Exploring sex-based differences in patient outcomes: A secondary analysis of Heartwatch, an Irish cardiovascular secondary prevention programme by Ivana Keenan, Fintan Stanley, Robyn Homeniuk, Joseph Gallagher, Michael O'Callaghan, Claire Collins

“…CCare scores also demonstrated the gap between male and female patients at baseline [mean(sd); M: 5.1(1.2), F: 4.8(1.2)] and after 4 years of structured care [mean(sd); M: 5.3(1.2), F: 4.9(1.2)]. …”
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FNDC3B promotes gastric cancer metastasis via interacting with FAM83H and preventing its proteasomal degradation by Yuying Zhang, Lingyu Ran, Yuying Liu, Wei Li, Ai Ran, Haiping Li, Bo Huang, Junwu Ren, Hao Ning, Qiang Ma, Xiaolin Wang, Feifei Yang, Xiaojuan Pan, Ce Liang, Shimin Wang, Changhong Qin, Yan Jiang, Kun Qian, Bin Xiao

“…In vitro cellular experiments and in vivo nude mouse models were constructed to validate the biological functions of FNDC3B. …”
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The validity and reliability of the Hungarian version of smartphone addiction scale – Short version (SAS-SV-HU) among university students by Bettina Tóth, Alexandra Makai, Monika Gyuró, Márk Komáromy, Gabriella Császár

“…The reliability of the SAS-SV-HU was evaluated by internal consistency reliability and test-retest reliability, and the validity of the SAS-SV-HU was evaluated by structural, convergent, and discriminant validity. The internal consistency was assessed by Cronbach's alpha coefficient, which showed a good level of internal consistency (α = 0.79). …”
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Enhancing authenticity, diagnosticity and equivalence (AD-Equiv) in multicentre OSCE exams in health professionals education: protocol for a complex intervention study by Geoff Wong, Kathy Cullen, Rhian Goodfellow, Gareth McCray, Richard Fuller, Robert K McKinley, Ruth Kinston, Peter Yeates, Adriano Maluf, Natalie Cope, Vikki O’Neill, Aidan Cole, Rebecca Vallender, Ching-Wa Chung

“…Introduction Objective structured clinical exams (OSCEs) are a cornerstone of assessing the competence of trainee healthcare professionals, but have been criticised for (1) lacking authenticity, (2) variability in examiners’ judgements which can challenge assessment equivalence and (3) for limited diagnosticity of trainees’ focal strengths and weaknesses. …”
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Taxonomy of advanced access practice profiles among family physicians, nurse practitioners and nurses in university-affiliated team-based primary healthcare clinics in Quebec by Arnaud Duhoux, Catherine Hudon, France Légare, Isabelle Vedel, Isabelle Gaboury, Djamal Berbiche, Mylaine Breton, Sabina Abou Malham, Lara Maillet, Nadia Deville-Stoetzel, Nassera Touati

“…Objectives The advanced access model is highly recommended to improve timely access to primary healthcare (PHC). …”
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Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures by Johannes Laengle, Julijan Kabiljo, Jakob Homola, Gerda Egger, Michael Bergmann, Wolfgang Weninger, Matthias Farlik, Askin Kulu, Anna Theophil, Annalena F Renner, Nathalie Stürzenbecher, Daphni Ammon, Rebecca Zirnbauer, Simone Stang, Loan Tran, Anna Chen, Markus Fabits, Velina S Atanasova, Oliver Pusch, Henning Walczak, Dietmar Herndler Brandstetter, Helmut Dolznig, Anna Kusienicka

“…Yet, a major limitation is the absence of cells from the tumor microenvironment, thereby prohibiting potential investigation of treatment responses on immune and structural cells. Currently there are sparse reports describing the interaction of PDOs, cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) in complex primary co-culture assay systems.Methods Primary PDOs and patient matched CAF cultures were generated from surgical resections. …”
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A multifunctional hydrogel system with synergistic effects against Staphylococcus aureus infections and inflammation in perioperative cataract surgery by Wendi Zheng, Meiting Lin, Hong Cheng, Xiang Gao, Yongguo Xiang, Wenjuan Wan, Shijie Zheng, Xiaobei Huang, Ke Hu

“…Herein, multifunctional hydrogel eye drops (designated as FQT) were synthesized through a simple one-pot synthesis, employing thermosensitive F127 as the structural scaffold and incorporating quaternized chitosan (QCS) and tannic acid (TA). …”
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Displacement-related stressors in a Sudanese war-affected community; identifying the impact of war exposure and ongoing stressors on trauma symptom severity: a national multi-cente... by Lina Hemmeda, Alaa S. Ahmed, Gasm Alseed Abdelmonim Gasm Alseed Fadlalmoula, Doaa Rabeie Hassan, Mohammed Haydar Awad, Gotof Salim, Abeer Osman Mukhtar Elabid, Alaa Azhary mohammed Ali, Asmaa O. Algasim, Ethar Hamad, Fatima Afif, Fatima Mustafa, Maha Rhamttallah, Mai Fathi Awadalla Alsedig, Miada Ali Mohammed Taha, Muram Ahmed Sayed Khaleel, Nazik Abdalla Nourin, Roaa Salah Eltaheir Mohieldin, Sara Ali, Shimaa Suliman, Khabab Abbasher Hussien Mohamed Ahmed

“…The data analysis was conducted using R software. A structural equation model was generated to visualize the comprehensive relationship between the study variables. …”
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A Novel Electrocardiographic Approach for Accurate Diagnosis of Prior Inferior Myocardial Infarction by Hailei Liu, MD, Thien Tan Tri Tai Truyen, MD, Harpriya Chugh, MSHS, Kyndaron Reinier, PhD, Ashkan Ehdaie, MD, Eugenio Cingolani, MD, Archana Ramireddy, MD, Eric D. Braunstein, MD, Michael Shehata, MD, Xunzhang Wang, MD, Sumeet S. Chugh, MD

“…Objectives: The aim of the study was to use predictive model building to select the optimal ECG criteria specific to the diagnoses of true-IMI. …”
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Micro-Computed Tomographic Evaluation of the Shaping Ability of Vortex Blue and TruNatomy^TM Ni-Ti Rotary Systems by Batool Alghamdi, Mey Al-Habib, Mona Alsulaiman, Lina Bahanan, Ali Alrahlah, Leonel S. J. Bautista, Sarah Bukhari, Mohammed Howait, Loai Alsofi

“…Pre- and post-instrumentation micro-CT scans were analyzed to measure the following parameters: percentage of untouched canal surface area, changes in canal surface area, changes in canal volume, structural model index (SMI), changes in canal angulation, changes in dentin thickness, transportation, and centering ability. …”
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Acceptability of the Moyo device for intrapartum fetal heart rate monitoring at a referral hospital in Uganda: a qualitative study by Milton W. Musaba, Ritah Nantale, Julius N. Wandabwa, Agnes Napyo, Albert Ssesanga, Usaama Ssewankambo, Akello Eunice, Kenneth Mugabe, Brendah Nambozo, Faith Oguttu, John Stephen Obbo, Andrew D. Weeks, David Mukunya

“…Participants were purposively selected and interviewed using a semi-structured interview guide. The interviews were audio recorded and transcribed verbatim. …”
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The prevalence of hypertension and diabetes, and associated factors among people receiving antiretroviral therapy in Ethiopia by Yadessa Tegene Woldie, Selamawit Mengesha Bilal, Rianne Tanis, Babette Spaargaren, Mekdes Redi Umer, Kebede Tefera Betru, Alemayehu Toma, Mark Spigt

“…Nine trained nurses collected data using a pre-tested structured questionnaire, and SPSS version 20 was employed for analysis. …”
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Barriers and facilitators to housing and healthcare services for people experiencing homelessness with concurrent brain injury, mental health and substance use disorders: a qualita... by Grace C. Warren, Cole J. Kennedy, Cole J. Kennedy, Cole J. Kennedy, Nicholas Gavas, Julia Schmidt, Julia Schmidt, Erica Woodin, Erica Woodin, Janelle Breese Biagioni, Mauricio A. Garcia-Barrera, Mauricio A. Garcia-Barrera

“…The objective of this study was to identify barriers and facilitators to housing and healthcare services for people experiencing homelessness with ABI and concurrent MHSU disorders.MethodsData were collected during a one-day workshop as part of the British Columbia Consensus for Brain Injury, Mental Health and Addiction project. Semi-structured focus groups involving ABI survivors, service providers, and community stakeholders explored barriers, facilitators, and recommendations for service improvements. …”
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MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis by Maika Itsuno, Hirokazu Tanabe, Etsuko Sano, Takashi Sasaki, Chisato Oyama, Hiroko Bannai, Koichi Saito, Kazuhiko Nakata, Setsu Endoh-Yamagami, Hideyuki Okano, Sumihiro Maeda

“…In addition, transcriptomic analysis revealed structural changes specific to excitatory neurons with the A152T mutation. …”
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Improved Quantification of Circulating Tumor DNA in Translocation‐Associated Myxoid Liposarcoma by Simultaneous Detection of Breakpoints and Single Nucleotide Variants by A. Schmid, U. Lausch, A. Runkel, J. Kiefer, T. Pauli, M. Boerries, B. Bogner, S. U. Eisenhardt, D. Braig

“…Methods Using MLS as a model for translocation‐driven tumors, this study evaluates a refined analytical approach for detecting both single nucleotide variants (SNVs) and structural variants (SVs) with the highest possible sensitivity and specificity. …”
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Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

“…In this study, three biochars were synthesized at 500 °C from pre-impregnated date palm fronds (DPFs) with 1 M solutions containing either MgCl2 (DPF-Mg-B), AlCl3 (DPF-Al-B) or a combination of MgCl2/AlCl3 (DPF-Mg/Al-B). Subsequently, the structural, textural, and surface chemistry properties of these biochars were assessed. …”
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Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…The secondary outcome assessed the association between demographic factors (age, gender, income, education, smoking status) and KAP scores using structural equation modelling (SEM).Results The mean KAP scores were 1.26±2.85 for knowledge, 30.46±3.63 for attitudes and 34.58±5.55 for practices. …”
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Temporal evolution of microstructural integrity in cerebellar peduncles in Parkinson’s disease: Stage-specific patterns and dopaminergic correlates by Chentao He, Rui Yang, Siming Rong, Piao Zhang, Xi Chen, Qi Qi, Ziqi Gao, Yan Li, Hao Li, Frank-Erik de Leeuw, Anil M. Tuladhar, Marco Duering, Rick C. Helmich, Rick van der Vliet, Sirwan K.L. Darweesh, Zaiyi Liu, Lijuan Wang, Mengfei Cai, Yuhu Zhang

“…Conclusions: Our findings suggest a non-linear evolution of microstructural integrity in CP throughout the course of PD, indicating the adaptive structural reorganization of the cerebellum simultaneously with progressive striatal dopaminergic degeneration in PD.…”
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Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation by Cefan Zhou, Xueying Dong, Shi Li, Yue Xi, Yuan Liu, Xuehong Qian, Ziyan Song, Li Zhou, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Weiyong Liu, Yan Xiong, Zhentian Wang, Chaojun Yan, Zijian Zhang, Haichuan Zhu, Xing-Zhen Chen, Zhiyin Song, Jingfeng Tang

“…We further showed that STYK1-mediated GSK3β sequestration is impaired by autophagy inhibitors or in ATG7 knockout cells, linking this process to autophagic regulation. Structural analysis identified conserved tyrosine-based (Y191QRL194) and dileucine-based (GDLL203-204) sorting motifs in STYK1, which facilitate clathrin/AP2-dependent internalization essential for GSK3β sequestration. …”
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Dissolved organic matter fosters core mercury-methylating microbiomes for methylmercury production in paddy soils by Q. Pu, B. Meng, J.-H. Huang, K. Zhang, K. Zhang, J. Liu, Y. Liu, M. A. Abdelhafiz, M. A. Abdelhafiz, M. A. Abdelhafiz, X. Feng, X. Feng

“…The partial Mantel test revealed strong linkages among core Hg-methylating microbiome composition, DOM, and MeHg concentration. Structural equation models further indicated that core Hg-methylating microbiome composition significantly impacted soil MeHg concentration, contributing 89 % of the observed variation, while DOM plays a crucial role in determining core Hg-methylating microbiome composition, accounting for 65 %. …”
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