Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy by Zhibo Hu, Yu Zhou, Cailing Gao, Junfen Liu, Congqing Pan, Jun Guo

“…Conclusions The anti-pyroptosis effect of AS-IV via the TXNIP-NLRP3-GSDMD axis improves the renal function and podocyte damage of db/db mice and delays the onset of DKD, according to in vivo and in vitro experimental data.…”
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The relationship between a numbers of administrative instructions in implementation the process of reducing employees by Agreen Abdoulla Azeez, Tarik Atan

“…Coronbach. (1951) Coefficient of Alpha and Internal Structure of Test, Psychometrika, 16(3) Manfred, F. …”
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Expression characteristics and functional identification of PpD2 gene in peach (Prunus persica) by XIE Hefang, ZHANG Yajia, ZHANG Junjie, LIAN Xiaodong, ZHANG Haipeng, CHENG Jun, WANG Wei, HOU Nan, WANG Lei, ZHENG Xianbo, FENG Jiancan, WANG Xiaobei, TAN Bin

“…In this context, pillar peach germplasm, which exhibits smaller branch angles and fewer secondary branches, offers a promising alternative for improving tree structure. Optimizing tree architecture can enhance light interception, reduce labor inputs, and improve fruit quality, thereby contributing to sustainable peach production. …”
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Genome-wide identification and expression of the HB gene family during overwintering in Korla pear (Pyrus sinkiangensis) by LIU Xiaoyan, WANG Lijuan, YANG Shenghui, LUO Guanghong, ZHU Jianbo

“…Comprehensive analyses were performed, including phylogenetic relationships, chromosomal localization, gene structure, promoter cis-acting elements and family-wide collinearity. …”
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Adherence to Life’s Essential 8 enhances gut microbiota diversity and cognitive performance by Yannick N. Wadop, Jazmyn Muhammad, Rebecca Bernal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Alexa Beiser, Alexa Beiser, Alexa Beiser, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramnik Xavier, Ramnik Xavier, Ramnik Xavier, Tiffany Kautz, Tiffany Kautz, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Bernard Fongang, Bernard Fongang, Bernard Fongang

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The glaciers of the Dolomites: the last 40 years of melting by A. Securo, A. Securo, A. Securo, C. Del Gobbo, G. Baccolo, G. Baccolo, C. Barbante, C. Barbante, C. Barbante, M. Citterio, M. Citterio, F. De Blasi, F. De Blasi, F. De Blasi, M. Marcer, M. Marcer, M. Valt, R. R. Colucci, R. R. Colucci, R. R. Colucci

“…Calculations are based on geodetic data: high resolution and accuracy are obtained with uncrewed aerial vehicle (UAV), structure from motion (SfM), and airborne light detection and ranging (lidar) methods, from 2010 to 2023. …”
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The microbiologist's guide to metaproteomics by Tim Van Den Bossche, Jean Armengaud, Dirk Benndorf, Jose Alfredo Blakeley‐Ruiz, Madita Brauer, Kai Cheng, Marybeth Creskey, Daniel Figeys, Lucia Grenga, Timothy J. Griffin, Céline Henry, Robert L. Hettich, Tanja Holstein, Pratik D. Jagtap, Nico Jehmlich, Jonghyun Kim, Manuel Kleiner, Benoit J. Kunath, Xuxa Malliet, Lennart Martens, Subina Mehta, Bart Mesuere, Zhibin Ning, Alessandro Tanca, Sergio Uzzau, Pieter Verschaffelt, Jing Wang, Paul Wilmes, Xu Zhang, Xin Zhang, Leyuan Li, The Metaproteomics Initiative

“…As the primary catalytic and structural components of microbiomes, proteins provide unique insights into the active processes and ecological roles of microbial communities. …”
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Genomic landscape of diffuse glioma revealed by whole genome sequencing by Ben Kinnersley, Josephine Jung, Alex J. Cornish, Daniel Chubb, Ross Laxton, Anna Frangou, Andreas J. Gruber, Amit Sud, Giulio Caravagna, Andrea Sottoriva, David C. Wedge, Thomas Booth, Safa Al-Sarraj, Samuel E. D. Lawrence, Erminia Albanese, Giulio Anichini, David Baxter, Alexandros Boukas, Yasir A. Chowdhury, Pietro D’Urso, Robert Corns, Andrew Dapaah, Ellie Edlmann, Fay Greenway, Paul Grundy, Ciaran S. Hill, Michael D. Jenkinson, Sandhya Trichinopoly Krishna, Stuart Smith, Susruta Manivannan, Andrew J. Martin, Samir Matloob, Soumya Mukherjee, Kevin O’Neill, Puneet Plaha, Jonathan Pollock, Stephen Price, Ola Rominiyi, Bobby Sachdev, Fozia Saeed, Saurabh Sinha, Lewis Thorne, Ismail Ughratdar, Peter Whitfield, Amir Saam Youshani, Helen Bulbeck, Prabhu Arumugam, Richard Houlston, Keyoumars Ashkan

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Development of a zoonotic influenza distribution assessment and ranking system (ZIDAR): Technical application in Nepal to support cross-sectoral risk-based surveillance by Adam Charette-Castonguay, Dipendra Gautam, Binay Shrestha, Hemant Chandra Ojha, Barun Kumar Sharma, Mukul Upadhayaya, Sujan Rana, Roshika Shrestha, Lok Bandu Chaudhary, Bhawana Kandel, Rudra Prasad Marasini, Sharmila Chapagain, Tulsi Ram Gompo, Surendra Karki, Apsara Poudel, Saugat Shrestha, Avinash Sunny Kayastha, Arun Kumar Govindakarnavar, Reuben Samuel, Allison Gocotano, Pushpa Ranjan Wijesinghe, Nilesh Buddha, Edwin Ceniza Salvador, Manish Kakkar, Ricardo J. Soares Magalhães

“…This is then followed by a technical phase involving model building, model structure validation, data gathering and assessment of model performance. …”
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Humoral and cellular response to SARS-CoV-2 mRNA vaccine in paediatric heart transplant recipients by Amanda Bermejo-Gómez, Laura Tarancon-Diez, Beatriz Lazaro-Martin, Begoña Santiago-Garcia, Nuria Gil Villanueva, Roberto Alonso, Mª Ángeles Muñoz-Fernández, Manuela Camino López, Alicia Hernanz-Lobo, María Luisa Navarro Gómez

“…The T-lymphocyte phenotype and SARS-CoV2-specific CD4+ and CD8+ T-cell response was studied by multiparametric flow cytometry through peripheral blood mononuclear cells by the quantification of degranulation markers (CD107a) and intracellular cytokines (IFN-γ, TNF-α and IL-2) after in vitro stimulation with SARS-CoV-2 peptides from structural proteins (S, M, N, E) and non-structural viral proteins. …”
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Faster efficacy and reduced nodule occurrence with PLLA (poly-l-lactic acid) porous microspheres by Qihua Cao, Qihua Cao, Qihua Cao, Jiayu Chen, Jiayu Chen, Jiayu Chen, Jiayu Chen, Zijun Zhang, Yufei Xiong, Jinxia Ma, Wei Sun, Xin Chen, Qilei Lou, Kaijia Tang, Kaijia Tang, Kaijia Tang, Kaijia Tang, Feng Lin, Feng Lin, Feng Lin, Yueliang Zhu, Yueliang Zhu, Yueliang Zhu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu

“…Post-euthanasia, tissue sections underwent histological examination through hematoxylin and eosin (H&E) staining and Masson’s trichrome technique, with subsequent statistical analysis of the observational data.ResultsThe PLLA porous microsphere group demonstrated significantly faster onset of action compared to the control, with observable collagen deposition as early as week 2, enhanced inflammatory cell infiltration, more homogeneous tissue distribution, and substantially fewer microaggregates upon histological examination.DiscussionStructural modification of PLLA microspheres has successfully accelerated their onset of action while reducing nodule formation, thereby providing novel insights for clinical applications.…”
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An open-source simulation platform to support and foster research collaboration in natural hazards engineering by Adam Zsarnóczay, Gregory G. Deierlein, Frank McKenna, Matthew Schoettler, Sang-Ri Yi, Barbaros Cetiner, Aakash Bangalore Satish, Jinyan Zhao, Justin Bonus, Abiy F. Melaku, Sina Naeimi, Pedro Arduino, Rachel Davidson, Rachel Davidson, Catherine Gorle, Sanjay Govindjee, Ahsan Kareem, Tracy L. Kijewski-Correa, Tracy L. Kijewski-Correa, Laura N. Lowes, Michael Motley, Seymour M. J. Spence, Ertugrul Taciroglu, Alexandros A. Taflanidis, Matthew DeJong

“…This paper presents the conceptual foundation and current capabilities of the SimCenter platform, covering hazard characterization, structural response analysis, damage and loss estimation, and recovery modeling. …”
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Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection by Mark Tsz Kin Cheng, Mazharul Altaf, Jesu Castin, Ann-Kathrin Reuschl, Benjamin L. Sievers, Kimia Kamelian, Dejan Mesner, Rebecca B. Morse, Adam Abdullahi, Bo Meng, Kata Csiba, Steven A. Kemp, Darren P. Martin, Clare Jolly, Christopher Ruis, Lipi Thukral, Ravindra K. Gupta

“…These data shed light on the balance between SARS-CoV-2 upper airway adaptation/immune evasion, syncytium formation, and pathogenic potential.…”
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Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function by Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl

“…Our knowledge of the mechanisms underlying the formation and maintenance of the sound‐receptive structure is limited. Utilizing a large‐scale forward genetic screen in mice, genome mapping and gene complementation tests, we identified Clrn2 as a new deafness gene. …”
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Socioeconomic status and lifestyle as factors of multimorbidity among older adults in China: results from the China Health and Retirement Longitudinal Survey by Wei Gong, Wei Gong, Wei Gong, Xiaoxiao Hu, Huimin Cui, Huimin Cui, Yuxin Zhao, Yuxin Zhao, Hong Lin, Hong Lin, Hong Lin, Peng Sun, Peng Sun, Jianjun Yang, Jianjun Yang

“…Socioeconomic and functional variables were dominant factors associated with multimorbidity, suggesting structural roots of health inequality. These findings offered empirical and theoretical support for early risk stratification and targeted public health interventions aimed at mitigating multimorbidity in aging populations.…”
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Landslide susceptibility assessment in Western Henan Province based on a comparison of conventional and ensemble machine learning by Wen-geng Cao, Yu Fu, Qiu-yao Dong, Hai-gang Wang, Yu Ren, Ze-yan Li, Yue-ying Du

“…These areas have large terrain fluctuations, complicated geological structural environments and frequent human engineering activities. …”
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Whole-Genome Resequencing Analysis of Copy Number Variations Associated with Athletic Performance in Grassland-Thoroughbred by Wenqi Ding, Wendian Gong, Tugeqin Bou, Lin Shi, Yanan Lin, Xiaoyuan Shi, Zheng Li, Huize Wu, Manglai Dugarjaviin, Dongyi Bai

“…These findings provide new insights into the genetic structural variation in racing performance and adaptability, fill the gap in CNV studies in the genomics of Grassland-Thoroughbred horses, and offer valuable genomic data for optimizing breeding strategies in native racing horse populations.…”
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Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs by Jinjun Li, Kai Zhao, Guotai Yang, Haohao Lv, Renxin Zhang, Shuhan Li, Zhiyuan Chen, Min Xu, Naixue Yang, Shaoxing Dai

“…In the DrugBank database, 98 structurally novel candidate compounds with potential senolytic activity were identified. …”
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Effect of low-moderate intensity traditional Chinese exercises combined with acupuncture on patients with stable chronic obstructive pulmonary disease: study protocol for a randomi... by Hongxia Duan, Yidie Bao, Linhong Jiang, Peijun Li, Yingqi Wang, Yuchen He, Xinliao Deng, Weibing Wu, Wei Zhang, Xiaodan Liu, Xiaodan Liu

“…Secondary outcomes will include lung function, degree of dyspnea, diaphragmatic function, respiratory muscle strength, skeletal muscle structure, skeletal muscle function, psychological states, and quality of life. …”
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CORRECTION OF HYPODINAMY AS A FACTOR OF THE RISK OF OBESITY DEVELOPMENT IN FIRE-RESCUERS by E. V. BURDYUKOVA, A. N. ARKHANGELSKAYA, S. N. ALEKSEENKO, I. A. YAKIREVICH, E. A. DMITRIEVA, O. P. KARAZHELYASKOV, M. V. IVKINA, K. G. GUREVICH

“…A questionnaire was conducted to identify hypodynamia (according to the IPAQ questionnaire) and the nutrition structure (according to the questionnaire on the food label literacy questionnaire, past). …”
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