A Metabolomic Strategy to Screen the Prototype Components and Metabolites of Shuang-Huang-Lian Injection in Human Serum by Ultra Performance Liquid Chromatography Coupled with Quad... by Mingxing Guo, Baosheng Zhao, Haiyu Liu, Li Zhang, Long Peng, Lingling Qin, Zhixin Zhang, Jian Li, Chengke Cai, Xiaoyan Gao

“…This identification and structural elucidation of the chemical compounds provided essential data for further pharmacological and pharmacokinetics study of SHLI.…”
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Echocardiographic Assessment of Embryonic and Fetal Mouse Heart Development: A Focus on Haemodynamics and Morphology by Nathan D. Hahurij, Emmeline E. Calkoen, Monique R. M. Jongbloed, Arno A. W. Roest, Adriana C. Gittenberger-de Groot, Robert E. Poelmann, Marco C. De Ruiter, Conny J. van Munsteren, Paul Steendijk, Nico A. Blom

“…High-frequency echocardiography is a promising and useful imaging modality for structural and hemodynamic analysis of embryonic/fetal mouse hearts.…”
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Person-centred care of people living with dementia and its regulation in German-speaking nursing homes: A qualitative focus group study by Anna Louisa Hoffmann-Hoffrichter, Andreas Hohmann, Bernhard Holle, Rebecca Palm, Martina Roes

“…Leadership is inextricably linked to other elements, such as setting priorities, mindset, structural requirements, internal regulations and outcomes. …”
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…IntroductionWhile the adjustment of intracranial volume (ICV) is reported to have a significant influence in the outcomes of the analyses of brain structural measures, our study offers a paradigm shift, positing that adjusting for lateral ventricle (LV) inter-individual variability may reveal more atrophic patterns that might be overlooked in analyses without this adjustment,—and such LV-adjusted atrophic patterns may reduce discrepancies observed in earlier studies and better elucidate complex conditions associated with HIV, such as HAND.MethodsTo test this hypothesis, we employed a number of adjustment strategies on MRI T1-image-derived data extracted using deep learning models and compared their ability to identify the presence and extent of HIV-specific atrophic patterns based on statistical measures and strength.ResultsOur results show that both ICV adjustments may be effective to identify atrophic patterns associated with either aging or HIV in areas of the thalamus, basal ganglia, ventral DC and lateral ventricle, some of which may be overlooked without these adjustments. …”
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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors by Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel

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Hepatoblastoma regional trends: dynamic SDI & joinpoint regression analysis by Miao Jia, Enyang He, Wenjing Sun, Hualei Cui, Hailan Zhao, Wei Zhao, Wei Liu, Zhenhua Guo, Yi Wang, Wei Feng

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Label‐Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening by Xiaofei Luo, Maike Chen, Han Shan, Xize Yu, Qibo Lin, Qian Tao, Xiongwei Wei, Changling Lv, Ziyan Chen, Fan Zhuo, Xi Zhu, Jiaxing He, Zhaoxi Li, Chunlong Fei, Jing Xu, Juan Su, Zeyu Chen, Shuang Zhao, Xiang Chen

“…The capabilities of the LFOPI system are evaluated by monitoring structural transformations in melanoma organoids. The LFOPI system is further employed for volumetric drug screening of melanoma tumor organoids. …”
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Uncovering the genetic architecture of inherited retinal disease in a consanguineous Iranian cohort by Lieselot Vincke, Kristof Van Schil, Hamid Ahmadieh, Afrooz Moghaddasi, Hamideh Sabbaghi, Narsis Daftarian, Tahmineh Motevasseli, Leila Javanparast Sheykhani, Mohammadreza Dehghani, Mohammad Yahya Vahidi Mehrjardi, Julie De Zaeytijd, Marieke De Bruyne, Quinten Mahieu, Ebrahim Al-Hajj, Marta Del Pozo-Valero, Toon Rosseel, Mattias Van Heetvelde, Reza Maroofian, Fatemeh Suri, Miriam Bauwens, Elfride De Baere

“…Variants in ROHs were found in 82.8% of patients from consanguineous backgrounds. The importance of structural variation (SV) was demonstrated, with CNVs identified in 5.3%, including several novel CNVs. …”
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Fractional amplitude of low-frequency fluctuations during music-evoked autobiographical memories in neurotypical older adults by Teresa Lesiuk, Kaitlyn Dillon, Giulia Ripani, Ioannis Iliadis, Gabriel Perez, Bonnie Levin, Xiaoyan Sun, Roger McIntosh

“…In addition to a T1 structural scan, neuroimaging data were collected while participants listened to familiar music (MEAM retrieval) versus unfamiliar music.ResultsWhen listening to familiar compared to unfamiliar music, greater fALFF activation patterns were observed in the right parahippocampal gyrus, controlling for age and GMV. …”
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Public policy and sustainability: How green core competence, government trust, and policy satisfaction influence green R&D investments in the private sector by Fadi Abdelfattah, Mohammed Salah, Khalid Dahleez, Riyad Darwazeh, Hussam Al Halbusi

“…Grounded in Dynamic Capabilities Theory and Institutional Theory, it explores the relationship between Green Product Innovation Performance (GPIP), Green Process Innovation Performance (GPcIP), Green Core Competence (GCC), and Green Research and Development (R&D) Investments. Data collected from 214 top management personnel across diverse industries in Oman were examined via Structural Equation Modeling. …”
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In Vitro Antioxidant, Antithrombotic and Anti-Inflammatory Activities of Bioactive Metabolites Extracted from Kiwi and Its By-Products by Anastasia Maria Moysidou, Konstantina Cheimpeloglou, Spyridoula Ioanna Koutra, Vasileios Manousakis, Anna Ofrydopoulou, Katie Shiels, Sushanta Kumar Saha, Alexandros Tsoupras

“…Polar lipid structural analysis revealed a predominance of phospholipids with unsaturated fatty acids at the sn-2 position. …”
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Translation, cross-cultural adaptation, and psychometric properties of the Finnish version of the Malocclusion Impact Questionnaire (MIQ) by Lucas Arrais Campos, Terhi Kaikkonen, Kaisa Ylitervo, Leena Ylikontiola, Anna-Sofia Silvola

“…Psychometric properties were estimated using factorial validity (confirmatory factor analysis [CFA]), convergent validity (Average Variance Extracted [AVE]), and reliability (αordinal and ω). Structural Equation Model estimated the effect of demographic characteristics on malocclusion impact. …”
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Study of Lysozyme Activity in Bird Egg Whites by Fluorescence Polarization Assay Using Chitooligosaccharide Tracer by Liliya I. Mukhametova, Dmitry O. Zherdev, Anton N. Kuznetsov, Olga N. Yudina, Sergei A. Eremin, Vadim B. Krylov, Nikolay E. Nifantiev

“…Lysozyme activity in the egg whites of duck, goose, turkey, peacock, and ostrich eggs has not been detected by using the obtained chitooligosaccharide tracers, which may be related to the structural features of lysozyme in different bird species. …”
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Effect of atomic ratio of ions on the particle diffusion and permeability of carbon nanotubes in reverse electrodialysis process using molecular dynamics simulation by Ali B.M. Ali, Karwan Hussein Qader, Murtadha M. Al-Zahiwat, Narinderjit Singh Sawaran Singh, Soheil Salahshour, S. Mohammad Sajadi, Ali Mokhtarian

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A novel missense pathogenic variant c.9455T > G (p.L3152R) in CDH23 underlies autosomal recessive non-syndromic hearing loss by Ladan Sadeghian, Marziyeh Hoseinzadeh, Mohammad reza Pourreza, Saeed Khalili, Najmeh Fattahi, Mohammad Amin Tabatabaiefar

“…This study aimed to identify the genetic cause of autosomal recessive non-syndromic hearing loss (ARNSHL) in a large Iranian family using next-generation sequencing and structural bioinformatics. Methods After a comprehensive clinical evaluation of a large family with a history of HL the GJB2 gene was sequenced, and 7 loci were screened through genetic linkage analysis. …”
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Aligning the principles and practice of research integrity and research fairness in global health: a mixed-methods study by Sandra Alba, Rutuja Patil, Martijn Wienia, Masja Straetemans, Francis Kombe, Gowri Gopalakrishna, Harry Coleman, Nima Yaghmaei, Joseph Bukulu Sempa, Jake D Mathewson, Hannah Kabelka, Preeti Sohoni

“…Despite extensive academic discussions, empirical data on these aspects, especially in the context of global health, remain limited.Methods To address this gap, we conducted a mixed-methods study focusing on research integrity and fairness. …”
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Culinary connections: The mediating role of customer brand co-creation behavior in gastronomic and revisit intentions by Ni Made Purnami, Ni Wayan Mujiati, Ayu Putu Laksmi Danyathi, Uswatun Siwi Kartika Sari, Desak Komang Dea Marcellina Putri Darmada

“…This study investigates the mediating role of customer brand co-creation behavior in the effect of gastronomic experience on revisit intention among Generation Z café visitors in Bali, Indonesia. Data were collected from 250 respondents via an online survey and analyzed using Partial Least Squares Structural Equation Modeling. …”
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Longitudinal study of foot-and-mouth disease virus in Northern Nigeria: implications for the roles of small ruminants and environmental contamination in endemic settings by Simon Gubbins, Emma Brown, Yiltawe Wungak, Olumuyiwa Oyekan, Adeyinka J. Adedeji, Sandra I. Ijoma, Rebecca B. Atai, Moses O. Oguche, Mark Samson, Banenat B. Dogonyaro, Fabrizio Rosso, Hayley Hicks, Britta A. Wood, Jemma Wadsworth, Nick Knowles, Donald P. King, Anna B. Ludi, Claire Colenutt, Andrew E. Shaw, Georgina Limon, David O. Ehizibolo

“…Serum samples (n = 780) were also tested for the presence of antibodies against FMDV non-structural proteins. The proportion of FMDV RNA positive samples increased in all sample types collected in one LGA during the period when an FMD outbreak was reported in the same LGA. …”
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Technology Anxiety in Virtual Reality Adoption: Examining the Impact of Age, Past Experience, and Cybersickness by Eman Al Khalifah, Ramy Hammady, Mahmoud Abdelrahman, Ons Al-Shamaileh, Mostafa Marghany, Hatana El-Jarn, Alyaa Darwish, Yusuf Kurt

“…Using an extended Technology Acceptance Model (TAM), the research integrates age and past use as antecedents of TA and evaluates their influence on perceived ease of use (PEoU), perceived enjoyment (PENJ), and user attitudes. Data from 206 participants were analysed using Partial Least Squares Structural Equation Modelling (PLS-SEM) following a VR pilgrimage experience. …”
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A multi-species corridor between the Andean Amazonian and Amazon floodplain landscapes: prioritizing ecological connectivity areas for jaguar and threatened ungulates in the north-... by Federico Mosquera-Guerra, Sebastian Barreto, Juan D. Palencia-Rivera, Alexander Velásquez-Valencia, Hugo Mantilla-Meluk, Gustavo A. Bruges-Morales, Alex M. Jiménez-Ortega, Fernando Trujillo, Dolors Armenteras-Pascual

“…However, there has been a lack of structural connectivity analysis in the Andean Amazonian and Amazon floodplain landscapes using a multi-species approach that considers predator–prey relationships among representative groups such as large felids and wild ungulate species. …”
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