Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy by Florencia B. González, Florencia B. González, Antonella Pacini, Araceli Castro, Susana Lioi, Silvina R. Villar, Silvina R. Villar, Luciano D’Attilio, Luciano D’Attilio, Rodolfo D. Leiva, Rodolfo D. Leiva, Liliana Favaloro, Oscar A. Bottasso, Oscar A. Bottasso, Carlos A. Vigliano, Carlos A. Vigliano, Ana Rosa Pérez, Ana Rosa Pérez

“…Heart control samples with no evidence of structural heart disease and from ischemic cardiomyopathy patients were included. …”
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Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation by Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi, Eriko Nitta, Hiroki Konishi, Kunihiko Kiuchi, Mitsuru Takami, Kimitake Imamura, Masayuki Taniguchi, Masatoshi Inoue, Toshihiro Nakamura, Yusuke Sonoda, Hiroyuki Takahara, Kazutaka Nakasone, Kyoko Yamamoto, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Shogo Yonehara, Atsushi Murakami, Ryuji Toh, Takenao Ohkawa, Tomoyuki Furuyashiki, Ryo Nitta, Tomoya Yamashita, Ken-ichi Hirata, Koji Fukuzawa

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Evidence-based medicine: 5 steps to navigate uncertainty by Rafael Martín-Masot, Carlos Ochoa Sangrador, Jaime Javier Cuervo Valdés, Carolina Blanco Rodríguez, Paz González Rodríguez, Javier González de Dios, M. Salomé Albi Rodríguez, Pilar Aizpurua Galdeano, María Aparicio Rodrigo, Nieves Balado Insunza, Albert Balaguer Santamaría, Fernando Carvajal Encina, Eduardo Cuestas Montañes, M. Jesús Esparza Olcina, Sergio Flores Villar, Garazi Frailea Astorga, M. Victoria Martínez Rubio, Manuel Molina Arias, Eduardo Ortega Páez, Begoña Pérez-Moneo Agapito, M. José Rivero Martín, Álvaro Gimeno Díaz de Atauri, Laura Cabrera Morente, Elena Pérez González, Juan Ruiz-Canela Cáceres

“…Evidence-based medicine provides a structured and practical approach for addressing the challenges of modern medicine, which is characterized by an overload of information and the need for well-founded clinical decision-making. …”
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Acmeological technology of forecasting individual professional-oriented trajectories of students’ personality development by E. F. Zeer, L. N. Stepanova

“…F. Flakhta. Statistical data processing was carried out using the standardised IBM SPSS Statistics 17.0 software package.   …”
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Modern approach to automation of internal control of quality and safety of medical care by S. Y. Morozov, M. A. Morozova, L. E. Morozova

“…Many engineers and programmers working in Moscow’s medical system organizations attempted uploading the medical record data and create automated logs within the UMIAS system; however, they failed [4, 8, 9, 10]. …”
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Characterising the effects of displacement on gender-based violence among women living with HIV in Ukraine: a cross-sectional study by Stefan David Baral, Carrie Lyons, Althea Wolfe, Mary Anne Roach, Gnilane Turpin, Omar Syarif, Pim Looze, Katarzyna Lalak, Jean de Dieu Anoubissi, Yi-Chi Chiu, Alexandra Volgina, Sophie Brion, Keren Dunaway, Olena Stryzhak, Daria Ocheret, Laurel Sprague, Carlos Garcia de Leon Moreno, Katherine B Rucinski

“…These forms of violence are conceptualised as severe forms of enacted stigma that are downstream outcomes of social, cultural and political norms, as well as social and structural stigmas related to misogyny and HIV.Methods Data were collected in Ukraine in 2020 as part of the People Living with HIV Stigma Index 2.0, led by 100% Life, the largest organisation for people living with HIV in Eastern Europe/Central Asia. …”
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RANK is a poor prognosis marker and a therapeutic target in ER‐negative postmenopausal breast cancer by Marina Ciscar, Eva M Trinidad, Gema Perez‐Chacon, Mansour Alsaleem, Maria Jimenez, Maria J Jimenez‐Santos, Hector Perez‐Montoyo, Adrian Sanz‐Moreno, Andrea Vethencourt, Michael Toss, Anna Petit, Maria T Soler‐Monso, Victor Lopez, Jorge Gomez‐Miragaya, Clara Gomez‐Aleza, Lacey E Dobrolecki, Michael T Lewis, Alejandra Bruna, Silvana Mouron, Miguel Quintela‐Fandino, Fatima Al‐Shahrour, Antonio Martinez‐Aranda, Angels Sierra, Andrew R Green, Emad Rakha, Eva Gonzalez‐Suarez

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Effectiveness of exercise in reducing symptom burden among hemodialysis patients: a non-pharmacological intervention approach by Bushra Alshammari, J. Silvia Edison, Sameer A. Alkubati, Awatif M. Alrasheeday, Bander Albagawi, Laila Lafi Alharbi, Hajer I. Motakef, Layla Alshammari, Bahia Galal Abd El-Razik Siam, Nawal Abdullah Alharbi, Wejdan Assiri, Amirah Abdulaziz Almoqad, Abdulrahman Ibrahim Aldibas, Farhan Alshammari

“…Participants engaged in a structured exercise program for 12 weeks, with sessions conducted three times per week for 30 min. …”
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H‐Shaped Anatomical Titanium Plate: Biomechanical Validation and Clinical Application in the Treatment of Complex Posterior Wall/Column Acetabular Fractures by Qiaoli Zhang, Liang Jin, Xiaorui Hao, Weijie Zheng, Fei Zhou, Shuxin Zhang, Tianfeng Li, Xiaohui Xiong, Yihan He, Xiaojie Chen, Jiexin Huang

“…Following anatomic reduction, cyclic loading and destructive experiments were conducted to assess the efficacy of different fixation devices under various loads for the posterior wall and column, as well as their peak load and structural stiffness. Additionally, we retrospectively analyzed the clinical data of 53 patients (46 males, 7 females; mean follow‐up 24.6 ± 3.2 months) with the HTP at our hospital from April 2017 to January 2023. …”
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Bicontinuous Nanophasic Conetworks of Polystyrene with Poly(dimethylsiloxane) and Divinylbenzene: From Macrocrosslinked to Hypercrosslinked Double-Hydrophobic Conetworks and Their... by Anna Petróczy, István Szanka, András Wacha, Zoltán Varga, Yi Thomann, Ralf Thomann, Rolf Mülhaupt, Laura Bereczki, Nóra Hegyesi, Béla Iván

“…The Korsmeyer–Peppas type evaluation of the swelling data indicates hindered Fickian diffusion of both solvents in the conetwork organogels. …”
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Morphological analysis and functional connectivity of the insular in patients with dysphagia after cerebral infarction based on resting-state fMRI by Ming Guo, Bingjie Li, Jun Zhao, Chen Bai, Weiyong Yu, Hongxia Zhang, Haoyuan Li, Yongxue Yuan, Qingsu Zhang, Tong Zhang

“…Resting-state functional magnetic resonance imaging (rs-fMRI) and high-resolution T1-weighted structural imaging data were acquired. Seed-based analysis (using the CONN FC toolbox) was employed to quantify the whole-brain functional connectivity (FC) of the insula, and voxel-based morphometry (VBM) was used to assess gray matter volume changes. …”
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Association between post-PCI vessel fractional flow reserve (vFFR) and optical coherence tomography (OCT) findings: Results from the FAST OCT study by Annemieke C. Ziedses des Plantes, Alessandra Scoccia, Frederik T.W. Groenland, Maria N. Tovar Forero, Mariusz Tomaniak, Janusz Kochman, Wojciech Wojakowski, Pawel Gąsior, Koen Ameloot, Tom Adriaenssens, Wijnand K. den Dekker, Rutger-Jan Nuis, Isabella Kardys, Nicolas M. Van Mieghem, Ernest Spitzer, Joost Daemen

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Curve Behavior of Distal Segments After Posterior‐Only Hemivertebra Resection for Congenital Cervicothoracic Scoliosis by Yang Li, Zezhang Zhu, Wanyou Liu, Saihu Mao, Zhen Liu, Xu Sun, Yong Qiu, Benlong Shi

“…However, the curve behavior of distal non‐structural compensatory curves and its possible mechanisms were unclear. …”
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Mechanism and quantitative traceability of anomalous outflow of unloaded gas from protective layer mining under complex tectonics by Xuexi CHEN, Xingyu CHEN, Jiaying HU, Aitao ZHOU, Jian XIAO, Jihong SUN, Zhilong YAN

“…By coupling simulation analysis of FLAC3D-COMSOL under complex structural stress, the mechanical evolution law and stress relief and permeability enhancement mechanism of protective layer mining are studied. …”
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Increased vulnerability to psychological distress and suicidal ideation among transgender women with self-reported disabilities in San Francisco, California by Abtin Shafie, Alexis Salvatore, Riley Shea, Eileen Yu, Oyku Ozyucel, Ansharan Akbar, Bow Suprasert, Erin C. Wilson, Willi McFarland, Kelly D. Taylor, Sean Arayasirikul

“…OBJECTIVE: Research among transgender women has found health, but especially mental health, to be shaped by social inequities and multiple, intersectional, structural vulnerabilities. While some studies have shown that transgender adults are also more likely to have a disability than cisgender adults, few studies have explored this intersection. …”
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Clinical profiles and health-related quality of life changes after treatment in advanced colorectal cancer patients: a nationwide study in China by Hongwei Liu, Ziyao Jia, Huifang Xu, Xiaoyang Wang, Hong Wang, Ruihua Kang, Qiong Chen, Xiaoli Guo, Ranran Qie, Mengfei Zhao, Cheng Cheng, Liyang Zheng, Shuzheng Liu, Yin Liu, Shaokai Zhang, China Working Group on Colorectal Cancer Survey

“…The multivariable regressions and structural equation model (SEM) were used to assess the association between characteristics and HRQOL. …”
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Overview of antimicrobial resistance mitigation efforts in Benin 2024 by Alain K. Aissi, Tokpanou E.C. Koudjo, Filémon T. Tokponnon, Al Fattah Onifade, Akpeedje A.C. Wadagni, Géraud S.R. Padonou, Hervé A. Gbegnide, Léopold A. Azakpa, Adrien M. Hodonou, Roch C. Johnson, Francis M. Dossou

“…Methods: A retrospective cross-sectional evaluation was performed from 05 August 2024 to 30 September 2024. Data were collected through a documentary review, standardised questionnaires, semi-structured interviews and group discussions. …”
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Assessing the performance of a new gum Arabic harvesting tool through the insight of gum producers in the gum belt of Sudan by Muneer Elyas Siddig Eltahir, Suhad Ismail Eltahir, Moayad Balal Zaid, Hatim Mohamed Ahmed Elamin, Zeinab Mohammed Hamad, Osman Elsaid Adlan Abdelkareem, Faisal Ismail Musa, Ahmed Ismail Ahmed Safi, Awadelkareem Suliman Osman Khalifa, Abdalaziz Elsaid Hamad, Mohammed Osman Hassan, Heba Abdalla Noureldeen, Mohammed Eltom Elhaja, Uttam Kumar Sahoo

“…We conducted a study in North and West Kordofan of Sudan to assess the performance, use, and efficiency of the newly designed harvesting tool, and to understand the level of its adoption by the gum Arabic producers. Data were collected through a structured questionnaire, and by group discussion involving 44 trained gum producers by a purposive selection method. …”
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The High Burden of Depression, Anxiety, and Stress among University Students in Southern Iraq: A Cross-Sectional Study by Hassan Al-Karagoly, Zahraa Al-attar, Hjar Al-asadi, Sajad Al-Lahibi, Sajad Al-Lahibi, Russul Al-Fartousi, Teeba Al-Jadry, Menatallah Bali, Menatallah Bali, Baneen Al-Hasnawi, Qassim Al-rubaie, Hanan Al-aboudi, Ali Al-mosawi, Mohsin Al-samawi, Abdulsalam Halboup

“…A cross-sectional study was conducted among Iraqi university students using a structured questionnaire, including the DASS-21, Insomnia Severity Index, and Internet Addiction Test. …”
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Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in <i>Trypanosoma cruzi</i>: Virtual Screening and In Vitro Studies by Eyra Ortiz-Pérez, Adriana Moreno-Rodríguez, Timoteo Delgado-Maldonado, Jessica L. Ortega-Balleza, Alonzo González-González, Alma D. Paz-González, Karina Vázquez, Guadalupe Avalos-Navarro, Simone Giovannuzzi, Claudiu T. Supuran, Gildardo Rivera

“…Future studies should focus on structural modifications to improve selectivity. Integrating docking, parasitological, and enzymatic data is crucial for optimizing drug candidates for Chagas disease.…”
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