snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation by Yusha Yang, Yusha Yang, Guanyu Zhang, Ting Yi, Ting Yi, Shuran Yang, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Xiuxuan Wu, Jun Li, Danfeng Yang

“…Subsequently, we employed single-nucleus RNA sequencing (snRNA-seq) to comprehensively characterize iWAT cellular dynamics during cold stimulation and the subsequent two-week period after the return to thermoneutrality.ResultsOur findings revealed that while iWAT phenotypically reverts to a white state after 2 weeks of rewarming, as evidenced by structural, functional, and bulk transcriptomic characteristics, significant cold-induced molecular and cellular signatures persist. …”
Get full text

Retinal Microvascular Changes in Association with Endothelial Glycocalyx Damage and Arterial Stiffness in Patients with Retinal Vein Occlusion: A Cross-Sectional Study by Konstantinos Pappelis, Alexia Risi-Koziona, Chrysa Agapitou, Emmanouil Korakas, John Thymis, George Pavlidis, Stamatios Lampsas, Aikaterini Kountouri, Loukia Pliouta, Ilias Georgalas, Panagiotis Theodossiadis, Vaia Lambadiari, Ignatios Ikonomidis, Irini Chatziralli

“…Conclusions: In patients with RVO, structural and microvascular retinal parameters were significantly associated with markers of endothelial dysfunction and arterial stiffness.…”
Get full text

A Systematic Literature Review on Li-Ion BESSs Integrated with Photovoltaic Systems for Power Supply to Auxiliary Services in High-Voltage Power Stations by Sergio Pires Pimentel, Marcelo Nogueira Bousquet, Tiago Alves Barros Rosa, Leovir Cardoso Aleluia Junior, Enes Goncalves Marra, Jose Wilson Lima Nerys, Luciano Coutinho Gomes

“…The methodology follows a structured review framework, including data collection, selection criteria, and evaluation of technical feasibility. …”
Get full text

Being heard, restoring a social connection and decreasing anger: Adult patients’ perceptions of clinical services addressing violent extremism in Montreal, Canada by Cécile Rousseau, Cindy Ngov, Samuel Veissière, Christian Desmarais, Tara Santavicca, Janique Johnson-Lafleur

“…Using a phenomenological framework, we conducted semi-structured interviews with 18 participants (17 men and 1 woman; ages 17–72, mean = 32) referred by a specialized clinical team. …”
Get full text

Digitally deployed, GP remote consultation video intervention that aims to reduce opioid prescribing in primary care: protocol for a mixed-methods evaluation by Nick Hex, Christopher Price, Yu Fu, Ben Allen, Tracy Finch, Denis Martin, Cormac G Ryan, Alan M Batterham, Niki Jones, Ewan Maule

“…Semi-structured interviews will be undertaken remotely with purposively selected participants including patients who received the video, and health professionals involved in sending out the videos and providing additional support. …”
Get full text

A Trade‐Off Between Leaf Carbon Economics and Plant Size Among Mangrove Species in Dongzhaigang, China by Dalong Jiang, Tao Nie, Qiuyu He, Jing Yan, Erhui Feng, Qing Ye

“…In this research, we investigated the leaf structural traits, plant height, and diameter at breast height or basal height (DBH) of 10 shrub and tree species. …”
Get full text

Smart Fault Detection, Classification, and Localization in Distribution Networks: AI-Driven Approaches and Emerging Technologies by Jianxian Wang, Hazlie Mokhlis, Nurulafiqah Nadzirah Mansor, Hazlee Azil Illias, Agileswari K. Ramasamy, Xingyu Wu, Siqi Wang

“…This review also explores the emerging potential of large language models to enhance the explainability of diagnostics, support multi-agent coordination, and enable natural language-based fault reasoning. …”
Get full text

Prevalence and factors associated with uptake of cervical cancer screening at primary care facilities in Trinidad: a cross-sectional study by Raveed Khan, Rohan G Maharaj, Waly Mohan, Syriah David, Sherrelle Davis, Brittany Deane, Thershus Chinapoo, Felice Cox, Reyann Cooper, Kristus David, Tiye Charles, Akilah Guevara

“…The questionnaire was structured along the Health Belief Model. χ2 analysis was used to determine differences and associations between categorical variables.Results 435 women were approached and 432 participated, yielding a response rate of 99.3%. …”
Get full text

Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration by Youfeng Guo, Xiao Liu, Chao Wang, Shuguang Wang, Yufeng Huang, Shuo Ding, Zeyu Wang, Feng Wang

“…It is important to note that SF/GO-gel@Trox stabilized phosphorylated Tie2 (Y992), which in turn improved the interaction between CBL and EGFR, thereby accelerating the turnover of EGFR. In a rat IDD model, Tie2 overexpression was able to mitigate disc structural damage through hydrogel delivery, whereas concurrent EGFR expression reversed these benefits. …”
Get full text

Investigating changes of forest aboveground biomass induced by Moso bamboo expansion with terrestrial laser scanner by Rui Jiang, Jiayuan Lin, Xianwei Zhang, Meiqi Kang

“…Subsequently, tree and bamboo classification was achieved via combining the structural features, stem texture features, and point distribution features of individual plants. …”
Get full text

Recommendations for a Communication Strategy to Support Informed Decision‐Making About Self or Clinician Sampling for Cervical Screening in the UK: Qualitative Study by Denitza Williams, Eleanor Clarke, Kate J. Lifford, Lindsay Haywood, Fiona Wood, Jo Waller, Adrian Edwards, Natalie Joseph‐Williams, Caroline Evans, Gareth Powell, Rhiannon Phillips, Andrew Carson‐Stevens, Katie Walbeoff, Ardiana Gjini, Kate Brain

“…Methods Qualitative co‐production explored communication preferences and decision‐support needs in a diverse sample of cervical screening‐eligible individuals using semi‐structured interviews with individuals eligible for cervical screening (n = 30) and stakeholders (n = 23). …”
Get full text

Coronary inflammation and atherosclerosis by CCTA in young adults (aged 18-45) by Annalisa Filtz, Daniel Lorenzatti, Henry A Dwaah, Carlos Espiche, Santiago F Galgani, Jake T Gilman, Alexandrina Danilov, Andrea Scotti, Piotr J Slomka, Daniel S Berman, Salim S Virani, Mario J Garcia, Khurram Nasir, Leslee J. Shaw, Ron Blankstein, Michael D Shapiro, Damini Dey, Leandro Slipczuk

“…Structured abstract: Background: Peri-coronary adipose tissue attenuation (PCAT), a marker of coronary inflammation, is linked to coronary artery disease (CAD), but data on the role of PCAT in young individuals are limited. …”
Get full text

Prevalence of hepatitis C virus co-infection in adults living with HIV in Mexico: a cross-sectional, seroprevalence study in a nationally representative sampleResearch in context by Pablo F. Belaunzarán-Zamudio, Juan L. Mosqueda-Gómez, J. Oggún Cano-Torres, Claudia Guillén-López, Teresa Muñoz-Trejo, Kenia Escobedo-López, Alejandro Rivera-Marroquín, Akio Murakami-Ogasawara, José L. Sánchez-Bello, Margarita M. Rosas-Dossetti, Elizabeth Papaqui-Limón, Alethse De la Torre-Rosas, Juana Díaz-García, Juan G. Sierra-Madero, Pablo F. Belaunzarán-Zamudio, Juan L. Mosqueda-Gómez, J. Oggun Cano-Torres, Claudia Guillén-López, Teresa Muñoz-Trejo, Kenia Escobedo-López, Alejandro Rivera Marroquin, Akio Murakami-Ogasawara, José L. Sánchez-Bello, Margarita M. Rosas-Dossetti, Elizabeth Papaqui-Limón, Alethse De la Torre-Rosas, Juana Díaz-García, Bibiana M. Barbosa-Ramírez, Oscar Castillo-Soria, Alain Espinoza-Pérez, Jorge Gaxiola-Lugo, Alfredo Pérez-Valenzuela, Krissel García-Hernández, Elvira E. Riojas-Moncada, Juana Díaz-García, Juan Beltrán-Saldaña, Felipe De Jesús Escobar-Del Real, Ma. del Pilar Abarca-de Hoyos, Susana Raviela, Ma. Eugenia Figueroa-Santana, Jorge A. Gamboa-Marroquin, Andrea Cárdenas-Ortega, Mario J. Hernández-Morales, Adonay Jiménez-Jiménez, Manuel Vidal-López, Roberto Rodríguez-Díaz, Berenice Robles-Villafuerte, Arturo Alatorre-Manjarrez, Corazón Moreno-Mex, Ivonne Sánchez-López, Jorge Silva-Herrera, Nora Mora-Suárez, Daniel Pérez-Larios, Juan G. Sierra-Madero

“…Methods: Using a complex-survey design, we collected blood samples and applied structured questionnaires between May 2nd, 2019 and February 17th, 2020 in a nationally, representative sample of adults receiving care for HIV-infection in 24 randomly selected HIV-care centres in 8 socio-demographically regions in Mexico. …”
Get full text

Effect of boron addition on Nb(C, N) refinement and dissolution behavior in Super 304H austenitic heat-resistant steel by Tong Wang, Jinyao Ma, Nan Dong, Shucai Zhang, Puli Wang, Peizhi Cui, Song Yang, Xudong Fang, Zhihua Wang, Peide Han

“…First-principles calculations demonstrate that B addition increases the binding energy of Nb(C, N), thereby reducing its structural stability. The kinetic analysis using the Johnson-Mehl-Avrami-Kolmogorov (JMAK) model also shows that B addition decreases the activation energy for Nb(C, N) dissolution from 324.1 kJ/mol to 294.7 kJ/mol, which significantly accelerates its dissolution rate. …”
Get full text

mHealth intervention delivered in general practice to increase physical activity and reduce sedentary behaviour of patients with prediabetes and type 2 diabetes (ENERGISED): statis... by Tomas Vetrovsky, Norbert Kral, Marketa Pfeiferova, Bohumil Seifert, Vaclav Capek, Katerina Jurkova, Michal Steffl, Richard Cimler, Jitka Kuhnova, Tess Harris, Michael Ussher, Charlotte Wahlich, Katerina Malisova, Jana Pelclova, Jan Dygryn, Steriani Elavsky, Iris Maes, Delfien Van Dyck, Alex Rowlands, Tom Yates

“…The trial incorporates the estimand framework to provide transparent and structured treatment effect estimation. Discussion This statistical analysis plan outlines a robust approach to addressing participant non-adherence, protocol violations, and missing data. …”
Get full text

Multicountry research on comprehensive abortion policy implementation in Latin America: a mixed-methods study protocol by Guillermo Carroli, Antonella Lavelanet, Silvina Ramos, Mariana Romero, Rodolfo Gomez Ponce de Leon, Berenise Carroli, Celina Gialdini, Agustina Ramón Michel, Mercedes Vila Ortiz

“…The aim is to identify barriers, facilitators and strategies to the implementation of abortion policies, looking at four key dimensions—regulatory framework, abortion policy dynamics, abortion service delivery and health system and health outcomes indicators—to draw cross-cutting lessons learnt to improve current implementation and inform future safe abortion policy development.Methods and analysis A mixed-method design will be used in the five countries to address the four dimensions through the Availability, Accessibility, Acceptability and Quality of Care model. The data collection tools include desk reviews and semi-structured interviews with key actors. …”
Get full text

The Association of Lipoprotein(a) and Stroke Recurrence: A Systematic Review and Meta-Analysis by Lina Palaiodimou, Konstantinos Melanis, Maria-Ioanna Stefanou, Aikaterini Theodorou, Sotirios Giannopoulos, Vaia Lambadiari, Diana Aguiar de Sousa, Simona Sacco, Mira Katan, Gerasimos Siasos, Georgios Tsivgoulis

“…Background and Purpose Lipoprotein(a) [Lp(a)] is a lipoprotein structurally similar to low-density lipoprotein and is considered a genetically determined risk factor for cardiovascular disease. …”
Get full text

Reducing frost heave and salt migration in saline soil foundations of channels in seasonal frozen regions using solidification by KANG Xinrui, LI Hongbo, TIAN Juncang, ZHANG Zhe, WANG Zi

“…【Objective】Saline soils in seasonal frozen regions are often used as channel foundations but are prone to frost heave and salt migration, which can compromise structural stability. The objective of this paper is to investigate the efficacy of soil solidification in improving frost resistance and mitigating salt migration, and provide insights for improving engineering design in cold regions. …”
Get full text

Hypovitaminosis D Does Not Aggravate the Progression of Gentamicin-Induced Kidney Injury in Rats by Ana Lívia D. Maciel, Amanda L. Deluque, Beatriz M. Oliveira, Cláudia S. Souza, Heloísa D. C. Francescato, Cleonice Giovanini, Francisco J. A. de Paula, Terezila M. Coimbra, Rildo A. Volpini

“…Despite the notable changes in functional, inflammatory, and structural parameters induced by gentamicin, hypovitaminosis D did not aggravate the renal injury in this experimental model. …”
Get full text

Impacts of Natural Organic Matter and Dissolved Solids on Fluoride Retention of Polyelectrolyte Multilayer-Based Hollow Fiber Nanofiltration Membranes by Hussein Abuelgasim, Nada Nasri, Martin Futterlieb, Radhia Souissi, Fouad Souissi, Stefan Panglisch, Ibrahim M. A. ElSherbiny

“…Feed salinity was shown to significantly affect separation efficiency, with PEC layers undergoing swelling and certain structural changes as the ionic strength increased. …”
Get full text