Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. …”
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Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice by Tao Lu, Huan Liu, Xiaoqing Yuan, Desheng Li, Guanqing Zhang, Yue Wang, Qiqiang Xie, Xinhao Wang, Jingjian Chi, Zhenzhen Wang, Shaoping Wang, Yanling Gao, Ling Zhou, Maolei Xu

“…The results confirmed, for the first time, that PET MPs can induce oxidative stress, lipid accumulation, and apoptosis in liver cells, resulting in structural damage and functional abnormalities in the liver. …”
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Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report by Manash Shrestha, Sanjaya Acharya, Josselyn Neukom, Karma Lhazeen, Ngo Duc Thang, Muhammad Naeem Habib, Lyndes Wini, Tobgyel Tobgyel, Kesang Wangchuk, Huy Rekol, Lek Dysoley, Siv Sovannaroth, Minerva Simatuopang, Helen Dewi Prameswari, Asik Surya, Zau Ring, Mohammad Qasim Khan, Boualam Khamlome, Mohd Hafizi Abdul Hamid, Ram Kumar Mahato, Top Thapa, Sheen Angelou Juangco, Hee Il Lee, Hyun Il Shin, Kumudu Gunasekera, Champa Aluthwera, Prayuth Sudathip, Rungrawee Timpontree, Hoang Dinh Canh, Sonia Cheung, Muhammad Zeeshan Haroon, Shreehari Acharya, Robert J. Commons, Bipin Adhikari, Varunika Ruwanpura, Phone Si Hein, Abhijit Sharma, Poe Poe Aung, Neena Valecha, Kamala Thriemer, Caroline A. Lynch

“…Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
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Comparison of porous and non-porous biochar for trimethoprim removal: Quantifying uncertainty in sorption and thermodynamic parameters over different pH and temperature by Nguyen Thi Phuong Thao, Pham Thi Le Na, Ky-Phuong-Ha Huynh, Bao-Trong Dang

“…The results showed that the non-porous structure of CN400 had a smaller surface area than that of CN600 (4 vs. 372 m2 g−1, respectively). …”
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HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines by Agnieszka Gogler, Agata Małgorzata Wilk, Damian Robert Sojka, Małgorzata Adamiec-Organiściok, Natalia Matysiak, Daria Kania, Klaudia Wiecha, Ewa Małusecka, Alexander Jorge Cortez, Dawid Zamojski, Michał Marczyk, Agnieszka Maria Mazurek, Sylwia Oziębło, Dorota Scieglinska

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The effects of parent-child relationship, study stress, and mobile phone use on depressive symptoms among Chinese elementary school students: a moderated mediation model by Yiting Kong, Yiting Kong, Zhewei Su, Zhewei Su, Rui Wang, Rui Wang, Jianyu Tan, Jianyu Tan, Yuancen Zhong, Yuancen Zhong, Ming Ai, Ming Ai, Wo Wang, Wo Wang, Su Hong, Su Hong, Qi Zhang, Qi Zhang, Li Kuang, Li Kuang

“…This study investigated the association between parent-child relationship and depressive symptoms among Chinese elementary school students while testing a moderated mediation model to examine the mediating role of significant study stress and the moderating effect of frequent mobile phone use on this relationship.MethodsWe recruited elementary school students from grades 3 to 6 in S district of Chongqing, China, totaling 33,285 participants (51.72% girls; mean age = 10.36 years, SD = 1.24). Data was analyzed using structural equation modeling to assess the mediating and moderating effects of study stress and mobile phone use, respectively, on the relationship between parent-child relationship and depressive symptoms.ResultsDepressive symptoms prevalence in our study population was 16.3%. …”
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Development and Assessment of a New Multichannel Electrocutaneous Device for Non-Invasive Somatosensory Stimulation for Magnetic Resonance Applications by Carolina Travassos, Alexandre Sayal, Paulo Fonte, Bruno Direito, Luis Lopes, Nuno Carolino, Sonia Afonso, Tania Lopes, Teresa Sousa, Miguel Castelo-Branco

“…Next, the device’s capacity to generate perceptible tactile sensations and user acceptability were assessed by testing the device on a single participant outside the MR environment. Finally, structural and functional data were acquired from three participants during a somatosensory stimulation experiment as a proof of concept to confirm the brain activity elicited by stimulation. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…Current propagation efforts face significant challenges, including low natural germination rates, and dependence on specific habitats and obligate mycorrhizal fungi, precluding the development of efficient large-scale cultivation and seedling production systems.ConclusionMarked progress has been made in characterizing small-molecule metabolites of G. conopsea, yet comprehensive structural elucidation of polysaccharides remains incomplete. …”
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OP-13 CHOLANGIOCARCINOMA IN LATIN AMERICA: A MULTICENTER OBSERVATIONAL STUDY ALERTS ON ETHNICAL DISPARITIES IN TUMOR PRESENTATION AND OUTCOME by Leonardo G Da Fonseca, Laura Izquierdo Sanchez, Pedro H Hashizume, Yanina Carlino, Estefanía Liza Baca, Cristina Zambrano, Santiago Sepulveda, Andrea Bolomo, Pedro M Rodrigues, Ioana Riaño, Andre Boonstra, Jose D Debes, Luis Bujanda, Flair J Carrilho, Marco Arrese, Juan C Roa, Enrique Carrera, Javier Díaz Ferrer, Domingo Balderramo, Claudia P Oliveira, Jesus M Banales

“…These findings highlight structural challenges in cancer screening and healthcare access among diverse ethnic backgrounds and lower socioeconomic statuses in the region. …”
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Open Innovation the Impact of Social Capital on Tourism Growth Through the Mediating Role of Open Innovation (Case study: The municipality of Khomam County) by Seyed Hamed Hashemi, Hossein Poorghasem

“…This research is applied in terms of purpose and is survey-based for data collection. Moreover, from a methodological perspective, it employs a correlational design; the data collection tool used in this study was a questionnaire, rated using a Likert scale, and its reliability was assessed using Cronbach's alpha. …”
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Quality of Life after Brain Injury in children aged six and seven years (QOLIBRI-KIDDY) – development and scale analysis of the first disease-specific self-report instrument for yo... by Nicole von Steinbuechel, Marina Zeldovich, Fabian Bockhop, Ugne Krenz, Dagmar Timmermann, Anna Buchheim, Inga K. Koerte, Michaela Veronika Bonfert, Steffen Berweck, Matthias Kieslich, Knut Brockmann, Maike Roediger, Sven Greving, Axel Neu, Ulrike Wartemann, Joachim Suss, Christian Auer, Holger Muehlan, Katrin Cunitz

“…After item reduction based on a confirmatory scale analysis considering the six-factor structure of the questionnaire versions for older children, adolescents, and adults (Cognition, Self, Daily Life & Autonomy, Social Relationships, Emotions, Physical Problems), its reliability and validity were investigated. …”
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A rare haplotype of the GJD3 gene segregating in familial Meniere’s disease interferes with connexin assembly by Alba Escalera-Balsera, Paula Robles-Bolivar, Alberto M. Parra-Perez, Silvia Murillo-Cuesta, Han Chow Chua, Lourdes Rodríguez-de la Rosa, Julio Contreras, Ewa Domarecka, Juan Carlos Amor-Dorado, Andrés Soto-Varela, Isabel Varela-Nieto, Agnieszka J. Szczepek, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez

“…The connexin monomer and the homomeric connexon structural models were predicted using AlphaFold2 and HDOCK. …”
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“A cure might help, but it won't erase it all”: a qualitative study of policy challenges and priorities for long‐term survivors of HIV in the United States by Ali Ahmed, Jeff Taylor, Rachel Lau, Joyce Ching‐Jung Lai, Sithara Deshan Diunugala, Michael Louella, Thomas J. Villa, William Freshwater, Dawn Averitt, Maile Karris, Jeff Berry, Lynda Dee, Karine Dubé

“…Using inductive thematic analysis, we identified key policy concerns and recommendations based on participants’ lived experiences. Data collection continued until thematic saturation was reached. …”
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Urgent natural foci infections transmitted by ticks in Saint-Petersburg by V. V. Nechaev, A. A. Yakovlev, A. N. Uskov, L. E. Boburina, N. V. Lavrova, M. N. Pogromskaya, B. I. Aslanov, A. O. Shapar, S. V. Pavlenko, L. N. Pozhidaeva, A. K. Ivanov, A. I. Kravtsova, S. A. Leppik, E. I. Vitovich, M. I. Fedunyak

“…The clinical forms of both diseases did not differ in their structure from the country data, however after 2012 subclinical forms were more common in women. …”
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Rapid escalation and release of risks to forest ecosystems triggered by warming: Insights from tree growth synchrony in temperate forests by Liangjun Zhu, Danyang Yuan, J. Julio Camarero, David J. Cooper, Mai-He Li, Shuguang Liu, Xiaochun Wang, Paolo Cherubini

“…These results provide crucial insights for forest management practice to enhance structural diversity and resilience capacity against climate change-induced synchrony shifts.…”
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Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…In this study, we employed bioinformatics methods to identify eight TaAkPHY genes in the Aikang58 wheat variety. Based on gene structure, conserved domains, and phylogenetic relationships, the TaAkPHY gene family exhibits a high degree of conservation. …”
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The effect of sociodemographic, socioeconomic, and health factors on healthcare utilization in cardiovascular patients in Serbia: a part of National Health Survey by Tamara Lekovic, Tamara Lekovic, Nikoleta Janicijevic, Milos Potezica, Nela Djonovic, Nela Djonovic, Dragan Vasiljevic, Katarina Janicijevic, Melanija Tepavcevic, Snezana Knezevic, Jelena Vuckovic Filipovic, Jelena Vuckovic Filipovic, Amela Rastoder Celebic, Amela Rastoder Celebic, Svetlana Vukosavljevic, Svetlana Vukosavljevic, Maja Mirocevic Rotolo, Maja Mirocevic Rotolo, Dalibor Stajic

“…ObjectivesThis cross-sectional analytical study explores the predictors of the healthcare utilization in the adult population with cardiovascular diseases.MethodologyThe research was carried out as part of the fourth Serbian National Health Survey, in the period from October to December 2019, as a descriptive, cross-sectional analytical study and included the population of cardiovascular patients (N = 4,712) aged over 20 years; Descriptive and inferential statistical methods, including percentage-based structure indicators, Chi-square (χ2) tests for categorical variable differences, and prevalence ratio for examining relationships between dependent and independent variables, were used in the data analysis.ResultsThe analysis identified several significant contributors to cardiovascular healthcare utilization, emphasizing distinct and overlapping factors that impact various types of healthcare use. …”
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“Vaccinating a child is upon the woman”: implications for improving uptake for the recently introduced second dose of measles-containing vaccine based on a rapid community assessme... by Adelline Twimukye, Nessa Ryan, Flavia Vivian Najjuma, Yvette Wibabara, Judith Nanyondo, Shillah Nakato, Maria Sarah Nabaggala, Ciara Sugerman, Daniel Kadobera, Rita Atugonza, John Kamulegeya, Joseph Magoola, Racheal Beyagira, Mohammed Lamorde, Alex Riolexus Ario, Alfred Driwale, Shibani Kulkarni

“…We conducted a rapid analysis based of debriefing notes and in-depth thematic analysis of translated transcripts. Data were analyzed using NVivo version 12, wherein we used the framework analysis approach to define and structure codes deductively and inductively to identify themes. …”
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Precise aftershock activity in the marine source region of the 2024 Noto-Hanto earthquake by rapid response observation using ocean bottom seismometers by Masanao Shinohara, Ryota Hino, Tsutomu Takahashi, Koichiro Obana, Shuichi Kodaira, Ryosuke Azuma, Tomoaki Yamada, Takeshi Akuhara, Yusuke Yamashita, Eiji Kurashimo, Yoshio Murai, Takehi lsse, Kazuo Nakahigashi, Hisatoshi Baba, Yusaku Ohta, Yoshihiro Ito, Hiroshi Yakiwara, Yukihiro Nakatani, Gou Fujie, Toshinori Sato, Hajime Shiobara, Kimihiro Mochizuki, Shin’ichi Sakai, The R/V Hakuho-maru KH-24-JE01 and KH-24-JE02C shipboard science parties

“…A velocity model was derived from the velocity structure by the marine seismic survey. Focal mechanisms were estimated using the grid search method based on the polarities of the first Pwave arrivals. …”
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How national leaders keep ‘us’ safe: A longitudinal, four-nation study exploring the role of identity leadership as a predictor of adherence to COVID-19 non-pharmaceutical interven... by Niklas K Steffens, S Alexander Haslam, Svenja B Frenzel, Nina M Junker, Aidos Bolatov, Valerie A Erkens, Jan A Häusser, Ronit Kark, Ines Meyer, Andreas Mojzisch, Lucas Monzani, Stephen D Reicher, Adil Samekin, Sebastian C Schuh, Liliya Sultanova, Dina Van Dijk, Llewellyn E van Zyl, Rolf van Dick

“…Hypotheses testing was conducted with structural equation modelling.Setting Data collection during the COVID-19 pandemic in China, Germany, Israel and the USA in April/May 2020 and four weeks later.Participants Adults in China (n=548, 66.6% women), Germany (n=182, 78% women), Israel (n=198, 51.0% women) and the USA (n=108, 58.3% women).Measures Identity leadership (assessed by the four-item Identity Leadership Inventory Short-Form) at Time 1, perceived shared national identification (PSNI; assessed with four items) and adherence to health-protective NPIs (assessed with 10 items that describe different health-protective interventions; for example, wearing face masks) at Time 2.Results Identity leadership was positively associated with PSNI (95% CI 0.11 to 0.30, p<0.001) in all countries. …”
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