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52461
Mechanisms of immune regulation and transplantation immunity in corneal transplants
Published 2020-01-01“…Unlike other kinds of transplants, corneal grafting is often performed without tissue typing and systemic immunosuppression.High frequency of transparent corneal engraftment (up to 90% of cases) in the absence of risk factors is due to special immunoprivileged area in the anterior eye segment (functionally, a structural aggregation of the cornea and anterior chamber, AC) accomplished by local and systemic immunoregulatory mechanisms, i.e., phenomenon of immune deviation associated with anterior chamber of the eye (ACAID), components of the internal liquid medium, a watery moisture with immunosuppressive properties, e.g., IL-1ra, TSP-1,TGF-β2, regulatory complement proteins, α-MSH (alpha-melanocyte stimulating hormone), VIP (vasoactive intestinal peptide), indolamine 2,3-dioxygenase (IDO), calcitonin-gene-bound peptide (CGRP), somatostatin, etc.In addition to ACAID and liquid AC components, a contribution to the maintenance of immune privilege which is extremely important for a successful outcome of keratoplasty, is provided by other mechanisms, in particular, immunologically active membrane-associated molecules of corneal endothelium, i.e., PDL-1 (Programmed death ligand 1), and sVEGFR-1, sVEGFR-2, sVEGFR-3 involved in maintaining avascularity of the corneal tissue. …”
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52462
Development and psychometric evaluation of the Infertility Public Stigma Scale for Japanese women: protocol for an exploratory sequential mixed method study of the Japanese populat...
Published 2025-05-01“…Quantitative research will be conducted using the initial scale. Structural validity will be examined using exploratory and confirmatory factor analyses. …”
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52463
Involving Knowledge Users in Health Services Research: Collective Reflections and Learning From a National Evaluation of Recurrent Miscarriage Services
Published 2024-12-01“…Themes constructed from the Word Café discussions highlighted that structural and relational spaces shaped the accessibility and experience of involvement. …”
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52464
Nexus among artificial intelligence implementation, healthcare social innovation, and green image of hospitals’ operations management in Egypt
Published 2024-06-01“…After applying structural equation modeling using SmartPLS-v4, the results illustrated that AII has a positive significant impact on HSI, which has a positive significant influence on HGI. …”
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52465
THE EFFECT OF SPLEEN LYMPHOCYTES TREATED WITH AN ORIGINAL ANTICONVULSANT ON HEMATOPOIESIS DURING LONG-TERM ALCOHOL CONSUMPTION
Published 2019-08-01“…AbstractExcessive alcohol consumption has a negative effect on hematopoiesis, which is expressed in a significant suppression of both the production of blood cells and structural changes in precursors, namely in the suppression of their maturation, up to pancytopenia. …”
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52466
An investigation into male infertility caused by hormonal imbalance and hypertension brought on by SARS-CoV-2
Published 2025-07-01“…Ethical approval was obtained from the relevant institutional review board prior to data collection. Semen samples were collected and analysed according to the World Health Organization (WHO) guidelines (2021) for conventional semen parameters. …”
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52467
Predicting digital contact tracing tool adoption during COVID-19 from the perspective of TAM: The role of trust, fear, privacy, anxiety, and social media
Published 2025-05-01“…Methods Using a quantitative, cross-sectional design, data were collected from Saudi participants through an online survey and analysed using Structural Equation Modeling (SEM) with SmartPLS4. …”
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52468
Transdiagnostic mechanisms of mental health during the COVID-19 pandemic: associations of childhood trauma, maladaptive personality traits, emotion regulation, mentalizing, and pan...
Published 2024-12-01“…The aim of this study is to examine the associations with these transdiagnostic factors in relation to PR distress and psychopathological symptoms.Materials and methodsUsing a cross-sectional study design, we investigated a convenience sample of 6,451 adults (mean age = 44.1; SD = 11.8; 69.1% female, 30.3% male, 0.01% diverse) recruited via social media platforms in German-speaking countries (August 2020 – February 2021) by utilizing self-report instruments (PID5BF+, MentS, DERS-SF, PHQ-9, GAD-7, a composite PR distress score). Structural equation modeling was performed for data analysis.ResultsThe results revealed significant associations between different types of childhood trauma and MPTs (−0.14 < β < 0.48) as well as a parallel mediation of the relationship between MPTs and psychopathological symptoms via mentalizing (βanxiety = −0.03; βdepression = 0.01) and emotion dysregulation (βanxiety = 0.24; βdepression = 0.23).DiscussionMentalizing and emotion dysregulation seem to play a significant role in relation between childhood trauma and MPTs and psychopathological symptoms during the COVID-19 pandemic. …”
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52469
Gender differences in L1 vertebral strength in adults 50+ using automated CT-based finite element analysis
Published 2025-03-01“…The focus is on establishing a prediction model for the structural strength of the L1 vertebral body using patient-specific CT data, thereby aiding in the prediction of vertebral fracture risk. …”
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52470
Outcomes and complications of pre-assisted reproductive technology hysteroscopic evaluation and treatment: a cross-sectional study at a Nigerian teaching hospital
Published 2025-07-01“…It is especially valuable for women seeking assisted reproductive technology (ART), as structural uterine abnormalities—such as adhesions, polyps, and fibroids—can reduce implantation success or increase the risk of miscarriage. …”
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52471
A Remote-Sensing-Based Method Using Rockfall Inventories for Hazard Mapping at the Community Scale in the Arequipa Region of Peru
Published 2024-10-01“…The generation component criteria consisted of source zone height, slope angle, and rockmass structural condition. Transport was characterized by rockfall runout distance, estimated rockfall trajectory paths, and hazard ratings of corresponding source zones. …”
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52472
A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1
Published 2025-08-01“…Conclusion The most frequent BIN1 variants are found in non-coding regions immediately upstream of the gene, and it is thus likely that their impact is regulatory and not structural. The variants can influence the levels of BIN1 or splicing between isoforms, especially the distribution of isoforms. …”
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52473
Molecular Determinants for the Binding of the Highly Infectious SARS-CoV-2 Omicron (BA.1) Variant to the Human ACE2 Receptor
Published 2025-02-01“…Additionally, allosteric effects improve the contributions of non-mutated residues (notably A475, Y453, and F486) via structural realignment and novel hydrogen bonding with ACE2 residues such as S19, leading to an overall increase in the electrostatic and π-system interaction energy. …”
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52474
Diversity and equity in medical education over the past decade: applications, matriculations, and the growing gaps
Published 2025-07-01“…Methods This study used data from the Association of American Medical Colleges from 2015 to 2024. …”
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52475
Association of workplace support for health with occupational health literacy and illness avoidance: moderated mediation by functioning through a salutogenic lens
Published 2025-08-01“…., WSH, OHL, functioning, and illness avoidance) were measured with Likert-type scales adopted in whole from the literature. Data were analysed with Hayes’ Process Model through structural equation modelling. …”
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52476
PSYCHOLOGICAL READINESS OF SECONDARY VOCATIONAL EDUCATION TEACHERS FOR MASTERING NEW ACTIVITIES IN THE CONTEXT OF PROFESSIONAL REORIENTATION
Published 2018-09-01“…The functionality of this technology, its tasks, structural components, possible methods and estimated effects of its implementation in practice of the SPE (Secondary Professional Education) system are noted.Practical significance. …”
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52477
Enhancing Accessibility in Philippine Public Bus Systems: Addressing the Needs of Persons with Disabilities
Published 2025-04-01“…Structural equation modeling (SEM) was used to analyze the hypothesized relationships between these variables, passenger satisfaction, and intention to reuse public transport. …”
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52478
Viral activity in lake analogs of anoxic early Earth oceans
Published 2025-04-01“…This suggests that viral lysis may contribute less to bacterial community structuring in these high-density microbial plates. …”
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52479
A descriptive analysis of significant factors influencing the behavioral intention to adopt robot kiosks/service robots in service stores: Integrating the UTAUT and higher-order SE...
Published 2025-06-01“…Utilizing the integrated Unified Theory of Acceptance and Use of Technology (UTAUT) model and SERVQUAL 5 dimensions higher-ordered structural equation modeling approach, the study found that tangibles (β: 0.807), empathy (β: 0.782), responsiveness (β: 0.765), assurance (β: 0.711), reliability (β: 0.646), and behavioral intention (β: 0.104) significantly affected customer satisfaction. …”
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52480
The Chain Mediating Effect of Health Literacy and Self-Care Ability on the Relationship Between Dysmenorrhea Symptoms and Negative Emotions Among Chinese Female College Students
Published 2025-04-01“…Multiple linear regression analysis was conducted to analyze the effects of variables with statistically significant differences (P < 0.05) identified through one-way ANOVA, independent sample t-tests, and correlation analysis on psychological levels. Structural Equation Modeling (SEM) was used to explore mediating effects.Results: This study shows that dysmenorrhea symptoms, health literacy, self-care ability, and negative emotions are significantly correlated. …”
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