Integrative analysis of saliva-derived exosomal proteome and lipidome for the diagnosis of esophageal squamous cell carcinoma by Wei Zhong, Jian Liu, Junhua Xie, Zhiyan Zhang, Zhiwen Gong, Zhixiang Yan, Qingdong Cao

“…The proteomic characteristics of ESCC were primarily manifested in immune responses, disruption of tissue structural homeostasis, and enhanced antifungal and antimicrobial humoral immune responses. …”
Get full text

Optimized enrichment of murine blood–brain barrier vessels with a critical focus on network hierarchy in post-collection analysis by Hanaa Abdelazim, Audra Barnes, James Stupin, Ranah Hasson, Carmen Muñoz-Ballester, Kenneth L. Young, Stefanie Robel, James W. Smyth, Samy Lamouille, John C. Chappell

“…Positioned between upstream arteries and downstream veins, these microvessels have unique structural features, such as the absence of vascular smooth muscle cells (vSMCs) and a relatively thin basement membrane, to facilitate highly efficient yet selective exchange between the circulation and the brain interstitium. …”
Get full text

Addressing System Challenges in Mental Health Services Research for Youth in the Child Welfare System: Insights From the Foster Care Family Navigator Trial by Marina Tolou‐Shams, Megan Ramaiya, Jannet L. Salas, Adrian Aguilera, Martha Shumway, Brian Borsari, Emily Dauria, Jill D. Berrick

“…Systems‐level challenges that impacted proposed research trial design and data collection included: (1) Limited system staff time and compensation processes; (2) Staff training and knowledge; and (3) System disruptions. …”
Get full text

A φSa3int (NM3) Prophage Domestication in Staphylococcus aureus Leads to Increased Virulence Through Human Immune Evasion by Roshan Nepal, Ghais Houtak, George Bouras, Sholeh Feizi, Gohar Shaghayegh, Keith Shearwin, Mahnaz Ramezanpour, Alkis James Psaltis, Peter‐John Wormald, Sarah Vreugde

“…Further, φSa3int prophage domestication led to reduced phagocytosis implying φSa3int prophage mediates escape of S. aureus from human innate immunity. Our data further show that in addition to adding novel prophage‐encoded virulence, φSa3int prophage domestication also affects the expression of non‐prophage (bacterial) genes and suppresses expression of structural proteins of resident prophages. …”
Get full text

Adsorptive Removal of Bisphenol A by Polyethylene Meshes Grafted with an Amino Group-Containing Monomer, 2-(Dimethylamino)ethyl Methacrylate by Kazunori Yamada, Saori Terada, Rena Yamamoto, Dương Cẩm Anh, Takaya Naitou, Sakura Yamamoto

“…The cycle of adsorption at pH 8.0 and desorption in a NaOH solution at 100 mM was repeated five times without loss or structural damage. These results indicate PE-g-PDMAEMA meshes can be used as a regenerative adsorbent for BPA removal from aqueous medium.…”
Get full text

Caregivers’ lived experiences of childhood probable pneumonia through a gendered lens in western Kenya by Sarah Hawi Ngere, Charles Olang'o, Kennedy Ochola, Patience Oduor, Caleb K. Sagam, Benard Ochieng, Dickens Omondi, Norbert Peshu, Erick Nyambedha

“…Contribution: This study’s findings emphasise the necessity of a holistic approach when developing intervention geared towards improving healthcare-seeking behaviour by considering the subtler factors beyond structural, social and economic influences.…”
Get full text

Association Between Anatomic and Clinical Indicators of Injury Severity After Moderate-Severe Traumatic Brain Injury: A Pilot Study Using Multiparametric Magnetic Resonance Imaging by Dmitry Esterov, Ziying Yin, Trevor Persaud, Xiang Shan, Mathew C. Murphy, Richard L. Ehman, John Huston III, Allen W. Brown

“…Future larger studies could lead to the development of prediction models that integrate clinical data with anatomical (MRI), structural (DTI), and mechanical (MRE) changes caused by TBI, to inform prognosis and care planning.…”
Get full text

Investigation of biomolecular dynamics by sensitivity-enhanced 1H–2H CPMAS NMR using matrix-free dynamic nuclear polarization by Thomas Biedenbänder, Aryana Rodgers, Mirjam Schröder, Liliya Vugmeyster, Björn Corzilius

“…Molecular dynamics of functional groups contain valuable information about structural properties and functional activities in biomolecules. …”
Get full text

Modelling economics students’ use of ChatGPT and academic performance: insights from self-determination theory and epistemic curiosity by Bernard Yaw Sekyi Acquah, Francis Arthur, Iddrisu Salifu, Enoch Mensah, Ernest Opoku, Sharon Abam Nortey, Solomon Adjatey Tetteh

“…The study used adapted scales of ICAP (i.e. measuring the use of ChatGPT), “desire to learn (DFL), self-efficacy (SE), beliefs about the future (BAF), epistemic curiosity (EP) and perceived academic performance (AP)”. Data were analysed using “partial least squares structural equation modelling (PLS-SEM) and fuzzy-set qualitative comparative analysis (fsQCA)”. …”
Get full text

Changes of EEG beta band power and functional connectivity during spaceflight: a retrospective study by Adrián Quivira-Lopesino, María Sevilla-García, Pablo Cuesta, Sandra Pusil, Ricardo Bruña, Patrique Fiedler, Ana Maria Cebolla, Guy Cheron, Michael Funke, Fernando Maestu

“…Astronauts often report temporary neurological symptoms, such as disorientation, visual disturbances, and motor issues, potentially linked to structural and electrophysiological brain changes. To investigate this, electroencephalography (EEG) is a reliable tool to study brain activity in space, measuring oscillatory activity and functional connectivity (FC). …”
Get full text

The interplay of coping styles and optimism/pessimism in shaping mental health in long-term survivors of malignant melanoma: a register-based cohort study by Judith Hirschmiller, Tamara Schwinn, Sabine Fischbeck, Ana Nanette Tibubos, Jörg Wiltink, Rüdiger Zwerenz, Sylke R. Zeissig, Elmar Brähler, Manfred E. Beutel, Mareike Ernst

“…We assessed sociodemographic and disease-related variables, optimism/pessimism (LOT-R), coping strategies (BC), depressive (PHQ-9), and anxiety symptoms (GAD-7). A structural equation model was conducted to analyse the hypothesized associations, modelling coping strategies (denial/self-blame, seeking external support, active coping) as mediators of the relationship of optimism/pessimism with depressive and anxiety symptoms. …”
Get full text

Comparison of the Metabolic Profiles Associated with Protonitazene and Protonitazepyne in Two Severe Poisonings by Romain Magny, Thomas Schiestel, Aymen M’Rad, Bertrand Lefrère, Jean-Herlé Raphalen, Stanislas Ledochowski, Laurence Labat, Bruno Mégarbane, Pascal Houzé

“…<b>Concusions</b>: To conclude, nitazene detection is highly challenging due to its extensive structural and metabolic diversity. Our findings highlight the contribution of the untargeted LC-HRMS screening approach and suggest that diagnostic product ions can serve as robust markers for nitazene identification.…”
Get full text

SHAZAM: Self-Supervised Change Monitoring for Hazard Detection and Mapping by Samuel Garske, Konrad Heidler, Bradley Evans, Kee Choon Wong, Xiao Xiang Zhu

Get full text

Generative AI and sustainable policy implementation: Expanding UTAUT2 to examine sustainable policy alignment and ambiguity impact on street-level bureaucrats’ discretion by Mohammed Salah, Alhamzah Alnoor, Fadi Abdelfattah, Khalid Dahleez, Saleh Al Sinawi, Jabbar Salman Hussein, Ahmed Kadim Bareas, Maria Mohd Ismail, Hussam Al Halbusi

“…By extending the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) to include sustainable policy alignment and policy ambiguity as moderating factors, the research explores how these policy elements influence the relationship between GenAI adoption and SLBs’ discretionary actions. Data was collected from 489 SLBs and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). …”
Get full text

Teacher perspectives on the socio-ecological barriers and enablers to food and nutrition education in primary schools: a scoping review by Emma K Esdaile, Lee Wharton, Helen Vidgen, Danielle Gallegos

“…These were (i) perceived food and nutrition responsibilities of teachers, (ii) teacher beliefs and self-efficacy, (iii) opportunities to build teacher nutrition knowledge and self-efficacy, (iv) interpersonal contributors and (v) broader environmental, structural and policy contributors. Conclusions: Multiple strategies are needed to build the capacity of teachers to undertake FNE within primary school settings. …”
Get full text

Identification of Recombinant Aichivirus D in Cattle, Italy by Francesco Pellegrini, Gianvito Lanave, Francesca Caringella, Georgia Diakoudi, Anna Salvaggiulo, Alessandra Cavalli, Alessandro Papaleo, Barbara Di Martino, Michele Camero, Krisztián Bányai, Jelle Matthijnssens, Vito Martella

“…Interestingly these three Aichivirus D strains showed a recombinant makeup, clustering with D1 genotype in the capsid region and with D2 genotype in the non-structural genes. These findings suggest that Aichivirus D KoVs are common components of livestock virome. …”
Get full text

Substrate stiffness-dependent metabolic reprogramming of iPSC-derived cardiomyocytes on physiological PDMS polymers by Leena Patel, Bryan P. Marzullo, Jonathan Barlow, Himani Rana, Amar J. Azad, Patricia Thomas, Daniel A. Tennant, Katja Gehmlich

“…Many cardiac pathologies are characterised by increased stiffness of the myocardium, due to excess deposition of extracellular matrix (ECM) proteins and structural remodelling, impacting the behaviour of cardiomyocytes (CMs). …”
Get full text

Specific Premature Ventricular Complex Characteristics in Women: Insights from a Patient Cohort by Ștefan Ailoaei, Laurențiu Șorodoc, Carina Ureche, Nicolae Sîtari, Alexandr Ceasovschih, Mihaela Grecu, Radu Andy Sascău, Cristian Stătescu

“…Patients with LGE were older and had worse clinical outcomes, including higher ICD implantation and hospitalization rates. Despite these structural differences, treatment efficacy was similar across groups. …”
Get full text

The Energy Footprint in the EU: How CO₂ Emission Reductions Drive Sustainable Development by Dariusz Sala, Oksana Liashenko, Michał Pyzalski, Kostiantyn Pavlov, Olena Pavlova, Karol Durczak, Roman Chornyi

“…Economic crises, such as the 2008 financial collapse and the COVID-19 pandemic, have led to temporary declines in emissions; however, lasting achievements in sustainability require structural transformations rather than short-term disruptions. …”
Get full text

Integrating advanced synthesis techniques and AI-driven approaches with nanofiber technology: A state-of-the-art approach to wound care management by Nisha Shankhwar, Awadhesh Kumar Verma, Ashab Noumani, Tanya Singh, Kalakuntla Sriharshitha Rao, Vivekanand, Neeta Raj Sharma, Satyendra Singh

“…This review emphasizes the ground-breaking potential of nanofiber technology, a novel approach that imitates the extracellular matrix (ECM) to promote targeted therapeutic administration and support cellular regeneration. Because of their structural compatibility with skin tissue, nanofiber dressings enhance natural healing, maintain optimal moisture levels, and significantly reduce the risk of infection. …”
Get full text