AI-driven MRI analysis reveals brain atrophy patterns in benign relapsing-remitting multiple sclerosis by M. Niiranen, M. Niiranen, P. Bendel, P. Bendel, J. Koikkalainen, J. Lötjönen, T. Selander, E. Solje, E. Solje, P. Hartikainen, S. Simula, R. Vanninen, R. Vanninen, A. M. Portaankorva

“…Based on this study, the corpus callosum is a crucial structure in monitoring disease progression in BRRMS.…”
Get full text

Type 2 gene expression signature in severe asthma associates with more advanced airway remodeling by Bogdan Jakiela, Karolina Górka, Iwona Gross‐Sondej, Sławomir Mikrut, Krzysztof Okoń, Piotr Sadowski, Anna Andrychiewicz, Hanna Plutecka, Tomasz Stachura, Grażyna Bochenek, Stanisława Bazan‐Socha, Krzysztof Sładek, Jerzy Soja

“…Severe asthma is linked to reduced ventilatory function due to airway structural changes. This study compared the extent of airway remodeling in different immunological endotypes of asthma. …”
Get full text

Exploring the relationship between intrinsic capacity and social participation in healthy ageing: Evidence from Singapore by Grace Cheong, William Tov, Robin Wai Munn Choo, Micah Tan, Lay Khoon Lau, Wee Shiong Lim, Yew Yoong Ding, Paulin Tay Straughan

“…We performed structural equation modelling to compare the direct and indirect effects (mediated by IADLs) of intrinsic capacity on social participation. …”
Get full text

Endothelial Damage in Sepsis: The Interplay of Coagulopathy, Capillary Leak, and Vasoplegia—A Physiopathological Study by Gianni Turcato, Arian Zaboli, Lucia Filippi, Alessandro Cipriano, Paolo Ferretto, Michael Maggi, Fabrizio Lucente, Massimo Marchetti, Lorenzo Ghiadoni, Christian J. Wiedermann

“…The Sepsis-Induced Coagulopathy (SIC) score, serum albumin (as a surrogate for capillary leak), and Total Peripheral Resistance Index (TPRI) (as a surrogate for vasoplegia) were assessed. Structural Equation Modeling (SEM) explored the relationship between variables, hypothesizing a common latent factor (endothelial damage). …”
Get full text

Long term emission and simulation on air quality from residential coal burning in China by Qin Yan, Tingyu Xiao, Wenjie Zhang, Shaofei Kong, Yuzhe Zhang, Qingxian Gao, Yun Shu, Hui Li, Han Wang

“…To address this, a suite of control policies has been implemented, leading to a shift in the energy structure and a limitation in pollution emission within RCB sector. …”
Get full text

THE ARTISTIC POTENTIAL OF CHORAL CONDUCTING IN CONTEMPORARY UKRAINE by Lyudmyla SHUMSKA, Yuliia PUCHKO-KOLESNYK, Lyudmyla KOSTENKO, Oleksandr VILA-BOTSMAN, Olha MARTYNOVSKA

“…As part of the methodological approach to the study, a comparative and structural analysis was applied, including the processing of statistical data on choral performances on the YouTube platform, as well as an analysis of the use of modern technologies in Ukrainian music institutions based on open sources. …”
Get full text

SIGnature Libraries: A roadmap for the formation of special interest group libraries by Young‐Min Kim, Eric M. Chin, Michael Fahey, Rose Gelineau‐Morel, Kate Himmelmann, Jennifer O'Malley, Maryam Oskoui, Bruce Shapiro, Michael Shevell, Jenny L. Wilson, Max Wiznitzer, the Child Neurology Society Cerebral Palsy Special Interest Group Consortium, Bhooma Aravamuthan

“…A final review by an 11‐member international advisory group determined threshold ratings for resource inclusion and the library's final structure. Results Seventy‐nine articles were submitted for the first Delphi round and 22 articles for the second Delphi round. …”
Get full text

Threshold of kurtosis on occupational hearing loss associated with non-steady noise by Yang LI, Haiying LIU, Linjie WU, Jinzhe LI, Jiarui XIN, Hua ZOU, Xin SUN, Wei QIU, Changyan YU, Meibian ZHANG

“…BackgroundKurtosis reflecting noise's temporal structure is an effective metric for evaluating noise-induced hearing loss (NIHL), and its threshold is still unclear. …”
Get full text

Older people and stroke: a machine learning approach to personalize the rehabilitation of gait by Elvira Maranesi, Federico Barbarossa, Leonardo Biscetti, Marco Benadduci, Elisa Casoni, Ilaria Barboni, Fabrizia Lattanzio, Lorenzo Fantechi, Daniela Fornarelli, Enrico Paci, Sara Mecozzi, Manuela Sallei, Mirko Giannoni, Giuseppe Pelliccioni, Giovanni Renato Riccardi, Valentina Di Donna, Roberta Bevilacqua

“…Notably, RF outperformed others, suggesting its efficacy in handling complex and nonlinear data relationships.DiscussionThe clinical implication emphasized a connection between gait parameters and cerebral lesion location, notably linking basal ganglia lesions to prolonged double support time. …”
Get full text

Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model by Frankangel Servin, Jarrod A. Collins, Jon S. Heiselman, Katherine C. Frederick-Dyer, Virginia B. Planz, Sunil K. Geevarghese, Daniel B. Brown, William R. Jarnagin, Michael I. Miga

“…Healthcare digital twins (DTs) are anatomically one-to-one biophysical models constructed from structural, functional, and biomarker-based imaging data to simulate patient-specific therapies and guide clinical decision-making. …”
Get full text

Effect of pretreatment type on the physico-chemical properties of activated carbons derived from an invasive weed Prosopis juliflora: potential applications by Subramaniyasharma Sivaraman, Saravanan Ramiah Shanmugam, Ponnusami Venkatachalam, Ratheeshkumar Shanmugam, Arul Chan Basha, Noori M Cata Saady

“…Results from this study revealed that the choice of activation agent significantly influences the material’s structure and chemistry. The activation process of activated carbon (AC) is significantly influenced by temperature and the agent used. …”
Get full text

Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites by Wisam A. Dawood, Gillian M. Fisher, Josefa Kremeyer, Fabian Fischer, Jessica L. Home, Christopher D. Goodman, Kwong Sum Lam, Alexander G. Maier, Thomas Kurz, Katherine T. Andrews

“…Furthermore, 4o was found to stabilise PfHDAC1 in P. falciparum protein lysates using solvent-induced protein stability Western blot assays with anti-PfHDAC1 antibody. Together, these data provide new structure-activity relationship and mechanistic insights on pentyloxyamide-based HDAC inhibitors as potential therapeutic starting points for malaria.…”
Get full text

Deep learning-based computational approach for predicting ncRNAs-disease associations in metaplastic breast cancer diagnosis by Saleem Ahmad, Imran Zafar, Shaista Shafiq, Laila Sehar, Hafsa Khalil, Nida Matloob, Mehvish Hina, Sidra Tul Muntaha, Hamid Khan, Najeeb Ullah Khan, Samreen Rana, Ahsanullah Unar, Muhammad Azmat, Muhammad Shafiq, Yousef A. Bin Jardan, Musaab Dauelbait, Mohammed Bourhia

“…SHAP analysis identified key sequence motifs (e.g., "UUG") and structural free energy (ΔG = − 12.3 kcal/mol) as critical predictors, validated by PCA (82% variance) and t-SNE clustering. …”
Get full text

Accounting for temporal and spatial autocorrelation to examine the effects of climate change on vegetation greenness trend in China by Lingwei Chen, Likai Zhu, Cuiyutong Yang, Zizhen Dong, Rui Huang, Jijun Meng, Min Liu

“…This method considers temporal and spatial autocorrelation structure, and aggregates pixel information to rigorously test the hypotheses about regional patterns. …”
Get full text

Molecular epidemiology of Neisseria gonorrhoeae isolates in Russia, 2015–2023: current trends and forecasting by Ilya Kandinov, Boris Shaskolskiy, Dmitry Kravtsov, Anatoliy Larkin, Alexei Kubanov, Marina Shpilevaya, Julia Shagabieva, Nikita Nosov, Dmitry Gryadunov

“…Two clusters of isolates pose a particular threat to Russia: NG-MAST G2212, linked to MLST 1901/1902, carries a mosaic structure in the penA gene; G12302, linked to MLST 9363, contains mosaic alleles in the mtrR and mtrD genes. …”
Get full text

A life cycle thinking-based environmental risk framework for screening sustainable feedstocks in early-stage bioeconomy projects by George Bishop, Carmen Girón-Domínguez, James Gaffey, Maeve Henchion, Réamonn Fealy, Jesko Zimmermann, Wriju Kargupta, David Styles

“…Criteria are proposed to structure evaluation of (i) probability and (ii) severity of environmental impact, in relation to four categories of feedstock: primary (determining product), high-value by-product, low-value by-product, and waste. …”
Get full text

Decentralized fintech platforms adoption intention in cyber risk environment among GenZ: A dual-method approach using PLS-SEM and necessary condition analysis by Md Sharif Hassan, Nguyen Hong Mai, Nor Shaipah Abdul Wahab, Mohammad Bin Amin, Md Maruf Hassan, Judit Oláh

“…A total of 391 valid responses were received. The data were analyzed through partial least squares structural equation modeling (PLS-SEM) and necessary condition analysis (NCA). …”
Get full text

Charting the path to the implementation of universal health coverage policy in Nigeria through the lens of Delphi methodology by Jibril M. Bashar, Sulaiman Hadiza, Ozoilo J. Ugochi, Lawal S. Muhammad, Adeoye Olufemi, Ukoh Eberechi, Yakubu Agada-Amade, Alhassan Yusuf, Abdulhamid H. Abdullahi, Hassan S. Musa, Ahmad A. Ibrahim, Kalu-Umeh Nnennaya, Jennifer Anyanti, Dayyabu Yusuf, Kenneth Okoineme, Jennifer Adebambo, Samuel O. Ikani, Dennis Aizobu, Musa Abubakar, Babandi S. Zaharaddeen, Lawal Aminu, Yusuf H. Wada

“…These seven priority areas that have been identified include enrolment, equity, organizational health and structure, data and technology, quality, market efficiency, and citizen engagement. …”
Get full text

Comparison of Molnupiravir Exposure‐Response Relationships for Virology Response and Mechanism of Action Biomarkers With Clinical Outcomes in Treatment of COVID‐19 by Akshita Chawla, Ruthie Birger, Brian M. Maas, Youfang Cao, Hong Wan, Julie Strizki, Arthur Fridman, Amanda Paschke, Carisa deAnda, Wei Gao, Matthew L. Rizk, Wendy Painter, Wayne Holman, Susanne Sardella, George Painter, Julie A. Stone

“…Exposure‐response (E‐R) analyses for viral RNA mutation rate and virologic outcomes were conducted using data from three phase 2/3 studies of molnupiravir (P006, MOVe‐IN, and MOVe‐OUT). …”
Get full text

Genomic investigation of NDM-1 producing Enterobacterales transmission in a South Korean hospital by Jeong-Ih Shin, Sun Hee Park, Chulmin Park, Seung-Hyun Jung, Dong-Gun Lee

“…These plasmids contained conserved mobile genetic elements, including the IS26-dsbD-trpF-ble-blaNDM-1 structure. Conclusions: This study highlights the dual roles of clonal spread and plasmid-mediated horizontal gene transfer in the dissemination of blaNDM-1 in hospital settings. …”
Get full text