Cryo-EM of prion strains from the same genotype of host identifies conformational determinants. by Forrest Hoyt, Parvez Alam, Efrosini Artikis, Cindi L Schwartz, Andrew G Hughson, Brent Race, Chase Baune, Gregory J Raymond, Gerald S Baron, Allison Kraus, Byron Caughey

“…Each monomer shares an N-terminal steric zipper, three major arches, and an overall V-shape, but the details of these and other conformational features differ markedly. Thus, variations in shared conformational motifs within a parallel in-register β-stack fibril architecture provide a structural basis for prion strain differentiation within a single host genotype.…”
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Molecular modelling of four penicillins: bencylpenicillin, phenoxymethylpenicillin, ampicillin and amoxicillin by Elso Manuel Cruz Cruz, Eslhey María Sánchez Domínguez

“…<p><strong>Background:</strong>Penicillins differ structurally among themselves by the lateral chains. …”
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The crustal juvenile and reworking in eastern Tibet due to tectonism and magmatism by Tianyu Zheng, Yumei He

“…The imaging results reveal widespread low-velocity layers in the mid-crust, alternating high- and low-velocity structures in the lower crust, and regional variations in the velocity at the bottom of the lower crust and the thickness of the entire crust. …”
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Influence Analysis of Underground Excavation on the Adjacent Buildings and Surrounding Soil Based on Scale Model Test by Suhui Yu, Yongchang Geng

“…In urban areas, it is common to construct underground structure nearby existing buildings. To investigate the impact of excavation construction on the adjacent existing buildings and surrounding soil, eight parallel scale model tests that considered the process of cut and cover construction are carried out with two kinds of the diameter of support piles, two kinds of the adjacent structure, and two kinds of the relative horizontal distance from the excavation in the laboratory. …”
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Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration by Rui Shi, Rui Shi, Fei Liu, Qihuang Qin, Pinxue Li, Ziqi Huo, You Zhou, Chunyan Jiang

“…Piezoelectric materials, known for modulating cellular functions and promoting stem cell proliferation and differentiation, have garnered increasing attention in tissue repair applications.MethodsIn this study, a biomimetic piezoelectric patch with progressive compositional and structural variations was designed and fabricated. The patch, composed of gelatin/PLGA/nHA/BTO, integrates aligned and random fiber structures. …”
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DeSPPNet: A Multiscale Deep Learning Model for Cardiac Segmentation by Elizar Elizar, Rusdha Muharar, Mohd Asyraf Zulkifley

“…Results: An analysis of multiple PPDM placement scenarios and structural variations revealed that the 3-path PPDM, positioned at the encoder layer 5, yielded optimal segmentation performance, achieving dice, intersection over union (IoU), and accuracy scores of 0.859, 0.800, and 0.993, respectively. …”
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Effect of cathodic protection of ordinary reinforcement on post-tensioned tendons: Case studies of post-tensioned bridges, Norway by Sharma Suraksha, Hornbostel Karla, Polder Rob, Arve Øverli Jan, Rica Geiker Mette

“…Corrosion in ordinary steel-reinforced and prestressed concrete structures is a global challenge, particularly when exposed to chlorides from de-icing salts or seawater. …”
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Light-Mediated Population Dynamics of Picocyanobacteria Shaping the Diurnal Patterns of Microbial Communities in an Atoll Lagoon by Ying Yu, Maosen Shangguan, Ping Sun, Xiaofeng Lin, Jiqiu Li

“…Our findings reveal the diurnal variation in microbial community structures is mediated by the light-driven fluctuation of dominant cyanobacterial populations, and the diurnal variation patterns of specific populations may vary with habitats and sampling timepoints. …”
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Modification of the Properties of Vanadium Oxide Thin Films by Plasma-Immersion Ion Implantation by Sergey Burdyukh, Olga Berezina, Alexander Pergament

“…Next, we explore the effect of PIII on composition, optical properties, and the internal electrochromic effect (IECE) in V2O5·nH2O films. The variations in the composition and structure caused by the hydrogen insertion, as well as those caused by the electrochromic effect, are studied by nuclear magnetic resonance, thermogravimetry, Raman spectroscopy, and X-ray structural analysis. …”
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The syntax of negative polarity items in Central Kurdish by Hussein Al-Bataineh, Sameerah Tawfeeq Saeed

“…CK data reveal support for the distinction between unary and binary NEG structures, while highlighting variations in the deletion of the NEG element. …”
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A multi-scale comparison of polar vortices on Earth, Mars, Titan, and Venus by Zheng Sheng, Gangyao Wu, Jie Zhang, Xiaohua Yang

“…Here, we demonstrate that: (1) The circulation characteristics of Mars above the 1 mbar level are very similar to those at 1000 mbar in the lower layers of Titan, with seasonal variations of the same height. (2) In contrast to the vortex structure that is stably maintained in the lead direction in the polar regions of Mars and Earth during the winter, the time of occurrence of the peak vortex intensity at Titan and Venus is gradually shifted forward with increasing altitude. (3) When Venus undergoes vortex instability drift, the polar vortex at an altitude of 1 mbar breaks up into banded structures, a phenomenon that closely resembles the twisting deformation of PV structures during weak stratospheric polar vortex events on Earth.…”
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Crop pangenomes by A. Yu. Pronozin, M. K. Bragina, E. A. Salina

“…However, large structural genome changes, including gene copy number variations (CNVs) and gene presence/absence variations (PAVs), prevail in crops. …”
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TRENDS IN CONCENTRATION OF BULGARIAN AGRICULTURE by Rositsa BELUHOVA-UZUNOVA

“…The implementation of Common agricultural policy caused significant transformations in farm structures. There are substantial variations in the number and the size of the agricultural holdings. …”
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Sensitivity Analysis of Integrated Sensors Created Through Additive Manufacturing for Monitoring Components Subject to Dynamic Loads by Agnese Staffa, Massimiliano Palmieri, Giulia Morettini, Filippo Cianetti

“…The progress in the development of sensors made using additive manufacturing (AM) techniques has opened up new possibilities for their integration into more complex structures, such as CubeSats. In this study, preliminary tests were conducted on printed sensors by FDM embedded in simple structures to evaluate their feasibility under simulated operational conditions, including temperature variations and dynamic loads. …”
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Deformation Characteristics and Control Measures for Deep Foundation Pit in Soil–Rock Composite Strata in the Guangzhou Area by Lianyan Jia, Jinhuan Zhu, Zhiqi Wang, Xiaoyan Liu

“…Our analysis shows that, due to significant variations in the thickness of soft soil layers in Guangzhou, the maximum lateral displacement of the support structures predominantly ranges from 15 to 30 mm, while vertical ground deformations range from 0.86‰ to 2.35‰ of the excavation depth. …”
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Study on Dynamic Response and Progressive Collapse Resistance of Space Steel Frame Under Impact Load by Junling Jiang, Zhishuang Zhang, Changren Ke

“…A total of 48 impact parameter combinations were defined, covering rational mass–velocity ranges while accounting for column position variations at the first story. Systematic comparisons were conducted on the influence of varying impact parameters on structural dynamic responses. …”
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Molecular modelling and gene expression analysis to probe the GT-γ trihelix transcription factors in Solanum tuberosum under drought stress by Tayyaba Bint Tariq, Faiza Munir, Ishrat Jabeen, Alvina Gul, Rabia Amir

“…GT-γ proteins likely regulate genes due to structural variations. This is based on the presence of DNA-binding domains and functional annotation suggesting roles in metabolism, gene expression, and stress response. …”
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Novel Insertion/Deletion Polymorphisms and Genetic Studies of the Shadow of Prion Protein (<i>SPRN</i>) in Raccoon Dogs by Da-In Choi, Mohammed Zayed, Eun-Jee Na, Jae-Ku Oem, Byung-Hoon Jeong

“…To date, the genetic polymorphisms of the <i>SPRN</i> gene and the predicted protein structure of the shadow of prion protein (Sho) have not been explored in raccoon dogs. …”
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Evaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulation. by Kana Kobayashi, Ohgi Takahashi, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Yurie Watanabe, Akifumi Oda

“…Some of these mutations influence drug metabolism activities, leading to individual variations in drug efficacy and pharmacokinetics. Using computational docking, we predicted the structure of the complex between the antimalarial agent artemether and CYP2B6 whose conformations were obtained by MD simulation. …”
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GrSrNMF: dynamic community detection with graph and symmetry bi-regularized non-negative matrix factorization by Wei Yu, Shihong Wu, Shigen Shen, Hongyan Li, Weiyan Yang, Xiaoming Li, Lei Wang

“…GrSrNMF can successfully identify community structures and appropriately address variations in the number of communities within network snapshots. …”
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