Martinostat as a novel HDAC inhibitor to overcome tyrosine kinase inhibitor resistance in chronic myeloid leukemia by Haeun Yang, Vladimir Li, Su Jung Park, Sang Won Cheon, Anne Lorant, Aloran Mazumder, Jin Young Lee, Barbora Orlikova-Boyer, Claudia Cerella, Christo Christov, Gilbert Kirsch, Dag Erlend Olberg, Guy Bormans, Hyoung Jin Kang, Byung Woo Han, Michael Schnekenburger, Marc Diederich

“…Methods and results Structural and biochemical analyses confirmed the efficient and selective binding of martinostat to HDAC isoenzyme ligand-binding pockets, resulting in histone and tubulin hyperacetylation in both imatinib-sensitive and resistant CML cells, outperforming vorinostat, a clinically used HDAC inhibitor (HDACi). …”
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Workload, job, and family satisfaction in dual-earning parents with adolescents: the mediating role of work-to-family conflict by Berta Schnettler, Berta Schnettler, Berta Schnettler, Berta Schnettler, Andrés Concha-Salgado, Ligia Orellana, Ligia Orellana, Mahia Saracostti, Katherine Beroiza, Héctor Poblete, Germán Lobos, Cristian Adasme-Berríos, María Lapo, Leonor Riquelme-Segura, José A. Sepúlveda, José A. Sepúlveda, Karol Reutter, Enid Thomas

“…Mothers and fathers completed assessments about workload, WtoFC, and the Overall Job Satisfaction Scale, while all three family members responded to the Satisfaction with Family Life Scale.ResultsThe data were analyzed using the mediation Actor-Partner Interdependence Model and structural equation modeling. …”
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“You do it for the patient”: a qualitative analysis of changes to primary care nurses’ workplace demands and resources during the COVID-19 pandemic in Canada by Sarah Spencer, Lindsay Hedden, Julia Lukewich, Emily Gard Marshall, Maria Mathews, Samina Idrees, Jennifer E. Isenor, Ruth Martin-Misener, Leslie Meredith, Crystal Vaughan, Dana Ryan, Dana Ryan

“…Accordingly, we sought to understand the personal and professional experiences of nurses working in primary care settings in Canada during the COVID-19 pandemic to inform future pandemic responses and health workforce planning that account for primary care nurses’ mental and physical needs.MethodsWe conducted semi-structured interviews with licensed and registered practical nurses, registered nurses, and nurse practitioners working in primary care in four Canadian provinces: British Columbia, Newfoundland and Labrador, Nova Scotia, and Ontario. …”
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Myths and misconceptions of intimate partner violence among sexual and gender minorities: a qualitative exploration by Stefan Kurbatfinski, Stefan Kurbatfinski, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Susanne Marshall, Dawn McBride, Jason Novick, Keira Griggs, Arielle Perrotta, Arielle Perrotta, Morgan Daye, Carrie McManus, Kendra Nixon

“…This study sought to: (1) develop a compendium of myths and misconceptions that SGM individuals exposed to IPV and relevant service providers shared they encountered; (2) describe the impacts of these myths and misconceptions on SGM individuals experiencing IPV; and (3) make recommendations to address these myths and misconceptions.MethodsThis qualitative study used data from a larger project focused on SGM IPV where SGM individuals who experienced IPV (n = 18) and service providers who supported SGM individuals experiencing IPV (n = 8) were interviewed using semi-structured formats. …”
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Evaluating the new family medicine internship programmes in the Western Cape, South Africa by Lauren N. Hutton, Louis S. Jenkins, Robert Mash, Klaus von Pressentin, Steve Reid, Jennie Morgan, Paul Kapp

“…Many interns reported no structured teaching programme (41.7% – 55.6%). Most supervision was from medical officers and registrars. …”
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Bayesian trial of adalimumab versus secukinumab for children with juvenile idiopathic arthritis associated uveitis or chronic anterior uveitis by Athimalaipet V Ramanan, Andrew D Dick, Thomas Jaki, Gianmarco Caruso, David S Robertson, Ashley P Jones, Ben Hardwick, Sian Drake, Balini Balasubramaniam, Coziana Ciurtin, Ivan Foeldvari, Elke O Kreps, Alice Leahy, Kristina May, Pierre Quartier, Matthieu P Robert, Gabriele Simonini, Catherine Guly, Michael W Beresford

“…Methods Nine international experts in paediatric rheumatology, paediatric ophthalmology and/or paediatric uveitis took part in a structured Bayesian prior elicitation meeting. Results The final consensus was that adalimumab is expected to yield a higher response rate than secukinumab (mean 0.67 vs. 0.55). …”
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Title: race and ethnicity and the risk of community-acquired third-generation cephalosporin-resistant uropathogens: a systematic review and meta-analysis by Sweta Balaji, Sarah Blackmon, Esther E. Avendano, Samson Alemu Argaw, Rebecca A. Morin, Nanguneri Nirmala, Shira Doron, Maya L. Nadimpalli

“…Conclusions: As antibiotic resistance rises in community settings, our findings support the need to understand the structural issues that underpin differential risk of 3GC-R uropathogens across race and ethnicity. …”
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Tertiary cancer center results of sterilized auto-graft prosthetic osteo-articular complex reconstruction following bone tumor resection by Himanshu Rohela, Anupam Lahiri, Irfan Ahmed, Kundan Singh Chufal, Kripa Mishra, Rajan Arora

“…Background: Bone tumor resections necessitate complex reconstruction methods to maintain limb function and structural integrity. Various approaches, including tumor prostheses and biological reconstructions, offer distinct advantages and disadvantages. …”
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Knowledge, attitudes, practices, and vaccination coverage of medical students toward hepatitis B virus in North Sudan, 2023 by Osama M.I. Mohamed, Hassan S.H. Mohammedali, Shimaa N.A. Mohamed, Hussein A.S. Ahmed, Alaa A.M. Mohamedsalih, Ola M.A. Abdalgani, Tebian A.A. Mohammedosman, Alaa A.A. Ali, Thuiba A.H. Ali, Othman N.O. Amin, Mohamed A. Issak, Mohamed O. Abdelaziz

“…Methods A cross-sectional study was conducted from January to June 2023 among medical students in North Sudan. Data were collected using a structured scale using online Google Forms. …”
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Assessment of knowledge, attitude, anxiety level and perceived mental healthcare needs toward mpox infection among nursing students: A multi-center cross-sectional study by Mona Gamal Mohamed, Md Rabiul Islam, Sirwan Khalid Ahmed, Shimaa Abdelrahim Khalaf, Hanan Abdelrazik Abdelall, Kochr Ali Mahmood, Ekram M. Abdel Khalek, Judie Arulappan, Syed Masudur Rahman Dewan

“…Participants completed a structured questionnaire covering sociodemographic information, knowledge of mpox, attitudes towards the disease, levels of anxiety, and perceived mental healthcare needs. …”
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Association of non-exercise physical activity with sarcopenia compared with that of exercise habits among community-dwelling older adults: A 7-year follow-up from the Kashiwa Cohor... by Weida Lyu, Tomoki Tanaka, Bo-Kyung Son, Yasuyo Yoshizawa, Katsuya Iijima

“…Therefore, NEPA may be a practical alternative to structured exercises for older adults.…”
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Development of Ecological Environment Monitoring Network System in China by Qiao Wang, Shaomin Liu, Guoqiang Wang, Yinglan A, Baolin Xue, Ziwei Xu, Jin Wu

“…Although China has built a large-scale, comprehensive, and well-structured ecological environment monitoring network, it is insufficient to meet the major national demands of the new era, such as reducing pollution and carbon emissions, ecological protection and restoration, and addressing climate change. …”
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Prevalence and intensity of intestinal and soil-transmitted helminths infection among children in internally displaced camps in Mogadishu Somalia by Bashiru Garba, Hodo Aideed Asowe, Najib Isse Dirie, Yushau Umar, Abdikani Omar Salah, Ahmed Abdirahim Hussien, Ikram Abdirahman Mohamud Alasow, Fartun Abdullahi Hassan Orey, Jihaan Hassan, Jamal Hassan Mohamoud, Mohamed Hussein Adam, Mohamed Adam Mahamud, Mohamed Mustaf Ahmed

“…This study was undertaken to assess the prevalence and intensity of intestinal and soil-transmitted helminth infections among school-aged children in the Deyniile and Kahda internally displaced persons camps. A well-structured questionnaire was used to collect sociodemographic, behavioral and environmental data from the respondents, while fresh stool samples were collected to detect helminths via the cellophane-based Kato–Katz technique. …”
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Subcutaneous electroencephalography monitoring for people with epilepsy and intellectual disability: co-production workshops by Edward Meinert, Madison Milne-Ives, Jennifer Sawyer, Liz Boardman, Sarah Mitchell, Brendan Mclean, Mark Richardson, Rohit Shankar

“…Remote electroencephalography (EEG) monitoring could capture objective data, but particular challenges and implementation strategies for this population need to be understood. …”
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Household resilience of women migrant worker sellers of Jamu Gendong [version 3; peer review: 2 approved] by Budiman Achmad, Endah Suhaendah, Sanudin Sanudin, Eva Fauziyah, Ary Widiyanto, Dian Diniyati, Rukmini Nugroho Dewi, Aji Winara, Sri Najiyati, Danarti Danarti, Tri Sulistyati Widyaningsih, Aditya Hani, Muhtar Muhtar

“…Methods The study was conducted in Ciamis Regency, West Java Province, Indonesia, in November 2022, using quantitative and qualitative methods. Primary data were collected through structured questionnaires and in-depth interviews. …”
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Balancing Care and Sacrifice: Lived Experiences and Support Needs of Primary Caregivers in Pediatric Chronic Pain Across Canada and Australia by Nicole Pope, Nicole Drumm, Kathryn A. Birnie, Melanie Noel, Carolyn Berryman, Nicki Ferencz, Tieghan Killackey, Megan Macneil, Darrel Zientek, Victoria Surry, Jennifer N. Stinson

“…Methods: We conducted a qualitative exploratory study involving 32 caregivers of youth with chronic pain across Canada and Australia. Semi-structured interviews were co-facilitated by caregiver partners. …”
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Malaria control among Myanmar migrants in Thailand: a qualitative study of healthcare providers by Nichakan Inthitanon, Piyarat Sripoorote, Yupaporn Wattanagoon, Pattamaporn Petchvijit, Ammarind Anantjitsupha, Kyawt Mon Win, Nattawan Rachaphaew, Khaing Zin Zin Htwe, Kritsana Suk-aum, Peeriya Watakulsin, Liwang Cui, Jetsumon Sattabongkot, Daniel M. Parker, Wang Nguitragool, Pyae Linn Aung

“…Methods A cross-sectional qualitative study was conducted in early 2024. Semi-structured interviews were held with 20 government healthcare providers and village health volunteers involved in malaria control across three districts in western Thailand with the highest malaria caseloads. …”
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Assessment of Pain and Associated Factors in Female Patients Undergoing Surgical Treatment for Breast Cancer: Cross-Sectional Study by Leonardo Breno do Nascimento de Aviz, Laerte Jonatas Leray Guedes, Raphaely Cristiny Sanches Progênio, Carolina Lima da Fonte, Victória Tavares Brioso, Maikon da Silva e Silva, Laura Maria Tomazi Neves, Saul Rassy Carneiro

“…Method: Cross-sectional study conducted between March 2021 and March 2022, in Belém, Pará, Brazil. A structured questionnaire was used to collect sociodemographic, clinical, and lifestyle data from patients in the postoperative period of breast cancer surgery. …”
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Family physicians’ attitudes and practice on screening and prevention of fragility fractures, and shared decision-making with postmenopausal women: a qualitative study in Spain by Montserrat León-García, Esther Cánovas Martínez, Yolanda Álvarez Pérez, María Antonia Pou, Alberto López García-Franco, Ana Sanz Bas, Sara Rodriguez-Moreno, Claudia Erika Delgado Espinoza, Pablo Roca, Aránzazu González Osuna, Diana Fernández Valverde, Betzabeth Marín Nanco, Melixa Medina-Aedo, Lilisbeth Perestelo-Pérez, Pablo Alonso-Coello

“…Data were analysed using an iterative, theory-driven approach to identify key themes and barriers. …”
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Implementing psychosocial guidelines into specialized spinal cord injury rehabilitation services to strengthen person-centred health care: protocol for a mixed methods study by Candice McBain, Candice McBain, Anne Marie Sarandrea, Anne Marie Sarandrea, Anne Marie Sarandrea, Ilaria Pozzato, Ilaria Pozzato, Mohit Arora, Mohit Arora, Daniel Myles, Daniel Myles, John Bourke, John Bourke, Yvonne Tran, Ian D. Cameron, Ian D. Cameron, James W. Middleton, James W. Middleton, James W. Middleton, Ashley Craig, Ashley Craig

“…Success of implementation will be determined by analyzing any shifts in perceived knowledge, attitudes, and behaviour of staff and cultural/structural processes observed through comparing baseline and post-intervention qualitative and quantitative data. …”
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