A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain by Nikolaj R Christensen, Marta De Luca, Michael B Lever, Mette Richner, Astrid B Hansen, Gith Noes‐Holt, Kathrine L Jensen, Mette Rathje, Dennis Bo Jensen, Simon Erlendsson, Christian RO Bartling, Ina Ammendrup‐Johnsen, Sofie E Pedersen, Michèle Schönauer, Klaus B Nissen, Søren R Midtgaard, Kaare Teilum, Lise Arleth, Andreas T Sørensen, Anders Bach, Kristian Strømgaard, Claire F Meehan, Christian B Vægter, Ulrik Gether, Kenneth L Madsen

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Synthesis and acute toxicity of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl) thiopyrimidines by Yu. V. Karpenko, O. I. Panasenko, S. M. Kulish, A. V. Domnich

“…The relevance of the study “structure – acute toxicity” relationship in a number of newly synthesized derivatives of 1,2,4-triazole-3(2H)-thione with pyrimidine-2-thiol is due to the synthesis of potential low molecular weight interferon inducers and antitumor agents, the search for molecular descriptors of their structure, important for establishing “structure – acute toxicity” laws, as a system for evaluating the biological effects of compounds. …”
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Research on Traction Speed Regulation and Braking Device of Pipeline Intelligent Plugging Robot by TANG Yang, PI Yunsen, LIU Xiang, WANG Guorong

“…Pressure values at varying valve openings are measured to verify the structural design’s reliability and effectiveness.Results and DiscussionsThe results show that the traction speed control and braking device’s performance is strongly affected by the structure and shape of the speed control valve. …”
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The relationship between organizational trust and voice behavior among neonatal intensive care unit nurses in tertiary A hospitals in Sichuan Province: the mediating role of career... by Xiujuan Zhang, Xiujuan Zhang, Xi Huang, Xi Huang, Yanling Hu, Yanling Hu, Qiong Chen, Qiong Chen, Xiufang Zhao, Xiufang Zhao

“…Mediation analysis using structural equation modeling confirmed that career resilience mediated the relationship between organizational trust and voice behavior, with a mediation effect of 0.340, accounting for 44.8% of the total effect. …”
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Efficiency evaluation of product oil pipeline under transportation market by Hao ZHANG, Renfu TU, Xu ZHANG, Xinyi YANG, Yiwei SU, Yuheng XIA, Jun YAN, Rui QIU

“…Objective The establishment of China Oil and Gas Pipeline Network Corporation marks a significant milestone in the structural reform of China's oil and gas industry. Consequently, oil and gas pipelines, now operating independently, have emerged as key players in the oil and gas logistics market, competing with railways, waterways, and highways. …”
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A Systematic Review and Meta-Analysis on the Prevalence of Variants in the Pancreaticobiliary Duct Junction and Its Association with Cancer by Juan José Valenzuela-Fuenzalida, Antonia Beas-Gambi, Josefa Matta-Leiva, Daniela Martínez-Hernández, Daniel Milos, Mathias Orellana-Donoso, Alejandra Suazo Santibáñez, Alejandro Bruna-Mejias, Andres Sebastian Riveros, Alvaro Becerra-Farfan, Juan Sanchis-Gimeno, Héctor Gutierrez-Espinoza, Carlos Bastidas-Caldes

“…<b>Background/Objectives:</b> The objective of this study was to describe the anatomical variants of the pancreaticobiliary junction and how its position or structural change could be associated with hepatic, duodenal, and pancreatic clinical complications. …”
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A Metabolomic Strategy to Screen the Prototype Components and Metabolites of Shuang-Huang-Lian Injection in Human Serum by Ultra Performance Liquid Chromatography Coupled with Quad... by Mingxing Guo, Baosheng Zhao, Haiyu Liu, Li Zhang, Long Peng, Lingling Qin, Zhixin Zhang, Jian Li, Chengke Cai, Xiaoyan Gao

“…This identification and structural elucidation of the chemical compounds provided essential data for further pharmacological and pharmacokinetics study of SHLI.…”
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Genebank Management Through Microsatellite Markers: A Case Study in Two Italian Peach Germplasm Collections by Elisa Vendramin, Cássia da Silva Linge, Daniele Bassi, Sabrina Micali, Giorgiana Chietera, Maria Teresa Dettori, Valeria Aramini, Jessica Giovinazzi, Igor Pacheco, Laura Rossini, Ignazio Verde

“…The DNA fingerprinting data allowed the discrimination of 80.95% of the analyzed accessions. …”
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Laser Scanning for Canopy Characterization in Hazelnut Trees: A Preliminary Approach to Define Growth Habitus Descriptor by Raffaella Brigante, Laura Marconi, Simona Lucia Facchin, Franco Famiani, Marta Sánchez Piñero, Silvia Portarena, Rodrigo José De Vargas, Fabiola Villa, Chiara Traini, Alessandra Vinci, Fabio Radicioni, Daniela Farinelli

“…This study utilized TLS to investigate the canopy structure of hazelnut trees of four different Italian varieties, with and without leaves. …”
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Study on the stiffness and damping properties of magnetorheological elastomers subjected to biaxial loads and a magnetic field by J. Luis Gomez-Color, Luis M. Palacios-Pineda, Imperio A. Perales-Martínez, Oscar Martínez-Romero, Daniel Olvera-Trejo, Claudia A. Ramírez-Herrera, Karina Del Ángel Sánchez, Alex Elías-Zúñiga

“…We discovered that micro-particle alignment in the elastomer matrix, its fractal structure, and the magnetic field modify stiffness and damping properties since the magnetic field restricts the polymer chains' reptation zone, thereby stiffening the polymer matrix and influencing its energy dissipation capacity.Furthermore, we proposed a constitutive material model to predict stress-softening and residual strains when the MRE samples are under biaxial loading-unloading cycles and magnetic field intensity with theoretical predictions that follow experimental data well. …”
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Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics by Lorenza Dall’Aglio, Saúl Urbina Johanson, Travis Mallard, Sander Lamballais, Scott Delaney, Jordan W. Smoller, Ryan L. Muetzel, Henning Tiemeier

“…Thanks to methodological advances, large-scale data collections, and longitudinal designs, psychiatric neuroimaging is better equipped than ever to identify the neurobiological underpinnings of youth mental health problems. …”
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Echocardiographic Assessment of Embryonic and Fetal Mouse Heart Development: A Focus on Haemodynamics and Morphology by Nathan D. Hahurij, Emmeline E. Calkoen, Monique R. M. Jongbloed, Arno A. W. Roest, Adriana C. Gittenberger-de Groot, Robert E. Poelmann, Marco C. De Ruiter, Conny J. van Munsteren, Paul Steendijk, Nico A. Blom

“…Currently, studies on animal models mainly focus on cardiac morphology and the availability of hemodynamic data, especially of the right heart half, is limited. …”
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Phase equilibrium of the Fe2O3-TiO2 system by Mengjiao Jiao, Yang Zhang, Guishang Pei, Zhuoyang Li, Xuewei Lv

“…Additionally, the ordered rutile phase was transformed into the high-temperature rutile-derived crystallographic shear structure at 1400 °C with Fe2O3 higher than 15 mol%. …”
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Genetic analysis of local pear varieties in Weixian county, Hebei province based on whole-genome resequencing and chloroplast DNA sequences by QI Dan, DONG Xingguang, LI Zhenjiang, CAO Yufen, LU Lu, TIAN Luming, LI Junxi, ZHANG Ying, HUO Hongliang, MIAO Xiuchen, XU Jiayu, LIU Chao, LI Jinling, ZHU Ruiying

“…We performed principal component analysis, population genetic structure and phylogenetic tree based on these SNPs. …”
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Transplantation Site Affects the Outcomes of Adipose-Derived Stem Cell-Based Therapy for Retinal Degeneration by Chengyu Hu, Huanzhi La, Xuancheng Wei, Yue Zhou, Qingjian Ou, Zhiyang Chen, Xiaoman Zhu, Jing-Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Lixia Lu, Guo-Tong Xu, Haibin Tian

“…Neural retina apoptosis and epiretinal membrane- (ERM-) like structure formation were investigated by immunostaining. …”
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The mediating role of biological age in the association between dietary index for gut microbiota and sarcopenia by Jingyuan Zhang, Jun Guo, Jing Zhang, Jing Zhang, Heng Liu, Lin Zhou, Chi Cheng, Hong Cao

“…Alterations in muscle structure are closely linked to DNA methylation-based biological age assessments and individual dietary patterns. …”
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Bridging the gap: cancer scientific equity, global child health, and distribution of CAR T-cell therapy clinical trials in childhood cancer by Kevin Fernando Montoya-Quintero, Johana Galván-Barrios, Darly Martinez-Guevara, Diana Dueñas, John Montenegro, Yamil Liscano

“…A mixed-method analysis was conducted using global health metrics, child cancer indicators, and data from the Global Observatory on Health Research and Development. …”
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L-Malic Acid Descaler for Drinking Water—Physicochemical Analysis and Biological Activity by Teodora Todorova, Krassimir Boydzhiev, Ignat Ignatov, Teodora Petrova Popova, Zhechko Dimitrov, Irina Gotova, Fabio Huether, Alexander Ignat Ignatov, Yordan Georgiev Marinov

“…The L-malic acid descaler contains L-malic acid as the active component, while polyethylene and activated charcoal function as structural and absorbent materials, respectively. The composition was analyzed in a licensed laboratory using Chemical Abstracts Service Number (CAS) and European List of Notified Chemical Substances (EINECS) standards. …”
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Systematic review and network meta-analysis of retinal imaging biomarkers in neurodegenerative diseases: Correlation with brain changes by Farzaneh Nikparast, Zohreh Ganji, Hoda Zare, Nooshin Akbari-Sharak

“…Introduction: The retina and brain share a common embryonic origin and neural composition. Both undergo structural, vascular, and physiological changes in neurodegenerative diseases (NDs). …”
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Impact of different genomic relationship matrix construction methods on the accuracy of genomic prediction in different species by Shiyi Wang, Yingjia Wei, Dengying Liu, Xiangzhe Zhang, Qishan Wang, Yuchun Pan, Peipei Ma

“…The learning curve for bull data showed the choice of G-matrix had minimal impact on prediction accuracy when the reference population size and genetic marker density reached a certain threshold.DiscussionThe study concluded that the optimal G-matrix construction method varies across species, with population structure being a key factor. …”
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