Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection by Mark Tsz Kin Cheng, Mazharul Altaf, Jesu Castin, Ann-Kathrin Reuschl, Benjamin L. Sievers, Kimia Kamelian, Dejan Mesner, Rebecca B. Morse, Adam Abdullahi, Bo Meng, Kata Csiba, Steven A. Kemp, Darren P. Martin, Clare Jolly, Christopher Ruis, Lipi Thukral, Ravindra K. Gupta

“…P812S conferred evasion of a FP-targeting monoclonal antibody, consistent with FP-region structural rearrangements. Finally, P812S-bearing viruses showed evasion of polyclonal neutralizing antibodies in sera from vaccinated individuals at 32C. …”
Get full text

Deep dive into hydrologic simulations at global scale: harnessing the power of deep learning and physics-informed differentiable models (<i>δ</i>HBV-globe1.0-hydroDL) by D. Feng, D. Feng, D. Feng, H. Beck, J. de Bruijn, J. de Bruijn, R. K. Sahu, Y. Satoh, Y. Wada, J. Liu, M. Pan, K. Lawson, C. Shen

“…Nevertheless, relative to LSTM, the differentiable model was hampered by structural deficiencies for cold or polar regions, highly arid regions, and basins with significant human impacts. …”
Get full text

Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate <i>Prorocentrum lima</i> Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microg... by Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv, Xin-Sheng Yao

“…Through this approach, four new (<b>1</b>–<b>4</b>) and nine known (<b>5</b>–<b>13</b>) PUFA analogues were obtained from large-scale cultures of the marine dinoflagellate <i>Prorocentrum lima</i>, with lipidomic profiling identifying FA18:5 (<b>5</b>), FA18:4 (<b>7</b>), FA22:6 (<b>8</b>), and FA22:6 methyl ester (<b>11</b>) as major constituents of the algal oil extract. Structural elucidation was achieved through integrated spectroscopic analyses of IR, 1D and 2D NMR, and HR-ESI-MS data. …”
Get full text

E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness by Alf Spitschak, Prabir Dhar, Krishna P. Singh, Rosaely Casalegno Garduño, Shailendra K. Gupta, Shailendra K. Gupta, Julio Vera, Luca Musella, Nico Murr, Anja Stoll, Brigitte M. Pützer, Brigitte M. Pützer

“…To explore E2F1’s role in immune regulation in presence of aggressive melanoma cells, we established a coculture system and utilized transcriptome and cytokine arrays combined with bioinformatics and structural modeling. We identified an E2F1-dependent gene regulatory network with IL6 as a central hub. …”
Get full text

Optimization of soil hydraulic parameters within a constrained sampling space by Meijun Li, Wei Shao, Wenjun Yu, Ye Su, Qinghai Song, Yiping Zhang, Hongkai Gao, Yonggen Zhang, Jianzhi Dong

“…The direct optimization of soil hydraulic parameters (SHP) in unconstrained parameter space introduces significant uncertainties in ecohydrological modeling, particularly when addressing the complex model structure of Richards’ equation combined with Penman-Monteith equation. …”
Get full text

Changes in Soil Properties Under the Influence of Microplastics in Plastic and Open Field Production in Three Serbian Valleys by Elmira Saljnikov, Tara Grujić, Marina Jovković, Veljko Perović, Dragan Čakmak, Aigul Zhapparova, Vesela Radović, Slobodan Stefanović, Vladimir Miladinović, Slađan Stanković, Žaklina Marjanović, Sayagul Kenzhegulova, Aigul Tleppayeva, Gulya Kunypiyaeva, Slobodan Krnjajić

“…The NA results support the main findings that the presence of microplastics leads to the destruction of soil structure, which reduces bulk density and increases soil porosity. …”
Get full text

Unveiling the dynamic effects of major depressive disorder and its rTMS interventions through energy landscape analysis by Chun-Wang Su, Chun-Wang Su, Yurui Tang, Nai-Long Tang, Nai-Long Tang, Nian Liu, Nian Liu, Jing-Wen Li, Shun Qi, Hua-Ning Wang, Zi-Gang Huang, Zi-Gang Huang

“…IntroductionBrain dynamics offer a more direct insight into brain function than network structure, providing a profound understanding of dysregulation and control mechanisms within intricate brain systems. …”
Get full text

Formation of H+ PUI Tails Downstream of Distant Interplanetary Shocks by E. J. Zirnstein, D. J. McComas, B. L. Shrestha, H. A. Elliott, P. C. Brandt, S. A. Stern, A. R. Poppe, J. Parker, E. Provornikova, K. Singer, A. Verbiscer, New Horizons Heliophysics Team

“…After we convert our distributions to count rates in the spacecraft frame, the results show similar structure to the data. We conclude that significant H ^+ PUI tails can form downstream of distant interplanetary shocks if there is a relatively large compression ratio (>2) and significant turbulence present.…”
Get full text

Effective Resistivity in Relativistic Reconnection: A Prescription Based on Fully Kinetic Simulations by Abigail Moran, Lorenzo Sironi, Aviad Levis, Bart Ripperda, Elias R. Most, Sebastiaan Selvi

“…The guide field dependence is encoded in α and p , which we fit to PIC data. This resistivity formulation—which relies only on single-fluid MHD quantities—successfully reproduces the spatial structure and strength of nonideal electric fields and thus provides a promising strategy for enhancing the reconnection rate in resistive MHD simulations.…”
Get full text

Signature of Strange Star as the Central Engine of GRB 240529A by Xiao Tian, HouJun Lü, WenJun Tan, ShaoLin Xiong, HaoYu Yuan, WenYuan Yu, ShuQing Zhong, WenLong Zhang, EnWei Liang

“…GRB 240529A is a long-duration gamma-ray burst (GRB) whose light curve of prompt emission is composed of a triple-episode structure, separated by quiescent gaps of tens to hundreds of seconds. …”
Get full text

Pubertal low dose exposure to benzophenone-3 (BP-3) alters murine mammary stem cell functions by Hui Gao, Xintong Yang, Pengge Pan, Xueli Liu, Yan Ma, Yadan Chen, Yunxin Liu, Yaqi Sun, Sinan Cao, Yuan Tian, Yanzhou Yang

“…These effects were accompanied by a decreased fraction of basal mammary stem cells and decreased self-renewal and differentiation abilities of basal mammary stem cells in vitro and in vivo such as decreased sphere formation ability, a smaller 3D structure, increased branching points and hyperplastic lesions in regenerated mammary glands. …”
Get full text

REVIRAL: roadmap for the elimination of viral hepatitis in Latin America by Javier Crespo, Javier Crespo, Javier Crespo, Joaquín Cabezas, Joaquín Cabezas, Graciela Castro-Narro, Hugo Cheinquer, Fernando Contreras, Nelia Hernandez, Christie Perelló, Christie Perelló, Christie Perelló, Ezequiel Ridruejo, José Luís Calleja, José Luís Calleja, José Luís Calleja

“…These factors hinder progress towards elimination, necessitating collaborative responses tailored to the epidemiological and socioeconomic realities of each country. The project’s structure is organized into three fundamental phases: The first phase involves an initial assessment, where the epidemiological situation of each country will be analyzed, specifically the prevalence and incidence data of viral hepatitis and the response capacity of each country’s health systems. …”
Get full text

Microstructural integrity of autonomic central nervous tracts is linked to cardiovascular health by Janis M. Nolde, Alexander Rau, Elias Kellner, Horst Urbach, Cornelius Weiller, Fabian Bamberg, Jakob Weiss, Marco Reisert, Jonas A. Hosp

“…Differential patterns were observed in cortical versus subcortical CAN structures, suggesting distinct pathophysiological roles within the heart-brain axis.…”
Get full text

Geological characteristics of biogenic gas formation and direction of favorable zones in the Quaternary mudstone of the Qaidam Basin, China by Jixian Tian, Zeyu Shao, Jian Li, Dekang Song, Zhou Fei, Ya'nan Li, Wei Sha, Hao Zhang, Lili Hou, Xiaoqiu Zhang, Haining Zhang, Yixuan Yang

“…The results of the study show that: (1) The Quaternary mudstone is mainly composed of dark grey mudstone in shallow and semi-deep lake, and influenced by the anoxic environment of brackish water and semi-brine water, exhibiting blocky, striped, and laminar structures. The mudstone layers frequently feature interbeds of sand and carbonate rocks. in which the mudstone is mainly concentrated in the Ⅲ, Ⅵ, and Ⅷ layer groups, characterized by large thickness and good continuity. (2) The low abundance of organic matter in the Quaternary mudstone, but a substantial proportion of organic matter suitable for microbial modification, and the large amount of different types of organic matter, such as hydrocarbons and algae, improve the biogas gas production capacity of the Quaternary system. (3) The Quaternary mudstone exhibits various pore types, including primary intergranular pores, dissolution pores, cracks, and a small number of organic pores. …”
Get full text

Metabolic capabilities are highly conserved among human nasal-associated Corynebacterium species in pangenomic analyses by Tommy H. Tran, Isabel F. Escapa, Ari Q. Roberts, Wei Gao, Abiola C. Obawemimo, Julia A. Segre, Heidi H. Kong, Sean Conlan, Matthew S. Kelly, Katherine P. Lemon

“…All species had similar genomic and pangenomic structures. Gene clusters assigned to all COG metabolic categories were overrepresented in the persistent versus accessory genome of each species indicating limited strain-level variability in metabolic capacity. …”
Get full text

Identification of serum biomarkers for cystic echinococcosis in sheep through untargeted metabolomic analysis using LC–MS/MS technology by Xiao-Xia Wu, Wan-Li Ban, Li-Jiang Wu, Wen-Jing Qi, Mehdi Borhani, Xiao-Ying He, Xiao-Lei Liu, Ming-Yuan Liu, Jing Ding

“…Orthogonal projections to latent structures–discriminant analysis (OPLS-DA) were used to analyze different metabolites in the serum of the two groups. …”
Get full text

FTIR-based molecular fingerprinting for the rapid classification of dengue and chikungunya from human sera using machine learning: an observational studyResearch in context by Souvik Das, Subhanita Roy, Aritri Bir, Arindam Ghosh, Tarun Kanti Bhattacharyya, Pooja Lahiri, Basudev Lahiri

“…Findings: FTIR analysis revealed distinctive group-specific vibrational signatures, particularly in the Amide I and III regions, where dengue-infected sera exhibited a marked increase in β-sheet content and loss of α-helical structures. Raman spectroscopy further identified differences in nucleic acid backbone vibrations and protein conformations. …”
Get full text

Global trends in esophageal cancer: sex and age disparities in health inequalities from 1990 to 2021, with projections to 2050 by Ying Liu, Ying Liu, Erman Wu, Erman Wu, Fang Cheng, Meng Zhang, Qian Rou, Zenati Nuertai, Maorong Xu, Shanshan Xu, Minghui Li, Lei Zhang, Aheli Nasiroula

“…Age-standardized rates (ASR) were calculated to account for population age structures. Trends over time were assessed using the estimated annual percentage change (EAPC). …”
Get full text

RNAO’s Artificial Intelligence Innovations: A Novel Strategy to Advance Evidence-Based Nursing Practice by Naik, Shanoja, Grinspun, Doris

“…Any artificial intelligence technique requires extensive data. To provide healthcare organizations with the best available evidence, purposeful efforts must be made to structure data collection and ensure data quality before expanding the development of artificial intelligence tools. …”
Get full text

MSA-3D: Dissecting Galaxies at z ∼ 1 with High Spatial and Spectral Resolution by Ivana Barišić, Tucker Jones, Kris Mortensen, Themiya Nanayakkara, Yuguang Chen, Ryan Sanders, James S. Bullock, Kevin Bundy, Claude-André Faucher-Giguère, Karl Glazebrook, Alaina Henry, Mengting Ju, Matthew Malkan, Takahiro Morishita, Danail Obreschkow, Namrata Roy, Juan M. Espejo Salcedo, Alice E. Shapley, Tommaso Treu, Xin Wang, Kyle B. Westfall

“…Here we describe the multiplexed slit-stepping method, which is >15 times more efficient than the NIRSpec IFS mode for our program. As an example of the data quality, we present a case study of an individual galaxy at z = 1.104 (stellar mass M _* = 10 ^10.3 M _⊙ , star formation rate, SFR = 3 M _⊙ yr ^−1 ) with prominent face-on spiral structure. …”
Get full text