Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice by Ashish Kumar Tripathi, Sadaf Dabeer, Jun Song, Tatyana Vikulina, Susanne Roser-Page, Jessica A. Alvarez, David. R. Archer, M. Neale Weitzmann

“…To investigate HU action on SCD-related vertebral defects, we used HU-treated “Townes” mice, an SCD animal model and performed high-resolution micro-computed tomography (µCT) imaging to resolve bone volume and micro-architectural structure of cortical and trabecular bone, the two major compartments contributing to bone mass and strength. …”
Get full text

A KLJN-Based Thermal Noise Modulation Scheme With Enhanced Reliability for Low-Power IoT Communication by Mohammed A. Salem, Hossam M. Kasem, Roayat I. Abdelfatah, Mohamed Youssef El-Ganiny, Radwa A. Roshdy

“…We propose P-Ther-Mod, a new asymmetric KLJN-based modulation scheme, which utilizes a four-resistor structure in order to improve the bit error rate (BER) without imposing additional noise samples per bit. …”
Get full text

Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study. by Jeannette Simino, Zhiying Wang, Jan Bressler, Vincent Chouraki, Qiong Yang, Steven G Younkin, Sudha Seshadri, Myriam Fornage, Eric Boerwinkle, Thomas H Mosley

“…Following inverse normal transformation of the residuals, seqMeta was used to conduct race-specific single-variant and gene-based association tests while adjusting for population structure. Linear regression models were fit on autosomal variants with minor allele frequencies (MAF)≥1%. …”
Get full text

Relation between Uric Acid Levels, Creatinine and Body Mass Index in Hypertensive Women and Men by Sklyarov E., Pylypiv O., Gutor T.

“…Arterial hypertension is taking one of the leading places in the structure of cardiovascular morbidity. As you know, obesity, hypodynamia, excessive intake of food salt, hypercholesterolemia, tobacco smoking, excessive use of alcohol are important among the risks of hypertension. …”
Get full text

Developing Immunoniosomes (INs): Antibody and Fab conjugations of niosomal nanoparticles via UV-NBS and EDC/NHS chemistry for treating glioblastoma cells by Nilufer Cakir, Hatice Oncel, Aylin Ozkan, Dilan Bicak, Sibel Akgun Bas, Nur Mustafaoglu

“…This study introduces immunoniosomes (INs), a novel class of antibody-conjugated niosomes, through two conjugation strategies: (i) UV-NBS, a site-specific covalent conjugation method utilizing an indole ring structure for moderate binding to the variable regions of antibodies and Fab fragments, and (ii) EDC/NHS chemistry, which conjugates antibodies to carboxylated niosomes via primary amines on lysine sidechains. …”
Get full text

Preparation of Ammonium Phosphotungstate Composite Loaded with Silica-calcium Alginate Hybrid Material and Its Adsorption Performance for Cs+ by DIAO Xinya1, 2, FAN Ye1, 2, HAO Lecun1, 2, ZHAO Xin1, 2, JIN Qiang1, 2, , CHEN Zongyuan1, 2, GUO Zhijun1, 2

“…Although ammonium phosphotungstate (AWP) has shown notable selectivity for Cs+ adsorption in HLLW, the micro-crystalline structure and fine powder morphology of AWP limit its industrial application with column separation. …”

The perspective of ceRNA regulation of circadian rhythm on choroidal neovascularization by Ying Yang, Shu Su, Jia Chen, Xiaowei Yang, Shenglai Zhang, Aimin Sang

“…GO and GSEA showed that the upregulated DEGs were mainly involved in reproductive structure development and reproductive system development. …”
Get full text

Sympathetic nerves are sparsely distributed in rat mesenteric perivascular adipose tissue by William F. Jackson, Emma D. Flood, D. Adam Lauver, Gregory D. Fink, Stephanie W. Watts, Brian D. Gulbransen

“…Z-stacks of the fluorescently labeled tissues were then acquired and fluorescence of labeled structure quantified in background-subtracted, maximum-intensity z-projections after thresholding. …”
Get full text

Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhibit ferroptosis in chondrocytes by Wenli Guan, Fahu Yuan, Xin Wang

“…The study confirmed that DHT IIA could improve the articular cartilage structure of OA rats by elevating PPARγ and inhibiting ferroptosis. …”
Get full text

Impact of physician group practice in the operations, quality of care, and service satisfaction in the non-urgent section of an emergency department in a tertiary hospital in the P... by Ma. Lourdes Concepcion D. Jimenez, Mark B. Carascal, Marlouie D. Figueras, John Q. Wong, Roemer D. Tanghal, Veincent Christian F. Pepito, Rafael Manzanera

“…In the quantitative and qualitative ratings, most patients provided positive citations on ED service quality, staff, structure, system, physician competency and compassion. …”
Get full text

Building Engagement‐Capable Environments for Health System Transformation: Development and Early Implementation of a Capability Framework for Patient, Family and Caregiver Engageme... by Julia Abelson, Laura Tripp, Reham Abdelhalim, Lotje Hives, Betty‐Lou Kristy, Maureen Smith, Laura Tenhagen, Lindsay Wingham‐Smith, the Engagement Capable OHT Working Group

“…We addressed this gap by developing a capability framework for Ontario Health Teams (OHTs), a newly established structure for planning, designing, organizing and delivering care in Ontario, Canada. …”
Get full text

High school students’ perceptions of the modern teacher image by E. A. Petrova, N. N. Akimova, A. V. Romanova, I. E. Sokolovskaya

“…Such method allowed the authors to structure the students’ ideas about the image of the teacher by categories related to personal characteristics: attitude to own profession, attitude to students and educational activities. …”
Get full text

Chitosan/Sodium Tripolyphosphate/Sodium Alginate/miRNA-34c-5p Antagomir Scaffolds Promote the Functionality of Rabbit Cranial Parietal Repair by Lin C, Bai X, Zhang L

“…SEM revealed scaffolds had the porous spongy structure. Cell activity staining confirmed the excellent biocompatibility of the CTS scaffolds. …”
Get full text

Parallel Jacobian Computation Based on Distance-2 Algorithm and Its Application in Coupling Problems by LIU Lixun, ZHANG Han, PENG Xinru, DOU Qinrong, WU Yingjie, GUO Jiong, LI Fu

“…By exploiting the sparsity of the Jacobian matrix, all structurally orthogonal columns can be computed simultaneously through one function evaluation. …”

Burden of Diabetes Mellitus in Nepal: An Analysis of Global Burden of Disease Study 2019 by Achyut Raj Pandey, Krishna Kumar Aryal, Niraj Shrestha, Dikshya Sharma, Jasmine Maskey, Meghnath Dhimal

“…Meanwhile, the current federal structure could be an opportunity for integrated, locally tailored public health and clinical interventions for the prevention of the disease and its consequences.…”
Get full text

INDIVIDUAL STYLE OF PROFESSIONAL ACTIVITY OF FUTURE PSYCHOLOGISTS: ESSENCE AND WAYS OF FORMATION IN THE EDUCATIONAL PROCESS OF A HIGHER EDUCATION INSTITUTION by Volkova Nataliia, Bykova Viktoriia

“…The content of the individual style of future psychologists’ professional activity includes motivational-value (a system of motives, and value attitudes); cognitive (a set of knowledge about the essence and structure of the individual style of professional activity of future psychologists, ways of its formation); personal-active (methods, techniques, procedures, productive technologies, and tools of implementing psychological knowledge in work by specialities); reflective-evaluative components (an ability to professional and personal reflective). …”
Get full text

Trait dissociation in borderline personality disorder: influence on immediate therapy outcomes, follow-up assessments, and self-harm patterns by Ana Macchia, David Mikusky, Cedric Sachser, Annabel Sandra Mueller-Stierlin, Sandra Nickel, Niklas Sanhüter, Birgit Abler

“…Based on the estimated network structure, treating dissociative symptoms could potentially mitigate self-injury while especially childhood emotional abuse was linked with suicide attempts.…”
Get full text

Loneliness and mental burden among German medical students during the fading COVID-19 pandemic: a mixed-methods approach by Marvik Leich, Jennifer Guse, Corinna Bergelt, Corinna Bergelt

“…Students' responses underscore the need for improved academic support by eased study program structure, improved counseling, and tailored services for students of different study years.…”
Get full text

Cost-Benefit Analysis of Genetic Testing as a Prenatal Diagnostic Tool for Thalassemia: A Single-Center Study From Central Thailand by Malasai K, Jittikoon J, Udomsinprasert W, Talungchit P, Youngkong S, Sangroongruangsri S, Mahasirimongkol S, Chaikledkaew U

“…From a governmental perspective, with a full uptake of genetic testing, the incremental budget required was estimated to be 3.7 million USD (131 million THB) for one year.Conclusion: These findings are particularly valuable for policymakers, as they provide robust evidence supporting potential revisions to the reimbursement structure within Thailand’s Universal Health Coverage benefit package, facilitating better management of thalassemia and improving prenatal care.Keywords: cost-benefit analysis, genetic testing, prenatal screening, thalassemia, pregnancy…”
Get full text

Development of Injectable Formulation of 4’-O-benzyloxycarbonyl-etoposide Derivative Based on Human Serum Albumin for the Chemotherapy of Breast Cancer by T. S. Kovshova, S. A. Boiko, M. A. Merkulova, N. S. Osipova, N. I. Moiseeva, Ju. A. Malinovskaya, S. N. Mantrov, S. E. Gelperina

“…Development of the injectable formulation of a novel 4'-О-benzyloxycarbonyl derivative of etoposide (ETP-cbz) based on human serum albumin and evaluation of its cytotoxicity against breast carcinoma cells (BC).Materials and methods. The structure of ETP-cbz was confirmed by NMR spectroscopy and elemental analysis; log P was calculated in silico using Molinspiration Cheminformatics. …”
Get full text