The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking by Jia-Qi Wang, Jia-Qi Wang, Yuan-Yu Liang, Yuan-Yu Liang, Zhong-Xue Zhao, Zhong-Xue Zhao, Wei Xie, Wan-Ning Sun, Wan-Ning Sun, Ji-Yu Zou, Ji-Yu Zou, Xiao-Dong Lv, Xiao-Dong Lv, Youfu He, Li-Jian Pang, Li-Jian Pang

“…Gender-stratified analysis showed that the risk burden of smoking was higher in older men in Asia, whereas the high BMI-related burden was higher in women in more developed regions.ConclusionThis study demonstrates a structural shift in the composition of asthma risk factors among older adults, with high BMI emerging as a dominant contributor amid declining traditional behavioral risks such as smoking. …”
Get full text

Population-based cross-sectional seroprevalence study of SARS-CoV-2 infection in urban residential areas in Ghana by John H Amuasi, Aurélia Souares, Eva Lorenz, Wibke Loag, Anthony Afum-Adjei Awuah, Sylvester Newton, Christian Obirikorang, Evans Asamoah Adu, Eric Ebenezer Amprofi Boham, Alexander Owusu Boakye, Hakim Alani, Nana Safi Almoustapha, James Deke, Welbeck Odame Dzadey, Louis Adu-Amoah, Sally-Ann Kroduah, Mary Ama Grant, Gracelyn Asare, Amos Amoako-Adusei, Jenny Kettenbeil, Yaw Adu Sarkodie, Ebenezer Oduro, Alfred E Yawson, Stephen Apanga, Rose Odotei Adjei, Austin Gideon Adobasom Anane, Oumou Maiga Ascofare, May Jurgen, Nicole S Struck

“…Bayesian models with poststratification weighting of the demographic structure of the sample population were used for seroprevalence estimates, accounting for the uncertainty of diagnostic assay in a hierarchical model. …”
Get full text

Advances in diffuse glial tumors diagnosis by Luis Filipe de Souza Godoy, Vitor Ribeiro Paes, Aline Sgnolf Ayres, Gabriela Alencar Bandeira, Raquel Andrade Moreno, Fabiana de Campos Cordeiro Hirata, Frederico Adolfo Benevides Silva, Felipe Nascimento, Guilherme de Carvalho Campos Neto, Andre Felix Gentil, Leandro Tavares Lucato, Edson Amaro Junior, Robert J. Young, Suzana Maria Fleury Malheiros

“…This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. …”
Get full text

Determination of Macro- and Microelements in the Inflorescences of Banana Tree Using ICP OES: Evaluation of the Daily Recommendations of Intake for Humans by Rafaela Henriques Rosa, Melina Ribeiro Fernandes, Elaine Silva de Pádua Melo, Daniela Granja Arakaki, Nayara Vieira de Lima, Luana Carolina Santos Leite, Paulo Renato Espindola, Igor Domingos de Souza, Valdir Aragão do Nascimento, Paula Fabiana Saldanha Tschinkel, Fabiane La Flor Ziegler Sanches, Valter Aragão do Nascimento

“…The inflorescence of Musa paradisiaca, known as “banana heart” is a structure that includes flowers and bracts of banana, commonly used as food source worldwide. …”
Get full text

Distinct subnetworks of the mouse anterior thalamic nuclei by Houri Hintiryan, Mitchell Rudd, Sumit Nanda, Adriana E. Gutierrez, Darrick Lo, Tyler Boesen, Luis Garcia, Jiandong Sun, Christian Estrada, Hyun-Seung Mun, Seita Yamashita, Yeji E. Han, Ian Bowman, Lin Gou, Chunru Cao, Jennifer Gonzalez, Keivan Moradi, Qiuying Zhao, Inga Yenokian, Aishwarya Dev, Brian Zingg, Hanpeng Xu, Qing Xue, Muye Zhu, Lijuan Liu, Xin Chen, Zhixi Yun, Hanchuan Peng, Nicholas N. Foster, Hong-Wei Dong

“…Therefore, the ATN provide a promising avenue to investigate the relationship between structural and functional complexity with neuron type diversity. …”
Get full text

The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree by Chaochao Li, Yuan Yuan, Zhiyi Nie, Tingkai Wu, Zhiyuan Wang, Jiangxia Qiao, Zhi Deng, Xiaobo Wang, Dong Xu, Xu Wang, Shuo Cao, Bingqin Li, Zewei An, Wenguan Wu, Zhongxin Jin, Huasun Huang, Wei Hu, Yongfeng Zhou, Han Cheng

“…We present the haplotype-resolved, telomere-to-telomere, gap-free genome assembly of the cultivar CATAS 7-33–97, with both haplotypes containing complete telomeric and centromeric regions. Structural variations, including a 32.71 Mb inversion on chromosome 8, are identified. …”
Get full text

Rainfall as an important process for net N gain during the initial phase of natural recovery in karst desertification by Xia Li, Yu Pang, Hengsheng Lao, Linfang Luo, Tongxin He, Guangting Pei, Shuangshuang Xiao, Baoqing Hu, Jianfei Sun

“…Abstract Nitrogen (N) losses driven by rapid hydrologic processes in karst regions were once considered a potentially key mechanism of N limitation during the initial phase of natural recovery following karst desertification. However, field data are still lacking for studying the hydrologic N budget. …”
Get full text

Efficacy and safety of cannabidiol in a single-center pediatric drug-resistant epilepsy cohort: a retrospective study by Ambra Butera, Ambra Butera, Giulia Spoto, Graziana Ceraolo, Maria Grella, Ivana Giunta, Maria Ludovica Albertini, Carla Consoli, Caterina Sferro, Maria Spanò, Gabriella Di Rosa, Antonio Gennaro Nicotera

“…Clinical, demographic, and instrumental data were retrospectively extracted from the medical records and caregivers’ reports. …”
Get full text

Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary... by Shigeharu Muto, Ayako Furuhama, Mika Yamamoto, Yasuteru Otagiri, Naoki Koyama, Seiji Hitaoka, Yusuke Nagato, Hirofumi Ouchi, Masahiro Ogawa, Kisako Shikano, Katsuya Yamada, Satoshi Ono, Minami Hoki, Fumiya Ishizuka, Soichiro Hagio, Chiaki Takeshita, Hisayoshi Omori, Kiyohiro Hashimoto, Satsuki Chikura, Masamitsu Honma, Kei-ichi Sugiyama, Masayuki Mishima

“…Abstract Background Primary aromatic amines (PAAs) present significant challenges in the prediction of mutagenicity using current standard quantitative structure activity relationship (QSAR) systems, which are knowledge-based and statistics-based, because of their low positive prediction values (PPVs). …”
Get full text

Phenotypically distinguishable eosinophilic cells do not impact epithelial functions in a triple-culture in vitro intestinal model by Christoph Benkstein, Laurin Mosig, Daniel Vondran, Heidi Schlichting, Lea Kissing, Bente Wohlert, Ida Gensmer, Larissa Nogueira de Almeida, Peter König, Peter König, Kerstin Fibelkorn, Anna Kordowski, Stefanie Derer-Petersen, Christian Sina, Christian Sina, Yves Laumonnier, Yves Laumonnier

“…In-depth characterization by real-time PCR, flow cytometry, functional assay and electron microscopy showed that only butyrate and dibutyryl-cAMP generated phenotypically distinct eosinophilic cells with different activation statuses, marked by differential expression of surface markers CD11c and CD62L, increased expression of eosinophil specific genes, and development of eosinophilic structural features. Then, a triple-culture system encompassing the enterocytic cell line Caco-2 and the secretory cell line HT29-MTX complemented with eosinophilic differentiated cells was established. …”
Get full text

Feasibility study of single-image super-resolution scanning system based on deep learning for pathological diagnosis of oral epithelial dysplasia by Zhaochen Liu, Zhaochen Liu, Peiyan Wang, Peiyan Wang, Nian Deng, Hui Zhang, Hui Zhang, Fangjie Xin, Xiaofei Yu, Xiaofei Yu, Mujie Yuan, Mujie Yuan, Qiyue Yu, Yuhao Tang, Keke Dou, Jie Zhao, Bing He, Jing Deng, Jing Deng

“…Both the DS30R and Nikon scanners demonstrate high sensitivity and specificity for detecting structural features in OED pathological images; however, DS30R excels at identifying certain cellular features. …”
Get full text

Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
Get full text

Quality of Surface and Groundwater in the Sierra de Amula Region, Jalisco, Mexico by Oscar Raúl Mancilla-Villa, Fabiola Villafaña-Castillo, Álvaro Can-Chulim, Rubén Darío Guevara-Gutiérrez, José Luis Olguín-López, Elia Cruz-Crespo, Jonas Alan Luna-Fletes, Juan Uriel Avelar-Roblero

“…Each sample was evaluated for its pH, electrical conductivity, and ionic concentration (Ca²⁺, Mg²⁺, Na⁺, K⁺, CO₃²⁻, HCO₃⁻, CI⁻, SO₄²⁻). For data analysis, we determined the ionic concentrations and the salinity and sodicity indexes, including the electrical conductivity, pH, sodium adsorption ratio (SAR), and cationic ratio of soil structural stability (CROSS). …”
Get full text

Investigating the Mediating Role of Self-Efficacy in the Relationship between Job Demand and Role Ambiguity with Employee Well-Being by Mahnaz Rahimi, Mohammad Hassani, Hasen Ghalavand

“…</p> <p style="text-align: left;"><strong>3.Methodology</strong></p> <p style="text-align: left;">In this article, we intended to model the factors affecting employees' well-being with the mediation of self-efficacy using a quantitative approach and structural equation modeling. For this purpose, we first determined the independent, dependent and mediating variables based on the backgrounds. …”
Get full text

3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration by Lincong Luo, Weihan Zheng, Jiaying Li, Tingting Chen, Wanting Xue, Tao Lin, Mingrui Liu, Zi Yan, Jiaxin Yang, Jiamin Li, Jiahao Pu, Yaobin Wu, Konghe Hu, Shiyu Li, Wenhua Huang

“…Abstract Current Ti‐6Al‐4V bone implants lack trabecular structure and pro‑angiogenic cues, both essential for regeneration. …”
Get full text

Resolving Turbulence Drivers in Two Luminous Obscured Quasars with JWST/NIRSpec Integral Field Unit by Mandy C. Chen, Hsiao-Wen Chen, Michael Rauch, Andrey Vayner, Weizhe Liu, David S. N. Rupke, Jenny E. Greene, Nadia L. Zakamska, Dominika Wylezalek, Guilin Liu, Sylvain Veilleux, Nicole P. H. Nesvadba, Caroline Bertemes

“…Utilizing high-resolution data from the NIRSpec integral field unit onboard the James Webb Space Telescope, we analyze the velocity fields of line-emitting gas in and around these quasars and construct the second-order velocity structure functions (VSFs) to quantify turbulent motions across different spatial scales. …”
Get full text

Searching for Planets Orbiting Vega with the James Webb Space Telescope by Charles Beichman, Geoffrey Bryden, Jorge Llop-Sayson, Marie Ygouf, Alexandra Greenbaum, Jarron Leisenring, Andras Gaspar, John Krist, George Rieke, Schuyler Wolff, Kate Su, Klaus Hodapp, Michael Meyer, Doug Kelly, Martha Boyer, Doug Johnstone, Scott Horner, Marcia Rieke

“…Su et al. argue that planets larger than 0.3 M _J would disrupt the smooth disk structure seen at MIRI wavelengths. Eight additional objects are found within 60″ of Vega, but none have astrometric properties or colors consistent with planet candidates. …”
Get full text

Synergetic adsorptive mechanisms, reusability and cost evaluations of green fabricated hybrid barium cobalt nanocomposites for methylene blue and lead removal from wastewater by Titus Chinedu Egbosiuba, Chibuike Christogonus Njoku, Ijeoma Jacinta Ani, Godwin Ifeanyi Ogbuehi, Abdulkareem Omeiza Yusuf, Abiodun Azeez Saka, Ugochukwu Ewuzie, Ebuka Emmanuel Ezennajiego, Blessing Onyinye Okafor, Walter Chibuike Anene, Cecilia Chika Unegbu, Florence Acha, Monday Uchenna Okoronkwo

“…The nanoparticles and nanocomposites were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), high-resolution scanning electron microscopy (HRSEM), and Brunauer-Emmett-Teller (BET) analysis to assess their functional groups, crystalline structure, morphology, and surface properties, confirming successful synthesis. …”
Get full text

Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…Methods: This registry study collected data up to 10 years posttransplant. Survival analysis for a composite end point of graft loss or estimated glomerular filtration rate (eGFR) ≤ 30 ml/min per 1.73 m2 or ≥50% decline from eGFR at month 3 posttransplant was performed. …”
Get full text

Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a b... by Surajit Dey, Wenying Lu, Prabuddha S. Pathinayake, Maddison Waters, Greg Haug, Josie Larby, Heinrich C. Weber, Peter A. B. Wark, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal

“…Additionally, the degree of RBM fragmentation was evaluated, a key tissue structural marker of EMT.ResultsCompared to healthy controls and asthmatics, ACO had the greatest fragmentation of RBM (P &lt; 0.01). …”
Get full text