Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution by Chunliang Liu, Xiang Wang, Erdong Liu, Yali Zong, Wenlong Yu, Youhai Jiang, Jianan Chen, Mingye Gu, Zhengyuan Meng, Jingfeng Li, Yang Liu, Yongjie Zhang, Jing Tang, Hongyang Wang, Jing Fu

“…Findings were validated using external multi-omics datasets, tissue microarray cohort, spatial RNA in situ sequencing, CCA patient-derived organoids (PDOs), and mouse models. …”
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Expression of RNA-binding motif 10 is associated with advanced tumor stage and malignant behaviors of lung adenocarcinoma cancer cells by Guofang Guan, Ranwei Li, Wenfang Tang, Tiecheng Liu, Zhenzhong Su, Yan Wang, Jingjin Tan, Shan Jiang, Ke Wang

“…Levels of RNA-binding motif 10 messenger RNA and protein were significantly lower in lung adenocarcinoma tissues than those in paired non-tumor tissues (p < 0.001). …”
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Expression and prognostic significance of MLH1 and GPRC5C in resectable hepatocellular carcinoma by Jun Lu, Lei Li, Qing Chen, Bingqi Li, Siqian Ren, Meng Yuan, Meng Meng, Jian Lei, Yuntao Bing, Hangyan Wang, Zhaolai Ma, Dianrong Xiu, Chunhui Yuan

“…Methods We detected MLH1 and GPRC5C expression using the tissue microarray-based immunohistochemical staining in tumor and matched adjacent non-tumor liver (ANL) specimens from 230 patients who underwent radical resection for HCC. …”
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TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27 by Vanajothi Ramar, Rajveer Singh Sidhu, Osei Pako, Cheyenne R. Cisse, Alyssa A. Guo, Jason Li, Kelcey Stapleton, Shanchun Guo, Guangdi Wang, Mingli Liu

“…Immunohistochemistry on glioma patient tissue microarray (TMA) assessed TRIM21 expression and its association with FOSL1, IDH status, and glioma grade. …”
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Therapeutic role of aripiprazole in cartilage defects explored through a drug repurposing approach by Jun-Ku Lee, Hyunjeong Yeo, Sujin Choi, Kyeong Mi Kim, Hannah Kim, Sung-Sahn Lee, Hyun Il Lee, Younghoon Jeong, Hyun-Ju An, Soonchul Lee

“…This study aimed to identify a drug capable of improving cartilage defects by analyzing chondrogenesis-related microarray data from the Gene Expression Omnibus (GEO) public database. …”
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Clinicopathological significance of microRNA‐21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal t... by Shiori Watabe, Yoshinao Kikuchi, Shigeki Morita, Daisuke Komura, Satoe Numakura, Arisa Kumagai‐Togashi, Masato Watanabe, Noriyuki Matsutani, Masafumi Kawamura, Masanori Yasuda, Hiroshi Uozaki

“…Methods The Cancer Genome Atlas dataset comprising of 448 cases of lung adenocarcinoma, tissue microarray of 144 cases of lung adenocarcinoma, and pleural lavage fluid of 41 cases was used to examine miR‐21 expression levels. …”
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Overexpression of KMT9α is associated with poor outcome in cholangiocarcinoma patients by Maximilian N. Kinzler, Eric Metzger, Rebecca Schulz, Katrin Bankov, Anna Ramos-Triguero, Falko Schulze, Steffen Gretser, Nada Abedin, Armin Wiegering, Stefan Zeuzem, Dirk Walter, Henning Reis, Roland Schüle, Peter J. Wild

“…For the first time, we investigated the presence of KMT9α in cholangiocarcinoma, the association with histologic subtypes, and its impact on survival. Methods A tissue microarray cohort of all CCA patients who underwent surgical resection with curative intent between 08/2005 and 12/2021 at the University Hospital Frankfurt was immunohistochemically analyzed with the KMT9α antibody. …”
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Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation by Sota Iwatani, Akemi Shono, Makiko Yoshida, Keiji Yamana, Khin Kyae Mon Thwin, Jumpei Kuroda, Daisuke Kurokawa, Tsubasa Koda, Kosuke Nishida, Toshihiko Ikuta, Kazumichi Fujioka, Masami Mizobuchi, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

“…In the present study, we isolated UC-MSCs from 23 infants delivered at 22–40 weeks of gestation and analyzed their gene expression and cell proliferation. Microarray analysis revealed that global gene expression in preterm UC-MSCs was distinct from term UC-MSCs. …”
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Nanopore-based random genomic sampling for intraoperative molecular diagnosis by Francesco E. Emiliani, Abdol Aziz Ould Ismail, Edward G. Hughes, Gregory J. Tsongalis, George J. Zanazzi, Chun-Chieh Lin

“…This streamlined workflow—from tissue arrival to automatic generation of CNV and methylation reports—can be completed within 105 min. …”
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Genome-wide analysis in the search for candidate genes associated with meat productivity traits in meat-and-dairy goats by M. I. Selionova, A.-M. M. Aibazov, A. A. Sermyagin, A. A. Belous, N. A. Zinovieva

“…GWAS analysis using Goat 50K BeadChip high-density DNA microarray determined a genome-wide level of significance for six SNPs located on chromosomes 5, 6, 10 and 16 associated with the live weight of young animals (4 and 8 months old). …”
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PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma by Chen-Hong Ding, Fang-Zhi Yan, Bo-Nan Xu, Hui Qian, Xia-Lu Hong, Shu-Qing Liu, Yuan-Yuan Luo, Si-Han Wu, Ling-Yan Cai, Xin Zhang, Wei-Fen Xie

“…Tissue microarray analysis showed a positive correlation between PRMT3 and PD-L1 expression in HCC patients. …”
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Deciphering the methylation landscape of long noncoding RNAs in hepatocellular carcinoma: a focus on LINC00942 by Zhaoqi Shi, Xiaolong Liu, Duguang Li, Jing Yang, Haonan Chen, Hui Lin, Xiaoxiao Fan

“…Methods We conducted a methylation microarray analysis on 11 HCC samples alongside adjacent non-tumor tissue specimens. …”
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Spatial transcriptomics reveal high T cell and monocyte status as predictive and prognostic markers in pancreatic cancer by Yeon Bi Han, Sejoon Lee, Jin-Ok Lee, Se In Jeong, Ki Rim Lee, Soomin Ahn, Kwangrok Jung, Jong-Chan Lee, Yoo-Seok Yoon, Jin-Hyeok Hwang, Ho-Seong Han, Hee Young Na, Jaihwan Kim

“…Methods Forty-eight PDAC cases that were surgically resected with or without NAT were included. A tissue microarray was constructed for DSP and IHC. …”
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Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA seq... by Yuqing Li, Jiandong Zhang, Xuemeng Qiu, Yifei Zhang, Jiyue Wu, Qing Bi, Zejia Sun, Wei Wang

“…However, the role of different regulated cell death (RCD) pathways in post-transplant allograft fibrosis remains unclear.Methods and Results: Microarray transcriptome profiling and single-nuclei sequencing data of post-transplant fibrotic and normal grafts were obtained and used to identify RCD-related differentially expressed genes. …”
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Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

“…Results TSG-6 treatment significantly attenuated DSS-induced colitis symptoms and inflammatory cell infiltration. Microarray analysis revealed that TSG-6 decreased pro-inflammatory cytokine levels in colon tissue. …”
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The significance of Trk receptors in pancreatic cancer by Matthew D Johnson, Brandon Stone, Bryan J Thibodeau, Andrew M Baschnagel, Sandra Galoforo, Laura E Fortier, Billie Ketelsen, Samreen Ahmed, Zakiya Kelley, Alaa Hana, Thomas G Wilson, John M Robertson, Robert P Jury, George D Wilson

“…A specific inhibitor of TrkA, B, and C, AstraZeneca 1332, was investigated in vitro and in vivo in combination with radiation. A tissue microarray was constructed from 77 pancreatic ductal adenocarcinoma patients who had undergone neoadjuvant chemoradiation and the Trk receptor, and neurogenic differentiation 1 expression was assessed and correlated with overall survival. …”
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Screening of endoplasmic reticulum stress characteristic genes and immune infiltration manifestations in chronic obstructive pulmonary disease by ZHANG Shuang, LUO Chenyang, HE Zhiyi

“…Finally the lncRNA-miRNA-mRNA ceRNA network of key genes was constructed and the mRNA expression levels of lung tissue in the mouse emphysema model were verified. …”
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CD68 as a multi-omic prognostic biomarker in digestive system cancers: correlations with tumor-infiltrating immune cells and immune checkpoints by Hui Li, Hui Zhang, Rujiang Dai, Dian Zheng, Jianghai Zhao, Hong Jing, Xuhui Ma, Lin Zhang, Weihong Sun, Zhimin Suo

“…This study aims to investigate the expression levels, prognostic significance, and clinical implications of CD68, as well as its correlations with six TIICs and four common TICs in DSC.Materials and methodsWe analyzed CD68 mRNA and protein expression using online databases and immunohistochemistry (IHC) on tissue microarray (TMA) sections, comparing DSC tumor tissues with adjacent normal tissues. …”
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KRT6A, KRT6B, PKP1, and PKP3 as key hub genes in esophageal cancer: A combined bioinformatics and experimental study by Shayan Marhamati, Morvarid Hamrahjoo, Zeinab Seyedkhan, Mahdi Bahmani, Nasrin Ziamajidi, Iraj Khodadadi, Mohadese Pouryani, Roghayeh Abbasalipourkabir

“…In this study, we downloaded the microarray datasets GSE157808 and GSE92396 from the Gene Expression Omnibus (GEO). …”
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CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression by Dayu Huang, Xianglin Chu, Chunxiao Wu, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dapeng Li, Xuyu Gu

“…Subcutaneous xenograft and orthotopic isograft tumor models were generated for in vivo verification. Tissue microarray (TMA) and bioinformatics analyses were employed to evaluate the clinical prognostic value of CCNY, TET2, and PRC1 in NSCLC. …”
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