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57761
Mapping Urban Villages in Beijing–Tianjin–Hebei Core Cities Through a Dual-Stage Fusion of Individual Building Footprints and Glimmer Imagery
Published 2025-01-01“…Subsequently, spatial structural and socioeconomic features are incorporated into a random forest classification model for the accurate UV identification. …”
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57762
Expert adaptation and validation of a verbal autopsy instrument in Chile using the Delphi method
Published 2025-06-01“…Its comprehensive approach would allow identifying social and structural factors associated with maternal deaths, favoring more equitable and culturally relevant interventions aimed at preventing avoidable maternal deaths. …”
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57763
Factors Affecting on Environmental Strategy in SMEs manufacturing Firms of a developing country: Mediating role of Green Employee Behavior [version 2; peer review: 2 approved, 1 ap...
Published 2025-07-01“…The research gathered data from 211 participants by applying a pre-tested instrumental questionnaire and structural equation modelling (SEM) SmartPLS version 3 was used for data analysis. …”
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57764
Exploring the nexus between climate change, political stability, and income inequality in Somalia
Published 2025-01-01“…In fragile states like Somalia, climate change and political instability exacerbate economic inequality, limiting opportunities and deepening structural inequities. This study empirically examines the impact of climate change, political stability, and macroeconomic variables—including GDP per capita, inflation, population growth, and urbanization—on income inequality in Somalia from 1980 to 2022. …”
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57765
Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study
Published 2025-06-01“…Purpose: Computed tomography (CT) screening has established itself as the routine method to monitor lung conditions by providing pulmonary structural and functional information. However, the reference ranges of CT indices are still lacking. …”
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57766
The Particle Size of Wheat Bran Dietary Fiber Influences Its Improvement Effects on Constipation
Published 2025-03-01“…With the decrease in particle size, its morphology exhibited an increase in fiber fragmentation, larger pore sizes, and the formation of structural faults. The oil-holding capacity (OHC) and swelling capacity (SC) of WBDF were found to change with particle size, with the highest OHC observed at 37.39 μm and the greatest SC at 84.14 μm. …”
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57767
Temporal RAGE Over-Expression Disrupts Lung Development by Modulating Apoptotic Signaling
Published 2024-12-01“…Despite the compensatory upregulation of inhibitors of apoptosis proteins (cIAP-2, XIAP, and Survivin), tissue loss and structural damage persisted. These findings underscore RAGE’s role as a pivotal modulator of lung development. …”
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57768
Disaster governance, energy insecurity, and public health in rural Puerto Rico: how communities resist political abandonment
Published 2025-07-01“…Our findings reveal that political abandonment is not merely a failure of governance but an intentional strategy that limits recovery efforts and sustains structural inequalities. The privatization of PR’s electrical grid has exacerbated disparities, reinforcing patterns of disaster capitalism. …”
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57769
α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy
Published 2025-06-01“…To address these issues, we developed a modified LNP system that incorporates α-galactosylceramide (α-GalCer), a CD1d-binding glycolipid known to activate invariant natural killer T (iNKT) cells. Through structural optimization, we created the α-GalCer-LNP (G-LNP), which offers three primary advantages over conventional four-component LNPs: (1) enhanced mRNA transfection efficiency due to improved endosomal/lysosomal escape, (2) increased capacity for in vivo DC transfection, leading to robust activation of tumor-specific CD8+ T cells via MHC-I and iNKT cells via the CD1d pathway, and (3) reprogramming of the tumor microenvironment, resulting in a 1.5-fold increase in iNKT cell infiltration and sustained elevation of IFN-γ (>24 h) in lymph nodes. …”
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57770
Energy dissipation and dilation processes of rock mass under incremental cyclic loading and unloading
Published 2025-05-01“…The reason for this observation is that the energy dissipation rate is greater due to the particle compaction in the initial compaction stage and structural damage of rock material in failure stage. …”
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57771
Converse effects of warming and reclamation on methane uptake in alpine meadows
Published 2025-04-01“…Soil C and N nutrient contents and three enzyme activities were determined in 2021, and their effects on CH4 uptake were elucidated using the Mantel test as well as structural equation modelling. The results showed that warming significantly increased CH4 uptake by 23.84 %, reclamation significantly reduced CH4 uptake by 58.64 %, warming interacted with reclamation significantly reduced CH4 uptake by 33.45 % in growing season, and warming interacted with reclamation significantly reduced CH4 uptake by 21.46 % in the non-growing season, as compared to CK. …”
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57772
Dihydromyricetin ameliorates lipopolysaccharide‒induced hepatic injury in chickens by activating the Nrf2/Keap1 pathway and regulating mitochondrial dynamics
Published 2025-05-01“…Moreover, DHM modulated the expression of mitochondrial dynamics related factors, including Mfn1/2, Opa1, Drp1, and Fis1, meanwhile, DHM ameliorated mitochondrial structural damage and increased the MMP. Overall, these results suggested that DHM activated the Nrf2/Keap1 pathway and regulated the balance between mitochondrial fusion and fission, ultimately alleviating chicken hepatic injury induced by LPS.…”
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57773
Genome-Wide Identification and Characterization of bHLH Transcription Factors and Their Expression Profile in Potato (<i>Solanum tuberosum</i> L.)
Published 2025-04-01“…Using bioinformatics approaches, we examined their physicochemical properties, conserved structural domains, motifs, and cis-acting elements. …”
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57774
An experimental optimization environment for developing an intracycle pitch control in cross flow turbines
Published 2025-06-01“…Evolutionary algorithms are to be employed to solve two objectives: (1) maximizing the efficiency and (2) minimizing the structural loads. These kind of problems are usually solved with numerical simulations, which commonly comes with very high computational efforts and uncertainty. …”
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57775
Perspectives on the pH-Influenced Design of Chitosan–Genipin Nanogels for Cell-Targeted Delivery
Published 2025-07-01“…Rheological studies and SAXS analysis assessed structural properties. Biocompatibility was evaluated via MTT assay, and internalisation was monitored by fluorescence microscopy on mammalian cell lines. …”
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57776
DFT/TD-DFT study of novel triphenylamine-based dyes with azo moieties and π-spacer variations for enhanced dye-sensitized solar cell performance
Published 2024-12-01“…This study involves a computational analysis of new D-π-A dyes obtained from triphenylamine (TPA), which contain various azo-dye components. The structural, molecular, electrical, and optical properties of these dyes were computed using Density Functional Theory (DFT) and Time-Dependent DFT, utilizing the B3LYP/6–31 G model. …”
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57777
Network-based analysis and experimental validation of identified natural compounds from Yinchen Wuling San for acute myeloid leukemia
Published 2025-05-01“…ADME analysis suggested favorable pharmacokinetics, and molecular dynamics simulations confirmed structural stability. In vitro, these compounds exhibited dose-dependent cytotoxicity, induced apoptosis, modulated the cell cycle, and downregulated SRC expression. …”
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57778
Radiomics in the differential diagnosis of glioblastoma under the primary neurooncoimaging conditions
Published 2025-04-01“…Our conclusion is that relatively uniform preprocessing techniques based on uniform voxel intensity changes, which allow to preserve the structural detail, are feasible in clinical practice. …”
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57779
Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation
Published 2025-01-01“…Hong Liu,1,* Manxue Mei,1,* Hua Zhong,2 Shuyin Lin,1 Jiahui Luo,1 Sirong Huang,1 Jiuyao Zhou1 1Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiuyao Zhou, Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China, Email yaoli@gzucm.edu.cn, zhoujiuyao@vip.tom.comBackground: Chronic kidney disease (CKD) is a progressive condition that arises from diverse etiological factors, resulting in structural alterations and functional impairment of the kidneys. …”
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57780
Diabetic Retinopathy Screening Among at Risk Populations: Protocol for Distributional Cost-Effectiveness Analysis
Published 2025-04-01“…Experiences at this intersection are influenced by interpersonal and structural systems of oppression. Studies have found that tele-retina is the preferred strategy over standard of care screening for at-risk populations. …”
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