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  1. 52781
  2. 52782

    Case Report: Phenotypic heterogeneity within an NF1 family: assessment of the pathogenicity of a de novo c.6640dupA shift mutation and a splice variant with an epilepsy phenotype by Sijing Ren, Sijing Ren, Sijing Ren, Yanling Wang, Xinhua Tong, Xiaoyu Wu, Xiaoyu Wu, Huan Yan, Huan Yan, Qing-Xia Kong, Qing-Xia Kong, Qing-Xia Kong

    Published 2025-07-01
    “…The identified genes were validated using Sanger sequencing, and alterations in the tertiary structural physicochemical properties of the mutant proteins were analyzed using AlphaFold2 bioinformatics software.ResultsWe identified two mutation sites in the NF1 gene of the patient. …”
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  3. 52783

    The relationship between educational and scientific regulatory interventions and socio-economic development in military conflict-affected countries: A Sustainable Development Goals... by Dariusz Krawczyk, Nadiia Artyukhova, Dmytro Svynarenko, Anna Vorontsova, Artem Artyukhov, Robert Rehak, Tetiana Vasylieva

    Published 2025-08-01
    “…Type of the article: Research Article AbstractThis study investigates the structural relationships between educational and scientific regulatory interventions and socio-economic development in countries affected by armed conflict and political instability, using the framework of Sustainable Development Goals (SDGs), specifically SDG 4 (Quality Education), SDG 8 (Decent Work and Economic Growth), and SDG 9 (Industry, Innovation and Infrastructure). …”
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  4. 52784
  5. 52785

    The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation by Belayneh Mengist, Mojtaba Lotfaliany, Julie A. Pasco, Bruno Agustini, Michael Berk, Malcolm Forbes, Melissa M. Lane, Suzanne G. Orchard, Joanne Ryan, Alice J. Owen, Robyn L. Woods, John J. McNeil, Mohammadreza Mohebbi

    Published 2025-03-01
    “…We applied inverse probability treatment weighting to balance confounders. Marginal structural models were employed to estimate the population-level average effect of intervention using generalised estimated equations. …”
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  6. 52786

    Exploring key factors related to child well-being: a community-based participatory research together with children with migration background residing in socio-economically disadvan... by Louise Burenby Yxne, Louise Burenby Yxne, Rathi Ramji, Rathi Ramji, Elisabeth Mangrio, Elisabeth Mangrio, Elisabeth Mangrio, Katarina Sjögren Forss, Katarina Sjögren Forss, Therese Sterner, Therese Sterner, Margareta Rämgård, Margareta Rämgård

    Published 2025-07-01
    “…The themes covered structural aspects, such as school, healthcare and human rights, but also more personal dimensions, like close relations and the near environment, related to Bronfenbrenner’s ecological theory of human development.ConclusionThe dialogs with the children provided a deeper understanding and a holistic view of the perceptions of children with migration backgrounds residing in socio-economically disadvantaged areas regarding essential factors for their well-being. …”
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  7. 52787

    Understanding Associations Between Patient‐Level Factors and Participation in a Breast Cancer Clinical Trial by Nicole E. Caston, Luqin Deng, Courtney P. Williams, Emily B. Levitan, Andres Azuero, Russell Griffin, Karen L. Smith, Antonio C. Wolff, Michelle E. Melisko, Eileen H. Shinn, Kathleen Gallagher, Rebekah Angove, Stephanie B. Wheeler, Gabrielle B. Rocque

    Published 2025-08-01
    “…Standardized total effects (bTot) were estimated using a prespecified Structural Equation Model with 0.1, 0.3, and 0.5 indicating weak, medium, and large magnitude, respectively. …”
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  8. 52788

    Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus by Ling Wang, Yu Zhang, Rui Zhao, Yan Huang, Xinghao Wang, Yuyou Huang, Jiancheng Zhang, Han Lv, Pengfei Zhao, Zhenghan Yang, Qian Chen, Zhenchang Wang

    Published 2025-09-01
    “…Objective: To examine structural and functional changes in auditory cortex(AC) subregions of patients with tinnitus and identify potential predictive indicators for sound therapy. …”
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  9. 52789

    Influencing Factors and Paths of the Coupling Relationship Between Ecosystem Services Supply–Demand and Human Well-Being in the Hexi Regions, Northwest China by Yongge Li, Wei Liu, Meng Zhu, Qi Feng, Linshan Yang, Jutao Zhang, Zhenliang Yin, Xinwei Yin

    Published 2025-05-01
    “…Here, we assessed dynamic changes in ecosystem services supply–demand, human well-being, their coupling relationships and influencing factors in the Hexi Regions by integrating remote sensing data, ecological model, ecosystem services supply–demand ratio (ESDR), coupling coordination degree (CCD) model, and the partial least squares structural equation modeling (PLS-SEM). …”
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  10. 52790

    Ecotype-specific responses of Typha domingensis to microplastics: Antioxidant defense and biochemical adaptations in wetland ecosystems by Muhammad Aqeel, Ali Noman, Saher Nawaz, Noreen Khalid, Muhammad Kashif Irshad, Muhammad Faisal Iqbal, Modhi O. Alotaibi, Motirh Al-Mutairi, Mohamed O. Alshahrani, Nahaa M. Alotaibi, Fahad Mohammed Alzuaibr

    Published 2025-01-01
    “…The inherent ability of plants to withstand microplastic (MP) stress is primarily governed by complex structural and physio-biochemical adaptations. In this study, the MP tolerance mechanisms of six naturally occurring ecotypes of Typha domingensis Pers. were assessed by examining plant pigments, ionic homeostasis, secondary metabolites, and antioxidant defense responses in MP-contaminated wetlands. …”
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  11. 52791

    Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

    Published 2024-11-01
    “…In this study, three biochars were synthesized at 500 °C from pre-impregnated date palm fronds (DPFs) with 1 M solutions containing either MgCl2 (DPF-Mg-B), AlCl3 (DPF-Al-B) or a combination of MgCl2/AlCl3 (DPF-Mg/Al-B). Subsequently, the structural, textural, and surface chemistry properties of these biochars were assessed. …”
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  12. 52792

    snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation by Yusha Yang, Yusha Yang, Guanyu Zhang, Ting Yi, Ting Yi, Shuran Yang, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Xiuxuan Wu, Jun Li, Danfeng Yang

    Published 2025-05-01
    “…Subsequently, we employed single-nucleus RNA sequencing (snRNA-seq) to comprehensively characterize iWAT cellular dynamics during cold stimulation and the subsequent two-week period after the return to thermoneutrality.ResultsOur findings revealed that while iWAT phenotypically reverts to a white state after 2 weeks of rewarming, as evidenced by structural, functional, and bulk transcriptomic characteristics, significant cold-induced molecular and cellular signatures persist. …”
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  13. 52793

    Mediation of nutritional status between the number of teeth and depressive symptoms in multi-ethnic older adults from Western China by Xin Tian, Xin Xia, Huixian Li, Yuexia Hu, Yuqing Xie, Xiuying Hu, Jirong Yue, Birong Dong, Bei Wu, Yanyan Wang

    Published 2025-04-01
    “…This study aimed to investigate the role of nutritional status in mediating the number of teeth and depressive symptoms.MethodA prospective multi-ethnic baseline data of 6,632 adults aged 50 years and older was derived from the 2018 West China Health and Aging Trend study. …”
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  14. 52794

    The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens by Xia Chen, Ming Kong, Chunxi Ma, Manyu Zhang, Zenglei Hu, Min Gu, Xiaoquan Wang, Ruyi Gao, Shunlin Hu, Yu Chen, Xiaowen Liu, Daxin Peng, Xiufan Liu, Jiao Hu

    Published 2025-12-01
    “…By analysing the polymorphism of this residue in various subtype viruses, we found that PA-X 100 was highly variable in H7N9 viruses. Structural analysis revealed that 100 V was generally close to the PA-X endonuclease active site, which may account for its host shutoff activity. …”
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  15. 52795

    Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence by Jessica Morrel, L. Nate Overholtzer, Kirthana Sukumaran, Devyn L. Cotter, Carlos Cardenas-Iniguez, J. Michael Tyszka, Joel Schwartz, Daniel A. Hackman, Jiu-Chiuan Chen, Megan M. Herting

    Published 2025-09-01
    “…Background: Outdoor air pollution exposure is associated with structural and functional brain differences and an increased risk for psychopathology. …”
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  16. 52796

    Age features of myocardial remodeling in men with ischemic chronic heart failure and renal dysfunction by D. A. Lashkul

    Published 2014-04-01
    “…However, in most studies structural remodeling of the myocardium was analyzed without sex and age characteristics. …”
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  17. 52797

    Multi-field information fusion-based analysis of the macroscopic and mesoscopic damage evolution and location identification of caving and water-conducting fracture zones for minin... by Jiangbo WEI, Shuangming WANG, Lang LIU, Baoning WEI, Deyu CHONG, Zhizhen LIU, Dongkui LI, Dengdeng ZHUANG, Jing ZHOU

    Published 2025-04-01
    “…ObjectiveFor the coal mining areas in the middle reaches of the Yellow River, there is an urgent need to determine the failure characteristics of the mining overburden and the spatial structural evolution of caving and water-conducting fracture zones in the overburden, which is recognized as the major challenge in coal mining through gangue grouting filling in goaves. …”
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  18. 52798

    CLINICAL PROFILE OF PATIENTS WITH EARLY AXIAL SPONDYLOARTHRITIS (RUSSIAN COHORT OF PATIENTS) by E. E. Gubar', A. G. Bochkova, T. V. Dubinina, A. B. Dyomina, O. A. Rumyantseva, M. M. Urumova, S. V. Shubin, A. A. Godzenko, A. V. Smirnov, E. Yu. Tyukhova, S. I. Glukhova, Sh. F. Erdes

    Published 2014-10-01
    “…X-ray revealed definite SI in 49.3% of patients («classic» AS). According to MRI data, 30.1% of patients with active SI and without structural changes of sacroiliac joints had pre-radiological stage of AS (by Russian version of modified New York criteria). 74.0% of patients fulfilled both sets of ASAS criteria for axSpA, 5.5% – met only I criteria set, whereas 20.5% – only II criteria set. …”
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  19. 52799

    Etiological mechanisms underlying the hazard factors and inflammatory bowel disease: a prospective cohort study by Yi Tao, Yongjia Li, Tianyi Zhou, Lei Zhao, Pan Li, Minghong Sun, Lijuan Zhang, Lihong Yang, Ting Chen, Xuemei Lian, Xiaoni Zhong

    Published 2025-07-01
    “…Finally, we constructed a structural equation model to elucidate the complex pathogenic mechanisms and interactions among genetic risks, lifestyle factors, dietary habits, comorbidities, and immune metabolism in the progression of IBD. …”
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  20. 52800

    Facial Expression Recognition and Digital Images Infosecurity for Prevention Care System Application in Sudden Infant Death Syndrome Monitoring by Chih-Te Tsai, Chia-Hung Lin, Hsiang-Yueh Lai, Yu-En Cheng, Ping-Tzan Huang, Neng-Sheng Pai, Chien-Ming Li

    Published 2025-01-01
    “…For image infosecurity testing, the number of pixel changing rate (NPCR), unified averaged changed intensity (UACI), and structural similarity index measurement (SSIM) were employed to evaluate the performances for encryption and decryption processes, ensuring confidentiality, recoverability, and availability of transmitted images. …”
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