Simultaneous profiling of mercapturic acids, glucuronic acids, and sulfates in human urine by Jin Y. Chen, Saurin R. Sutaria, Zhengzhi Xie, Manjiri Kulkarni, Rachel J. Keith, Aruni Bhatnagar, Clara G. Sears, Pawel Lorkiewicz, Sanjay Srivastava

“…We annotated 424 metabolites (146 MAs, 171 GAs, 107 SAs) by querying chromatographic features with in-house structural libraries, filtering against fragmentation patterns (common neutral loss and ion fragment), and comparing mass spectra with in-silico fragmentations and external spectral libraries. …”
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Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci by Chenfu Shi, Danyun Zhao, Jake Butler, Antonios Frantzeskos, Stefano Rossi, James Ding, Carlo Ferrazzano, Charlotte Wynn, Ryan Malcolm Hum, Ellie Richards, Muskan Gupta, Khadijah Patel, Chuan Fu Yap, Darren Plant, Richard Grencis, Paul Martin, Antony Adamson, Stephen Eyre, John Bowes, Anne Barton, Pauline Ho, Magnus Rattray, Gisela Orozco

“…We generated 108 Hi-C libraries (49 billion reads), 128 RNA-seq libraries and 126 ATAC-seq libraries. These data enhance our understanding of the mechanisms by which GWAS variants impact gene regulation, revealing how genetic variation alters chromatin accessibility and structure in primary cells at an unprecedented scale. …”
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Polarization Characteristics of the Hyperactive FRB 20240114A by Jin-Tao Xie, Yi Feng, Di Li, Yong-Kun Zhang, Deng-Ke Zhou, Yuanhong Qu, Xiang-han Cui, Jian-Hua Fang, Jia-Ying Xu, Chen-Chen Miao, Mao Yuan, Chao-Wei Tsai, Pei Wang, Chen-Hui Niu, Xianglei Chen, Mengyao Xue, Junshuo Zhang

“…We analyze the fluence and waiting-time distributions of FRB 20240114A, revealing a right-skewed fluence distribution and a bimodal waiting-time structure, suggesting intrinsic emission timescales and potential multiple burst populations. …”
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Measurement-guided therapeutic-dose prediction using multi-level gated modality-fusion model for volumetric-modulated arc radiotherapy by Changfei Gong, Changfei Gong, Changfei Gong, Yuling Huang, Yuling Huang, Yuling Huang, Junming Jian, Junming Jian, Junming Jian, Wenheng Zheng, Wenheng Zheng, Wenheng Zheng, Xiaoping Wang, Xiaoping Wang, Xiaoping Wang, Shenggou Ding, Shenggou Ding, Shenggou Ding, Yun Zhang, Yun Zhang, Yun Zhang

“…Quantitative experimental predictions show that the proposed model achieved the lowest values for the mean absolute error (37.99) and root mean square error (4.916), and the highest values for the peak signal-to-noise ratio (52.622), structural similarity (0.986) and universal quality index (0.932). …”
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Cross-species comparison of rodent and human decision-making in the Iowa Gambling Task in select neurological and psychiatric disorders: translational approach to examine age- and... by Varsha Singh, Manjari Tripathi, Sarat P. Chandra, Rohit Verma, Sushil Kumar Jha, Harvinder Singh Chhabra, Mrinmoy Chakravarty, Mrinmoy Chakravarty, Shambhovi Mitra, Indupriya B, Ankit Jha, Sakshi Sharma, Jyotsna Pandey, Divyanshi Pandey, Insha Shamshad, Ekta Ahlawat, Titli Saha, Chloé César, Suman Jain

“…This non-analogous structural–functional mapping of brain regions and cognitive deficits result in rodent models that fail to establish causal links of brain pathophysiology and clinical conditions, and the model remains a poor depiction of cognitive deficits experienced by humans. …”
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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…Ceftriaxone free concentration was measured at three time-points: before the administration (C_min) and two and four hours after ceftriaxone administration (C₂ and C₄). Both structural and covariate population pharmacokinetic models were built. …”
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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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教育變革下偏遠教師的成就目標與 組織承諾之關係研究：社會網絡行為之 中介效果與多群組分析 The Relationship Between Achievement Goals and Organizational Commitment of Remote Teachers Under Educational Reform: The Mediating Eff... by 陳慧蓉 Karen Hui-Jung Chen

“…Multi-group analysis was conducted to compare structural relationships between remote and urbanr teachers. …”
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Unearthing the climate history of the Atacama Desert in northern Chile – deep drilling in two clay pans of the Coastal Cordillera by V. Wennrich, J. Diederich-Leicher, B. N. Blanco-Arrué, B. N. Blanco-Arrué, C. Büttner, S. Buske, E. Campos Sepulveda, T. Dunai, J. Feller, E. Galego, A. Hasberg, N. Leicher, D. A. López, J. Maldonado, A. Medialdea, A. Medialdea, L. Ninnemann, L. Ninnemann, R. Perryman, J. C. Ríos-Contesse, B. Ritter, S. Scheidt, B. Vargas-Machuca, P. Yogeshwar, P. Yogeshwar, M. Melles

“…Electromagnetic and seismic surveys yielded a three-layer structure in both basins consisting of the resistive basement overlain by a low-resistivity basal and a high-resistivity upper sediment unit with total sediment thicknesses of more than <span class="inline-formula">∼</span> 100 and <span class="inline-formula">∼</span> 160 m in the Playa Adamito Grande (PAG) and Paranal clay pans, respectively. …”
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Ecological responses of Orientallactaga sibirica: Variations in body size and trophic niche across changing habitats by Qi-qige Buren, Xin Li, Guo-kang Chen, Guo-hui Ye, Shan-shan Sun, Yong-ling Jin, Ming-ming, He-Ping Fu, Shuai Yuan

“…The trophic niche width of O. sibirica varied across habitat types, being widest in the warm-temperate semi-humid zone and at mid-altitudes. Segmented structural equation modeling revealed that elevation and mean annual temperature exerted significant negative effects on O. sibirica body size by affecting FVC, whereas annual precipitation had a significant positive effect on body size, mediated through FVC. …”
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The effect of age and sex on brain metabolites: from childhood to adulthood by María Ortuño, Adriana Fortea, Isabel Valli, Emma Muñoz-Moreno, Roger Borràs, Irene Martínez-Serrano, Mireia Masias Bruns, Patricia Camprodon-Boadas, Enric Vilajosana, Lydia Fortea, Joaquim Raduà, Elena de la Serna, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes

“…This cross-sectional study set out to examine the relationship between levels of neurometabolites and age and sex —key modulators of brain function and structure—, continuously from childhood to early adulthood, in areas relevant to the study of psychiatric disorders.Magnetic resonance spectroscopy (¹H MRS) data was acquired in the dorsomedial prefrontal region (dmPF) and the medial temporal lobe (mTL) in 128 healthy individuals aged 7 to 34 years, 68.5 % females (ndmPF = 124; nmTL = 75). …”
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Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted... by Manuel Recio-Rufián, Teresa López-Viñau, Víctor Gálvez-Soto, Ángela Cano, Rafael Ruiz-Montero, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Germán Peñalva, Juan Antonio Marín-Sanz, Miriam Marín-Sanz, David Segorbe, Juan Jesús Pineda-Capitán, Montserrat Muñoz-Rosa, Cristina Riazzo, Federico Giovagnorio, Elisa Ruiz-Arabi, José David Torres-Peña, Juan José Castón, Isabel Machuca, Inmaculada Salcedo-Leal, Luis Martínez-Martínez, Elena Pérez-Nadales, Julián Torre-Cisneros, KLEBMAN study group

“…Whole-genome sequencing and PERMANOVA evaluated the genomic structure of ST512/KPC-3 isolates. Multivariable regression analysed the association between infection type and clinical outcomes. …”
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Abnormal Granger causal connectivity based on altered gray matter volume and associated neurotransmitters of adolescents with internet gaming disorder revealed by a multimodal neur... by Xiaoyu Niu, Mengzhe Zhang, Xinyu Gao, Jinghan Dang, Jieping Sun, Qiuying Tao, Yan Lang, Weijian Wang, Yarui Wei, Shaoqiang Han, Huayan Xu, Yingkun Guo, Jingliang Cheng, Yong Zhang

“…Therefore, we aimed to integrate structural, functional and molecular data to explore the GMV-based Granger causal connectivity abnormalities and their correlated neurotransmitter systems in IGD adolescents. …”
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Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular... by Louis Bherer, Louis Bherer, Louis Bherer, Tudor Vrinceanu, Emma Gabrielle Dupuy, Emma Gabrielle Dupuy, Mathieu Gayda, Thomas Vincent, Pierre-Olivier Magnan, Pierre-Olivier Magnan, Hanieh Mohammadi, Claudine Gauthier, Claudine Gauthier, Christine Gagnon, Simon Duchesne, Kirk I. Erickson, Daniel Gagnon, Frédéric Lesage, Sonia Lupien, Judes Poirier, Marie-Pierre Dubé, Éric Thorin, Martin Juneau, Juliana Breton, Sylvie Belleville, Sylvie Belleville, Guylaine Ferland, Guylaine Ferland, Flavie Gaudreau-Majeau, Flavie Gaudreau-Majeau, Caroll-Ann Blanchette, Caroll-Ann Blanchette, Paolo Vitali, Anil Nigam, Anil Nigam

“…Moreover, functional and structural cerebral mechanisms involved are still poorly documented. …”
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Right atrial strain in Anderson–Fabry disease by Rosa Lillo, Rosa Lillo, Alessio Cianci, Maria Chiara Meucci, Giulia Iannaccone, Giulia Iannaccone, Claudio Di Brango, Filippo Tusa, Mario Marsilia, Gaetano Antonio Lanza, Gaetano Antonio Lanza, Antonella Lombardo, Antonella Lombardo, Francesco Burzotta, Francesco Burzotta, Francesca Graziani

“…BackgroundTo date, only limited data are available on right atrium (RA) morphofunctional remodeling in Fabry disease (FD).PurposeWe aimed to investigate RA structural and functional remodeling in patients with FD vs. healthy controls using 2D speckle tracking echocardiography (STE) and to explore whether any differences exist in FD patients with and without left ventricular hypertrophy (LVH).MethodsWe prospectively enrolled patients with FD and controls matched for age, sex, and cardiovascular risk factors. …”
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Multi-omics insights into functional alterations of the liver in growth-retarded offspring: transcriptomic, epigenetic and metabolomic profiles by Qun Lan, Sui Liufu, Xin Xu, Bohe Chen, Wenwu Chen, Kaiming Wang, Caihong Liu, Lanlin Xiao, Xiaolin Liu, Lei Yi, Jingwen Liu, Qiuchun Deng, Haiming Ma, Meng Kang

“…Finally, integrative analysis of RNA-seq and ATAC-seq data revealed several differentially accessible regions (DARs), which were annotated to the genes ACSL3, ITGA11, COL6A3, CYP2C49, and STXBP3. …”
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Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…Inspection of the coefficient arrays reveals that they are governed predominantly by first-order rate processes, and that each array class exhibits preferred structure that is mainly independent of the others. …”
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Key Drivers Affecting the Future of Power Relations in Tehran Metropolis with a Scenario-Writing Approach by Afshin Mottaghi, Arash Ghorbani Sepehr, Joseph Saloukadz

“…The Delphi method was also used to screen the propellants. The data were analyzed using the MicMac and Scenario Wizard software. …”
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Design and analysis of spiral plating solution flow and rotating magnetic field device for electroplated diamond wire saw by Wei HUANG, Yanming HE, Jinbao XU, Zhenya SONG, Xiang HUANG, Yumeng SUN, Ximeng YU

“…The research focuses on solving three core problems: (1) the structural design of the spiral bath flow electroplating device and the optimization of flow rate and spiral speed of the spiral bath flow; (2) the structural design of the rotating magnetic field device and the optimization of rotation speed and magnetic field strength; (3) the optimal process parameters for electroplating diamond wire saws in the new composite field electroplating device, and the production of wire saws for silicon wafer cutting experiments.MethodsThe electroplating mixture spirals in the same direction around the baseline, which can improve the consistency of diamond particle concentration around the baseline circumference and enhance the uniformity of the mixed solution stirring. …”
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Gonadal Histology and Expression Analysis of Sex Characteristic Genes in Grass Carp at Different Ages by Bo QI, Shengjie LI, Jinxing DU, Xiaofang XIAO, Dongyun ZHANG, Tao ZHU, Caixia LEI, Zhijun LIU, Hongmei SONG

“…Anti-Müllerian hormone (amh) regulates the structure of reproductive organs and the differentiation and development of reproductive cells. …”
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