Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular outcomes in older adults with type 2 diabetes mellitus:... by Weihong Zeng, Tiansheng Wang, Til Stürmer, Na He, Peng Shen, Hongbo Lin, Xiaodong Guan, Yang Xu

“…Propensity scores were calculated to balance 44 identified confounders. Marginal structure models were applied to estimate per-protocol hazard ratios. …”
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Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis by Xize Wu, Yuxi Huang, Jiaqi Ren, Xue Pan, Qiuying Wu, Qicheng Cai, Ruiying Wang, Teng Feng, Shan Gao, Bo Wang, Meijia Cheng, Meijia Cheng, Yue Li, Lihong Gong

“…Single-cell data analyzes the gene structure and gene expression status of individual cells.ResultsSix ASLMRFeGs (CTSB, CYBB, DPP4, HILPDA, HMOX1, IL1B) alter the immune microenvironment in AS. …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…Cardiovascular magnetic resonance were utilized to assess RV structure, function, and global myocardial strain [including peak strain (PS), peak systolic (PSSR) and diastolic strain rate (PDSR) in longitudinal, circumferential, and radial directions]. …”
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Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation by Jessica Hernandez, Fabian Johannes Pflieger, Julia Schäffer, Leona Bähr, Jenny Schneiders, Thomas Reichel, Marita Meurer, Marita Meurer, Benjamin Lamp, Natali Bettina Bauer, Karsten Krüger, Lois Harden, Maren von Köckritz-Blickwede, Maren von Köckritz-Blickwede, Christoph Rummel, Christoph Rummel, Christoph Rummel

“…At 4 h or 24 h after LPS-stimulation, brain and serum samples were collected and analyzed for peripheral and brain inflammatory markers.ResultsAfter stimulation with LPS, PMN-pretreated mice showed neutropenia (significantly by ~25% of the control value) and attenuated NG recruitment to the brain in a structure dependent manner. LPS-induced hypothermia was more severe in PMN-pretreated mice while other physiological parameters were only altered by LPS alone. …”
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The potential spatiotemporal distribution patterns of Avena nuda and Avena sativa from global perspective provide new insights for the cultivation of commonly cultivated oats by Huanhuan Lu, Yuying Zheng, Ting Zhao, Liuban Tang, Fan Zhang, Wengang Xie

“…Abstract Background Commonly cultivated oats (Avena nuda and Avena sativa) play an important role in agricultural planting structure adjustment, ecological environment protection and grassland animal husbandry development, and their effective cultivation is conducive to food security and grassland degradation restoration. …”
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In situ endoscopic photodynamic therapy combined with immature DC vaccination induces a robust T cell response against peritoneal carcinomatosis by Davide Brusa, Caroline Bouzin, Charline Degavre, Anouk Lepez, Sebastien Ibanez, Clémence François, Katarzyna Głowacka, Céline Guilbaud, Florine Laloux-Morris, Hrag Esfahani, Olivier Feron

“…These actions induced the sequential activation of CD8+ and CD4+ T cells as revealed by a significant spheroid 3D structure deterioration and, remarkably, were not recapitulated by conventional ferroptosis inducer RSL3. …”
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Reduction of mangrove carbon stock ecosystems due to illegal logging using a combination of unmanned aerial vehicle imagery and field surveys by M. Basyuni, R. Amelia, A.A. Aznawi, A. Wirasatriya, S.B. Iryanthony, B. Slamet, S.S. Al Mustaniroh, R. Rahmania, Y.I. Rahmila, E. Sumarga, S.H. Larekeng, S. Salmo III, T. Kajita, I. Sivaipram, H.M. Ali

“…Both research sites produced orthophotos and digital surface models, and the integration of unmanned aerial vehicle with the photometry approach led to the development of the structure from motion method of data processing.FINDINGS: This study compared carbon stores in the mangrove forest of Lubuk Kertang Village in 2022 with carbon stock in 2023 or after the recurrence of illegal logging using an unmanned aerial vehicle photogrammetric field survey. …”
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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibit­ed normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
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Analogs of Precambrian microbial communities formed de novo in Caucasian mineral water aquifers by Daria G. Zavarzina, Alexey A. Maslov, Alexander Y. Merkel, Nataliya A. Kharitonova, Alexandra A. Klyukina, Ekaterina I. Baranovskaya, Elena A. Baydariko, Evgeniy G. Potapov, Kseniya S. Zayulina, Andrey Y. Bychkov, Nikolay A. Chernyh, Elizaveta A. Bonch-Osmolovskaya, Sergey N. Gavrilov

“…Correlation analysis of the obtained data revealed stable and highly stratified microbial communities inhabiting four distinct ecosystems. Their structure and the metabolic traits of their prokaryotic populations were similar to those presumed to have dominated the Earth’s biosphere during several critical periods of its evolutionary history, that is, the Early Archean, the period of banded iron formations accumulation, and the Great Oxidation Event. …”
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Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysisResearch in context by Wanqing Dong, Jie Bai, Qibin Yuan, Yingyu Zhang, Yongjiang Zhang, Ziyue Zhang, Maoxing Yang, Hanxiao Li, Ziyue Zhao, Hongwei Jiang

“…Pathological assessments revealed improvements in neuronal structure and brain tissue integrity in the mazdutide-treated group. …”
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Assessing eco-physiological patterns of Ailanthus altissima (Mill.) Swingle and differences with native vegetation using Copernicus satellite data on a Mediterranean Island by Flavio Marzialetti, Vanessa Lozano, André Große-Stoltenberg, Maria Laura Carranza, Michele Innangi, Greta La Bella, Simonetta Bagella, Giovanni Rivieccio, Gianluigi Bacchetta, Lina Podda, Giuseppe Brundu

“…A set of spectral eco-physiological indices proxies related to leaf chlorophyll and carotenoid content (Chlorophyll Vegetation Index − CVI, Structure Intensive Pigment Index 3 − SIPI3), productivity and canopy biomass (Enhanced Vegetation Index − EVI, Leaf Area Index − LAI), leaf water content (Normalized Multi-band Drought Index − NMDI, Moisture Stress Index − MSI), daily evapotranspiration (ET), and soil features (Coloration Index − CI) were calculated. …”
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Usefulness of differential somatic cell count for udder health monitoring: Association of differential somatic cell count and somatic cell score with quarter-level milk yield and m... by Mariana Fonseca, Daryna Kurban, Jean-Philippe Roy, Débora E. Santschi, Elouise Molgat, Simon Dufour

“…Given the hierarchical structure of the data, a linear mixed model was built with either milk yield or milk components as the outcomes. …”
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Development and validation of a multidimensional, culturally and socially inclusive Child Resilience Questionnaire (parent/caregiver report) to measure factors that support resilie... by Deirdre Gartland, Elisha Riggs, Rebecca Giallo, Stephanie Janne Brown, Karen Glover, Kelsey Hegarty, Amanda Mitchell, Jane Yelland, Josef Szwarc, Sue Casey, Donna Weetra, Mardi Stowe, Sharon Mongta, Helen Herman, Selena White, Tanya Koolmatrie, Georgie Paxton

“…Recruitment via a large tertiary hospital’s outpatient clinics, Aboriginal and refugee background communities (Aboriginal and bicultural researchers networks) and nested follow-up of mothers in a pregnancy cohort and a cohort of Aboriginal families.Analysis Exploratory and confirmatory factor analyses conducted to assess the structure and construct validity of CRQ-P/C subscales. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
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Targeting YY1-DR5 Axis by Pyripyropene O as a Novel Therapeutic Strategy Against Prostate Cancer: Molecular Mechanisms and In Vivo Zebrafish Validation by Wenxuan Fang, Ying Chen, Mingyi Nie, Xuefeng Zhou, Yonghong Liu, Huaming Tao, Bin Yang, Xueni Wang

“…Transmission electron microscopy was used to observe the changes in the internal structure of prostate cancer cells after treatment with pyripyropene O. …”
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Insight into hybridization of iron scrap derived Fe3O4 on TiO2: Facile synthesis of an eco-friendly photocatalyst, characterization, and photoelectric properties by Bonface Orero, Tumeletso Lekgoba, Major Mabuza, Joyce Elisadiki, Thandiwe Sithole, Freeman Ntuli, Tebogo Mashifana

“…In addition, PL revealed prolonged electron-hole recombination in TiO2-Fe3O4 hybrid, confirming an improved charge separation due to Fe3O4 mixed valence state structure, which prevents charge carrier accumulation and induces electron hopping between the Fe ions. …”
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Genome-Wide Identification and Expression Analysis of Pseudo-Response Regulators (PRRs) in the Tea Plant <i>Camellia sinensis</i> (L.) O. Kuntze by Lili Ye, Huaqian Xue, Nana Li, Meng Ye, Jianyan Huang, Xinchao Wang, Juan Wu, Changqing Ding

“…Domain, phylogenetic evolution, gene structure, motifs, and <i>cis</i>-acting element analysis revealed their sequence characters and suggested that the first subgroup members, <i>CsPRR1a</i>, <i>1b</i>, <i>5a</i>, <i>5b</i>, <i>7</i>, and <i>37</i>, may be responsible for circadian rhythm regulation and abiotic stress responses, while the second subgroup member, <i>CsPRR2</i>, may be involved in development and chloroplast function regulation. …”
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Dynamics of heart rate variability in rats with streptozotocin-induced diabetes by Maria P. Morozova, Svetlana A. Gavrilova, Evgeniy V. Ivanov, Anna M. Gorbacheva, Ekaterina M. Rzhavina, Aleksey K. Erdyakov, Zera N. Dzhemilova, Ekaterina V. Artemova, Alla Y. Tokmakova, Vladimir B. Koshelev, Gagik R. Galstyan

“…The reaction to CP in the SD group differs from the norm by the severity of the individual components of the HRV structure, which indicates functional denervation of the heart and the development of diabetic neuropathy. …”
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RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral dis... by Weibin Chen, Defang Li, Lihan Chen, Jichang Fei, Mengxuan Bian, Qingmin Zeng, Zengxin Jiang, Jingping Wu

“…In vivo, RTA 408 preserved disc structure, decreased Pfirrmann scores, and improved MRI indices (enhanced T2 signal intensity). …”
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Effectiveness of clindamycin-based exposure strategies in experimental mature staphylococcal biofilms by S. C. J. van Dun, M. Verheul, B. G. C. W. Pijls, H. Scheper, A. M. van der Does, P. H. Nibbering, M. G. J. de Boer

“…Confocal laser scanning and atomic force microscopy were applied to evaluate the biofilm structure. Single exposure to clindamycin for 24 h or prolonged up to 72 h did not result in any relevant reduction in bacterial load. …”
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