darke, Joanne Ross, Tim Slade, Katherine Haasnoot, Madeleine Keaveny, Chris Tremonti

“…The 18–20-year follow-up will consist of: (1) a structured interview; (2) physical health assessment; and (3) data linkage. …”
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Prevalence of tick-borne pathogens in feeding and questing Ixodes ricinus ticks from Southern Sweden by Chiara Cialini, Alessandra Cafiso, Mattias Waldeck, Åsa Lundgren, Johan Fält, Bo Settergren, Phimphanit Choklikitumnuey, Giulia Chiappa, Eleonora Rosso, Laura Roveri, Elisa Fesce, Nicola Ferrari, Per-Eric Lindgren, Chiara Bazzocchi, Giulio Grandi

“…This study highlights the presence of several zoonotic TBPs in Skåne, emphasizing the need for a structured monitoring plan and preventive strategies within a One Health framework.…”
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Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China by Bo Qu, Hui Chen, Xuhua Tan, Xiaohang Wu, Haotian Lin, Zhenzhen Liu, Lixia Luo, Bo Zhang, Erping Long, Duoru Lin, Weirong Chen, Yizhi Liu, Haofeng Jiang, Jingjing Chen, Zhuoling Lin, Xiaoyan Li, Jinzhu Tang, Yingfen Lin

“…In this study, participants who underwent free cataract surgery between January and August 2014 received a telephone interview based on a structured questionnaire. Data were collected on patient demographics, resources, health conditions, reasons for undergoing the free surgery and overall evaluation of the free cataract surgery programme.Results Among the 833 participants, the mean surgical age was 76.85±7.46 years (95% CI 76.34 to 77.36), and the male to female ratio was 385:448. …”
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Enhancing regeneration and functionality of excitable tissues via integrating bioelectronics and bioengineered constructs by Zijie Meng, Bingsong Gu, Cong Yao, Jiaxin Li, Kun Yu, Yi Ding, Pei He, Nan Jiang, Dichen Li, Jiankang He

“…We explore the synergistic effects of these electrical microenvironments, combined with structural and mechanical guidance, on the regeneration of excitable tissues using tissue engineering scaffolds. …”
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OrthoticS for TReatment of symptomatic flat feet In CHildren (OSTRICH): a randomised controlled trial by Sarah Cockayne, Kalpita Baird, Sally Gates, Caroline Fairhurst, Joy Adamson, Rachel M Bottomley-Wise, Amie Woodward, Michael R Backhouse, Rachel Bye, Nina Davies, Catherine Hewitt, Colin Holton, Peter Knapp, Anne-Maree Keenan, Stewart Morrison, Daniel Parker, Daniel C Perry, Sarah Ronaldson, Mark Smith, Tim Theologis, Victoria Exley, Jane McAdam, David J Torgerson

“…Limitations We could not deliver the study objectives as planned. Due to the limited data available, we were unable to undertake the planned analysis. …”
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Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya by Konyin Adewumi, Aparna Ghosh Kachoria, Everlyn Adoyo, Mercy Rop, Mercy Rop, Antony Owaya, Jennifer H. Tang, Jennifer H. Tang, Lisa Rahangdale, Lisa Rahangdale, Lisa Rahangdale, Chemtai Mungo, Chemtai Mungo, Chemtai Mungo

“…Quantitative data were analyzed using descriptive statistics. …”
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Feasibility of a tailored, combined intervention with mind-body elements to prevent burnout in healthcare professionals (LAGOM) in a mixed-methods multicenter single-arm trial by Marleen Schröter, Anna K. Koch, Julia Berschick, Julia K. Schiele, Martin Bogdanski, Melanie Steinmetz, Judith Czakert, Wiebke Stritter, Christian S. Kessler, Georg Seifert

“…The feasibility of electrophysiological measures like pulse and respiration activity was assessed. Semi-structured interviews with a subgroup were qualitatively analyzed following a qualitative content analysis approach. …”
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Engagement in hepatitis C virus cascade of care and factors associated with testing among people who inject drugs in Iran by Mehrdad Khezri, Fatemeh Tavakoli, Soheil Mehmandoost, Heidar Sharafi, Omid Zamani, Maliheh Sadat Bazrafshani, Naser Nasiri, Hossein Mirzaei, Hossein Moameri, Ali Akbar Haghdoost, Courtney McKnight, Don Des Jarlais, Mohammad Karamouzian, Hamid Sharifi

“…Methods We recruited PWID in 14 cities using respondent-driven sampling. PWID completed structured interviews capturing measures on socio-demographics, behaviors, and HCV CoC. …”
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Factors Influencing Measles Vaccine Compliance: A Descriptive-correlational Study in Barangay C, Northern Mindanao by Rhy Kenji Enguio, Zenju Espinosa, Ashley Jenn Fallarna, Ferdinand Gabriel Galarrita, Justine Jean Guillermo, Jasimah Gutoc, Rhea Mae Janolino, Aleks Jimenez, Kayle Mae Labasano, Jade Godwin Lagua, Ariel Lacdo-O, Edmund Zheen Regor Moreno, Paolo Araune, Ivy Go

“…Materials and Methods: This study utilized a non-experimental quantitative descriptive design to examine factors influencing measles vaccination compliance among residents of barangay C. The study data were collected using a structured survey questionnaire that served as the instrument designed to measure compliance across psychosocial factors and behavioral-specific cognitions. …”
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Longitudinal associations between air pollution and incident dementia as mediated by MRI-measured brain volumes in the UK Biobank by Rhiannon Thompson, Xinning Tong, Xueyi Shen, Jinjun Ran, Shengzhi Sun, Xiaoxin Iris Yao, Chen Shen

“…Estimates of residential air pollution, traffic noise, and greenspace exposure have been modelled. Structural brain MRI was conducted from 2014 to 2022, with brain volumes relevant to dementia identified a priori. …”
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Mechanical signaling regulates vascular smooth muscle cell adaptation in aging by Amin Mohajeri, Song Yi Shin, Samuel Padgham, Devon J. Boland, Dana Pittman Ratterree, Jacob Blizman, Gang Han, Christopher R. Woodman, Andreea Trache, Andreea Trache

“…To dissect the mechanisms involved, the structural and functional properties of VSM cells were assessed by using mechanical stimulation combined with fluorescence confocal microscopy. …”
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Chronic unilateral vestibular hypofunction: a qualitative study exploring the full spectrum of symptoms and impacts through the ICF framework by Mustafa Karabulut, Hamide Avci, Eda Yalçınkaya, Merel Kimman, Wolfgang Viechtbauer, Alfarghal Mohamad, Vincent Van Rompaey, Nils Guinand, Angélica Perez Fornos, Levent Özlüoğlu, Osman Nuri Özgirgin, Raymond van de Berg

“…Data collection continued until thematic saturation was reached. …”
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Targeting macrophages and ion homeostasis in T2D: new genes and therapeutic pathways identified by Lisha Mou, Lisha Mou, Tony Bowei Wang, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Yuxian Chen, Ziqi Luo, Xinyu Wang, Zuhui Pu, Zuhui Pu

“…Machine learning models were developed to predict T2D, and structural predictions of the hub proteins were performed. …”
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STREAM: a system for tracing radiative transfer and energy balance in heterogeneous surfaces by Tengyuan Fan, Zunjian Bian, Jean-Louis Roujean, Huaguo Huang, Hua Li, Junhua Bai, Biao Cao, Yongming Du, Qing Xiao, Qinhuo Liu

“…To address this problem, this study introduces a system for tracing radiative transfer and energy balance in heterogeneous surfaces, hereafter called STREAM, in which the three-dimensional structural heterogeneity is obtained through LiDAR data and a voxel-based radiosity method is proposed for radiative transfer process. …”
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Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An in vivo biomechanical study by Mingfeng Lu, Mingfeng Lu, Wei Chen, Jinpeng Lin, Jinpeng Lin, Wenhan Huang, Junqing Gao, Junqing Gao, Lilian Zhao, Shilin Li, Lilei He, Yu Zhang

“…ObjectiveThe aim of this study is to assess the kinematic changes in the knee joint during walking in patients with isolated PCL-deficiency (PCLD) to determine the presence of walking-related joint instability (mechanical instability—abnormal displacement form structural damage). Additionally, the study seeks to provide biomechanical insights into the observed differences between subjective and objective assessments.Methods35 healthy volunteers and 27 patients with isolated PCLD (both involved and uninvolved sides) were included in the study. …”
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