Deep learning-based computational approach for predicting ncRNAs-disease associations in metaplastic breast cancer diagnosis by Saleem Ahmad, Imran Zafar, Shaista Shafiq, Laila Sehar, Hafsa Khalil, Nida Matloob, Mehvish Hina, Sidra Tul Muntaha, Hamid Khan, Najeeb Ullah Khan, Samreen Rana, Ahsanullah Unar, Muhammad Azmat, Muhammad Shafiq, Yousef A. Bin Jardan, Musaab Dauelbait, Mohammed Bourhia

“…SHAP analysis identified key sequence motifs (e.g., "UUG") and structural free energy (ΔG = − 12.3 kcal/mol) as critical predictors, validated by PCA (82% variance) and t-SNE clustering. …”
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Decentralized fintech platforms adoption intention in cyber risk environment among GenZ: A dual-method approach using PLS-SEM and necessary condition analysis by Md Sharif Hassan, Nguyen Hong Mai, Nor Shaipah Abdul Wahab, Mohammad Bin Amin, Md Maruf Hassan, Judit Oláh

“…A total of 391 valid responses were received. The data were analyzed through partial least squares structural equation modeling (PLS-SEM) and necessary condition analysis (NCA). …”
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Comparison of Molnupiravir Exposure‐Response Relationships for Virology Response and Mechanism of Action Biomarkers With Clinical Outcomes in Treatment of COVID‐19 by Akshita Chawla, Ruthie Birger, Brian M. Maas, Youfang Cao, Hong Wan, Julie Strizki, Arthur Fridman, Amanda Paschke, Carisa deAnda, Wei Gao, Matthew L. Rizk, Wendy Painter, Wayne Holman, Susanne Sardella, George Painter, Julie A. Stone

“…E‐R relationships were best represented by an Emax structural model with reasonable consistency in the estimated AUC50s (~2.3‐fold), across the models, of 10,260 and 4390 nM*hr. for day 5 viral load change from baseline and LNS error rate, respectively. …”
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Mapping rapeseed (Brassica napus L.) aboveground biomass in different periods using optical and phenotypic metrics derived from UAV hyperspectral and RGB imagery by Chuanliang Sun, Chuanliang Sun, Weixin Zhang, Genping Zhao, Qian Wu, Wanjie Liang, Ni Ren, Hongxin Cao, Lidong Zou, Lidong Zou

“…Vegetation indices (VI), texture features (TF), and structural features (SF) were extracted from UAV hyperspectral and ultra-high-resolution RGB images to assess their correlation with rapeseed biomass at different growth stages. …”
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Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicryResearch in context by Xin Ma, Jian Zhang, Qianling Jiang, Yong-Xin Li, Guan Yang

“…Of note, half of these analogs could bind to MHC II and interact with TCR through structural modeling of the interaction using fine-tuned AlphaFold. …”
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Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failure by Zhenglong Guo, Yunfei Liu, Zhiming Zhou, Jianchao Chen, Lin Guo, Keke Liang, Yibin Hao, Bingtao Hao, Bin Yang, Shixiu Liao

“…Conclusions These findings suggest that the epigenetic dysregulation of cardiac stress-response and structural genes contributes to the pathogenesis of DCM-HF. …”
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A systematic review and meta-analysis: prevalence and clinical implications of anatomical variants of the hepatic portal vein by Juan José Valenzuela-Fuenzalida, Benjamín Rodríguez-Osorio, Cristian Salgado-Torres, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandro Bruna-Mejías, Roberto Avila-Sepulveda, Álvaro Becerra-Farfán, Macarena Rodríguez-Luengo, Juan Sanchis-Gimeno, Guinevere Granite, Héctor Gutiérrez-Espinoza

“…The knowledge of HPV and its anatomical variants is of utmost importance for both medical professionals and anatomists, as it is one of the vessels that collects blood from many important viscera found in the abdominal cavity, any structural alteration could be crucial in diagnosis and surgical procedures.…”
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Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project by Linda Sharp, Sarah Bailey, Colin Rees, Willie Hamilton, Dawn Craig, Joe West, David Humes, Gary Abel, James Turvill, Brian Nicholson, Chloe Thomas, Jim Chilcott, Colin Crooks, Olena Mandrik, John Whelpton

“…Cost-effectiveness improves as risk thresholds rise. High structural uncertainty around cancer progression during diagnostic delay and diagnosis of other serious bowel diseases considerably affects cost-effectiveness.Conclusions COLOFIT is likely to be more cost-effective than FIT alone and could help alleviate pressure on diagnostic services. …”
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Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects by Jeongah Oh, Sneha Muralidharan, Qing Zhao, Johannes Scholz, Iris D. Zelnik, Shani Blumenreich, Tammar Joseph, Tamir Dingjan, Pradeep Narayanaswamy, Hyungwon Choi, Heiko Hayen, Federico Torta, Anthony H. Futerman

“…The sphingolipidome contains thousands of structurally distinct sphingolipid (SL) species. This enormous diversity is generated by the combination of different long-chain bases (LCBs), N-acyl chains and head groups. …”
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Sociodemographic factors associated with trajectories of depression among urban refugee youth in Kampala, Uganda: A longitudinal cohort study by Zerihun Admassu, Sikky Shiqi Chen, Carmen H. Logie, Moses Okumu, Frannie MacKenzie, Robert Hakiza, Daniel Kibuuka Musoke, Brenda Katisi, Aidah Nakitende, Peter Kyambadde, Lawrence Mbuagbaw

“…Sociodemographic (older age, gender [cisgender women vs. cisgender men], longer time in Uganda), and socioecological (structural: unemployment, food insecurity; interpersonal: parenthood, recent intimate partner violence) factors were significantly associated with the sustained high trajectory of depression. …”
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Empowering knowledge graphs with hybrid retrieval-augmented generation for the intelligent mix scheme of mass concrete by Yuqing Shang, Zhijiang Ke, Peng Lin, Qianhui Ren, Wenshan Zhang, Xiongwu Wang, Xiaotao Li, Fuyuan Gong, Shiqi Wang, Baofa Wang, Zhengkui Xu, Minglun Sun, Shunli Tan

“…Firstly, a total of 1723 mix proportioning records collected from 15 hydropower stations were structurally extracted using a customized data transformation tool. …”
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Uncovering the breeding contribution of transposable elements from landraces to improved varieties through pan-genome-wide analysis in rice by Xiaoxia Li, Xiaoxia Li, Xiaofan Dai, Xiaofan Dai, Huiying He, Wu Chen, Qian Qian, Qian Qian, Lianguang Shang, Lianguang Shang, Longbiao Guo, Wenchuang He

“…Advances in pan-genomes and enhanced capacity for analyzing structural variations have increasingly highlighted their role in rice genetic improvement. …”
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Medium-Chain Acyl-CoA Deficiency: Outlines from Newborn Screening, In Silico Predictions, and Molecular Studies by Serena Catarzi, Anna Caciotti, Janita Thusberg, Rodolfo Tonin, Sabrina Malvagia, Giancarlo la Marca, Elisabetta Pasquini, Catia Cavicchi, Lorenzo Ferri, Maria A. Donati, Federico Baronio, Renzo Guerrini, Sean D. Mooney, Amelia Morrone

“…Bioinformatics predictions based on both phylogenetic conservation and functional/structural software were used to characterize the new identified variants. …”
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Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…Methods: This population-based cohort study used Swedish and Danish registry data for over 5.1 M individuals born between 1958 and 1993/1996. …”
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Temperature and excipient mediated modulation of monoclonal antibody interactions revealed by kD, rheology, and Raman spectroscopy by Olivia Noelle Eskens, Sabitoj Singh Virk, Akashdeep Singh Virk, Deepika Venkataramani, Maureen Crames, Maria Calderon Vaca, Matthew Matusewicz, Connor Smith, Joshin George, Collin Taylor, Michael S. Marlow, Samiul Amin

“…Raman spectral analysis of Amide I/III regions confirmed structural invariance under thermal and shear stress, attributing viscosity modulation to colloidal rather than conformational perturbations. …”
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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Despite studies conducted, there are no unambiguous data showing how IMQ affects the condition of tumor blood vessels. …”
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EXPERIMENTAL EVALUATION OF LONG-TERM ADVERSE SIDE EFFECTS OF CYTOSTATIC DRUGS ON FEMALE REPRODUCTIVE FUNCTION AND PHARMACOLOGICAL WAYS TO REDUCE THEM by T. G. Borovskaya, V. E. Goldberg, M. E. Poluektova, A. V. Vychuzhanina, Yu. A. Shchemerovа, V. A. Grigoreva, A. A. Ligacheva, E. A. Bokhan

“…Ovarian reserve was evaluated using morphological analysis of the ovaries using quantitative assessments of structural damage. Concentration of anti-Muller hormone in the blood of adult rats-females receiving etoposide and rhG-CS F were evaluated by enzyme immunoassay (IFA, ELISA , Cloud clone, Corp. …”
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Development of the 10-question household foodwork interactional assessment questionnaire (FIA-Q10) by Leah E. Cahill, Sharon I. Kirkpatrick, Catherine L. Mah, Jennifer LP. Protudjer, Cynthia Kendell, Mary E. Jung, Helen Wong, Ellen T. Crumley, Meghan Day, Karen T. Y. Tang, Yan Huang, Jyoti Sihag, Laura Brady, Karthik K Tennankore, Navdeep Tangri, Rebecca C. Mollard, Dylan MacKay

“…An optional accompanying module was developed to collect self-identified demographic data to provide context for understanding how social-structural positionality factors may interact to influence foodwork. …”
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Preliminary observations of glucose metabolism dysregulation in pediatric Huntington’s disease by Federica Graziola, Federica Rachele Danti, Martina Penzo, Antonio Spagarino, Eleonora Minacapilli, Marco Moscatelli, Federica Zibordi, Caterina Mariotti, Giovanna Zorzi, Giovanna Zorzi

“…Clinical, neuroimaging, and neuropsychological data were collected alongside metabolic assessments, including cerebrospinal fluid (CSF) and plasma glucose and lactate levels, CSF-to-serum glucose ratio, and red blood cell GLUT1 expression using the METAglut1 test. 18F-FDG PET imaging and brain MRI were performed to assess cerebral metabolism and structural changes.ResultsBoth patients exhibited progressive motor and cognitive decline with dystonia-parkinsonian features, learning disabilities, and behavioral disturbances. …”
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CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation by Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark

“…Furthermore, binding of one mAb, DCR‐2, to CD300f exposes a structural epitope recognized by a second CD300f mAb, UP‐D2. …”
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