Academic response to improving value and reducing waste: A comprehensive framework for INcreasing QUality In patient-oriented academic clinical REsearch (INQUIRE). by Belinda von Niederhäusern, Gordon H Guyatt, Matthias Briel, Christiane Pauli-Magnus

“…The Delphi process ultimately achieved consensus on structure and content. The framework addresses 5 study stages (concept, planning and feasibility, conduct, analysis and interpretation, and reporting and knowledge translation) and includes the following dimensions: (i) protection of patient safety and rights, (ii) relevance/patient centeredness and involvement, (iii) minimization of bias (internal validity), (iv) precision, (v) transparency/access to data, and (vi) generalizability (external validity) of study results. …”
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Identification of WRKY gene family and analysis of drought stress expression in Poncirus polyandra by ZHANG Shanshan, RUAN Sunmei, YANG Wenzhong

“…[Methods] Based on the genome-wide data of P. polyandra, WRKY genes were identified by HMMER, NCBI-CDD and SMART searches. …”
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Interest groups in Lithuania: dynamics of development and characteristics of institutionalization by Alvidas Lukošaitis

“…Therefore, in this article, the author embarks to ground the analysis by generalizing the empirical data. The focus of the study is to identify and analyze tendencies manifested during the initial institutionalization period of the interest group system. …”
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EVALUATION OF THE EFFECTIVENESS OF TREATMENT OF CHRONIC CATARRHAL GINGIVITIS IN CHILDREN WITH DIABETES MELLITUS IN LONG-TERM OBSERVATIONS by L.F. Kaskova, V.A. Honcharenko

“… Epidemiological studies in recent years indicate a significant prevalence with an increasing tendency to periodontal disease in the structure of all dental diseases in children. The prevalence of chronical catarrhal gingivitis (CCG) is about 90% of all forms of the disease [1–6]. …”
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<i>α</i> Effect and Magnetic Diffusivity <i>β</i> in Helical Plasma Under Turbulence Growth by Kiwan Park

“…The coefficients <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>α</mi><mi>semi</mi></msub></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>β</mi><mi>semi</mi></msub></semantics></math></inline-formula> are obtained from large-scale magnetic field data as estimates of the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>α</mi></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>β</mi></semantics></math></inline-formula> tensors, while <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>β</mi><mi>theo</mi></msub></semantics></math></inline-formula> is derived from turbulent kinetic energy data. …”
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O-prenylchalcones inhibit cell proliferation and activate apoptosis by inducing mitochondrial dysfunction in gastric cancer cells by José C. Espinoza-Hicks, Yarely M. Salinas-Vera, Javier Camarillo-Cisneros, Alejandro A. Camacho-Dávila, Jessica L. Hernández-Rivera, Nadia Flores-Huerta, Eloisa Ibarra-Sierra, Carlos Pérez-Plasencia, María Elizbeth Álvarez-Sánchez, Ángeles C. Tecalco-Cruz, César López-Camarillo

“…The interactions between the O-prenylchalcones and selected oncoproteins were predicted by first identifying the most stable conformers, and approximately 5,000 structures were evaluated by force field molecular dynamics. …”
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Integrated assessment of antimicrobial stewardship in carbapenem resistant Klebsiella pneumoniae prevalent hospitals in China: a multidisciplinary surveillance network-based survey by Haishaerjiang Wushouer, Weibin Li, Junxuan Yu, Lin Hu, Xiaodong Guan, Xiaolin Liu, Anhua Wu, Xiaoqiang Yang, Minggui Wang, Yingchun Xu, Yanping Luo, Xun Huang, Luwen Shi

“…Five key areas were identified for improving multidisciplinary AMS: organizational structure, staffing and training, drug formulary and prescription management, laboratory testing and quality control, and clinical sampling and data reporting. …”
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Multifractal Analysis and Experimental Evaluation of MCM-48 Mesoporous Silica as a Drug Delivery System for Metformin Hydrochloride by Mousa Sha’at, Maria Ignat, Liviu Sacarescu, Adrian Florin Spac, Alexandra Barsan (Bujor), Vlad Ghizdovat, Emanuel Nazaretian, Catalin Dumitras, Maricel Agop, Cristina Marcela Rusu, Lacramioara Ochiuz

“…<b>Results</b>: SEM-EDX confirmed the uniform distribution of silicon and oxygen, while TEM images revealed a highly ordered cubic mesoporous structure. Nitrogen adsorption analyses showed a high specific surface area of 1325.96 m²/g for unloaded MCM-48, which decreased with drug loading, confirming efficient incorporation of metformin hydrochloride. …”
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Global variation in antibiotic prescribing guidelines and the implications for decreasing AMR in the future by Emmama Jamil, Emmama Jamil, Zikria Saleem, Brian Godman, Brian Godman, Brian Godman, Matti Ullah, Afreenish Amir, Abdul Haseeb, Johanna C. Meyer, Johanna C. Meyer, Muhammad Usman Qamar, Safa S. Almarzoky Abuhussain

“…The findings highlighted significant disparities in the development, adaptation, and implementation of guidelines across different WHO regions, confirming the previously noted lack of standardization and comprehensiveness in LMICs.ConclusionSignificant disparities exist in the availability, structure, and methodological rigor of antibiotic prescribing guidelines across countries with different income levels. …”
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New Epitopes for the Serodiagnosis of Human Borreliosis by Mônica E. T. Alcón-Chino, Virgínia L. N. Bonoldi, Rosa M. R. Pereira, Gilberto S. Gazeta, João P. R. S. Carvalho, Paloma Napoleão-Pêgo, Andressa M. Durans, André L. A. Souza, Salvatore G. De-Simone

“…Cross-reactivity was assessed through data bank access and in vitro analysis. Among the 19 epitopes identified, four were selected for further investigation based on their signal intensity, secondary structure, and peptide matching. …”
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Dalbavancin to facilitate early discharge in the treatment of complex musculoskeletal infections: a multi-centre real-life application by T. Azamgarhi, S. Warren, A. Scobie, N. Karunaharan, C. Perez-Sanchez, R. Houghton, S. Hassan, J. Lourtet-Hascoët, J. Lourtet-Hascoët, H. Kershaw, P. Sendi, K. Saeed, K. Saeed

“…Although dalbavancin is approved for acute bacterial skin and skin structure infections, its off-label use in complex musculoskeletal infection (MSKI) is increasing. …”
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Genome-wide identification of the regulatory network of mitogen-activated protein kinase signaling cascades gene families in Hevea Brasiliensis by Xiaojuan Huang, Manman Sun, Xiaoyu Du, Lin Quan, Jinquan Chao, Xiaomin Deng, Hongze Liao

“…Conserved motifs, gene structure, and motif analysis further bolster the validity of phylogenetic classification. …”
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Efficacy of psychosocial interventions on social functioning in individuals with childhood maltreatment experiences: a protocol for a systematic review and network meta-analysis by Natalia E. Fares-Otero, Silvia Amoretti, Brisa Solé, Sarah L. Halligan, Eduard Vieta, Stefan Leucht, Soraya Seedat, Mathias Harrer

“…Other candidate moderators/mediators (personality, post-traumatic symptoms, brain structure/function, cognitive reserve) will also be explored and narratively summarised. …”
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Mapping, Modeling and Designing a Marble Quarry Using Integrated Electric Resistivity Tomography and Unmanned Aerial Vehicles: A Study of Adaptive Decision-Making by Zahid Hussain, Hanan ud Din Haider, Jiajie Li, Zhengxing Yu, Jianxin Fu, Siqi Zhang, Sitao Zhu, Wen Ni, Michael Hitch

“…UAV methodology involved data collection using a DJI Mavic 2 Pro (20 MP camera) with 4 K resolution images captured at 221 m altitude and 80 min flight duration. …”
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Ethical issues in implementation science: perspectives from a National Heart, Lung, and Blood Institute workshop by Neal W. Dickert, Donna Spiegelman, Jennifer S. Blumenthal-Barby, Garth Graham, Steven Joffe, Jeremy M. Kahn, Nancy E. Kass, Scott Y. H. Kim, Meeta P. Kerlin, Aisha T. Langford, James V. Lavery, Daniel D. Matlock, Kathleen N. Fenton, George A. Mensah

“…Fifth, there is significant overlap between implementation science and quality improvement, and the ideal regulatory oversight structure for implementation science remains unclear. …”
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Usefulness of differential somatic cell count for udder health monitoring: Effect of intramammary infections, days in milk, quarter location, and parity on quarter-level differenti... by Mariana Fonseca, Daryna Kurban, Jean-Philippe Roy, Débora E. Santschi, Elouise Molgat, Simon Dufour

“…Given the hierarchical structure of the data, a 4-level, linear mixed model with herd, cow, and quarter as random intercepts was built with either SCS or DSCC as the outcome. …”
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Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…Characterization techniques such as FTIR, XRD, SEM, and EDS reveal a highly porous morphology due to NiO nanoparticle integration within the OP matrix, a structure that provides numerous active sites for adsorption. …”
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Synthesis of the serotonin derivative 5-PT and establishment of a research system for protein serotonylation by XIAO Shuyu, TULAMATI Aziguli, YANG Yan, ZHANG Zhigang, YANG Xiaomei, DU Chang, ZHANG Xueli

“…Mass spectrometry analysis data showed that a significant amount of serotonylated proteins were enriched in various cells treated with 5-PT. …”
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The antioxidant property of CAPE depends on TRPV1 channel activation in microvascular endothelial cells by Miltha Hidalgo, Bárbara Railef, Vania Rodríguez, Carolina Navarro, Vanessa Rubio, Jorge Meneses-Pacheco, Sandra Soto-Alarcón, Christine Kreindl, Carolina Añazco, Leandro Zuñiga, Omar Porras

“…Herein, we hypothesized that a subfamily of TRP ion channels works as the molecular entity that recognizes CAPE at the plasma membrane and allows a fast shift in the antioxidant capacity of intact endothelial cells (EC).By monitoring cytoplasmic Ca2+ in a microvascular EC model, we compared the calcium responses evoked by three structurally related compounds: caffeic acid phenethyl ester, neochlorogenic acid and caffeic acid. …”
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The Class III Peroxidase Gene Family in <i>Populus simonii</i>: Genome-Wide Identification, Classification, Gene Expression and Functional Analysis by Lu Han, Yishuang Ren, Xinru Bi, Guowei Yao, Jinwang Zhang, Hongtao Yuan, Xiaoyu Xie, Junbo Chen, Yunchang Zhang, Sitong Du, Wanying Chen, Kewei Cai, Xiyang Zhao

“…Conserved domain and motif analyses demonstrated that all <i>PsPOD</i> proteins contain the characteristic peroxidase domain and share highly conserved motif structures. Cis-acting element analysis of promoter regions revealed the presence of numerous regulatory elements associated with light responsiveness, phytohormone signaling, stress responses, and plant growth and development. …”
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