Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. by Robin G Walters, Lachlan J M Coin, Aimo Ruokonen, Adam J de Smith, Julia S El-Sayed Moustafa, Sebastien Jacquemont, Paul Elliott, Tõnu Esko, Anna-Liisa Hartikainen, Jaana Laitinen, Katrin Männik, Danielle Martinet, David Meyre, Matthias Nauck, Claudia Schurmann, Rob Sladek, Gudmar Thorleifsson, Unnur Thorsteinsdóttir, Armand Valsesia, Gerard Waeber, Flore Zufferey, Beverley Balkau, François Pattou, Andres Metspalu, Henry Völzke, Peter Vollenweider, Kári Stefansson, Marjo-Riitta Järvelin, Jacques S Beckmann, Philippe Froguel, Alexandra I F Blakemore

“…Analyses of genome-wide genotyping data have identified genomic structural variants (GSVs) as a source of such rare causal variants. …”
Get full text

Sixteen New Complete Plastid Genomes in the Tribe Loteae (Leguminosae): Structure and Phylogenetic Analysis by Tahir H. Samigullin, Yury O. Kopylov-Guskov, Olga V. Nikitina, Anastasiya A. Krinitsina, Svetlana V. Polevova, Tatiana E. Kramina

“…The tribe Loteae (Papilioniodeae-Leguminosae), according to plastid data, belongs to the Robinioid clade, which also includes the tribes Robinieae and Sesbanieae. …”
Get full text

Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function by Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen

“…These cohesin interactome data are a resource for future studies aimed at characterizing the functional interactions between cohesin and numerous chromatin-associated proteins in regulating chromosome structure and gene control.…”
Get full text

Study on the Microscopic Pore Characteristics and Mechanisms of Disturbance Damage in Zhanjiang Formation Structural Clay by Yanhua Xie, Bin Tang, Shuaiyu Liu, Jicheng Xu, Binghui Zhang

“…The model can rapidly estimate the unconfined compressive strength from porosity data, facilitating the assessment engineering properties of the soil. (3) The microscopic pore structure of Zhanjiang Formation structural clay exhibits prominent Menger fractal characteristics. …”
Get full text

Seed yield limitations of coriander (Coriandrum sativum L.) based on plant structure analysis by S. Kalenska, B. Mazurenko, L. Harbar, M. Zhovtun, A. Yunyk, V. Mokrienko

“…The aim of the research was to establish the patterns of coriander yield formation through the prism of plant structure considering modifications in nutrient conditions and sowing rates. …”
Get full text

Prostruc: an open-source tool for 3D structure prediction using homology modeling by Shivani V. Pawar, Wilson Sena Kwaku Banini, Musa Muhammad Shamsuddeen, Toheeb A. Jumah, Nigel N. O. Dolling, Abdulwasiu Tiamiyu, Olaitan I. Awe

“…The tool enables researchers to input protein sequences, identify homologous templates from databases such as the Protein Data Bank (PDB), and generate high-quality 3D structures with minimal computational expertise. …”
Get full text

Research on postural behavior and structural response prediction of scraper conveyor based on digital twin by Qiang ZHANG, Wei LIU, Yang WANG, Shouxiang MA, Jinpeng SU, Runxin ZHANG

“…Limited by the contradiction between the scale of numerical simulation and computational performance, it is currently difficult to synchronize the structural mechanical response states of fully mechanized mining equipment with their digital twin models in real time. …”
Get full text

Development of a biobank in the structure of scientific and diagnostic and treatment institutions and prospects for interregional integration by R. S. Kalinin, O. V. Goleva, R. A. Illarionov, V. V. Tsai, A. L. Mukomolova, Yu. E. Konstantinova, I. V. Markin, A. V. Krylov, N. V. Rogozina, M. K. Bekhtereva, M. S. Tyan, E. D. Orlova, M. Yu. Donnikov, L. V. Kovalenko, L. N. Kolbasin, A. S. Glotov, O. S. Glotov

“…The formation of biobanks in the structure of scientific and treatment and diagnostic institutions with prospects for interregional integration is a fundamental link in monitoring and predicting diseases of various origins, creating and testing highly effective diagnostics, and developing novel therapeutic agents.Aim. …”
Get full text

Impact of socio-demographic structure of the deaf people communities in prevalence of hereditary hearing loss by O. L. Posukh, M. S. Bady-Khoo, M. V. Zytsar, V. Yu. Mikhalskaia, S. A. Lashin, N. A. Barashkov, G. P. Romanov

“…Information about the sociodemographic structure of deaf communities in the past is extremely limited by an almost complete lack of relevant archival data. …”
Get full text

Comparative analysis of pore structure parameters of coal adsorbed by different gas probe molecules by Lin HONG, Wentong LIU, Dameng GAO, Wei LIANG, Jundan ZHAO, Xingzhu CHE

“…Under the condition of liquid nitrogen (77 K), the low pressure argon adsorption experiment (LPGA-Ar), low pressure nitrogen adsorption experiment (LPGA-N2) and low pressure oxygen adsorption experiment (LPGA-O2) are carried out on the coal with three kinds of metamorphic degrees, and the changes of coal adsorption are analyzed. Using experimental data and non-local density functional theory (NLDFT), the pore structure parameters of coal are characterized. …”
Get full text

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex by Guido C. Paesen, Weng M. Ng, Simon Kimuda, Geoff Sutton, Katie J. Doores, Thomas A. Bowden

“…To glean insights into the architecture of this key therapeutic target, we determined the crystal structures of NW GP1−GP2 heterodimeric complexes from Junín virus and Machupo virus. …”
Get full text

Functional Index Questionnaire: structural validity study in Brazilian patients with anterior knee pain by André Pontes-Silva, Almir Vieira Dibai-Filho, Flávio de Oliveira Pires, Carlos Eduardo Girasol, Gabriel Gardhel Costa Araujo, Plínio da Cunha Leal, José Djalma Arrais Junior, Cid André Fidelis-de-Paula-Gomes, Christian Emmanuel Torres Cabido

“…ABSTRACT OBJECTIVE: To assess the Functional Index Questionnaire (FIQ) structure using confirmatory factor analysis (CFA) in Brazilian patients with anterior knee pain. …”
Get full text

Effects of severe scoliosis on cardiac structure and function in resting patients: a retrospective study by Jie Xiao, Tao Li, Yingsong Wang, Zhi Zhao, Jingming Xie, Jin Zhou

“…Abstract Background Severe scoliosis may impair cardiac structure and function. This study aims to evaluate the cardiac structural and functional changes in patients with severe thoracic scoliosis at rest, using echocardiography to inform perioperative strategies. …”
Get full text

Population Structure Dynamics of Elasmobranchs Susceptible to Shrimp Trawling Along the Southern Gulf of Mexico by Heber Zea-de la Cruz, César Meiners-Mandujano, Javier Tovar-Ávila, Lourdes Jiménez-Badillo, Jorge Luis Oviedo-Pérez

“…Understanding the diversity, segregation, and population structure of species at risk of capture is critical for enhancing their conservation. …”
Get full text

Sensitivity Analysis of Engineering Demand Parameters: Empirical and Analytical Approaches to Structural Loss Estimation by Roi Milyardi, Krishna Pribadi, Muhamad Abduh, Irwan Meilano, Erwin Lim, Reini Wirahadikusumah, Patria Kusumaningrum, Eliza Puri

“…Three school buildings are used as case studies, with existing structural data collected through non-destructive testing on each building used for the analytical method. …”
Get full text

Landscape structure coupled to instream features shape freshwater biodiversity in Cerrado agricultural landscapes by Juliana Silveira dos Santos, Erica Hasui, Fabrício Barreto Teresa, João Carlos Nabout, Karine Borges Machado, Felipe Martello, Ludgero Cardoso Galli Vieira, Rosane Garcia Collevatti

“…We analyzed the data at different spatial scales (50, 100, 150, and 200 m, and watershed level), using structural equation modeling. …”
Get full text

Structural Disorder by Octahedral Tilting in Inorganic Halide Perovskites: New Insight with Bayesian Optimization by Jingrui Li, Fang Pan, Guo‐Xu Zhang, Zenghui Liu, Hua Dong, Dawei Wang, Zhuangde Jiang, Wei Ren, Zuo‐Guang Ye, Milica Todorović, Patrick Rinke

“…Structural disorder is common in metal‐halide perovskites and important for understanding the functional properties of these materials. …”
Get full text

Structural basis of β-glucopyranoside salicin recognition by a human bitter taste GPCR by Xin Wang, Cui Zhou, Weizhen Ao, Lijie Wu, Yiran Wu, Weixiu Xu, Shenhui Liu, Qiwen Tan, Ling Wang, Fei Zhao, Junlin Liu, Yuan Pei, Suwen Zhao, Tian Hua

“…Together with molecular docking and mutagenesis data, this study uncovers the structural underpinnings of TAS2R16’s group-specific recognition, receptor activation, and subsequent gustducin and Gi protein coupling. …”
Get full text

Unveiling the Dynamics and Genesis of Small-scale Fine-structure Loops in the Lower Solar Atmosphere by Annu Bura, Tanmoy Samanta, Alphonse C. Sterling, Yajie Chen, Jayant Joshi, Vasyl Yurchyshyn, Ronald L. Moore

“…Recent high-resolution solar observations have unveiled the presence of small-scale loop-like structures in the lower solar atmosphere, often referred to as unresolved fine structures, low-lying loops, and miniature hot loops. …”
Get full text

Foraging strategy and tree structure as drivers of arboreality and suspensory behaviour in savannah-dwelling chimpanzees by Rhianna C. Drummond-Clarke, Susan Chege Reuben, Fiona A. Stewart, Fiona A. Stewart, Fiona A. Stewart, Alex K. Piel, Alex K. Piel, Alex K. Piel, Tracy L. Kivell

“…However, the link between foraging positional behaviour and tree structure remains understudied.MethodsWe collected data on arboreal foraging behaviour and corresponding tree structural characteristics over five months in the dry season, and used generalized linear mixed models to test for any effect of food type and tree structural characteristics on (1) duration of foraging bouts, (2) frequency of locomotion, and (3) use of suspensory behaviour.ResultsWe found that food types and tree structures found in woodland vegetation are associated with more time spent in foraging trees, a higher rate of locomotion, and the use of suspension in particular.DiscussionOur results suggest that arboreal, and especially suspensory, locomotion can be advantageous for foraging in a savannah-mosaic and not just closed forest habitats. …”
Get full text