Research on sediment reduction benefits of engineering measures on waste rock slope under different rainfall intensities by Yuning ZHANG, Gang LYU, Taiyu ZHANG, Shuzhen XIONG

“…The dump slope of open-pit coal mines is characterized by steep gradients, loose structure, and poor stability, leading to severe soil erosion under heavy rainfall. …”
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Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin by Bayazit Yunusbayev, Anna Bogdanova, Nadezhda Nadyrchenko, Lavrentii Danilov, Viktor Bogdanov, Grigory Sergeev, Radick Altinbaev, Fanil Bilalov, Milyausha Yunusbaeva

“…We found no evidence for depleted gut community diversity and apparent divergence in structure between patients and healthy individuals. …”
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Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells by Giulia Girolimetti, Sinforosa Gagliardi, Paola Cordella, Grazia Bramato, Riccardo Di Corato, Roberta Romano, Flora Guerra, Cecilia Bucci

“…Seahorse assays, Western blot analysis, mitochondrial staining, and Transmission Electron Microscopy (TEM) were used to assess silencing effects on mitochondrial structure and functioning. Western blotting was used to investigate expression of late endocytic pathway proteins and of the invasion marker vimentin. …”
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Correlation between severity of knee joint osteoarthritis and alignment of patellofemoral and patellar height on radiographs by Zhenlei Yang, Mingjie Shen, Deshun Xie, Junzhe Zhang, Qingjun Wei, Yanjie Yin

“…The correlation between the morphological structure of the patellofemoral joint (PFJ) and the severity of knee joint osteoarthritis (KOA) remains uncertain. …”
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Medical Marijuana Documentation Practices in Patient Electronic Health Records: Retrospective Observational Study Using Smart Data Elements and a Review of Medical Records by Donielle Beiler, Aanya Chopra, Christina M Gregor, Lorraine D Tusing, Apoorva M Pradhan, Katrina M Romagnoli, Chadd K Kraus, Brian J Piper, Eric A Wright, Vanessa Troiani

“…This absence of a formal data sharing structure necessitates tools aiding in consistent documentation practices to enable comprehensive patient care. …”
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Antimicrobial peptides (AMPs) of lizards: a first comprehensive characterization of beta-defensins, ovo-defensins and cathelicidins from Podarcis lilfordi and closely related Lacer... by Katherin Otalora, Jessica Gómez-Garrido, Laura Baldo

“…Abstract Background Reptiles exhibit remarkable resistance to infections, making them a critical model for studying the molecular basis of innate immunity. …”
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Core histones govern echinocandin susceptibility in Candida glabrata by Aditi Pareek, Rupinder Kaur

“…ABSTRACT The dynamic chromatin structure regulates many biological processes including gene expression, DNA repair, and genome stability in eukaryotic cells. …”
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Identifying Key Drivers Influencing the Future of Auditing: A Meta-Synthesis Approach by Mohammad Javad Mansouri, Gholamreza Karami, Hamid Reza Yazdani

“…Additionally, 34 drivers related to the near environment were organized into eight general categories: human resources, academic and professional education, audit procedures and approaches, professional structure, stakeholders, work standards, reporting frameworks and corporate governance, and customers and the business environment. …”
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Improving Patient Communication by Simplifying AI-Generated Dental Radiology Reports With ChatGPT: Comparative Study by Daniel Stephan, Annika S Bertsch, Sophia Schumacher, Behrus Puladi, Matthias Burwinkel, Bilal Al-Nawas, Peer W Kämmerer, Daniel GE Thiem

“…Questionnaire results revealed significantly higher ratings for texts 2 and 3 across clarity (P<.001), tone (P<.001), structure, and patient engagement. For example, patients rated the ability to understand findings without help highest for text 3 (mean 1.5, SD 0.7) and lowest for text 1 (mean 3.1, SD 1.4). …”
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Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism by Yujie Huang, Weiqi Xu, Wei Dong, Guijie Chen, Yi Sun, Xiaoxiong Zeng

“…Additionally, analysis of gut microbiota structure and functions was conducted concurrently with the examination of DiCQAs’ impact on gut microbiota carrying the bile salt hydrolase (BSH) gene, as well as on the enterohepatic circulation of BAs and related signaling pathways. …”
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A novel function of short cationic peptide FP-CATH9 without antimicrobial activity reverses resistance to minocycline in common multidrug-resistant gram-negative bacteria by Yingqi Tang, Jiye Liu, Jiani Yan, Zhixiong Xie, Lipeng Zhong

“…FP-CATH9 is a short cationic peptide derived from FP-CATH (snake cathelicidin antimicrobial peptide) with an amphiphilic α-helical structure and no discernible antibacterial activity. …”
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Research on the Bearing Characteristics of Narrow Coal Pillars in Double-Roadway Excavation Under the Influence of Full Dynamic Pressure by Wei Gu, Hao Zhang, Zhenfei Han, Haokun Tang, Jingyong Pei, Shixin Wu, Dalong Xu

“…Taking the 2109 double-roadway excavation of Qingwa Coal Mine as the engineering background, the roof mechanical structure model of a narrow coal pillar in a double-roadway excavation layout was established, and the bearing characteristics of different coal pillar widths under the influence of full dynamic pressure were studied. …”
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Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration by Dan Wu, Chen Yan, Linhui Han, Fudong Li, Ximing Xu, Jingchuan Sun, Yong Cao, Kaiqiang Sun, Jiangang Shi, Yuan Wang

“…Through integrative analysis of single-cell RNA-seq data from intervertebral discs (IVDs), we have firstly uncovered that the aberrant accumulation of R-Loops—a type of triple-stranded nucleic acid structure—can result in the cytoplasmic accumulation of double-stranded DNA (dsDNA) and activate cGAS/STING signaling and induce cellular senescence in nucleus pulposus cells (NPCs) during IVDD. …”
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595 Is PHASTR faster? A target trial emulation case study in the N3C by Steve Johnson, Carolyn Bramante, Til Stürmer, John Buse, Talia Wiggen, Jared Huling, Andrew Toler

“…The PHASTR contract structure helped produce high-quality results quickly by not only providing funding but also requiring a compressed timeline for a small team to focus on the study. …”
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Dynamics of Steel Gas Pipelines: Finite Element Simulation of Damaged Sections Reinforced with Composite Linings by Arman Moldagaliyev, Nurlan Zhangabay, Marco Bonopera, Raimberdi Ristavletov, Ulzhan Ibraimova, Shairbek Yeshimbetov

“…In this case, the oscillation modes significantly differ from those of the same pipeline structure when unloaded. The results ensure the optimal stress distribution in the defect area of a steel pipeline wall and improve the reliability and safety of pipelines under seismic actions. …”
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Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment by Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um, Wootae Ha, Soo Min Lee, Junseong Park, Min Jeong Kye, Jungyo Suh, Jin Woo Choi

“…Considering the challenges of limited pharmaco-accessibility to the bladder due to its pathophysiological structure and the partially undruggable nature of target molecules, we designed a dual siRNA system targeting both mRNAs. …”
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M6A Methyltransferase METTL3 Modulates Traumatic Brain Injury by Targeting Ferroptosis by Fei Qin, Fan Li, Wenxiao Zhao, Suqin Zhang, Jiang Shen, Xinyu Yang

“…Background: Traumatic brain injury (TBI) is a disease caused by external forces that damage brain structure and function. After TBI, iron accumulation and reactive oxygen species (ROS) increase lipid peroxidation, promoting ferroptosis. …”
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Giant transposons promote strain heterogeneity in a major fungal pathogen by Emile Gluck-Thaler, Adrian Forsythe, Charles Puerner, Cecilia Gutierrez-Perez, Jason E. Stajich, Daniel Croll, Robert A. Cramer, Aaron A. Vogan

“…These findings support a new model of fungal evolution wherein Starships help generate variation in genome structure, gene content, and expression among fungal strains. …”
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Rheological properties study of high-viscosity asphalt based on direct coal liquefaction residue by Liu Yong, Wang Yong, Ru Yanyan, Li Yandan, Li Yongxiang, Gao Zhong

“…Fluorescence microscopy results revealed that the DCLR system formed a stable three dimensional colloidal skeleton structure between the modifier molecules and the asphaltenes, which is the fundamental reason for its superior performance and low-temperature properties compared to the LT high-viscosity asphalt.…”
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Effects of Electroacupuncture on Syt3 and GluA2 in Rats With Limb Spasms After Intracerebral Hemorrhage by Xudong Lu, Huiling Ren, Hequn Chen, Guosheng Shi, Xuanbo Luo, Kai Liu, Qinglin Zhao, Dawei Zhao, Changfa Li, Wei Bu

“…Rats in the EA group showed increased neuron numbers, normal mitochondrial morphology, and improved synaptic structure in Nissl staining, immunofluorescence, and transmission electron microscopy. …”
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