Cytotoxic Activity of Bisphosphonic Derivatives Obtained by the Michaelis–Arbuzov or the Pudovik Reaction by Zsuzsanna Szalai, Janka Bednárik, Boldizsár Szigfrid Tóth, Angéla Takács, Szilárd Tekula, László Kőhidai, Konstantin Karaghiosoff, László Drahos, György Keglevich

“…Hydroxy-containing bisphosphonates and their rearranged derivatives demonstrated varying effects depending on structural modifications. While myeloma (U266) cells indicated greater sensitivity overall, the most significant reductions in cell viability were observed in PANC-1 cancer cells, raising potential therapeutic applications of bisphosphonates beyond myeloma-associated bone disease, particularly for malignancies like pancreatic ductal adenocarcinoma.…”
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Contrast in the density and biomass of fish in a reef system with different fishing intensity in the Mexican Caribbean by José Manuel Castro-Pérez, Carmen Amelia Villegas-Sánchez, Alejandro Medina-Quej, Rigoberto Rosas-Luis, Jesús E. Arias-González

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Genome-Wide Identification of HSP70 Gene Family and Their Roles in the Hybrid Tea Rose Heat Stress Response by Xinyu Yan, Yaoyao Huang, Minghua Deng, Jinfen Wen

“…Phylogenetic analysis showed that the identified TFs could classify into three (I, II, and III) subfamilies, with most members (51 TFs) falling in subfamily II. Wide gene structural variations were observed among the three subfamilies, with group I and II members lacking introns, while group III members only harbored 1~4 exons and introns. …”
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Whole-genome resequencing reveals genetic diversity and selection signatures of Tongjiang and five goat breeds by Siyuan Zhan, Siyuan Zhan, Jing Luo, Jing Luo, Ruiyang Li, Ruiyang Li, Guangyao Li, Guangyao Li, Linxiang Li, Dandan Li, Tao Zhong, Tao Zhong, Linjie Wang, Linjie Wang, Jiazhong Guo, Jiazhong Guo, Jiaxue Cao, Hongping Zhang, Hongping Zhang, Li Li, Li Li

“…The population genetic structure analysis showed that significant differentiation of Tongjiang goats from other goat breeds, as evidenced by their distinct clustering and considerable genetic distance from other groups. …”
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Comprehensive analysis of the mitochondrial genome of Iris domestica emphasizing multichromosomal organization and repeat-mediated homologous recombination by Lizhi Ouyang, Xinyu Li, Ruili Wang, Yixuan Chen, Shuo Wang, Jianfang Wang, Yelin Tian

“…Furthermore, 545 RNA editing sites were identified, with notable variations across genes, suggesting that RNA editing plays a significant role in regulating mitochondrial gene expression.ConclusionThe complete assembly of the I. domestica mitochondrial genome reveals a complex multichromosomal structure characterized by recombination events. …”
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Population Dynamics of Ervilia castanea (Montagu, 1803) Hints at Evolutionary Processes Shaping North‐East Atlantic Insular Sandy Habitats by Livia Sinigaglia, Lara Baptista, Manuel Curto, António Múrias Santos, Patrícia Madeira, Thapasya Vijayan, Harald Meimberg, Sérgio P. Ávila

“…Little to no genetic structure was observed between insular populations with both nuclear microsatellites and the mitochondrial cytochrome c oxidase subunit I. …”
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Retinal Vessel Flicker Light Responsiveness and Its Relation to Analysis Protocols and Static and Metabolic Data in Healthy Subjects by Dmitri Artemiev, Christophe Valmaggia, Scott Tschuppert, Konstantin Kotliar, Cengiz Türksever, Margarita G. Todorova

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Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA... by Carlos H. Trasviña-Arenas, Upeksha C. Dissanayake, Nikole Tamayo, Mohammad Hashemian, Wen-Jen Lin, Merve Demir, Nallely Hoyos-Gonzalez, Andrew J. Fisher, G. Andrés Cisneros, Martin P. Horvath, Sheila S. David

“…The structure of the bacterial MutY variant R149Q, along with molecular dynamics simulations of the human enzyme, support a model in which the cofactor functions to position and activate the catalytic Asp. …”
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Geographic Variation in Signal Preferences in the Tropical Katydid <i>Neoconocephalus triops</i> by Oliver M. Beckers, Johannes Schul

“…Importantly, the reduced selectivity for call structure or pulse rate allows calls to display the necessary variation for the communication system to evolve.…”
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Variations of Absolute Source Positions Determined from Quad-band VLBI Observations by Ming Hui Xu, Patrick Charlot

“…For 6% of the sources, the offsets are larger than 0.8 mas. The source structure may be divided into two parts: the invisible structure (within the beam size) and the visible structure (on larger scales). …”
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Fine‐Scale Geographic Variation of Cladocopium in Acropora hyacinthus Across the Palauan Archipelago by Katrina C. Armstrong, Marilla Lippert, Erik Hanson, Victor Nestor, Brendan Cornwell, Nia S. Walker, Yimnang Golbuu, Stephen R. Palumbi

“…Here, we mapped short reads from 271 holobiont genome libraries of individual Acropora hyacinthus colonies to protein coding genes from the chloroplast genome to identify patterns of symbiont population genetic structure. Utilizing this low‐pass method, we assayed over 13,000 bases from every individual, enabling us to discern genetic variation at a finer geographic scale than previously reported at the population level. …”
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L’Éducation sentimentale / La Vie mode d’emploi. Variations perecquiennes by Pierre Laforgue

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Parameters of Cross-linguistic Variation in Expectation-based Minimalist Grammars (e-MGs) by Cristiano Chesi

“…The crucial simplification consists of driving structure building only using lexically encoded categorial top-down expectations. …”
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Age variation of the concentration of toxicants in organs and tissues of sheep in the zone of technogenic pollution by A. K. Mikhailenko

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Arctic plant-fungus interaction networks show major rewiring with environmental variation by Bastien Parisy, Niels M. Schmidt, Alyssa R. Cirtwill, Edith Villa-Galaviz, Mikko Tiusanen, Cornelya F. C. Klütsch, Paul E. Aspholm, Katrine Raundrup, Eero J. Vesterinen, Helena Wirta, Tomas Roslin

“…Abstract Global environmental change may lead to changes in community structure and in species interactions, ultimately changing ecosystem functioning. …”
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Calculating slope gradient variations in the submarine landforms by R and Python statistical libraries by Polina Lemenkova

“…Multiple factors affect submarine geomorphology causing variations in the gradient slope: geological settings (rock composition, structure, permeability, erodibility of the materials), submarine erosion, gravity flows of water streams, tectonics, sediments from the volcanic arcs, transported by transverse submarine canyons. …”
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Compressing Neural Networks Using Tensor Networks with Exponentially Fewer Variational Parameters by Yong Qing, Ke Li, Peng-Fei Zhou, Shi-Ju Ran

“…Our study suggests that the deep TN is an exceptionally efficient mathematical structure for representing the variational parameters of NNs, one that exhibits better compressibility than the commonly used matrices and multiway arrays.…”
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TO DETERMINATION OF INFLUENCE FOR VARIATIONS IN LASER TREATMENT MODES ON TRIBOLOGICAL CHARACTERISTICS OF CUTTING TOOL by O. V. Diachenko, M. A. Kardapolova, O. V. Seriakova

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Relationship Between Genetic and Phenotypic Variations in Natural Populations of Perennial and Biennial Sagebrush by Khurelpurev Oyundelger, Lisa Großmann, Veit Herklotz, Dörte Harpke, Oyuntsetseg Batlai, Karsten Wesche, Christiane M. Ritz

“…Population genetic structure in the biennial A. scoparia was weak, while the perennial A. frigida showed some spatial genetic structure, which was impacted by geographical factors, soil nutrients, and precipitation amount. …”
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ANALYSIS OF ASIR VARIATION EFFECT TO SNR ON UNENHANCED ABDOMINAL CT SCAN IN UROLITHIASIS by Rizki Aditiya Pratama Putra, Paulus Rahardjo, Pramono Pramono

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